Comprehensive evaluation of the MeltPro MTB/PZA assay for prediction of pyrazinamide resistance in multidrug-resistant tuberculosis by Guiqing He, Chunxia Tu, Yelei Zhu, Qingyong Zheng, Qiulong Zhou, Wenzhen Zhou, Ouyang Huang, Bin Chen, Zhengwei Liu, Ye Xu, Xiangao Jiang

“…Demonstrating sensitivity and specificity comparable to WGS and pDST, this assay offers a practical, accessible approach for timely PZA resistance prediction. It supports more tailored and effective MDR-TB treatment strategies, which are essential for optimizing patient care in both well-resourced and constrained settings.…”
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Long-term outcomes in leucine-rich glioma inactivated-1 autoimmune encephalitis and associated biomarkers of inflammation and neuronal and glial injury by Tyler L. Borko, Tyler L. Borko, Phillip Winters, Kelli M. Money, Stefan Sillau, Sadie Eggmann, Sean Selva, Alanna Ritchie, Ryan Kammeyer, Ryan Kammeyer, Gregory P. Owens, Jeffrey L. Bennett, Jeffrey L. Bennett, Amanda L. Piquet

“…MoCA scores tended to recover more quickly in patients presenting with lower Nfl scores at symptom onset.ConclusionImproved clinical symptoms were correlated with improvements in initially high NfL and GFAP levels. …”
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Efficacy and safety of a new original interleukin 17A inhibitor in the treatment of patients with active ankylosing spondylitis: results of a basic (BCD-085-3/AILAS) and extended (... by Sh. Erdes, V. I. Mazurov, T. V. Dubinina, I. Z. Gaydukova, S. A. Lapshina, E. V. Zonova, D. G. Krechikova, T. V. Plaksina, O. V. Reshetko, S. A. Smakotina, P. А. Shesternya, I. G. Gordeev, T. G. Makulova, T. V. Povarova, T. A. Raskina, N. F. Soroka, A. M. Pristrom, E. V. Kunder, Yu. V. Usacheva, E. Yu. Stukalina, A. V. Eremeeva, E. V. Chernyaeva, R. A. Ivanov

“…In the extended study, an ASAS20 response at week 52 was recorded in 86.4% of patients. One or more AEs during the first 16 weeks of therapy were reported in 11 (50.0%) patients of the 40-mg group; in 6 (27.3%) of the 80 mg group; in 4 (18.2%) of the 120 mg group and in 7 (31.8%) of the placebo group (p=0.183). …”
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Harmonization of multi-center diffusion tensor tractography in neonates with congenital heart disease: Optimizing post-processing and application of ComBat by Benjamin Meyers, Vincent K. Lee, Lauren Dennis, Julia Wallace, Vanessa Schmithorst, Jodie K. Votava-Smith, Vidya Rajagopalan, Elizabeth Herrup, Tracy Baust, Nhu N. Tran, Jill V. Hunter, Daniel J. Licht, J. William Gaynor, Dean B. Andropoulos, Ashok Panigrahy, Rafael Ceschin

“…Advanced brain imaging of neonatal macrostructure and microstructure, which has prognosticating importance, is more frequently being incorporated into multi-center trials of neonatal neuroprotection. …”
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An outbreak investigation of a highly fatal Lassa Fever in Bo District, Sierra Leone, 2023 by Ibrahim Conteh, Hassan Swarray, Gbessay Saffa, Amara Alhaji Sheriff, Solomon Aiah Sogbeh, Umaru Sesay, Kassim Kamara, Anna Jammeh, Adel Hussein Elduma, Gebrekrstos Negash Gebru

“…Methods: We adapted the Lassa fever surveillance case definition, and a suspected case of Lassa Fever was any person who presented with gradual onset of one or more of the following: malaise, fever, headache, cough, nausea, vomiting, myalgia, chest pain, hearing loss and either history of contact with excreta or urine of rodents or history of contact with confirmed Lassa fever case from January 1 to March 14, 2023. …”
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RAD-Seq-derived SSR markers: a new paradigm for genetic analysis and construction of genetically improved production populations in Pinus koraiensis by Pingyu Yan, Wanying Zhang, Junfei Hao, Xiaotian Miao, Jun Wu, Zixiong Xie, Zhixin Li, Lei Zhang, Hanguo Zhang

“…A production population of 20 individuals was constructed via the simulated annealing algorithm, which exhibited a more reasonable mating system (F=−0.028) and demonstrated superior cone production compared with that of the plus tree population, with an increase of 79.6%. …”
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Slow virologic control but strong immune and metabolic recovery with dolutegravir-anchored therapy in an HIV cohort in Ghana by Mark Appeaning, Edwin Magomere, Alberta Mawulawoe Abotsi, Nana Ama Yeboaa Amoako, Kirk Elorm Kouffie, Becky Ewurama Tetteh, Bridget Nana Darkoa Quist, Christèle Nguepou Tchopba, Gloria Akosua Ansa, Evelyn Yayra Bonney, Peter Kojo Quashie

