MicroRNA-Based Delivery Systems for Chronic Neuropathic Pain Treatment in Dorsal Root Ganglion by Stefan Jackson, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, Roberta Censi

“…Neuropathic pain is a significant global clinical issue that poses substantial challenges to both public health and the economy due to its complex underlying mechanisms. …”
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Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the treatment and control of hookworm infections in dogs by Samuel Charles, Katrin Deuster, Xinshuo Wang, Scott Wiseman, Craig R. Reinemeyer, Luther van der Mescht, Abdelmoneim Mansour, Imad Bouzaidi Cheikhi, Lisa Young

“…Abstract Background Hookworms, specifically Ancylostoma caninum and Uncinaria stenocephala, have a clinical impact on the health of dogs, with A. caninum posing a zoonotic risk worldwide. The studies presented here were conducted to evaluate the efficacy of a novel, oral chewable tablet (Credelio Quattro) containing lotilaner, moxidectin, praziquantel, and pyrantel (as pamoate salt) against fourth-stage larvae (L4), immature adult, and adult A. caninum, as well as adult U. stenocephala, infections in dogs. …”
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LNT-YOLO: A Lightweight Nighttime Traffic Light Detection Model by Syahrul Munir, Huei-Yung Lin

“…Traffic light detection systems, as a key part of autonomous vehicles, play a key role in navigation during challenging traffic scenarios. Nighttime driving poses significant challenges for autonomous vehicle navigation, particularly in regard to the accuracy of traffic lights detection (TLD) systems. …”
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Development of a candidate mRNA vaccine based on Multi-Peptide targeting VP4 of rotavirus A: an immunoinformatics and molecular dynamics approach by Cena Aram, Leila Karami, Mohammad Mehdi Ranjbar

“…With significant morbidity and mortality, this pathogen poses a serious global health challenge, particularly in underdeveloped countries. …”
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Wearable device-based interventions in heat-exposed outdoor workers — a scoping review and an explanatory intervention model by Julian Friedrich, Teresa S. Schick, Filip Mess, Simon Blaschke

“…Abstract Background Global climate change poses a challenge to the health prevention of heat-exposed outdoor workers. …”
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The impact COVID-19 pandemic on coverage and inequalities in childhood immunization in Peru by Larissa A N Silva, Francine S Costa, Bianca O Cata-Preta, Luis Huicho, Claudio F Lanata, Maria Ana Mendoza Araujo, Theresa J Ochoa, Tewodaj Mengistu, Dan Hogan, Aluisio J D Barros, Cesar G Victora

“…Since the 1990s, Peru has worked to improve childhood vaccine coverage, but the COVID-19 pandemic posed significant challenges to the health system. …”
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Attapulgite/oyster shell composite reduces cadmium and lead bioavailability in acidic agricultural soils through synergistic adsorption and pH regulation by Hongyan Zhu, Yangping Wen, Qingyin Shang, Xinyu Chen, Yuzhen Huang, Peiyue Liu, Chengcheng Wang, Xiuxia Yang

“…Abstract Heavy metal contamination in acidified agricultural soils poses significant environmental and health risks. …”
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Deep Classification of Algarrobo Trees in Seasonally Dry Forests of Peru Using Aerial Imagery by Wilson Castro, Himer Avila-George, William Nauray, Roenfi Guerra, Jorge Rodriguez, Jorge Castro, Miguel de-la-Torre

“…Seasonally dry forests require tailored strategies to address the challenges posed by deforestation and desertification, particularly for the conservation of protected tree species. …”
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Comprehensive evaluation and mechanisms of Bacillus velezensis AX22 against rice bacterial blight by Xin Shan, Jiawei Dai, Zhaofeng Xu, Yuting Diao, Ning Yang, Yongjie Fan, Meiqi Ma, Jiahui Zhao, Xiang Li, Shenghan Gao, Ming Xiao, Junmin Pei

“…Rice bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo) poses a serious threat to global rice production, leading to substantial yield losses. …”
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An Optimal Internet of Things-Driven Intelligent Decision-Making System for Real-Time Fishpond Water Quality Monitoring and Species Survival by Saima Kanwal, Muhammad Abdullah, Sahil Kumar, Saqib Arshad, Muhammad Shahroz, Dawei Zhang, Dileep Kumar

“…This study marks a significant step forward in climate-smart aquaculture, contributing to enhanced fish health, survival, and yield while mitigating the risks posed by climate change on aquatic ecosystems.…”
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Use of agroindustrial wastes as pozzolanic materials in cementitious systems: A review by Elias Rocha Gonçalves Júnior, Juliana Fadini Natalli, Marília Gonçalves Marques, Afonso Rangel Garcez de Azevedo, Markssuel Teixeira Marvila

“…Additionally, solid waste management poses a major challenge for society, given the diversity and quantity of waste, as well as population growth and consumption trends. …”
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N‐methylation of histidine to tune tautomeric preferences in histidine‐heme coordination and enzyme‐mimetic catalysis by Ruikai Du, Yunbo Lv, Haifeng Wu, Baoli Zhang, Yuanxi Liu, Shichao Xu, Shan Li, Zhen‐Gang Wang

