Model systems for emulating human tissue and physiology in psychiatric research by Kai Cheng, Anannya Kshirsagar, John Nixon, Jonathan Lau, Kun Yang, Akira Sawa, Annie Kathuria, Annie Kathuria

“…The modeling of psychiatric disorders poses significant challenges due to the complex nature of these conditions, which encompass a range of neuropsychiatric diseases such as autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), post-traumatic stress disorder (PTSD), anxiety disorder (AD) and depression. …”
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Identification of novel variants in carbamoyl phosphate synthetase 1 gene and comparative pathogenicity assessments of CPS1 missense variants following ACMG/AMP-ClinGen recommendat... by Fei Li, Qin Cai, Wei Ji, Miao Xu, Guoli Tian, Fanyi Zeng

“…Since the employment of genetic testing as a clinical diagnostic tool, distinguishing pathogenic from polymorphic changes poses significant problems for geneticists. As recommendation for PP3/BP4, the computational tools for missense variant have been published, we performed a comparative evaluation for pathogenicity interpretation in our patients and in ClinVar database regarding CPS1 missense variants under the updated guidelines of ACMG/AMP-ClinGen. …”
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Eco-friendly approach to corrosion inhibition of aluminum by Congo red dye in alkaline media: Experimental assessment, QSAR modeling, diffusion studies, and DFT/MC/MD simulations by Ayoub Chahid, Said Meftah, Mohamed Essahli, Mohammed Chafi, Rachid Kellal, Driss Benmessaoud Left, Mustapha Zertoubi

“…Aluminum corrosion in alkaline media poses a significant limitation for its industrial use. …”
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Prevalence of bacterial contamination on wild meat processing and cooking surfaces in rural Cameroon by Sara M. Soto, Laura Castellsagués, Victoria Ballén, Yaiza Gabasa, Pedro Mayor, Guillermo Ros Brull, Stephan M. Funk, Julia E. Fa

“…The transmission of food-borne pathogens from wildlife to humans presents a significant public health challenge. The recent COVID-19 pandemic has highlighted the critical need to enhance our understanding of wild animals' role in transmitting infectious diseases. …”
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Modern radiation-hygienic state of the territories of the Globus-4 and Gorizont-1 peaceful nuclear explosions in the Komi Republic by A. M. Biblin, K. V. Varfolomeeva, K. A. Sednev, S. A. Ivanov, V. S. Repin, A. G. Georgieva

“…The article presents results of a study of the radiation environment on territories adjacent to the sites of the “Globus-4” and “Gorizont-1” peaceful nuclear explosions in the Komi Republic. …”
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A phage-displayed nanobody-based competitive immunoassay for the detection of African swine fever virus antibodies by Wenting Chen, Jifei Yang, Qingli Niu, Jinming Wang, Yanghe Liu, Xuesai Li, Yaru Zhao, Zhonghui Zhang, Zhijie Liu, Guiquan Guan, Hong Yin

“…Abstract African swine fever (ASF) is a highly infectious and devastating disease that poses a significant threat to the global swine industry. …”
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A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1 by Lu Lu, Guoqing Guo, Jiahao Guo, Hanyang Li, Kexin Chen, Yuli Chen, Qiuhui Li, Qiunuo Li, Yuhao Diao, Ming Sun, Hao Wu, Xianghua Liu

“…Abstract Gastric cancer (GC), a malignant neoplasm originating in the stomach epithelium, is characterized by substantial global incidence and mortality rates, posing a substantial threat to public health systems worldwide. …”
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Quercetin as a Potential Therapeutic Agent for Malignant Melanoma—A Review of Current Evidence and Future Directions by Teodora Hoinoiu, Victor Dumitrascu, Daniel Pit, David-Alexandru Schipor, Madalina Jabri-Tabrizi, Bogdan Hoinoiu, David Emanuel Petreuș, Corina Seiman

“…This malignancy is distinguished by its rapid and uncontrolled growth, as well as its propensity for metastasis to vital organs, thereby posing significant challenges to therapeutic intervention and prognostication. …”
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Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model by Jiarui Zhang, Yaowen Liang, Weiyue Zeng, Xiaoyan Gao, Dingchen Wang, Cong Mai, Zhuoheng Lin, Haishan Zhao, Xin Li

“…Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with complex mechanisms and a notably high mortality rate. …”
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Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany by Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand

“…Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. …”
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Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach by Cristina Solomon, Valentina Anuța, Iulian Sarbu, Emma Adriana Ozon, Adina Magdalena Musuc, Veronica Bratan, Adriana Rusu, Vasile-Adrian Surdu, Cătălin Croitoru, Abhay Chandak, Roxana Mariuca Gavriloaia, Teodora Dalila Balaci, Denisa Teodora Niță, Mirela Adriana Mitu

