Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…Researchers are increasingly focusing on the development of safer and more selective alternatives, with natural compounds being studied as potential starting points for the creation of more effective drug candidates with a favorable therapeutic index. …”
Get full text

Deterministic and Stochastic Study of the X-Ray Emission from the TeV Blazar Mrk 421 by Radim Pánis, Gopal Bhatta, Tek P. Adhikari, Maksym Mohorian, Suvas Chandra Chaudhary, Adithiya Dinesh, Rajesh K. Bachchan, Niraj Dhital, Zdeněk Stuchlík

“…We present a comprehensive timing analysis of X-ray data from the XMM-Newton satellite, examining 50 light curves covering 17 yr of observations of the blazar Mrk 421. …”
Get full text

Differentiation grade as a risk factor for lymph node metastasis in T1 colorectal cancer by Osamu Shiina, Shin‐ei Kudo, Katsuro Ichimasa, Yuki Takashina, Yuta Kouyama, Kenichi Mochizuki, Yuriko Morita, Takanori Kuroki, Shun Kato, Hiroki Nakamura, Shingo Matsudaira, Masashi Misawa, Noriyuki Ogata, Takemasa Hayashi, Kunihiko Wakamura, Naruhiko Sawada, Toshiyuki Baba, Tetsuo Nemoto, Fumio Ishida, Hideyuki Miyachi

“…However, whether the grading is based on the least or most predominant component when the lesion consists of two or more levels of differentiation varies among institutions. …”
Get full text

Identification and Distribution of Begomoviruses Infecting Cassava Fields in Sierra Leone by Musa Decius Saffa, Alusaine Edward Samura, Mohamed Alieu Bah, Angela Obiageli Eni, Ezechiel B. Tibiri, Saïdou Zongo, William J.-L. Amoakon, Fidèle Tiendrébéogo, Justin Simon Pita, Prince Emmanuel Norman

“…The results indicate more prevalence of the EACMCMV variant in Sierra Leone. …”
Get full text

Assessment of body composition, sarcopenia and protein intake in mild to moderate Parkinson’s disease by Danielle Pessoa Lima, Danielle Pessoa Lima, Pauliana Alencar Monteiro, João Rafael Gomes de Luna, Antonio Brazil Viana-Júnior, Lucas Tadeu Rocha Santos, Samuel Brito de Almeida, Rayanne Rego Ferreira Saldanha, Madeleine Sales de Alencar, Fábia Karine de Moura Lopes, Átila Pereira Alencar, Raisa Carvalho de Brito Arcanjo Chaves, Wallena Cavalcante Brito, Paulo Ribeiro Nóbrega, Alexandre Bastos Lima, Pedro Braga-Neto, Pedro Braga-Neto, Jarbas de Sá Roriz-Filho, Renan Magalhaes Montenegro Júnior

“…We did not include patients with severe disease who exhibit more malnutrition, dysphagia, cognitive impairment, dyskinesias, and consequently more sarcopenia. …”
Get full text

The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques. by Andrea J Radtke, Ifeanyichukwu U Anidi, Leanne Arakkal, Armando J Arroyo-Mejias, Rebecca T Beuschel, Katy Börner, Colin J Chu, Beatrice Clark, Menna R Clatworthy, Jake Colautti, Fabian Coscia, Joshua Croteau, Saven Denha, Rose Dever, Walderez O Dutra, Sonja Fritzsche, Spencer Fullam, Michael Y Gerner, Anita Gola, Kenneth J Gollob, Jonathan M Hernandez, Jyh Liang Hor, Hiroshi Ichise, Zhixin Jing, Danny Jonigk, Evelyn Kandov, Wolfgang Kastenmüller, Joshua F E Koenig, Rosa K Kortekaas, Aanandita Kothurkar, Alexandra Y Kreins, Ian T Lamborn, Yuri Lin, Katia Luciano Pereira Morais, Aleksandra Lunich, Jean C S Luz, Ryan B MacDonald, Chen Makranz, Vivien I Maltez, John E McDonough, Ryan V Moriarty, Juan M Ocampo-Godinez, Vitoria M Olyntho, Annette Oxenius, Kartika Padhan, Kirsten Remmert, Nathan Richoz, Edward C Schrom, Wanjing Shang, Lihong Shi, Rochelle M Shih, Emily Speranza, Salome Stierli, Sarah A Teichmann, Tibor Z Veres, Megan Vierhout, Brianna T Wachter, Adam K Wade-Vallance, Margaret Williams, Nathan Zangger, Ronald N Germain, Ziv Yaniv

