Dynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation. by Shane E Gordon, Daniel K Weber, Matthew T Downton, John Wagner, Matthew A Perugini

“…By means of umbrella sampling we show that these binding intermediates are thermodynamically metastable, consistent with both the available experimental data and the substrate binding model presented in this study. Our results provide insight into an important enzyme-substrate interaction in atomistic detail that offers the potential to be exploited for the discovery of more effective DHDPS inhibitors and, in a broader sense, dynamic protein-drug interactions.…”
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The optimal method of surgical treatment of patients with floating thrombosis of the iliac-femoral venous segment by O. A. Alukhanyan, R. A. Solovev, Kh. G. Martirosyan, D. S. Aristov, E. A. Petrosyan

“…The scientific work presents analysis of an examination of 78 patients with floating thrombosis in the iliac-femoral venous segment. …”
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NeuroAdaptiveNet: A Reconfigurable FPGA-Based Neural Network System with Dynamic Model Selection by Achraf El Bouazzaoui, Omar Mouhib, Abdelkader Hadjoudja

“…This paper presents NeuroAdaptiveNet, an FPGA-based neural network framework that dynamically self-adjusts its architectural configurations in real time to maximize performance across diverse datasets. …”
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Integrating Machine Learning and IoT for Effective Plant Disease Management by Bhoi Manjulata, Dubey Ahilya

“…This helps in establishing that there is still room for disruption in smart agriculture technologies, and that the future holds promise in enabling more breakthroughs related to this area.…”
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Efficiency Analysis of Sheep Farms in Cyprus by Sokratis Sokratous, Athanasios Ragkos, Georgios Arsenos, Alexandros Theodoridis

“…The main features of the most efficient farms are presented, and a comparative financial analysis is implemented between the efficient and less efficient farms. …”
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Effective Estimation of Hourly Global Solar Radiation Using Machine Learning Algorithms by Abdurrahman Burak Guher, Sakir Tasdemir, Bulent Yaniktepe

“…The results show that the estimations developed with the feature selection method were more successful for target locations, and the radiation potentials were similar. …”
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Electron beam irradiation of combined pharmaceuticals: propranonol and fluoxetine and related ecotoxicity by Nathalia Fonseca Boiani, Vanessa Silva Garcia Granadeiro, Sueli Ivone Borrely

“…In mixture, values ranged from 6.4 to 9.8. Fluoxetine was more toxic than propranolol for D.similis. The different pharmaceuticals concentrations employed in a mixture showed no difference in toxicity values. …”
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Nanotechnology-driven strategies in postoperative cancer treatment: innovations in drug delivery systems by Jun-Jie Zhou, Yan-Chuan Feng, Min-Long Zhao, Qi Guo, Xi-Bo Zhao

“…The emergence of nanomedicines presents a new frontier in postoperative cancer treatment, offering potential to inhibit tumor recurrence and manage postoperative complications. …”
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Benchmarking Spiking Neural Network Learning Methods With Varying Locality by Jiaqi Lin, Sen Lu, Malyaban Bal, Abhronil Sengupta

“…Spiking Neural Networks (SNNs), providing more realistic neuronal dynamics, have been shown to achieve performance comparable to Artificial Neural Networks (ANNs) in several machine learning tasks. …”
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Contextual Peano Scan and Fast Image Segmentation Using Hidden and Evidential Markov Chains by Clément Fernandes, Wojciech Pieczynski

“…The new HEMC-CPS model presents potential for the modeling and segmentation of more complex images, such as three-dimensional or multi-sensor multi-resolution images. …”
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Fishbone ingestion is a non-negligible cause of intestinal perforation by Wenwei Zuo, Jiexin Bai, Jiexin Bai, Jing Wei, Chuan Long

“…A case involving a 39-year-old patient presenting with acute abdominal pain was diagnosed as FIIP. …”
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Digital Financial Inclusion Promotes Economic Environment-Inclusive Growth in Underdeveloped Regions: Evidence from Gansu, China by Dandan LI, Nik Hadiyan Nik AZMAN

“…Finally, this study summarizes and presents prospects for future research.…”
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Point-of-Care Ultrasound Use in Hemodynamic Assessment by Ahmed Noor, Margaret Liu, Alan Jarman, Travis Yamanaka, Malvika Kaul

“…Beyond assessing volume status, this review discusses the role of POCUS in predicting fluid responsiveness and supporting more individualized, precise management strategies. …”
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Application of Temperature Fall-Off Interpretation Method in Superheavy Oil or Oil Sand SAGD Process by Guangyue Liang, Qian Xie, Shangqi Liu

“…The findings of this study can help determine the SAGD conversion timing from the preheating stage simpler and faster especially for the case of long horizontal well section deployed with more temperature measurement points.…”
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Rigidity of the affected femurs with systems of surgical treatment by N. Shidlovskiy, M. Dyman, A. Ilnitsky, V. Shytikov

“…The reinforced metal osteosynthesis with application of a extramedullar plate and bone cement is more stable method of fixing in comparison with rod devices of external fixing like AVF-K. …”
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Comparison of Numerical Results With Experiment Using Digital Image Correlation System of Multiobjective Structural Optimised Wind Turbine Blade by Ramazan Özkan, Mustafa Serdar Genç

“…This innovative approach offers significant insights for designing more efficient and sustainable turbine blades.…”
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Deepening our capacity for teaching with Place by Bronwyn A. Sutton, Robin Bellingham, Peta J. White

“…This paper presents a learning journey about deepening capacity for teaching with Place through relational learning and shares three pedagogical ingredients that are integral in enacting more ethical, decolonial place pedagogies. …”
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Lsz ghostbusters in the quadratic gravity stage by Osvaldo P. Santillán

“…Abstract The present letter considers the quantization method developed in (Salvio et al. in Eur Phys J C 78(10):842, 2018; Salvio in Front Phys 6:77, 2018, Phys. …”
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Comparison of TLS and photogrammetric workflows for tracking Alpine rock slope failures by L. Raffl, L. Lucks, C. Holst

“…This paper presents a comparative analysis of photogrammetric and Terrestrial Laser Scanning (TLS) workflows for geo-monitoring alpine rock slope failures, focusing on the quality of the resulting point clouds and 3D displacement vectors. …”
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Water security and sustainable development by Zineb Moumen, Najiba El Amrani El Idrissi, Manuela Tvaronavičienė

“…In this light, Morocco should be more realistic, and adopt the appropriate management strategies, which go hand in hand with the sustainable development goals.…”
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