Methods for Preclinical Assessment of the Efficacy of Anticancer Medicines <i>in vivo</i> (Review) by M. L. Vasyutina, K. V. Lepik, M. S. Istomina, K. A. Levchuk, A. V. Petukhov, E. V. Shchelina, A. E. Ershova, O. N. Demidov, Ya. G. Toropova

“…The main risk to the clinical translatability of preclinical results for anticancer medicinal products is posed by the difficulty of simulating clinical conditions in an experimental model. …”
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The Role of Kidney Biopsy in Fabry Disease by Irene Capelli, Laura Martano, Gian Marco Berti, Gisella Vischini, Sarah Lerario, Vincenzo Donadio, Alex Incensi, Valeria Aiello, Francesca Ciurli, Benedetta Fabbrizio, Stefano Chilotti, Renzo Mignani, Gianandrea Pasquinelli, Gaetano La Manna

“…Despite the challenges posed by overlapping diseases and potential misdiagnoses, kidney biopsy remains an essential component of FD diagnosis and management, facilitating early detection, the monitoring of disease progression, and the evaluation of therapeutic responses.…”
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Proton beam therapy in paediatric radiation oncology: Defining the limitations, uncertainties and optimisation of treatment plans by C.S.M. Gillies, P. Lim, C. Dunlea, B. Timmermann, C. Alapetite, S. Bolle, I.F. Kristensen, K. Seiersen, Y. Lassen-Ramshad

“…The review aims to highlight how these are of particular importance for a paediatric cohort and present methods of mitigation to best utilise this modality.Despite clinical benefits, the limited availability of PBT centres poses challenges in communication, patient travel, and resource allocation. …”
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A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein by Yongpeng Sun, Liqin Liu, Hongsheng Qiang, Hui Sun, Yichao Jiang, Luo Ren, Zemin Jiang, Siyu Lei, Li Chen, Yizhen Wang, Xue Lin, Guosong Wang, Yang Huang, Yuhao Fu, Yujin Shi, Xiuting Chen, Hai Yu, Shaowei Li, Wenxin Luo, Enmei Liu, Qingbing Zheng, Zizheng Zheng, Ningshao Xia

“…Abstract Respiratory syncytial virus (RSV) poses a significant public health challenge, especially among children. …”
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An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV by Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu

“…The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. …”
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Clinical and Epidemiological Characteristics of Pediatric Pertussis Cases: A Retrospective Study from Southeast Romania by Cristina Maria Mihai, Ancuta Lupu, Tatiana Chisnoiu, Adriana Luminita Balasa, Ginel Baciu, Silvia Fotea, Vasile Valeriu Lupu, Violeta Popovici, Simona Claudia Cambrea, Mircea Grigorian, Felicia Suciu, Florin-Daniel Enache, Anna Sora, Ramona Mihaela Stoicescu

“…The persistence of pertussis despite vaccination efforts highlights the challenges posed by waning immunity and diagnostic limitations, reinforcing the need for strengthened public health strategies.…”
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cfDNA Key genomic markers in HCV-Induced hepatocellular carcinoma in Egyptian patients by Mohamed Khalifa, Ahmed A. Hmed, Khaled S. Elfeky, Sayed Bakry, Manal El Hamshary, Ahmed R. Sofy

“…Background: Malignant liver disease is among the highest in the world, with hepatocellular carcinoma (HCC) accounting for up to 90 % of all cases. In Egypt, HCC poses a significant public-health concern, representing 47.17 % of cancer cases. …”
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Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR by Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal

“…However, the high conservation of its orthosteric binding site poses significant challenges for drug development. …”
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Integrating formal surveys and local knowledge: Insights into the subterranean fauna of Apulia by Sarah Boulamail, Salvatore Inguscio, Sara Ventruti, Benedetta Barzaghi, Damiano Brognoli, Raffaele De Giorgi, Joachim Langeneck, Elia Lo Parrino, Emanuele Mancini, Raoul Manenti, Alejandro Martínez, Martina Pulieri, Emanuela Rossi, Francesco Cozzoli

“…In the Apulian region of Southern Italy, a biodiversity hotspot for subterranean life, the paucity of recent systematic surveys and reliance on expert knowledge poses both opportunities and challenges for ecological research. …”
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The COVID-19 Infection Did Not Aggravate the Mortality of Long-Term Care Facility Residents Under Strict Infection Control and with Immediate Anti-Viral Treatment: Real-World Analy... by Hideyasu Shimizu, Jin Kawase, Yuko Higashi, Hiroyuki Nabeno, Masamichi Hayashi, Kazuyoshi Imaizumi, Yuji Ito, Masaaki Matsunaga, Mitsushi Okazawa

“…Despite reduced virulence, Omicron’s high transmissibility poses ongoing risks. The effect of infection under strict control measures and early antiviral treatment remains unclear. …”
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Multi-layer feature fusion and attention-enhanced YOLOv9 for rapid field detection of greenhouse blueberry maturity at long and short distances by Ziwei Pan, Lei Xu, Wanjin Zhao, Cong Fan, Xihao Zhang, Weihui Chen, Yonglin Shen, Nengcheng Chen

