Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease by Carolin Meyer, Theresa Niedermeier, Paul L. C. Feyen, Felix L. Strübing, Boris-Stephan Rauchmann, Katerina Karali, Johanna Gentz, Yannik E. Tillmann, Nicolas F. Landgraf, Svenja-Lotta Rumpf, Katharina Ochs, Karin Wind-Mark, Gloria Biechele, Jessica Wagner, Selim Guersel, Carolin I. Kurz, Meike Schweiger, Danilo Prtvar, Yuan Shi, Richard B. Banati, Guo-Jun Liu, Ryan J. Middleton, Gerda Mitteregger-Kretzschmar, Robert Perneczky, Thomas Koeglsperger, Jonas J. Neher, Sabina Tahirovic, Matthias Brendel, Jochen Herms, Lars Paeger

“…Reducing phagocytosis genetically preserves LC axons and olfaction. Prodromal AD patients display elevated TSPO-PET signals in the OB, similarly to App NL-G-F mice. …”
Get full text

Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism by Yonatan Perez, Dmitry Velmeshev, Li Wang, Matthew L. White, Clara Siebert, Jennifer Baltazar, Guolong Zuo, Juan Andrés Moriano, Songcang Chen, David M. Steffen, Natalia Garcia Dutton, Shaohui Wang, Brittney Wick, Maximilian Haeussler, Stormy Chamberlain, Arturo Alvarez-Buylla, Arnold Kriegstein

“…Using single-cell and single-nucleus RNA sequencing of cortical organoids from dup15q patient-derived iPSCs and post-mortem brain samples, we identify increased glycolysis, disrupted layer-specific marker expression, and aberrant morphology in deep-layer neurons during fetal-stage organoid development. …”
Get full text

Gender-Specific Differences in Diastolic Dysfunction and HFpEF: Pathophysiology, Diagnosis, and Therapeutic Strategies by Francesca Coppi, Gianluca Pagnoni, Francesca Grossule, Ashraf Nassar, Arianna Maini, Giuseppe Masaracchia, Francesco Sbarra, Elisa Battigaglia, Enrico Maggio, Daniela Aschieri, Federica Moscucci, Marcello Pinti, Anna Vittoria Mattioli, Francesco Fedele, Susanna Sciomer

“…Significant gender-specific differences are observed, with women, particularly post-menopausal, experiencing higher prevalence and distinct clinical profiles compared to men. …”
Get full text

Pure pancreatic hepatoid carcinoma: a surgical case report and literature review by Takahiro Tomino, Mizuki Ninomiya, Rumi Matono, Fumiya Narutomi, Yumi Oshiro, Kenji Watanabe, Daisuke Taniguchi, Sho Nishimura, Yoko Zaitsu, Yuichiro Kajiwara, Tomoyuki Yokota, Kazuhito Minami, Takashi Nishizaki

“…Laparoscopic spleen-preserving distal pancreatectomy was performed. Histology was identical to hepatocellular carcinoma of the liver. …”
Get full text

An experimental study of resveratrol effect on neurotrophic and structural changes in retinal ischemia by T. N. Kiseleva, A. V. Chudin, N. V. Balatskaya, A. I. Shchipanova, I. P. Khoroshilova-Maslova, M. S. Zaytsev, A. M. Maybogin, K. V. Lugovkina

“…The histological examination of the retina on day 3 showed reduced retinal ischemic lesions and signs of inflammation, decrease of the apoptosis of ganglion cells and zones of preserved retina with intact nuclear layers and a layer of photoreceptors in late post-ischemic period (after 30 days). …”
Get full text

Evaluation of Perforator Fasciocutaneous Flaps for Oncoplastic Immediate Reconstruction Following Breast Conservative Surgery in Lower and Lateral Breast Quadrant Lesions Perforato... by Mahmoud Ali Mohamed Abd El Mohsen, Ismail Ahmed Shafik, Shadin Hamza Hassan Abas, Mostafa Mahmoud Abdelfatah

“…Materials and Methods: This prospective study included women with lower outer quadrant, lower inner quadrant, and upper outer quadrant tumors who underwent upfront or post-neoadjuvant chemotherapy breast conserving surgery with immediate volume replacement surgery. …”
Get full text

ACL repair vs. reconstruction: a meta-analysis of outcomes across different tear characteristics by Hongcheng Zheng, Yongtao Zeng, Nacke Daoerji, Husen Wang, Bin Tang, Li Shu

“…Modern ACL repair techniques theoretically preserve native proprioception and enable faster rehabilitation. …”
Get full text

Inmigración, escuela y construcción nacional: algunas notas sobre la República Argentina by Xosé Manuel Malheiro Gutiérrez

“…This paper presents some notes on the trend of the different collective immigrants to keep and preserve its hallmarks in the destination by means of own educational experiences and strategies of State and legislative created instruments are built to improve a sense of belonging, inherent in the education of a new citizen in the new post-colonial political time. …”
Get full text

Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity by Guoqing Bao, Siliang Zhang, Zhengchen Ye, Ding Luo, Pinduan Bi, Bin Yang

“…In vitro, Kynu inhibition, using shRNA or the inhibitor benserazide (BSZ), ameliorated tight junction impairment and attenuated inflammatory damage in hypoxic biliary epithelial cells. In vivo, post-ischemia Kynu blockade reduced bile duct damage, inflammation, and biliary barrier permeability. …”
Get full text

