Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids by Verena Schmied, Medina Korkut-Demirbaş, Alessandro Venturino, Juan Pablo Maya-Arteaga, Sandra Siegert

“…Abstract Prenatal immune challenges pose significant risks to human embryonic brain and eye development. …”
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Confidence-Based Knowledge Distillation to Reduce Training Costs and Carbon Footprint for Low-Resource Neural Machine Translation by Maria Zafar, Patrick J. Wall, Souhail Bakkali, Rejwanul Haque

“…This could pose a challenge for translation service providers (TSPs), as they may have limited budgets for training. …”
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Lightweight Deep Learning Model for Fire Classification in Tunnels by Shakhnoza Muksimova, Sabina Umirzakova, Jushkin Baltayev, Young-Im Cho

“…Tunnel fires pose a severe threat to human safety and infrastructure, necessitating the development of advanced and efficient fire detection systems. …”
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Predicting the Evolution of Extreme Water Levels With Long Short‐Term Memory Station‐Based Approximated Models and Transfer Learning Techniques by Samuel Daramola, David F. Muñoz, Paul Muñoz, Siddharth Saksena, Jennifer Irish

“…Abstract Extreme water levels (EWLs) resulting from cyclones pose significant flood hazards and risks to coastal communities and interconnected ecosystems. …”
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Influence of Talc Substitution with Starches from Different Botanical Origins on Rheological and Absorption Properties of Stiff Zinc Oxide Paste Formulations by Dragana Zaklan, Nikola Davidović, Jovana Milutinov, Dejan Ćirin, Veljko Krstonošić, Nebojša Pavlović

“…However, prolonged use of talc, usually present in zinc oxide pastes, may pose health risks due to potential contamination with asbestos and quartz, highlighting the need for alternative excipients. …”
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Deeply supervised two stage generative adversarial network for stain normalization by Zhe Du, Pujing Zhang, Xiaodong Huang, Zhigang Hu, Gege Yang, Mengyang Xi, Dechun Liu

“…Abstract The color variations present in histopathological images pose a significant challenge to computational pathology and, consequently, negatively affect the performance of certain pathological image analysis methods, especially those based on deep learning techniques. …”
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YED-Net: Yoga Exercise Dynamics Monitoring with YOLOv11-ECA-Enhanced Detection and DeepSORT Tracking by Youyu Zhou, Shu Dong, Hao Sheng, Wei Ke

“…Future work aims to integrate 3D pose estimation to develop a closed-loop biomechanical analysis system, thereby advancing sports science toward intelligent decision-making paradigms.…”
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DRLinSPH: an open-source platform using deep reinforcement learning and SPHinXsys for fluid-structure-interaction problems by Mai Ye, Hao Ma, Yaru Ren, Chi Zhang, Oskar J. Haidn, Xiangyu Hu

“…Fluid-structure interaction (FSI) problems are characterized by strong nonlinearities arising from complex interactions between fluids and structures. These pose significant challenges for traditional control strategies in optimizing structural motion, often leading to suboptimal performance. …”
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De Hegel à Sartre : la question du sens de l’histoire et ses enjeux by Benjamin EYOUNGA

“…Résumé : Dans un monde où les actes humains constituent la matière qui anime le processus historique temporel (le passé, le présent et le futur), on se demande si l’humanité n’a pas toujours été au cœur de l’histoire. …”
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Nocardia otitidiscaviarum meningitis in an immunocompetent patient diagnosed by metagenomic next-generation sequencing: a case report by Ping Chen, Juan Li, Ping-Xian Liu, Hui Gou, Ming Yu, Lin-Lin Li, Luwen Huang

“…This opportunistic infection may also pose life-threatening risks to immunocompetent individuals. …”
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Detection of calcium deficiency in indoor-grown lettuce under LED lighting using computer vision by Zhian Li, Saeed Karimzadeh, Alise Chavanapanit, Ali Moghimi, Md Shamim Ahamed

“…Calcium deficiency and its associated physiological disorders, such as tip burn, pose considerable challenges for indoor hydroponic lettuce production, impacting both yield and quality. …”
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Recommendations for the Diagnosis, Treatment, and Management of Gestational and Congenital Toxoplasmosis in Brazil by Lara Ferreiro Cassemiro, Igor Rosa Meurer, Karolayne Helena Capistrano Andrade, Lauren Hubert Jaeger