“…Multiplexed imaging is a powerful approach in spatial biology, although it is complex, expensive and labor-intensive. Here, we present the IBEX Knowledge-Base, a central resource for reagents, protocols and more, to enhance knowledge sharing, optimization and innovation of spatial proteomics techniques.…”
Get full text

Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series by Zachary B. Koloff, Daniel A. Hamstra, John T. Wei, Jeffrey S. Montgomery, Scott A. Tomlins, Angela J. Wu, Todd M. Morgan, Javed Siddiqui, Kellie Paich, Arul M. Chinnaiyan, Felix Y. Feng, Alon Z. Weizer, Lakshmi P. Kunju, Brent K. Hollenbeck, David C. Miller, Ganesh S. Palapattu, Rohit Mehra

“…GS 3 + 4 with TP5 was also associated with positive surgical margins (SM), seminal vesicle involvement (SVI), and higher pre-operative prostate-specific antigen (PSA) values, but without statistical significance. GS 4 + 3 with TP5 more commonly presented with EPE, positive SM, SVI, and greater TD and pre-operative PSA level than GS 4 + 3 alone. …”
Get full text

Lymphocyte-Infiltrated Periportal Region Detection With Structurally-Refined Deep Portal Segmentation and Heterogeneous Infiltration Features by Hung-Wen Tsai, Chien-Yu Chiou, Wei-Jong Yang, Tsan-An Hsieh, Cheng-Yi Chen, Che-Wei Hsu, Yih-Jyh Lin, Min-En Hsieh, Matthew M. Yeh, Chin-Chun Chen, Meng-Ru Shen, Pau-Choo Chung

“…Moreover, the statistics of the ratio of the detected infiltrated portal boundary have high correlation to the Ishak grade (Spearman&#x0027;s correlations more than 0.87 with p-values less than 0.001) and medium correlation to the liver function index aspartate aminotransferase and alanine aminotransferase (Spearman&#x0027;s correlations more than 0.63 and 0.57 with p-values less than 0.001). …”
Get full text

Swedish national guidelines on urothelial carcinoma: 2024 update on advanced and metastatic disease by Anders Ullén, Firas Aljabery, Pär Dahlman, Karin Falkman, Truls Gårdmark, Tomas Jerlström, Susanna Holst, Sofia Kjellström, Anna-Karin Lind, Dimitrios Papantoniou, Jonas Stenlund, Viveka Ströck, Karin Söderkvist, Helena Thulin, Elin Trägårdh, Ingrida Verbiene, Jonas Wallström, Elisabeth Öfverholm, Fredrik Liedberg

“…The Swedish guidelines apply a more structured and liberal recommendation for the use of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in patients with locally advanced urothelial carcinomas compared to the EAU-guidelines and recommend such examinations prior to transurethral resection. …”
Get full text

Case Report: Intra-articular injection of tocilizumab for arthritis treatment in chronic graft-vs.-host disease by Mingyu Xie, Mingyu Xie, Mingyu Xie, Qin Liu, Huiting Yuan, Yumei Chen, Xian Zou, Zhenhong Zhang, Zhenhong Zhang, Baimao Zhong, Baimao Zhong, Huasong Zeng, Haisheng Zeng, Haisheng Zeng

“…Although his clinical symptoms showed remission at early stages, his knee joints were more swollen, and he could not stand after being infected with COVID-19. …”
Get full text

Computed tomography angiography in the diagnosis of non-ST-elevation myocardial infarction: redefining our first line of defense by Yvonne J.M. van Cauteren, Marie-Julie D.K. Lemmens, Sebastiaan C.A.M. Bekkers, Bas L.J.H. Kietselaer, Jordi Heijman, Ralph A.L.J. Theunissen, Braim Rahel, Talitha Voorn, Sander M.J. van Kuijk, Robin Nijveldt, Kevin Vernooy, Joachim E. Wildberger, Casper Mihl, Martijn W. Smulders

“…Nineteen patients (29%) met the criteria of ≥2 high-risk plaque (HRP) features, which was more often present in patients with NSTEMI compared to those without NSTEMI (43% and 8%, respectively, p = 0.002). …”
Get full text

Modern Approaches in Immunoprophylaxis of Infectious Diseases During Pregnancy by Leyla S. Namazova-Baranova, Marina V. Fedoseenko, Liliya R. Selimzyanova, Tatiana A. Kaliuzhnaia, Firuza Ch. Shakhtakhtinskaya, Svetlana V. Tolstova, Arevaluis M. Selvyan

“…Every year more countries recommend vaccination for pregnant women. …”
Get full text

