Spectrum and epidemiology of rare diseases in a Chinese natural population of 14.31 million residents, 2012–2023 by Ming-Jia Li, Qi Li, Miao-Miao Zhao, Hanna Kim, Ruo-Qi Feng, Mo-Ning Guo, Jian-Peng heng, Jin-Kui Yang, Chang Liu

“…These findings underscore the critical need for healthcare policies that address the unique challenges posed by rare diseases in China.…”
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Landslide Detection in Long-Term and Low-Coherence Scenario Using Faster Intermittent Stacking InSAR Method by Huayan Dai, Lixin Wu, Yunping Liao, Lichuan Chen, Yong Yang

“…This often leads to the minimal capability of conventional time-series InSAR methods, which poses challenges for effective ground deformation detection, particularly in low-coherence areas over long-term scenarios. …”
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Hepatoprotective effects of Curcuma xanthorrhiza Roxb. extract via free radical scavenger, inhibiting apoptosis and inflammation mechanisms in acetaminophen-induced liver injury by I Nyoman Lister, Linda Chiuman, Maya Mutia, Hartono Hartono, Ermi Girsang, Annisa Sutendi, Hanna Kusuma, Dhanar Hadiprasetyo, Wahyu Widowati

“…Objective(s): Acetaminophen (APAP)-mediated liver injury poses a significant public health concern. Curcuma xanthorrhiza extract (CXE) has been traditionally used for its hepatoprotective properties. …”
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Case Report: Whole genome sequencing identifies a novel deep intronic COL4A5 variant of uncertain significance in X-linked Alport syndrome by Hoon Seok Kim, Hoon Seok Kim, Myungshin Kim, Myungshin Kim, Jin-Soon Suh, Yeonhee Lee

“…Here, we report the case of a 4-year-old boy who presented with persistent microscopic hematuria detected during routine urinalysis. …”
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Phycomediation of cadmium contaminated aqueous solutions using Chlamydomonas sp.: process optimization and adsorption characterization by Reem Mohammed Alharbi, Neveen Abdel-Raouf, Neveen Abdel-Raouf, Mostafa Shaaban Mohamed, Wael A. Fathy, Ibraheem Borie M. Ibraheem, Walaa Gamal Hozayen

“…The contamination resulting from heavy metals present in industrial effluents represents a critical global challenge, posing profound risks to aquatic ecosystems and human health. …”
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Multidrug-Resistant Infections and Metabolic Syndrome: An Overlooked Bidirectional Relationship by Carlo Acierno, Riccardo Nevola, Fannia Barletta, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…Although current data remain largely associative and fragmented, the emerging MetS–MDR syndemic model poses substantial challenges for translational research, antimicrobial stewardship, and personalized therapeutic strategies. …”
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Effects of Antibiotic Residues on Fecal Microbiota Composition and Antimicrobial Resistance Gene Profiles in Cattle from Northwestern China by Wei He, Xiaoming Wang, Yuying Cao, Cong Liu, Zihui Qin, Yang Zuo, Yiming Li, Fang Tang, Jianjun Dai, Shaolin Wang, Feng Xue

“…Metagenomic sequencing revealed that carbapenemase-resistant genes (<i>bla</i>_KPC and <i>bla</i>_VIM) were also present in considerable abundance, accounting for about 10% of the total ARGs detected in three provinces. …”
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Comparative transcriptomic analysis reveals the important role of hepatic fatty acid metabolism in the acute heat stress response in chickens by Zi Mei, Zhenquan Song, Haobo Zhou, Bin Zheng, Yiwei Xiong, Zheya Sheng, Yanzhang Gong

“…Abstract Background Heat stress poses a major challenge to global poultry production, but the molecular mechanisms driving the acute heat stress response in multiple organs of chickens remain poorly understood. …”
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Specific Detection of African Swine Fever Virus Variants: Novel Quadplex Real-Time PCR Assay with Internal Control by Lihua Wang, Yuzhen Li, Xirui Zhang, Rachel Madera, Homer Pantua, Aidan Craig, Nina Muro, Danqin Li, Jamie Retallick, Franco Matias Ferreyra, Quang Lam Truong, Lan Thi Nguyen, Jishu Shi

“…The emergence of ASF virus (ASFV) variants with varying genomic deletions poses significant challenges for ASF control. This study presents a novel, sensitive, and reliable quadplex real-time PCR assay for detecting ASFV variants lacking key genes (<i>I177L</i>, <i>EP402R</i>, and <i>MGF360-14L</i>), either individually or in combination. …”
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Identification of novel variants in carbamoyl phosphate synthetase 1 gene and comparative pathogenicity assessments of CPS1 missense variants following ACMG/AMP-ClinGen recommendat... by Fei Li, Qin Cai, Wei Ji, Miao Xu, Guoli Tian, Fanyi Zeng