“… Toxoplasmosis is a zoonosis caused by the protozoan Toxoplasma gondii. It presents severity in patients of certain risk groups, such as pregnant women, fetuses, newborns, and immunocompromised patients. …”
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Spontaneous transient size reduction of a solitary pulmonary metastasis from a leiomyosarcoma by Nao Ito, Shuhei Iizuka, Kanji Sasaki, Yoshiro Otsuki, Toru Nakamura

“…Abstract Background A solitary pulmonary nodule (SPN) poses a diagnostic challenge, which includes both a benign and malignant etiology. …”
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Septic pulmonary embolism at a tertiary care hospital in Bahrain: clinical features and treatment outcomes by Amit Panjwani, Husain Kadhem, Subhi Isa Akleh, Jalila Sayed Mohamed, Sornali Roy, Layal Omaruddin

“…Introduction Septic pulmonary embolism (SPE) is a type of nonthrombotic pulmonary embolism that poses a clinical challenge due to its rarity of occurrence, varied presentation, and need for distinctive diagnostic and management options. …”
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The Public and Private Epistolary Practice of Giovanni Querini, Ambassador of the Venetian Republic in Spain (1768-1773) by Javier ANTÓN PELAYO

“…Through examination of the official letters sent by him to his government and though the correspondence he maintained with his wife Caterina Contarini, the author describes the contingencies of the post, the duality of these epistolary discourses and the effectiveness of private letters for preserving marital intimacy and family sociability from a distance.…”
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Semantic-Aware Low-Light Image Enhancement by Learning from Multiple Color Spaces by Bo Jiang, Xuefei Wang, Naidi Yang, Yuhan Liu, Xi Chen, Qiwen Wu

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Two‐Stage Tumor Resection for Locally Advanced Renal Cell Carcinoma With Level IV Tumor Thrombus and Pulmonary Embolism: A Case Report by Takanari Kambe, Kei Mizuno, Yuki Teramoto, Takayuki Sumiyoshi, Yuki Kita, Kimihiko Masui, Takayuki Goto, Shusuke Akamatsu, Ryoichi Saito, Takashi Kobayashi

“…ABSTRACT Introduction We report a case of renal cell carcinoma with an inferior vena cava tumor thrombus extending into the right atrium and pulmonary embolism, treated using a staged surgical approach. Case Presentation A man in his 60s was diagnosed with left clear cell renal cell carcinoma with a tumor thrombus extending to the right atrium, posing a risk of sudden death. …”
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Robot‐Assisted Laparoscopic Radical Nephrectomy in a Renal Cell Carcinoma Patient With Severe Scoliosis: A Case Report by Tatsuya Kawamura, Daiki Ikarashi, Ayato Ito, Ei Shiomi, Shigekatsu Maekawa, Renpei Kato, Mitsugu Kanehira, Ryo Takata, Wataru Obara

“…ABSTRACT Introduction Laparoscopic nephrectomy in patients with severe scoliosis presents significant challenges due to altered anatomy and limited space. …”
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Saffron—Crocus sativus L. by James M. Stephens

“…The document details harvesting practices, emphasizing the labor-intensive process of hand-picking stigmas during a short blooming period. It also describes post-harvest handling and storage to preserve saffron’s quality, and highlights its culinary uses and distinctive flavor profile. …”
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Impact of Mother Wavelet Choice on Fast Wavelet Transform Performances for Integrated ST Segment Monitoring by Béatrice Guénégo, Caroline Lelandais-Perrault, Emilie Avignon-Meseldzija, Gérard Sou, Philippe Bénabès

“…It exhibits an area utilization of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1.18</mn></mrow></semantics></math></inline-formula> mm² and a post-layout power consumption of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>4.89</mn></mrow></semantics></math></inline-formula> <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>W, while preserving the ST segment in compliance with the IEC standard, thanks in particular to its effective baseline wandering filtering of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>6.9</mn></mrow></semantics></math></inline-formula> dB. …”
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