Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants by Hara Kang, Yun Ji Ga, Jung Won Kim, Chaeyeon Kim, Se-Hwan Son, Chaeeun Gwak, Jung-Yong Yeh

“…However, the emergence of viral escape mutants poses a major barrier to the sustained antiviral activity of siRNA-based therapy. …”
Get full text

Mitigating Bovine Mastitis and Raw Milk Pathogen Risks: Inhibition of <i>Staphylococcus xylosus</i> by Mediterranean Plants’ Essential Oil by Rosario De Fazio, Giacomo Di Giacinto, Paola Roncada, Domenico Britti, Rosangela Odore, Paola Badino, Cristian Piras

“…Milk is frequently susceptible to contamination by potential pathogens, posing risks to both food safety and public health. …”
Get full text

The role of seed transmission in the spread of cereal viruses: Global challenges and prevalent threats in Ukraine by Halyna Snihur, Tetiana Shevchenko, Oleksiy Shevchenko, Anhelina Kyrychenko

“…Hereby, the biological properties of these viruses, the risks posed by seed transmission, and the economic impact on crop production are discussed. …”
Get full text

Architecture of Ti–6Al–4V thin-walled microthrusters fabricated via laser powder bed fusion by Jeongrak Lee, Junghoon Lee, Rae Eon Kim, Seonghyeon Kim, Kyungtae Kim, Youngsam Kwon, Hongjae Kang, Gunsu Yun, Dongsik Kim, Anna Lee, Hyoung Seop Kim

“…While laser powder bed fusion (PBF-LB/M) enables the realisation of complex geometries, the application of PBF-LB/M to fabricate such devices has posed critical challenges, including dimensional inaccuracies, limited feature resolution, and process-induced defects that can compromise mechanical reliability and propulsion performance. …”
Get full text

Repurposing Etalocib suppresses multidrug-resistant Staphylococcus aureus by disrupting the bacterial membrane by Xuancheng Huang, Congcong Li, Chaoqin Zhang, Yong Xiang, Zhijian Yu, Peiyu Li, Bing Bai, Zewen Wen, Tieying Hou

“…Abstract Background The emergence of multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) seriously poses a serious threat to human health and presents a significant clinical challenge. …”
Get full text

The morphological response to the 13 May 2022 major explosive event at Stromboli volcano, Italy, characterised by high-resolution UAS surveys by Markus Schmid, Ulrich Kueppers, Tullio Ricci, Riccardo Civico, Valeria Cigala, David Fee, Julia E. Gestrich, Alexandra M. Iezzi, Corrado Cimarelli, Caron E. J. Vossen, Richard M. Buzard, Maurizio Ripepe, Giorgio Lacanna, Donald B. Dingwell

“…Since 2019, the frequency of major explosive eruptions at Stromboli volcano (Italy) has increased, heightening the exposure of population and scientists to the hazards posed by ejecta. Morphological changes can directly alter the hazard potential associated with these phenomena. …”
Get full text

From waste to resource: King coconut biochar as a green adsorbent for bisphenol A removal by Hashinika Matharage, Mahesh Jayaweera, Nilanthi Bandara, Jagath Manatunge, Daham Jayawardana, Janith Dissanayake

“…The widespread presence of BPA in water bodies poses significant environmental and health concerns, highlighting the need for sustainable and efficient removal technologies. …”
Get full text

Molecular identification of Coranus spp. in a pregnant patient: A case of misidentified Chagas disease vector in Spain by Jorge Ligero-López, María Dolores Bargues, Patricio Artigas, Giulia Colangeli, Fabiola Peiró-Codina, María Ducons-Márquez, Beatriz López-Alonso, Pilar Goñi, Antonio Beltrán-Rosel

“…Our findings highlight the challenges posed by invasive species and the need for vigilance in regions where Chagas disease is not endemic. …”
Get full text

The Complete Genomes of <i>Microcystis ichthyoblabe</i> Kützing and <i>Microcystis protocystis</i> (Crow) Komárek & Anagnostidis Reveal the Complexity and Plasticity of <i>Microcys... by Jina Kim, Hyaekang Kim, Jaeduk Goh, Seung Won Nam, Eu Jin Chung, Miyoung Shin, Donghyeok Seol, Ki Hwan Kim, Woori Kwak

“…<i>Microcystis</i> is a genus of cyanobacteria responsible for harmful algal blooms (HABs) in freshwater ecosystems, posing significant ecological and public health risks. …”
Get full text

Managing Insomnia: A Review of Pharmacological and Non-Pharmacological Approaches by Martyna Kłossowska, Magdalena Badziąg, Karolina Skonieczna, Paulina Szulc, Laura Kurczoba, Olimpia Wiciun, Olga Kądziołka, Kacper Ordon

“…Introduction and Aim: Insomnia is one of the most common sleep disorders, affecting about 10% of the population. It poses a significant public health concern due to its association with increased risk of depression, hypertension, obesity, diabetes, substance abuse, and suicide. …”
Get full text