“…Since the employment of genetic testing as a clinical diagnostic tool, distinguishing pathogenic from polymorphic changes poses significant problems for geneticists. As recommendation for PP3/BP4, the computational tools for missense variant have been published, we performed a comparative evaluation for pathogenicity interpretation in our patients and in ClinVar database regarding CPS1 missense variants under the updated guidelines of ACMG/AMP-ClinGen. …”
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Eco-friendly approach to corrosion inhibition of aluminum by Congo red dye in alkaline media: Experimental assessment, QSAR modeling, diffusion studies, and DFT/MC/MD simulations by Ayoub Chahid, Said Meftah, Mohamed Essahli, Mohammed Chafi, Rachid Kellal, Driss Benmessaoud Left, Mustapha Zertoubi

“…Aluminum corrosion in alkaline media poses a significant limitation for its industrial use. …”
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Prevalence of bacterial contamination on wild meat processing and cooking surfaces in rural Cameroon by Sara M. Soto, Laura Castellsagués, Victoria Ballén, Yaiza Gabasa, Pedro Mayor, Guillermo Ros Brull, Stephan M. Funk, Julia E. Fa

“…The transmission of food-borne pathogens from wildlife to humans presents a significant public health challenge. The recent COVID-19 pandemic has highlighted the critical need to enhance our understanding of wild animals' role in transmitting infectious diseases. …”
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A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1 by Lu Lu, Guoqing Guo, Jiahao Guo, Hanyang Li, Kexin Chen, Yuli Chen, Qiuhui Li, Qiunuo Li, Yuhao Diao, Ming Sun, Hao Wu, Xianghua Liu

“…Abstract Gastric cancer (GC), a malignant neoplasm originating in the stomach epithelium, is characterized by substantial global incidence and mortality rates, posing a substantial threat to public health systems worldwide. …”
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Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany by Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand

“…Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. …”
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Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach by Cristina Solomon, Valentina Anuța, Iulian Sarbu, Emma Adriana Ozon, Adina Magdalena Musuc, Veronica Bratan, Adriana Rusu, Vasile-Adrian Surdu, Cătălin Croitoru, Abhay Chandak, Roxana Mariuca Gavriloaia, Teodora Dalila Balaci, Denisa Teodora Niță, Mirela Adriana Mitu

“…<b>Background/Objectives</b>: Rivaroxaban, an oral anticoagulant, shows poor aqueous solubility, posing significant challenges to its bioavailability and therapeutic efficiency. …”
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Epidemiology, Transmission, and Evolution of Japanese Encephalitis Virus by Chengcheng Peng, Huiling Qin, Fan Yu, Yujia Hao, Yuge Yuan, Wenzhou Ma, Duo Zhang, Pengpeng Xiao, Nan Li

“…The Japanese encephalitis virus is an arbovirus that causes severe damage to the central nervous system. At present, there are still 67,900 cases of Japanese encephalitis worldwide every year, which poses a global public health concern and causes great economic losses to animal husbandry. …”
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Coexistence of bla NDM-1, mcr-1 and bla CTX-M-199 in an ST499 multidrug resistant Klebsiella pneumoniae Isolate by Xinjun Hu, Bingyou Yin, Ruishan Liu, Lu Gong, Xiaolu Yang, Zhenghao Lou, Haowei Ye, Bingyang Shang, Yibing Shang, Yingjian Zhang

“…Enhanced surveillance and targeted interventions are essential to manage the public health risks posed by multidrug-resistant strains.…”
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Self-locking Fe-based shape memory couplers: Insights into SME and interface contact mechanics by Ali Jafarabadi, Maryam Mohri, Elyas Ghafoori, Eleni Chatzi, Christian Leinenbach, Christoph Czaderski

“…Notably, Fe-based shape memory couplers present an alternative to welded and machined mechanical joints, offering advantages such as self-locking assembly and reduction of stress concentrations. …”
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Short‐Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial by Farzad Akbarzadeh, Andisheh Talaei, Mohsen Nematy, Dina Ganji, Alireza Ebrahimi, Ali Talaei

“…ABSTRACT Background Drug resistance poses a formidable challenge in managing acute manic episodes in bipolar I disorder, leading to suboptimal treatment outcomes. …”
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Use of an anatomical atlas in real-time EIT reconstructions of ventilation and pulsatile perfusion in preterm infants by Christopher J. Rocheleau, Trevor D. Overton, Nilton Barbosa da Rosa, Gary J. Saulnier, Omid Rajabi Shishvan, Christopher D. Baker, Katelyn G. Enzer, Jennifer L. Mueller

“…Due to the severe ill-posedness of the inverse problem, good spatial resolution poses a challenge in EIT. Conversely, the temporal resolution is high, facilitating dynamic bedside imaging. …”
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