Telehealth for the Initial Evaluation of Musculoskeletal Disorders: Qualitative Study of Patients, Health Care Providers, and Key Stakeholders in the Province of Quebec in Canada by Raphaël Vincent, Pauline Lemersre, Geneviève Ferland, Annie Bélanger, Audrey-Anne Cormier, Kadija Perreault, Jean Sébastien Roy, Nicolas Pinsault, Dahlia Kairy, François Desmeules

“…However, remote physical examination poses challenges associated with concerns about diagnostic accuracy and limited remote physical examination procedures and components. …”
Get full text

Multi-omics profiling reveals Poria cocos polysaccharides mitigate PEDV-induced intestinal injury by modulating lipid metabolism in piglets by Qian Zhang, Shuaijie Wang, Mengjun Wu, Zihan Tan, Tao Wu, Dan Yi, Lei Wang, Di Zhao, Yongqing Hou

“…Abstract Background Porcine epidemic diarrhea virus (PEDV) infection poses a significant challenge to the swine industry, with limited effective control measures available. …”
Get full text

Innovation and Risk Avoidance of Smart Library Services Based on Generative Artificial Intelligence by Jia LIU

“…The emergence of generative artificial intelligence (Generative AI) presents unprecedented opportunities and challenges for innovation in smart library services. …”
Get full text

Digital removal of dermal denticle layer using geometric AI from 3D CT scans of shark craniofacial structures enhances anatomical precision by Sang Wha Kim, Adams Hei Long Yuen, Hyun Woo Kim, Seyoung Lee, Sung Bin Lee, Young Min Lee, Won Joon Jung, Cherry Tsz Ching Poon, Dasol Park, Sangyun Kim, Sang Guen Kim, Jung Woo Kang, Jun Kwon, Su Jin Jo, Sib Sankar Giri, Hyunjung Park, Jong-pil Seo, Deok-Soo Kim, Byung Yeop Kim, Se Chang Park

“…However, the fragile cartilaginous nature of shark craniofacial skeleton poses significant challenges for traditional specimen preparation, often resulting in damaged cranial landmarks and compromised measurement accuracy. …”
Get full text

Optimizing SVC placement for enhanced voltage stability using a novel index and hybrid ABC-PSO algorithm by Hafizur Rahman, Roman Mia, Mustafizur Rahman, Md. Faiyaj Ahmed Limon, Md. Shahid Iqbal, Md. Fahad Jubayer, Md. Rabiul Karim, Md. Janibul Alam Soeb

“…Voltage instability poses a great threat to power systems, typically leading to catastrophic failures such as voltage collapse. …”
Get full text

ESR1 testing on FFPE samples from metastatic lesions in HR + /HER2- breast cancer after progression on CDK4/6 inhibitor therapy by Konstantinos Venetis, Giulia Cursano, Roberta Scafetta, Pier Paolo Maria Berton Giachetti, Alberto Concardi, Elisa De Camilli, Marianna D’Ercole, Eltjona Mane, Chiara Frascarelli, Antonio Marra, Sara Gandini, Francesco Pepe, Simone Scagnoli, Silvia Maria Rossi, Raffaella Troiano, Elena Speziale, Carmine De Angelis, Giancarlo Troncone, Umberto Malapelle, Giuseppe Perrone, Andrea Botticelli, Giuseppe Viale, Giuseppe Curigliano, Elena Guerini Rocco, Carmen Criscitiello, Nicola Fusco

“…Co-mutations in actionable pathways, particularly PIK3CA, were observed in n = 10 ESR1 mutant tumors (41.6%), highlighting their contribution to resistance mechanisms and posing significant challenges for treatment selection, as these alterations may necessitate combination therapies to effectively target multiple resistance pathways. …”
Get full text

First detection of a cervidpoxvirus in Europe—disease occurrence in semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway and Sweden by Ingebjørg H. Nymo, Cathrine Arnason Bøe, Javier Sánchez Romano, Hans Lian, Renate Thorvaldsen, Faisal Suhel, Mette Boye, Øivind Øines, Lars P. Folkow, Hans-Arne Solvang, Tomas Jinnerot, Jonas Johansson Wensman, Rebecca K. Davidson, Torill Mørk, Line Olsen, Morten Tryland, Ulrika Rockström, Bjørn Spilsberg