“…ART-naïve participants were 19 times more likely to have unsuppressed viral loads at baseline compared to ART-experienced participants. …”
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Impact of COVID-19 on the prevalence of dyslipidemia in Ecuador: A cross-sectional study between 2017 and 2022 by Josue Rivadeneira, Luis Fuenmayor-González, Michelle Jácome-García, Nancy Flores-Lastra, Hugo Delgado, Tamara Otzen

“…Dyslipidemia was considered present when one or more parameters exceeded specific thresholds. …”
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Overlapping turbulent boundary layers in an energetic coastal sea by A. F. Valcarcel, A. F. Valcarcel, A. F. Valcarcel, C. L. Stevens, C. L. Stevens, J. M. O'Callaghan, J. M. O'Callaghan, S. H. Suanda

“…These overlapping boundary layers were present in water depths 5-fold deeper than previously observed, which has implications for the vertical extent of material fluxes from the surface or seafloor. …”
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In Vitro Enzymatic and Computational Assessments of Pyrazole–Isatin and Pyrazole–Indole Conjugates as Anti-Diabetic, Anti-Arthritic, and Anti-Inflammatory Agents by Ahmed M. Naglah, Abdulrahman A. Almehizia, Mohammed Ghazwani, Asma S. Al-Wasidi, Abdelrahman A. Naglah, Wael M. Aboulthana, Ashraf S. Hassan

“…In the future, our research team will present in vitro, in vivo biological, and computational assessments to hopefully obtain effectual agents such as anti-diabetic, anti-arthritic, and anti-inflammatory.…”
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Protomaster of the frescoes in the paracclesion of the Holy Anargyroi in the Vatopedi Monastery (1365/1366-1368) by Gavrilović Anđela Đ.

“…John Chrysostom in the central apse (fig. 2, 3a-b, 5) offers a comprehensive analysis, on the basis of which this fresco is, in the present paper, attributed to Serbian painter Metropolitan Jovan Zograf. …”
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THE AESTHETICS OF RUINS IN VERNACULAR PHOTOGRAPHY IN RUSSIAN SOCIAL MEDIA: STATING THE RESEARCH PROBLEM / ЭСТЕТИКА РУИН В ВЕРНАКУЛЯРНОЙ ФОТОГРАФИИ РУССКОЯЗЫЧНЫХ СОЦИАЛЬНЫХ МЕДИА: П... by CHUMAKOVA VARVARA PAVLOVNA / ЧУМАКОВА ВАРВАРА ПАВЛОВНА

“…The symbolic aspect is often associated more with the “Studium” of the photographs. Thereby, the global historical narrative is destroyed; the past, the present and the future are no longer connected in a single chain, but grow out of individual private memories, stories, or commentaries. …”
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Design and implementation of virtual reality instructional tools for 3D printing processes in digital manufacturing by Daniel Cubillos, Magesh Chandramouli

“…As both the general public and institutions become better acquainted with VR, more opportunities are created for instruction. VR has been associated with entertainment as the primary use for the technology, however, there is potential for VR in both business and educational as an effective learning tool. …”
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An Evaluation of Recent Global Geopotential Models for Strip Area Project in Turkey by Serkan Doganalp

“…The aim of this study is to present the evaluations based on comparisons of geoid heights that are computed from several global geopotential models (GGMs) and the GNSS/levelling data. …”
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Immununohistochemical Analysis of Progesterone Receptor and Ki-67 in Meningioma: A Cross-sectional Study by Rathin Hazra, Saurabh Dash, Prasenjit Kumar Bar, Sarbari Kar Rakshit

“…Conclusion: The results indicate that middle-aged females are more likely to develop meningiomas, with the most common site being intracranial. …”
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Causes of the Outer Spiral Rainbands in Typhoon Yagi （ 2018） in Shandong Province of China by Chunyan SHENG, Sudan FAN, Qiaona QU, Shijun LIU, Wengang ZHU