Balloon-expandable Myval valve-in-valve transcatheter aortic valve implantation with bailout left main coronary artery chimney stenting: a case report by Dibya Ranjan Behera, Kiran Kumar Shetty

Get full text

The Effect of Perinatal Hypoxia on Red Blood Cell Morphology in Newborns by S. A. Perepelitsa, V. A. Sergunova, O. E. Gudkova

“…These changes may represent adaptive responses to hypoxia aimed to preserve the functional capabilities of red blood cells. …”
Get full text

Evaluation of the viability and functionality of human peripheral blood mononuclear cells cryopreserved up to 2 years in animal-protein-free freezing media compared to the FBS-supp... by Frédérique Jantet-Blaudez, Joseline Ruiz, Sylviane Gautheron, Anke Pagnon

“…Cell viability and functionality were assessed at 3 weeks (M0), 3 months (M3), 6 months (M6), 1 year (M12), and 2 years (M24) post-freezing. Media with DMSO concentrations below 7.5% were excluded after M0 due to lower viability. …”
Get full text

Improved clinical outcomes with a modified warming protocol in donor oocyte cycles by Chun-I Lee, Hsiu-Hui Chen, Shu-Hui Lin, Chun-Chia Huang, Pin-Yao Lin, Tsung-Hsien Lee, Ming-Jer Chen, Maw-Sheng Lee, Chien-Hong Chen

“…Oocyte degeneration rates post-intracytoplasmic sperm injection (ICSI) were similar for vitrified-warmed and fresh oocytes (2.7–3.4% vs. 2.8%). …”
Get full text

Rituximab induced lung injury by Rohit Chari, Youmna Abdelghany, Madeleine Purcell, Blaine Kenaa

“…Conclusion Rituximab and Cyclophosphamide are well described causes of acute pneumonitis post R-CHOP administration. Given curative effect of R-CHOP, careful changes in management plan and co-treatment with steroids could help preserve lung function while allowing for full continuation of the chemotherapy regimen.…”
Get full text

Academician Viktor Sergeyevich Savelyev (1928–2013) (on the 95th anniversary of his birth) by Al. A. Kurygin, V. V. Semenov

“…Savelyev was a major organizer of domestic healthcare, for 34 years he held the post of the chief surgeon of the Ministry of Health of Russia. …”
Get full text

Development of Low-Cost Monitoring and Assessment System for Cycle Paths Based on Raspberry Pi Technology by Salvatore Bruno, Ionut Daniel Trifan, Lorenzo Vita, Giuseppe Loprencipe

“…In this regard, in cities throughout the world, there has been a significant increase in the construction of bicycle paths in recent years, requiring effective maintenance strategies to preserve their service levels. The continuous monitoring of road networks is required to ensure the timely scheduling of optimal maintenance activities. …”
Get full text

Mitigation of radiation mediated testicular dysfunction by α-tocopheryl succinate: PPAR-γ related pathway by Heba A. Gheita, Ghada M. Shafey, Maha M. Aziz, Noha A. Fadel

“…Methods Animals were subjected to 6 Gy of whole-body gamma radiation and received α-TCS (200 mg/kg, P.O.) pre- and post-radiation. After the termination of the experiment, serum testosterone was estimated, and the testis weight was recorded. …”
Get full text

The efficacy of intraoperative OCT combined with foldable artificial vitreous balloon (FCVB) implantation in eyes with complex retinal detachment and silicone oil dependence by Mingxuan Huang, Haomin Lu, Minghao Sun, Jin Lv, Haotian Yu, Bo Jiang, Dawei Sun

“…Two cases experienced elevated IOP at 1 week post-op (34 mmHg and 22 mmHg), both of which normalized after treatment. …”
Get full text

Treatment of Denervated Muscle Atrophy by Injectable Dual‐Responsive Hydrogels Loaded with Extracellular Vesicles by Ziheng Bu, Jianxing Jing, Wei Liu, Zhen Fan, Junchao Huang, Zheng Zhou, Jianhai Hu, Jinxi An, Jiachang Hong, Jianing Yu, Daolin Tang, Min Sun, Jianzhong Du, Peng Wu

“…In vivo studies using a rat model of nerve injury demonstrated that the EV‐loaded hydrogel (EVs@UR‐gel) significantly preserved muscle function. Six weeks post‐nerve reconstruction, treated rats exhibited muscle strength, circumference, and wet weight reaching 89.53 ± 0.96%, 76.02 ± 7.49%, and 88.0 ± 2.65% of healthy controls, respectively, alongside an improvement in the sciatic nerve index (−0.11 ± 0.09). …”
Get full text

Improved survival and neurological outcomes with lysophosphatidylcholine supplementation in severe cardiac arrest model by Muhammad Shoaib, Muhammad Shoaib, Mitsuaki Nishikimi, Rishabh C. Choudhary, Tsukasa Yagi, Kei Hayashida, Tai Yin, Blanca B. Espin, Lance B. Becker, Lance B. Becker, Lance B. Becker, Junhwan Kim, Junhwan Kim, Junhwan Kim

“…Specifically, the use of LPC in combination emerges as a promising strategy for mitigating organ damage and enhancing recovery outcomes post-CA.…”
Get full text