“…Commencing in 2018, a novel disease presenting with periorbital lesions was reported in reindeer in multiple locations in Norway and Sweden, as individual cases and outbreaks. …”
Get full text

A novel formation mechanism of sulfamic acid and its enhancing effect on methanesulfonic acid–methylamine aerosol particle formation in agriculture-developed and coastal industria... by H. Wang, S. Wei, J. Yang, Y. Yang, R. Li, R. Wang, C. Zhu, T. Zhang, C. Zhang

“…<p>Sulfamic acid (SFA) significantly impacts atmospheric pollution and poses potential risks to human health. Although traditional sources of SFA and their role in sulfuric acid–dimethylamine new particle formation (NPF) have received increasing attention, the formation mechanism of SFA from HNSO<span class="inline-formula">₂</span> hydrolysis with methanesulfonic acid (MSA) and its enhancing effect on MSA-methylamine (MA) NPF have not been studied, which will limit understanding on the source and loss of SFA in agriculture-developed and coastal industrial areas. …”
Get full text

Analysis of genomic heterogeneity and the mutational landscape in cutaneous squamous cell carcinoma through multi-patient-targeted single-cell DNA sequencing by Wen Chen, Jiawei Xu, Chengdong Yu, Meng Zhou, Yong Ai, Wenbing Rao, Qingchuan Wang, Siyi Xu, Lei Tang, Si Gong, Jun Rao

“…Abstract Background Cutaneous squamous cell carcinoma (CSCC) is a prevalent skin cancer with aggressive progression that poses significant challenges, especially in metastatic cases. …”
Get full text

Metallicity Scatter Originating from Subkiloparsec Starbursting Clumps in the Core of a Protocluster at z = 7.88 by Takahiro Morishita, Massimo Stiavelli, Eros Vanzella, Pietro Bergamini, Kristan Boyett, Marco Chiaberge, Claudio Grillo, Nicha Leethochawalit, Matteo Messa, Guido Roberts-Borsani, Piero Rosati, Anowar J. Shajib

“…We present new JWST NIRSpec integral field unit (IFU) G395H/F290LP observations of a merging galaxy system at z = 7.88, part of A2744-z7p9OD, the most distant protocluster to date. …”
Get full text

Patient-reported quality of outpatient healthcare in patients with chronic back or arthrosis pain with long-term opioid therapy in Germany by Anja Niemann, Nils Frederik Schrader, Christian Speckemeier, Carina Abels, Nikola Blase, Milena Weitzel, Anja Neumann, Cordula Riederer, Joachim Nadstawek, Wolfgang Straßmeir, Jürgen Wasem, Silke Neusser

“…Long-term opioid therapy is an option for treatment responders with guideline recommended indications. However, opioid use poses risks of severe side effects, including misuse, and therefore needs to be integrated into a high-quality healthcare process. …”
Get full text

Cloning, bioinformatics analysis, and expression of the ubiquitin 2 (ubq-2) gene from the dog roundworm Toxocara canis by Pengchen Zhu, Xin Hu, Jiali Huang, Lidan Wang, Zhao Wang, Ruixi Wang, Xinyi Fan, Guoshan Wei, Qin He, Zhaoruiyi Li, Xuan Zhou, Hui Wang, Yue Xie

“…Toxocariasis, caused by the dog roundworm Toxocara canis, is a globally distributed zoonotic parasitic disease that poses a significant threat to veterinary and public health. …”
Get full text

Dental caries prevalence, preventive behaviour and related factors among adolescents in Nigeria: a 10-year systematic review and meta-analysis by Adebukunola O. Afolabi, Adebola O. Ehizele, Ukachi Chiwendu Nnawuihe, Francisca O. Nwaokorie, Ucheoma Nwaozuru, Foluso Owotade, Joanne Lusher, George Uchenna Eleje, Omolola T. Alade, Folahanmi T. Akinsolu, Oliver C. Ezechi, Moréniké Oluwátóyìn Foláyan