“…Given the dense growth of blueberry plants and small fruit size, detecting blueberry maturity at long distances poses significant challenges. Therefore, this paper presents an improved algorithm, YOLOv9-MSAS, for detecting greenhouse blueberry maturity at long and short distances. …”
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A novel eco-friendly Acinetobacter strain A1-4-2 for bioremediation of aquatic pollutants by Rui Wang, Jiahua Wang, Ling Wang, Yulun Cai, Yuan Wang, Huifang Luo, Bing Chen, Junlv Chen, Jiasong Fang, Zengfu Song

“…Abstract The increasing accumulation of hydrocarbons and aromatic compounds in aquatic ecosystems, stemming from anthropogenic activities, poses severe ecological challenges, including disrupting biodiversity and threatening human health through the food chain. …”
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Process‐Based Atmosphere‐Hydrology‐Malaria Modeling: Performance for Spatio‐Temporal Malaria Transmission Dynamics in Sub‐Saharan Africa by Mame Diarra Bousso Dieng, Adrian M. Tompkins, Joël Arnault, Ali Sié, Benjamin Fersch, Patrick Laux, Maximilian Schwarz, Pascal Zabré, Stephen Munga, Sammy Khagayi, Ibrahima Diouf, Harald Kunstmann

“…Abstract With the goal of eradication by 2030, Malaria poses a significant health threat, profoundly influenced by meteorological and hydrological conditions. …”
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Tuberous Sclerosis Complex: New Insights into Pathogenesis and Therapeutic Breakthroughs by Aurora Alexandra Jurca, Alexandru Daniel Jurca, Codruta Diana Petchesi, Dan Bembea, Claudia Maria Jurca, Emilia Severin, Sanziana Jurca, Cosmin Mihai Vesa

“…Despite these advances, variability in disease expression poses challenges in diagnosis and individualized management strategies. …”
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Navigating Occupational Hazards: Musculoskeletal Disorders Among Slaughterhouse Workers in Brazil by Vando Aparecido Monteiro, Hercules Jose Marzoque, Marcelo Linon Batista, Maria do Carmo Baracho de Alencar, Lilian Dias Pereira, Irenilza de Alencar Nääs

“…(1) Background: The meatpacking industry in Brazil is vital for economic growth. It poses significant occupational health risks, particularly Work-Related Musculoskeletal Disorders (WMSDs). …”
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The Use of a New Benzothiadiazole Derivative for the Control of Cercospora Leaf Spot in Sugar Beet and Its Effect on the Yield by Agnieszka Kiniec, Maciej Spychalski, Rafal Kukawka, Katarzyna Pieczul, Adrian Zajac, Marcin Smiglak

“…Unfortunately, it is widely recognized that the use of PPPs poses a risk not only to the environment but also to human health. …”
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Assessment of heavy metal sources and health risks in soil-crop systems of fragmented farmland by Lei Tong, Aoran Yang, Mingyue Fan, Daikun Zheng, Ji Li, Hanlin Liu, Chenggen Li, Yongqiong Tang, Longfeng Cheng

“…Heavy metal contamination in agricultural ecosystems poses significant risks to human health. Metals accumulating in soil-crop systems can be absorbed and concentrated by crops. …”
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Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB by Josef Wagner, Amanda Handley, Celeste M. Donato, Eleanor A. Lyons, Daniel Pavlic, Darren Suryawijaya Ong, Rhian Bonnici, Nada Bogdanovic-Sakran, Edward P. K. Parker, Christina Bronowski, Jarir At Thobari, Cahya Dewi Satria, Hera Nirwati, Desiree Witte, Khuzwayo C. Jere, Ashley Mpakiza, Emma Watts, Ann Turner, Karen Boniface, Jonathan Mandolo, Frances Justice, Naor Bar-Zeev, Miren Iturriza-Gomara, Jim P. Buttery, Nigel A. Cunliffe, Yati Soenarto, Julie E. Bines

“…RV3-BB vaccine administered in a neonatal schedule modulates the early microbiome environment and presents a window of opportunity to optimise protection from rotavirus disease.…”
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Self-Medication with NSAIDs in Gondar city: prevalence, predictors, and public health implications by Wondim Ayenew, Addisu Afrassa Tegegne, Gebremariam Genet, Liknaw Workie Limenh, Lamrot Yohannes, Abdulwase Mohammed Seid, Tekletsadik Tekleslassie Alemayehu, Wudneh Simegn

“…However, this practice poses significant public health risks, including gastrointestinal complications, renal impairment, and cardiovascular events. …”
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Beyond N-Grams: Enhancing String Kernels With Transformer-Guided Semantic Insights by Nazar Zaki, Reem Alderei, Mahra Alketbi, Alia Alkaabi, Fatima Alneyadi, Nadeen Zaki

“…The rapid advancements in large language models (LLMs) have led to the generation of sophisticated AI-produced texts, posing significant challenges in distinguishing machine-generated content from authentic human writing. …”
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