A Case of Double Gallbladder with Adenocarcinoma Arising from the Left Hepatic Duct: A Case Report and Review of the Literature by Masahiro Kawanishi, Yukio Kuwada, Yutaka Mitsuoka, Shogo Sasao, Teruo Mouri, Eiichi Takesaki, Tadateru Takahashi, Kazuhiro Toyota, Tamaki Nakatani

“…A review of the literature is presented.…”
Get full text

YOLOv8-Scm: an improved model for citrus fruit sunburn identification and classification in complex natural scenes by Guoxun Cong, Guoxun Cong, Xinghong Chen, Xinghong Chen, Zongyu Bing, Zongyu Bing, Wenhuan Liu, Wenhuan Liu, Xiangling Chen, Qun Wu, Zheng Guo, Zheng Guo, Yongqiang Zheng, Yongqiang Zheng

“…Compared to other models like SSD, Faster R-CNN, YOLOv5n, YOLOv7-tiny, YOLOv8n, and YOLOv10n, YOLOv8-Scm outperforms in mAP50, Precision, and Recall, and is significantly more efficient in terms of computational parameters. …”
Get full text

Head and Neck Cancer in Suriname: An Epidemiologic Review of Clinical and Pathologic Features of Patients Treated Between 2009 and 2021 by Sangeeta K. Bisheshar, Els T.M. Dams, Mikel Chan, Lorian Slagter-Menkema, Harie Basdew, Tineke van der Sluis, Rabia N. Mohamedradja-Taus, Dave P. Ameerali, Ralph A.E. Akrum, Surya Sheorajpanday, Robert Mehilal, Rachel S. van Leeuwaarde, Lot A. Devriese, Boukje A.C. van Dijk, Stefan M. Willems, Bert van der Vegt, Gerben E. Breimer

“…Patients with LC were more often smokers, whereas patients with oropharyngeal carcinoma (OPC) more often consumed alcohol. …”
Get full text

Evaluation of forensic toxicological characteristics of cases under the age of eighteen with substance use: a sample from Türkiye by Kerem Sehlikoğlu, Murat Kamalak, Mehmet Dağlıoğlu, Seval Gülçiçek, Fatma Köse, Hicran Nermin Demir, Tuğba Çakır, Duygu Ülkü, Melek Rüveyda Koca, Demet Dönmez, Beyza Kılınç, Zeynep Bilge

“…While cannabis use was more prevalent among males, ATS use was more common among females. …”
Get full text

Repeat expansions in RFC1 gene in refractory chronic cough by Barnaby Hirons, Peter S.P. Cho, Katie Rhatigan, Joe Shaw, Riccardo Curro, Bianca Rugginini, Natalia Dominik, Richard D. Turner, Ewan Mackay, James H. Hull, Hisham Abubakar-Waziri, Harini Kesavan, Caroline J. Jolley, Robert D. Hadden, Andrea Cortese, Surinder S. Birring

“…The symptom of pins and needles was more frequent in RFC1++ (n=4, 100%) compared to RFC1−− (n=12, 33%) (p=0.01). …”
Get full text

Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood by Hanane Omichessan, Dzevka Dragic, Dzevka Dragic, Dzevka Dragic, Vittorio Perduca, Vittorio Perduca, Thérèse Truong, Silvia Polidoro, Marina Kvaskoff, German Cano-Sancho, Jean-Philippe Antignac, Laura Baglietto, Francesca Romana Mancini, Gianluca Severi, Gianluca Severi

“…BackgroundPerfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS) are among numerous chemicals in the Per- and polyfluoroalkylated substances (PFAS) group, which are commonly present in various consumer and industrial products. …”
Get full text

Succinimidyl Alginate-Modified Fibrin Hydrogels from Human Plasma for Skin Tissue Engineering by Ana Matesanz, Raúl Sanz-Horta, Alberto Gallardo, Cristina Quílez, Helmut Reinecke, Pablo Acedo, Diego Velasco, Enrique Martínez-Campos, José Luis Jorcano, Carlos Elvira

“…The objective was to evaluate whether this modification could create a more stable matrix suitable for supporting skin tissue development. …”
Get full text

Chickens perceive humans as social buffers and may follow human-given cues: A pilot study by Vitor Hugo Bessa Ferreira, Elise Calesse, Lucille Dumontier, Fabien Cornilleau, Julie Lemarchand, Auriane Foreau, Maxime Quentin, Léa Lansade, Céline Tallet, Xavier Boivin, Ludovic Calandreau

“…Conversely, MC birds displayed fewer calm behaviors and greater withdrawal when the experimenter was present. Brown birds showed more calm behaviors, reduced movement, and spent more time near the experimenter than white birds. …”
Get full text