Assessing phenotypic variability and environmental interactions in wheat (Triticum aestivum) using the Eberhart and Russell Model by PARAS, MOHINDER SINGH DALAL, YOGENDER KUMAR, V S MOR, SUMAN DEVI, SONU LANGAYA, MUKESH KUMAR POONIA, HARSH CHAURASIA

“…The study highlights the importance of integrating traits early maturity, reduced plant height and enhanced grain characteristics into aimed at enhancing wheat productivity and resilience are crucial for adapting to the challenges posed by climate change. …”
Get full text

Chronic Posttraumatic Nail Reconstruction with an Eponychium Flap: Technique Description and Case Series by Ricardo Kaempf de Oliveira, MD, Paula Fischer, MD, Luna Hussein Colombelli, MD, Monique Alves, MD, Pedro Delgado, MD, PhD, Matias Craviotto, MD, PhD

“…Conclusion: We conclude that the eponychium flap performed to increase the size and improve the shape of the nail is a safe, reproducible procedure that generates good cosmetic and functional results, presenting a low rate of complications. It poses few risks and can be associated with the volar flap for pulp reconstruction, without any result change. …”
Get full text

A critical review of soil pollution sources and advances in the remediation of arsenic-contaminated soil by Fei He, Fukang Liu, Shehong Li, Xiaomin Mu, Qiao Han, Lian Song, Jen-How Huang

“…Its environmental levels have risen globally due to increased mining, industrial activities, vehicle emissions, and other human actions, posing significant environmental and health concerns. …”
Get full text

Minimally Invasive Percutaneous Tendon Transfer of Extensor Digitorum Longus Second Toe to Extensor Hallucis Longus for Chronic Traumatic Extensor Hallucis Longus Rupture: Technica... by Ankit Khurana, Ambrish K Singh, Nitin Kumar, Karan Rajpal, Gyanendra Verma, Jujhar Singh

“…The described approach not only overcomes the challenges posed by tendon retraction and degeneration but also decreases the risks of donor site morbidity and disease transmission. …”
Get full text

Methods for Preclinical Assessment of the Efficacy of Anticancer Medicines <i>in vivo</i> (Review) by M. L. Vasyutina, K. V. Lepik, M. S. Istomina, K. A. Levchuk, A. V. Petukhov, E. V. Shchelina, A. E. Ershova, O. N. Demidov, Ya. G. Toropova

“…The main risk to the clinical translatability of preclinical results for anticancer medicinal products is posed by the difficulty of simulating clinical conditions in an experimental model. …”
Get full text

The Role of Kidney Biopsy in Fabry Disease by Irene Capelli, Laura Martano, Gian Marco Berti, Gisella Vischini, Sarah Lerario, Vincenzo Donadio, Alex Incensi, Valeria Aiello, Francesca Ciurli, Benedetta Fabbrizio, Stefano Chilotti, Renzo Mignani, Gianandrea Pasquinelli, Gaetano La Manna

“…Despite the challenges posed by overlapping diseases and potential misdiagnoses, kidney biopsy remains an essential component of FD diagnosis and management, facilitating early detection, the monitoring of disease progression, and the evaluation of therapeutic responses.…”
Get full text

Proton beam therapy in paediatric radiation oncology: Defining the limitations, uncertainties and optimisation of treatment plans by C.S.M. Gillies, P. Lim, C. Dunlea, B. Timmermann, C. Alapetite, S. Bolle, I.F. Kristensen, K. Seiersen, Y. Lassen-Ramshad

“…The review aims to highlight how these are of particular importance for a paediatric cohort and present methods of mitigation to best utilise this modality.Despite clinical benefits, the limited availability of PBT centres poses challenges in communication, patient travel, and resource allocation. …”
Get full text

A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein by Yongpeng Sun, Liqin Liu, Hongsheng Qiang, Hui Sun, Yichao Jiang, Luo Ren, Zemin Jiang, Siyu Lei, Li Chen, Yizhen Wang, Xue Lin, Guosong Wang, Yang Huang, Yuhao Fu, Yujin Shi, Xiuting Chen, Hai Yu, Shaowei Li, Wenxin Luo, Enmei Liu, Qingbing Zheng, Zizheng Zheng, Ningshao Xia

“…Abstract Respiratory syncytial virus (RSV) poses a significant public health challenge, especially among children. …”
Get full text

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV by Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu

“…The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. …”
Get full text

Clinical and Epidemiological Characteristics of Pediatric Pertussis Cases: A Retrospective Study from Southeast Romania by Cristina Maria Mihai, Ancuta Lupu, Tatiana Chisnoiu, Adriana Luminita Balasa, Ginel Baciu, Silvia Fotea, Vasile Valeriu Lupu, Violeta Popovici, Simona Claudia Cambrea, Mircea Grigorian, Felicia Suciu, Florin-Daniel Enache, Anna Sora, Ramona Mihaela Stoicescu

“…The persistence of pertussis despite vaccination efforts highlights the challenges posed by waning immunity and diagnostic limitations, reinforcing the need for strengthened public health strategies.…”
Get full text