Successful Long-Term Treatment of Pediatric Relapsing Idiopathic Optic Neuritis with Mycophenolate Mofetil by Shuhei Fujino, Keiji Akamine, Eiichiro Noda, Sahoko Miyama

“…Corticosteroids are typically used for acute management; however, their prolonged use in children poses significant risks, including central obesity, hypertension, and growth impairment, underscoring the need for nonsteroidal, long-term treatment options. …”
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Management of an infectious complication appearing in a transcanine implant: a case report by Maxime Delarue, Pierre Klienkoff, Mélanie Le Ven, Fabien Bornert

“…But in the longer term an implant therapy is nevertheless indicated. Case presentation A 42-year-old man presented with persistent swelling and pain in the maxillary region associated with a transcanine implant placed one year ago by his dental practitioner. …”
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The enigmatic wandering spleen: managing three cases in a tertiary setting by Mohammed Al Blooshi, Abdalla Aboelkheir, Avinash Hiremath, Ghadir Jaber, Mamoun AlMarzouqi

“…In pediatric patients, this condition can present with vague abdominal symptoms or acute torsion leading to infarction, posing a significant diagnostic challenge. …”
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Breast cancer survival in a rural setting in the Busoga Region of Uganda by Rasmus Kallestrup, Katinka Bolette Lorentzen, John Mwayi, Joanita Mbabazi, Per Kallestrup, Troels Alnor Einarson

“…Abstract Background Breast cancer (BC) poses a significant health challenge globally. While high-income countries benefit from robust healthcare systems, sub-Saharan Africa (SSA) faces elevated BC mortality rates. …”
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Confronting Dual Therapeutic Hurdles in Advanced HIV: A Case Report on INSTIs Resistance and Talaromyces marneffei Coinfection by Zou L, Diao Y, Huang Z, You C

“…Lun Zou, Yuting Diao, Zhihao Huang, Chunfang You Department of Infectious Diseases, Zigong First People’s Hospital, Zigong, Sichuan, People’s Republic of ChinaCorrespondence: Chunfang You, Department of Infectious Diseases, Zigong First People’s Hospital, No. 42, Shangyihao Branch Road 1, Zigong, Sichuan, 643000, People’s Republic of China, Email 2421662719@qq.comBackground: Treating patients with human immunodeficiency virus (HIV) integrase strand transfer inhibitors (INSTIs) resistance and concurrent Talaromyces marneffei (T. marneffei) infection poses a significant clinical challenge, requiring precise antiretroviral adjustments, timely anti-infection, and management of complex drug interactions.Case Presentation: Interrupted antifungal therapy and INSTIs resistance in an HIV patient coinfected with T. marneffei resulted in severe immunosuppression. …”
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Internet generation in religious cyberspace: worldview challenges of the digital age by Ірина Ломачинська, Юлія Гришина

“…The relevance and novelty of the research consists in determining the specifics of the religious cyberspace func-tioning in the context of the spiritual and intellectual needs of the Internet generation, clarifying the essence of worldview challenges that the globalized digital age poses to young people in the religious cyberspace. …”
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Primary Cerebral Venous Thrombosis in a Patient with Immune Thrombocytopenic Purpura by M. Taher Farfouti, Christina Masri, Mike Ghabally, George Roumieh

“…Her past medical history was significant for immune thrombocytopenic purpura that was treated with prednisolone 40 mg per day which posed a therapeutic challenge. High-dose prednisolone and platelet transfusion were initiated; enoxaparin was administrated and switched to warfarin after stabilization of platelet count. …”
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Lactic acidosis in hemophagocytic syndrome: diagnostic and therapeutic challenges in the intensive care unit—a case series by Tianqi Xu, Ming Tang, Meiqing Wu, Xiaoyan Xue

“…Severe lactic acidosis (lactate ≥ 10 mmol/L), a rare yet critical manifestation, poses unique diagnostic and therapeutic challenges in the intensive care unit. …”
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Application of Nuclear Medicine Liver-Spleen Scan for Evaluation of Littoral Cell Angioma of the Spleen: A Case Report by Aren Dermarderosian BS, Raffi Boghossian, Derek Tai DO, Javid Sadjadi MD, Mojtaba Akhtari MD

“…This case highlights the diagnostic challenge posed by LCA due to its nonspecific clinical presentation and imaging findings. …”
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Polymyalgia rheumatica - risk factors, pathogenesis, diagnostic methods, treatment - new literature reports by Anita Warzocha, Anita Krowiak, Gabriela Majka, Piotr Pitrus, Karolina Krowiak, Magdalena Kowalczyk, Karol Bednarz, Maria Jasiewicz, Wiktoria Hander, Aleksandra Karnas