“…However, evaluating the impact of Nδ and Nε is difficult, and directly integrating noncanonical N‐methylated histidine within enzymes poses risks due to laborious procedures. In this study, we present the self‐assembly of Fmoc‐Histidine (Fmoc‐His) with hemin to create a peroxidase‐mimetic catalyst, in which either the Nε or Nδ of histidine is methylated to modify the tautomeric preferences, thereby tuning hemin catalysis. …”
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YOLOv8-Scm: an improved model for citrus fruit sunburn identification and classification in complex natural scenes by Guoxun Cong, Guoxun Cong, Xinghong Chen, Xinghong Chen, Zongyu Bing, Zongyu Bing, Wenhuan Liu, Wenhuan Liu, Xiangling Chen, Qun Wu, Zheng Guo, Zheng Guo, Yongqiang Zheng, Yongqiang Zheng

“…In recent years, global warming has intensified extreme weather events, such as prolonged high temperature and strong solar radiation, posing increasing risks to citrus production,leading to significant economic losses. …”
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Urban morphology impacts on urban microclimate using artificial intelligence – a review by Ahmed Marey, Jiwei Zou, Sherif Goubran, Liangzhu Leon Wang, Abhishek Gaur

“…Despite extensive research in this field, these effects are intensified by climate change and rapid urbanization, posing challenges to urban sustainability, such as poor air quality, increased energy demands, and pedestrian discomfort. …”
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A Case Series of Septicemia Due to Community-acquired Panton–Valentine Toxin Positive Methicillin-resistant <i>Staphylococcus aureus</i> in Children in Abidjan, Côte d'Ivoire by Richard Azagoh-Kouadio, Adjoua Sonia Djè, Sy Kadidia Savané, Claude Ghislain Tué-Bi, Toutou Ismael Koné, Sanemba Aya Fanny, Melissa Cardenat

“…The emergence of highly virulent resistant strains such as MRSA-PVL is associated with severe infections and poses a threat to child health in resource-limited settings, where their recognition and treatment are often delayed. …”
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Leveraging ribosomal RNA as a molecular target for vaccine development against Acinetobacter baumannii by Elijah Kolawole Oladipo, Glory Jesudara Oluwasanya, Esther Oluwadarasimi Adaramola, Gbemisola Omolara Morawo, Blessing Jephthah Oluwalemu, Victor Oluwatobi Afolabi, Praise Akanni, Joel Damilare Ajagbe, Oluwadara Hannah Ojo, Fikayo Deborah Olayiwola, Shalom Busayo Akintola, Chris Olamide Balogun, Emmanuel Pelumi Kolapo, Ayomiposi Isaiah Oshoneye, Stephen Feranmi Adeyemo, Boluwatife Ayobami Irewolede, Bamidele Abiodun Iwalokun, Oluwatosin Akinola Ajibade, Olatunji Matthew Kolawole, Olubukola Monisola Oyawoye, Julius Kola Oloke, Helen Onyeaka

“…This characteristic of Acinetobacter baumannii as a multiple-drug resistant (MDR) organism poses a critical global health challenge, necessitating an urgent need for alternative therapeutic strategies, such as vaccine development, as a preventive measure. …”
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An overall study on efficient Cr (VI) adsorbents for improving of the application value of Chlorella pyrenoidosa by Yi-Tong Wang, Liang-Yi Zhang, Le-Le Kang, Ya-Jun Wang, Jun-Guo Li, Hang Zhao, Kai-Li Dong, Hong-Peng Li, Xuan Guo, Ren-Long Dong, Ming-Ming Chen, Zhen Fang

“…Chromium (Cr) is one of the most common pollutants in aquatic ecosystems, posing a serious threat to environmental protection and biological survival. …”
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Clinical lipidomics reveals high individuality and sex specificity of circulatory lipid signatures: a prospective healthy population study by Jessica Medina, Nicolas Goss, Gonçalo dos Santos Correia, Rebecca Borreggine, Tony Teav, Zoltan Kutalik, Pedro Marques Vidal, Hector Gallart-Ayala, Julijana Ivanisevic

“…The most prominent sex differences were reported for sphingomyelins and ether-linked phospholipids present in significantly higher concentrations in female plasma. …”
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Correlation of β2-microglobulin with postoperative delirium and 3-year mortality undergoing knee or hip replacement surgery: a prospective cohort study by Yuanlong Wang, Yuanlong Wang, Qian He, Kun Fu, Yanlin Bi, Bin Wang, Wenjie Kong, Wenjie Kong, Shuhui Hua, Shuhui Hua, Jian Kong, Jian Kong, Shanling Xu, Shanling Xu, Hongyan Gong, Jiahan Wang, Chuan Li, Yanan Lin, Xu Lin

“…The results of the logistic regression analysis indicated that B2M (OR = 1.394, 95% CI = 1.017–1.910, p = 0.002) and T-tau (OR = 1.006, 95% CI = 1.002–1.011, p = 0.007) posed a risk for POD. B2M and POD were partially associated through the mediation of CSF T-tau (10.0%). …”
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A Review on Innovative Biotechnological Approaches for the Upcycling of Citrus Fruit Waste to Obtain Value-Added Bioproducts§ by Mahalingam Divyasakthi, Yerasala Charu Lekha Sarayu, Dilip Kumar Shanmugam, Guruviah Karthigadevi, Ramasamy Subbaiya, Natchimuthu Karmegam, J. Jessica Kaaviya, Woo Jin Chung, Soon Woong Chang, Balasubramani Ravindran, Kuan Shiong Khoo

“…This in turn contributes to landfills and environmental pollution, and poses a risk to human health and the ecosystem. Proper recycling of citrus waste helps reduce pollution and also serves as a sustainable source for the production of different bio-based products. …”
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