Rapid Development of Breast Mass With Recurrent Episodes of Hypoglycemia Should Raise Suspicion of Breast Cancer With Insulinoma: A Case Report by Tingting Liu, Lin Deng, Ruohan Su, Lin Ni, Zhiwei Wang, Wanqiu Xiong, Bing Wang, Sheng Huang

“…Studies have demonstrated that hyperinsulinemia can promote tumor development through various pathways, posing substantial challenges to tumor treatment. …”
Get full text

Challenges of the COVID-19 Pandemic against Some elements of Modern Political Philosophy by bahram akhavan kazemi, javad salehi, Hosain Mohseni

“…The critical aspect of this article allows the author to present the relations emerging from the COVID-19 in human societies as unacceptable and replaceable. …”
Get full text

Physical model test on the sealing mechanism and reinforcement effect of flowing water grouting for water-sand mixture inrush in the Cuihongshan iron-polymetallic mine by Baofu WU, Wanghua SUI, Guilei HAN, Longfei LIANG, Xinhai YAO, Jiaxin FENG, Xingshuo XU

“…Under flowing-water conditions, water-sand mixture inrush in metal mines are highly destructive and sudden, posing a significant threat to mine safety. Effective and reliable treatment technologies remain underdeveloped. …”
Get full text

Pregnancy-induced thrombotic thrombocytopoenic purpura (TTP) complicated by atypical posterior reversible encephalopathy syndrome (PRES) and acute pancreatitis by Rithik Naik Korra, Nikhil Kumar Balagoni

“…Materials and Methods: A 28-year-old gravida 2, para 1 woman presented with seizures, vomiting, fever, decreased fetal movement and visual impairment. …”
Get full text

Plant-Based ZnO Nanoparticles for Green Nanobiocontrol of a Highly Virulent Bacterial Leaf Blight Pathogen: Mechanistic Insights and Biocompatibility Evaluation by Preeda Chanthapong, Duangkamol Maensiri, Paweena Rangsrisak, Thanee Jaiyan, Kanchit Rahaeng, Atcha Oraintara, Kunthaya Ratchaphonsaenwong, Jirawat Sanitchon, Piyada Theerakulpisut, Wuttipong Mahakham

“…<i>oryzae</i> (<i>Xoo</i>), poses a serious threat to rice cultivation. This study presents the green synthesis of zinc oxide nanoparticles (ZnO NPs) using an aqueous leaf extract of the medicinal plant <i>Centella asiatica</i> (L.) …”
Get full text

Deciphering the role of multi-functional Mg2GeO4:Eu3+, Sm3+ nanophosphors as a luminescent armour against counterfeiting and implementing its practical adaptability by Akshay Arjun, G.P. Darshan, S.C. Sharma, H. Nagabhushana, H.B. Premkumar

“…The escalating threat of counterfeiting poses a significant challenge across the world. Hence, the development of robust anti-counterfeiting measures and their ease of practical implementation are in demand. …”
Get full text

Role of structure-based drug design (SBDD) in the repurposing and discovery of anti-viral leads against Monkeypox virus disease by Jihane Touhtouh, Fettouma Chraa, Doha EL Meskini, Taoufiq Benali, Abdelhakim Bouyahya, Long Chiau Ming, Said Moshawih, Khalil Hammani, Tarik Aanniz

“…Although there are no specific approved MPOX drugs, here we present a thorough summary of current research on small molecules, encompassing both conventional and novel platforms. …”
Get full text

Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis by Jingjing Wei, Kai Wang, Yongkai Li, Jiao Huang, Ping Deng, Xianbo Xia, Cong Yang, Ling Xu, Junji Xu

“…The chronic inflammation in periodontitis suppresses the osteogenic potential of human periodontal ligament stem cells (hPDLSCs), posing a significant challenge to endogenous bone regeneration. …”
Get full text

Anionic Lipid Catalyzes the Generation of Cytotoxic Insulin Oligomers by Jhinuk Saha, Audrey Wolszczak, Navneet Kaur, Malitha C. Dickwella Widanage, Samuel D. McCalpin, Riqiang Fu, Jamel Ali, Ayyalusamy Ramamoorthy

“…Clinically, insulin aggregation at recurrent injection sites poses a challenge for diabetic patients who rely on insulin therapy. …”
Get full text

Long-term outcomes of light chain amyloidosis patients receiving heart transplant: A single-center experience by Khush Patel, MD, Zoe H. Tu, PharmD, Carrie Yuen, MD, Siddhartha Ganguly, MD, Allison N. Yun, PharmD, BCTXP, Janardhana R. Gorthi, MD, MBBS, Barry H. Trachtenberg, MD, Ashrith Guha, MD, MPH, Mahwash Kassi, MD, Ju Kim, MD, Rayan Yousefzai, MD, Kelty Baker, MD, Lawrence Rice, MD, Rammurti T. Kamble, MD, Horacio E. Adrogue, MD, Erik E. Suarez, MD, Mark Ghobrial, MD PhD, Ashish Saharia, MD, Constance M. Mobley, MD PhD, David W. Victor, MD, Jill C. Krisl, PharmD, BCPS, BCTXP, Richard Knight, MD, A. Osama Gaber, MD, Arvind Bhimaraj, MD, MPH, FACC, FHFSA