“…On August 14， 2018， Typhoon Yagi （2018） moved northward and impacted Shandong Province of China， resulting in widespread rainstorm and heavy rainstorm.The total rainfall caused by the typhoon in Shandong presents a round-shaped distribution.Specifically， on August 14， an outer spiral rainband appeared on the typhoon periphery in southeastern Shandong， bringing short-term heavy rainfall and local heavy rainstorms.Due to the relatively small scale of this rainband， both numerical forecasting models and forecasters face challenges in predicting its rainfall accurately.To study the mechanisms of the outer spiral rainbands of Typhoon Yagi， the characteristics and causes of the spiral rainbands are investigated in this study by using radar data and the observations from ground-based stations， radiosonde stations and aircraft.Numerical experiments are also conducted based on the Advanced Research WRF （Weather Research and Forecasting） model and its Hybrid-3DVAR （three-dimensional variational） data assimilation system.The model adopts 12 km and 4 km one-way nested grids， with 44 vertical layers.The initial ensemble perturbation fields are generated by using a stochastic perturbation method， and the Ensemble Transform Kalman Filter （ETKF） method is used for the bias correction of ensemble forecast， providing flow dependent background errors for the Hybrid-3DVAR assimilation module.Comparative experiments with and without the Aircraft Meteorological Data Relay （AMDAR） data assimilation are conducted by adopting 100% flow-dependent error covariance and by using a 45-minute assimilation time window.The results indicate that the outer spiral rainbands are formed by the merging and development of several linear mesoscale convective systems （MCSs）.The outer spiral rainbands exhibit distinct characteristics of the linear MCSs with leading stratiform precipitation， i.e.， the linear MCSs consist of several convective cells with back-building convection.There are several stronger linear MCSs merging laterally into other linear MCSs.Broad stratiform echoes appear in the front （eastern part） of the linear MCS in its maturity stage， and the convection develops up to 10 km or more.There is a weak-echo transition zone between the strong convective line and the sub-strong stratiform echo region.Short-term heavy rainfall occurs along the linear MCS at the maturity stage.The water vapor of heavy rainfall mainly comes from the near-surface layer （below 850 hPa） around the typhoon， and the water vapor flux convergence is mainly concentrated near the wind field convergence line.Before convection initiation， the middle and lower levels over Shandong are thermally unstable with high temperature and high humidity， and the wind rotates clockwise with height， which favor the development of convective systems.As the typhoon slowly moves northward， downward intrusion of cold air appears at 500 hPa.Below 900 hPa， on the southeast of the typhoon over central Shandong there are local convergence between southwesterly wind and southerly wind， and between southerly wind and southeasterly wind.The convergence-induced dynamic uplift triggers the release of unstable energy， stimulating several local linear MCSs.The MCSs develop northward along the steering flow.The linear MCSs merge and strengthen for several times， and finally the elongated spiral rainbands occur.During the convection lifetime， the updrafts are noticeably stronger than the downdrafts.At the mature stage of the convective systems， dry and cold downdrafts appear in the lower levels in the front of the MCS.Convective systems at the heights above 600 hPa move rapidly eastward with the upper-air steering flow， leading to the gradual weakening and dissipation of the linear MCS.Assimilation of AMDAR can improve the typhoon track and wind field forecasts of the WRF model， as well as the dynamical triggering mechanism of convective systems.Thus， the occurrence of spiral rainbands in the typhoon periphery could be accurately forecasted.Furthermore， central Shandong is a mountainous region， so how does the topography influence the triggering and developing of convective systems？ …”
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Factors Affecting Attitudes towards Cohabitation among Iranian Youth by Reyhane Ghasemi Neyasar, Rasoul Sadeghi, Fatemeh Torabi

“…Introduction In previous decades, marriage has been more prevalent, while cohabitation has been largely limited to specific social groups. …”
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Research on the pharmacological potential of 1-alkyl derivatives of 3,5-dimethyl-4-((4-nitrobenzylidene)amino)-1,2,4-triazolium bromide by O. I. Panasenko, T. S. Brytanova, A. S. Hotsulia

“…Particular attention should be paid to 3,5-dimethyl-1-nonyl-4-((4-nitrobenzylidene)amino)-1,2,4-triazolium bromide as a substance with significant potential for antifungal properties, which allows us to recommend this compound for further more constructive and extended in vitro and in vivo studies.…”
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Les tasques motrius significatives (TMS): òptims procediments d'ensenyament i d'aprenentatge by Francesc Buscà Donet, Oleguer Camerino Foguet, Marta Castañer Balcells

“…In this regard we believe that the essence of their contribution to the curriculum, which is more akin to active, participatory and experiential learning, enables the development of educational approaches based on motor activity. …”
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Transhumanism and New Challenges in Political Theories by Matin Anjomrooz, Mohammad Khezri

“…For example, Plato’s class-based system—predicated on innate talents—is undermined by genetic engineering technologies that can artificially alter those traits.Contemporary theories, such as liberalism and postmodernism, are more adaptable due to their emphasis on equality, autonomy, and identity diversity. …”
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