“…Summary Polymyalgia rheumatica continues to pose diagnostic and therapeutic challenges, particularly in patients with atypical presentations or treatment resistance. …”
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Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models by Saige K. Power, Sridevi Venkatesan, Sarah Qu, JoAnne McLaurin, Evelyn K. Lambe

“…We identified a significant and selective increase in post-synaptic nicotinic receptor signalling on prefrontal cortical neurons. …”
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All-Optical Format Conversion for Rectangular 8QAM Signals Based on Phase-Sensitive Amplification and Nonlinear Mach-Zehnder Interferometer by Qiankun Li, Xiongwei Yang, Huashun Wen, Yameng Li, Qi Xu, Jiali Yang, Pengfei Xu, Huajun Yang

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Management of urethral strictures and stenosis caused by the endo-urological treatment of benign prostatic hyperplasia—a single-center experience by Rajiv N. Kore

“…Overall average symptom score, flow rate, and post-void residue changed from 21 to 7, 6 mL/s to 19 mL/s, and 210 mL to 20 mL, respectively. …”
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Effect of regular physical activities and daytime nap intervention on enhancing mental health and self-esteem in healthy participants by Mohammad Ahsan, Mohammed Feroz Ali, Abdullah Alzahrani, Abdullah Alhusayni, Mumtaz Alam

“…To obtain these benefits and preserve a quality of life, daily physical exercises and mandatory rest are necessary. …”
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Study on the Basic Mechanical Properties of Waste Steel Fiber Reinforced Concrete After High-Temperature Exposure by Dan Yang, Xiaopeng Ren, Yongtao Gao, Tao Fan, Mingshuai Li, Hui Lv

“…The increasing incidence of urban fires poses significant threats to structural integrity, underscoring the urgent need for concrete materials with enhanced mechanical properties post-fire. Incorporating recycled waste steel fibers (WSF) from industrial byproducts into concrete not only bolsters its crack resistance but also advances circular economy principles by transforming industrial waste into valuable resources. …”
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Twenty-Four-Year Follow-up of Successful Total Hip Arthroplasty for Recurrent Proximal Femoral Aneurysmal Bone Cyst with a Pathologic Fracture Following Extended Curettage and Bone... by Javahir A Pachore, Vikram I Shah, H R Jhunjhunwalla, Clint Babu, Apurve Parameswaran, Krishna Kiran Eachempati

“…He was permitted partial weight-bearing for six weeks post-operatively, and full weight-bearing thereafter. …”
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Cryopreserved leukapheresis enables scalable and distributed CAR-T manufacturing: a multi-platform comparative study by Menglin Ren, Xiaodie Wang, Jiangrui Chen, Yuanjian Xu, Yan Sun, Tao Liu, Qijun Qian, Zenghui Xu

“…Initial viability (91.0%) was lower than fresh samples (99.0%), but functional recovery post-electroporation and compatibility with both platforms were confirmed. …”
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Review of Grippol Family Vaccine Studies and Modern Adjuvant Development by A. V. Karaulov, A. S. Bykov, N. V. Volkova

“…It contains a reduced antigen doses and adjuvant Polyoxidonium, but unlike the vaccine Grippol® is free from preservative thiomersal. There are no serious post-vaccination events, unexpected reactions, post-vaccinal complications to the vaccine were reported for Grippol regardless of the examined contingent. …”
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Clinical Outcomes of Allograft Superior Capsular Reconstruction for Irreparable Posterosuperior Rotator Cuff Tears in Patients Aged 65 and Older: A Retrospective Study by Hsin-Pei Sung, Wei-Cheng Chen, Yung-Chang Lu, Tsung-Yu Lin, Po-Ju Wu

“…Each patient underwent postoperative assessment, including routine radiographic analysis for acromiohumeral distances, ultrasound imaging at 1 and 3 months post-SCR, and magnetic resonance imaging (MRI) at least 6 months post-SCR. …”
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Evaluation of the Effectiveness of the UNet Model with Different Backbones in the Semantic Segmentation of Tomato Leaves and Fruits by Juan Pablo Guerra Ibarra, Francisco Javier Cuevas de la Rosa, Julieta Raquel Hernandez Vidales

“…A comparison of the best results of semantic segmentation versus those obtained with a color-dominant segmentation method optimized with a greedy algorithm is presented.…”
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