“…Light chain (AL) amyloidosis specifically poses challenges. While previous small studies have established the validity of OHT for AL amyloidosis, we present experience from a large contemporary series at a single center. …”
Get full text

Clinical and Molecular Characterization of Feline Sporotrichosis in the Brazilian Amazon: PCR-Based Identification of <i>Sporothrix brasiliensis</i> by Nayara Fátima Lazameth-Diniz, Danielle Barreto de Almeida, Flávia da Silva Fernandes, Adriana Oliveira da Silva Queiroz, Érica Simplicio de Souza, Kátia Santana Cruz, Ani Beatriz Jackisch Matsuura, Hagen Frickmann, João Vicente Braga de Souza

“…Sporotrichosis is a zoonotic fungal infection with increasing incidence in the Brazilian Amazon, primarily affecting domestic cats and posing risks to human health. This study characterized the clinical and epidemiological profiles of 29 feline sporotrichosis cases in Manaus and optimized molecular diagnostic methods for <i>Sporothrix</i> species identification. …”
Get full text

A high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes by Nidhi Patel, Alex Shen, Yuko Wada, Marcia Blair, Devyn Mitchell, Loren Vanags, Suah Woo, Matthew Ku, Kundivy Dauda, William Morris, Minjoo Yang, Björn C. Knollmann, Joe-Elie Salem, Andrew M. Glazer, Brett M. Kroncke

“…However, electrophysiological analysis can be complex and requires specialized expertise, posing a barrier to broader adoption in non-specialized labs. …”
Get full text

Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction by Boxuan Wei, Qingxiong Yu, Jiamin Jin, Danli Zhu, Bohan Lai, Jieyu Gu, Ran Yang, Huailiang Huang, Hongzhan Lin, Liang Zhang, Tao Zan, Feng Xie, Kang Zhang, Qingfeng Li

“…Abstract Giant congenital melanocytic nevus (GCMN) is a RAS/RAF mutation-driven syndrome characterized by extensive melanocytic lesions, posing psychological challenges and a lifelong risk of malignancy. …”
Get full text

A machine learning approach to predict phyllosphere resistome abundance across urbanization gradients by Rui-Ao Ma, Yi-Hui Ding, Shifa Zhong, Ting-Ting Jing, Xuechu Chen, Si-Yu Zhang

“…The heightened transmission potential in urban greenspaces may facilitate the spread of antibiotic resistance spread to human pathogens, which poses significant public health threats.…”
Get full text

An Oxidation Gradient Straddling the Small Planet Radius Valley by Collin Cherubim, Robin Wordsworth, Dan J. Bower, Paolo A. Sossi, Danica Adams, Renyu Hu

“…We present a population-level view of volatile gas species (H _2 , He, H _2 O, O _2 , CO, CO _2 , CH _4 ) distribution during the sub-Neptune to rocky planet transition, revealing in detail the dynamic nature of small planet atmospheric compositions. …”
Get full text

Exploring dihydropyrimidone derivatives as modulators of carbohydrate catabolic enzyme to mitigate diabetes by Syed Parween Ali, Farheen Mansoor, Shaymaa Fadhel Abbas Albaayit, Farman Ali, Ayed A. Dera, Muhammad Shahbaz, Jawad Ullah, Hailah M. Almohaimeed, Reem M. Gahtani, Ahmed M. Abdulfattah, Fahad M. Alshabrmi, Sarfaraz Alam, Saeed Ullah

“…Abstract Diabetes is a prevalent and serious metabolic disorder affecting millions globally, and it poses extensive health risks due to elevated blood glucose levels. …”
Get full text

Seasonal drought classification and its characteristics in the red soil region of southern China by Yong Zhong, Lei Gao, Xinhua Peng, Asim Biswas, Wei Hu, Yaji Wang

“…Study region: The red soil region of southern China Study focus: The red soil region of southern China faces serious seasonal drought, which poses a great threat to the sustainable development of local agriculture. …”
Get full text

Detection of Four Intermediate-mass Stars with Cool Companions in Low Mass Ratio Eclipsing Binaries by Linfeng Chang, Shengbang Qian, Lei Zang, Fuxing Li

“…\limits^{{\rm{d}}}$ 8) does not, which poses a challenge to the Kraft break. By plotting these components in the H-R diagram, it hints that all systems are main-sequence (MS) primaries with pre-MS companions. …”
Get full text

Microneedles-based local photothermal therapy promotes browning of white adipose tissue and combats obesity by Le Li, Hanxing Chen, Kexin Zhang, Xinying Hu, Mengfan Xu, Taotao Wen, Jialuo Ding, Mengyuan Zhao, Yeying Li, Yu Su, Zhenkun Lin

“…Obesity has emerged as a global epidemic, posing a significant threat to human health and imposing a huge burden on healthcare systems worldwide. …”
Get full text

Research on the Data-Driven Identification of Control Parameters for Voltage Ride-Through in Energy Storage Systems by Liming Bo, Jiangtao Wang, Xu Zhang, Yimeng Su, Xueting Cheng, Zhixuan Zhang, Shenbing Ma, Jiyu Wang, Xiaoyu Fang

“…By relying on measured data for parameter inversion, the method circumvents the limitations posed by commercial confidentiality, providing a novel technical pathway to enhance the fault ride-through (FRT) performance of energy storage systems (ESSs). …”
Get full text