“…<b>Background/Objectives</b>: Rivaroxaban, an oral anticoagulant, shows poor aqueous solubility, posing significant challenges to its bioavailability and therapeutic efficiency. …”
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The Role of ctDNA for Diagnosis and Histological Prediction in Early Stage Non-Small-Cell Lung Cancer: A Narrative Review by Carolina Sassorossi, Jessica Evangelista, Alessio Stefani, Marco Chiappetta, Antonella Martino, Annalisa Campanella, Elisa De Paolis, Dania Nachira, Marzia Del Re, Francesco Guerrera, Luca Boldrini, Andrea Urbani, Stefano Margaritora, Angelo Minucci, Emilio Bria, Filippo Lococo

“…<b>Results:</b> In this review, we summarize the increasing evidence suggesting that ctDNA has potential clinical applications in the management of patients with early stage NSCLC. ctDNA levels in early stage cancers are very low, posing many technical challenges in improving the detection rate and sensitivity, especially in clinical practice, if it is to be implemented for early detection. …”
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Epidemiology, Transmission, and Evolution of Japanese Encephalitis Virus by Chengcheng Peng, Huiling Qin, Fan Yu, Yujia Hao, Yuge Yuan, Wenzhou Ma, Duo Zhang, Pengpeng Xiao, Nan Li

“…The Japanese encephalitis virus is an arbovirus that causes severe damage to the central nervous system. At present, there are still 67,900 cases of Japanese encephalitis worldwide every year, which poses a global public health concern and causes great economic losses to animal husbandry. …”
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Coexistence of bla NDM-1, mcr-1 and bla CTX-M-199 in an ST499 multidrug resistant Klebsiella pneumoniae Isolate by Xinjun Hu, Bingyou Yin, Ruishan Liu, Lu Gong, Xiaolu Yang, Zhenghao Lou, Haowei Ye, Bingyang Shang, Yibing Shang, Yingjian Zhang

“…Enhanced surveillance and targeted interventions are essential to manage the public health risks posed by multidrug-resistant strains.…”
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Self-locking Fe-based shape memory couplers: Insights into SME and interface contact mechanics by Ali Jafarabadi, Maryam Mohri, Elyas Ghafoori, Eleni Chatzi, Christian Leinenbach, Christoph Czaderski

“…Notably, Fe-based shape memory couplers present an alternative to welded and machined mechanical joints, offering advantages such as self-locking assembly and reduction of stress concentrations. …”
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Neuroendocrine Tumor Metastases to the Breast Mimic Breast Primary Carcinoma: Mammography and Multimodality US Assessment in Challenging Differential Diagnosis by Francesco Marcello Aricò, Antonio Portaluri, Francesca Catanzariti, Elvira Condorelli, Demetrio Aricò, Mariagiovanna Zagami, Emilia Magliolo, Sara Monforte, Maria Adele Marino

“…Additionally, imaging characteristics of breast metastases from NETs are poorly documented in the literature, posing a diagnostic challenge that extends to pathology, particularly when in the absence of clinical suspicion. …”
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Short‐Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial by Farzad Akbarzadeh, Andisheh Talaei, Mohsen Nematy, Dina Ganji, Alireza Ebrahimi, Ali Talaei

“…ABSTRACT Background Drug resistance poses a formidable challenge in managing acute manic episodes in bipolar I disorder, leading to suboptimal treatment outcomes. …”
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Use of an anatomical atlas in real-time EIT reconstructions of ventilation and pulsatile perfusion in preterm infants by Christopher J. Rocheleau, Trevor D. Overton, Nilton Barbosa da Rosa, Gary J. Saulnier, Omid Rajabi Shishvan, Christopher D. Baker, Katelyn G. Enzer, Jennifer L. Mueller

“…Due to the severe ill-posedness of the inverse problem, good spatial resolution poses a challenge in EIT. Conversely, the temporal resolution is high, facilitating dynamic bedside imaging. …”
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PictureGuard: Enhancing Software-Defined Networking–Internet of Things Security with Novel Image-Based Authentication and Artificial Intelligence-Powered Two-Stage Intrusion Detect... by Hazem (Moh’d Said) Hatamleh, As’ad Mahmoud As’ad Alnaser, Said S. Saloum, Ahmed Sharadqeh, Jawdat S. Alkasassbeh

“…The rapid proliferation of IoT applications has led to a significant increase in security threats, posing challenges to the safe operation of IoT systems. …”
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Exploring the Antifibrotic Mechanisms of Ghrelin: Modulating TGF-β Signalling in Organ Fibrosis by Mei Li, Chang Zheng, Huiyi Wang, Shan Wang

“…This imbalance can lead to compromised organ function and potential failure, posing significant health risks. The condition’s complexity necessitates the exploration of effective treatments to mitigate its progression and adverse outcomes. …”
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