“…Abstract Background The paucity of actionable data on the epidemiological profile of dental caries among adolescents in Nigeria poses significant challenges to policy formulation and implementation. …”
Get full text

Regulation of type 3 fimbria expression by RstA affects biofilm formation and virulence in Klebsiella pneumoniae ATCC43816 by Xiaoyun Zhang, Yaxuan Zhai, Jie Zhu, Zhichen Zhu, Yicheng Wen, Qizhao Gao, Liang Wang, Jiayao Lin, Yan Qian, Liang Chen, Hong Du

“…ABSTRACT Klebsiella pneumoniae causes both community-acquired and healthcare-associated infections, presenting a major therapeutic challenge to global public health. …”
Get full text

Evaluating Quality of Care Indicators for Metastasis Development in Cutaneous Squamous Cell Carcinoma Among Mexican Renal Transplant Recipients by Andrea Malagon‐Liceaga, Jesus Alejandro Romero‐Aguila, Bonfilio Roberto Lazcano‐Prieto, Fanny Carolina Lopez‐Jimenez, Rebeca Palafox‐Romo, Samantha Paola Bermudez Rodriguez, Verónica Monserrat Díaz Sanchez, Judith Dominguez‐Cherit, Silvia Mendez‐Flores, Ana Lilia Ruelas‐Villavicencio

“…ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) poses a high metastatic risk in immunosuppressed individuals, especially organ transplant recipients (OTRs). …”
Get full text

Vision impairment and associated daily activity limitation: A systematic review and meta-analysis. by Masoud Rahmati, Lee Smith, Laurent Boyer, Guillaume Fond, Dong Keon Yon, Hayeon Lee, Tarnjit Sehmbi, Mapa Prabhath Piyasena, Shahina Pardhan

“…<h4>Background</h4>Vision impairment is a common disability that poses significant challenges to individuals' ability to perform activities essential for independent living, including activities of daily living (ADL) and instrumental activities of daily living (IADL). …”
Get full text

Painting the Portrait of Fibro-osseous Lesions: An In-vitro Study on Staining Duel of Modified Gallego versus Hematoxylin and Eosin (H&E) Staining by Akash Shegaonkar, Shilpa Patel, Jigna Pathak, Niharika Swain, Rashmi Hosalkar, Rutuj Waghmare

“…Introduction: Oral cavity tumours involve a mix of soft and hard tissues, with varying levels of calcification posing diagnostic challenges. Detecting the presence or absence of calcification in connective tissue tumours, whether central or peripheral, benign or malignant, is particularly challenging. …”
Get full text

The Overlooked Threat of Hospital Falls During the Discharge Period: A Statewide Retrospective Analysis of Patient Safety Event Reports by Christine E. Sanchez, Rebecca Jones

“…Taking a fresh perspective on patient falls, Patient Safety Authority researchers shine a light on the unique circumstances around hospital discharge to show that this time frame poses a greater threat to patient safety than ever considered before. …”
Get full text

Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation by Gu Q, Duan S, Tibenda JJ, Gou B, Huang S, Chen G, Ning N, Du Y, Liu W, Nan Y, Yuan L

“…In addition, ZP-ZR affected the expression of PI3K-Akt-related proteins and decreased the mRNA expression of Hub genes.Conclusion: ZP-ZR treats GC through the PI3K-Akt pathway.The present study provides a new idea for further investigation of ZP-ZR in the treatment of GC.Keywords: zanthoxyli pericarpium-zingiberis rhizoma, gastric cancer, network pharmacology, molecular mechanism, in vitro experimental validation…”
Get full text

Toward a circular carbon economy: Production of green C1 compounds through high-temperature CO2 electrolysis by Nan Zheng, Jing Zhu, Haitao Zhu, Jin Xuan, Haoran Xu, Meng Ni

“…Summary: The electrochemical reduction of CO2 to value-added carbon-containing chemicals using solid oxide electrolysis cells presents a significant opportunity for mitigating carbon emissions and enabling a circular carbon economy. …”
Get full text