Effect of remimazolam besylate versus midazolam on time to extubation in critically ill, mechanically ventilated patients: a randomized controlled trial by Renhuai Liu, Binxiao Su, Guifen Gan, Guangming Wang, Chengli Wang, Ning Xu, Guangcai Feng, Hao Guo, Qingxia Yuan, Aiguang Li, Wenping Zheng, Jiang Li, Yu Chen, Xijing Zhang

“…BackgroundPrevious studies have indicated that the administration of short-acting sedatives prior to weaning from mechanical ventilation is linked to a more rapid recovery and extubation process, in addition to lowering intensive care unit (ICU) treatment expenses. …”
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Cool topoclimates promote cold-adapted plant diversity in temperate mountain forests by Borderieux, Jeremy, De Lombaerde, Emiel, De Pauw, Karen, Sanczuk, Pieter, Vangansbeke, Pieter, Vanneste, Thomas, De Frenne, Pieter, Gégout, Jean-Claude, Serra-Diaz, Josep

“…Cold topoclimates harbored 30% more species than the average species richness across our plots. …”
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Integrated deep vertical rotary tillage and subsurface pipe drainage techniques for sustainable soil salinization management and cotton production in arid regions by Zhijie Li, Qiang Meng, Ling Li, Zhentao Bai, Yanjie Li, Hongguang Liu, Pengfei Li, Tangang Wang

“…Soil salinization impacts over 6 % of the world’s arable land, presenting an even greater challenge to agriculture in arid regions. …”
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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…Ventricular fibrillation (VF) was a recurrent event, which was counteracted with amiodarone, high blood potassium levels and in one case with propranolol. Males were more likely to experience VF than females and 15 of 20 animals survived the experiment. …”
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Tumor Deposits as an Adverse Prognostic Indicator in Stage III Colon Cancer: A Multicenter Database Study by Jeeyou Kim, MD, Dong Woon Lee, MD, Ji Won Park, MD, PhD, Seung-Bum Ryoo, MD, PhD, Heung-Kwon Oh, MD, PhD, Rumi Shin, MD, PhD, Jin Sun Choi, MD, Min Jung Kim, MD, Sung-Chan Park, MD, Duck-Woo Kim, MD, PhD, Seung Chul Heo, MD, PhD, Sung-Bum Kang, MD, PhD, Seung-Yong Jeong, MD, PhD, Kyu Joo Park, MD, PhD, Jae Hwan Oh, MD, PhD, On Behalf of the Seoul Colorectal Research Group (SECOG)

“…When lymph node metastases (LNMs) are present, their number is considered to determine nodal stages, such as N1a/b or N2a/b, regardless of TDs. …”
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Orchard variable-rate spraying method integrating GNSS and wind-excited audio-conducted leaf area density by Hangxing Zhao, Hangxing Zhao, Hangxing Zhao, Shenghui Yang, Shenghui Yang, Shenghui Yang, Wenwei Li, Wenwei Li, Han Feng, Han Feng, Shijie Jiang, Shijie Jiang, Weihong Liu, Weihong Liu, Jingbin Li, Yongjun Zheng, Yongjun Zheng, Songchao Zhang

“…Ground runoff of spray solution was reduced by 62.29%, and droplet deposition density on leaf surfaces exceeded 25 droplets/cm², meeting the standard for low-volume insecticide application.DiscussionThe integration of GNSS and wind-excited audio sensing for real-time canopy density assessment enables more precise and efficient pesticide application in orchards. …”
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A comprehensive integrated disease management program for phenylketonuria (IDMP-PKU) from Türkiye: rationale, design and patient characteristics by Mehmet Cihan Balci, Deniz Kor, Yilmaz Yildiz, Meryem Karaca, Fatma Derya Bulut, Ayca Burcu Kahraman, Alihan Yesil, Ezgi Burgac, Kismet Ciki, Arzu Selamioglu, Burcu Koseci, Asli Durmus, Irem Kaplan, Esra Kara, Halise Neslihan Mungan, Serap Sivri, Gulden Fatma Gokcay, Aysegul Tokatli, Mubeccel Demirkol, Turgay Coskun, Imran Ozalp

“…Homozygous mutations were more common in patients with parental consanguinity (76.8% vs 17.1%; p < 0.001). …”
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Genomic surveillance indicates high site-specific heterogeneity of West Nile virus in mosquitoes in rural regions of Germany across seasons by Corinna Patzina-Mehling, Anne Kopp, Leif Rauhöft, Tatiana Șuleșco, Terry C. Jones, Christian Drosten, Felix Gregor Sauer, Renke Lühken, Sandra Junglen

“…Surprisingly, genetically different variants were found at same sites, and, in a few cases, genetically more similar variants were found at different sites. …”
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HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya by Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen

“…In practice, accelerating flower formation and inducing more flowers usually result in higher yield. However, the genes for this purpose have not been well characterized in pitaya. …”
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Self-reported health and depression among EIRA cohort: a moderated mediation model of sex and perceived social support by Raquel Sánchez-Recio, Raquel Sánchez-Recio, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Fátima Méndez-López, Fátima Méndez-López, Fátima Méndez-López, Santiago Gascón-Santos, Santiago Gascón-Santos, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Olaya Tamayo-Morales, Olaya Tamayo-Morales, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, Marc Casajuana, Tomas López-Jiménez, Emma Motrico, Emma Motrico, Irene Gómez-Gómez, Irene Gómez-Gómez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, María Luisa Rodero-Cosano, Joan Llobera, Joan Llobera, Joan Llobera, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Patricia Moreno-Peral, Patricia Moreno-Peral, Bonaventura Bolíbar, Bonaventura Bolíbar, José I. Recio-Rodríguez, José I. Recio-Rodríguez, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Ana Clavería, Ana Clavería

“…Men reported experiencing more social support and self-perceived health (p &lt; 0.001) than women at the beginning of the study, but women reported higher social support at post-intervention. …”
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Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis-2 (AuToDeCRA-2) study: protocol for a single-centre, experimental medicine study investigating the route of delivery... by Ema-Louise Long, James Stanway, Michael White, Nicola Goudie, Julia Phillipson, Miranda Morton, Asma Abdul Malek, Philip Brown, Geoff Hide, Ralph Jackson, Colin Nice, John Tuckett, Julie Diboll, Amy Anderson, Arthur Pratt, Catharien M. U. Hilkens, John Isaacs

“…Abstract Background Dendritic cells are professional antigen presenting cells with the ability, in their immature state, to induce tolerance in T cells. …”
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Long-term risk of irritable bowel syndrome associated with MASLD, MASLD type and different cardiometabolic risk factors: a large-scale prospective cohort study by Yesheng Zhou, Zhirong Yang, Si Liu, Sian Xie, Qian Zhang, Shutian Zhang, Shengtao Zhu, Shanshan Wu

“…The increased risk was present in both pure MASLD (HR = 1.12, 1.03–1.21) and MetALD (HR = 1.26, 1.09–1.45) patients. …”
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Biogeographic patterns and adaptive strategies of microbial carbon metabolic profiles in paddy soils in the Chinese Mollisol region by Xiaojing Hu, Haidong Gu, Mikhail Semenov, Yongbin Wang, Jinyuan Zhang, Zhenhua Yu, Yansheng Li, Junjie Liu, Jian Jin, Xiaobing Liu, Guanghua Wang

“…Among these, high-quality MAG292, assigned to the Nanopelagicales order, had a significantly positive correlation with TC and was more abundant in HCS. Contrarily, MAG153, assigned to the Chitinophagales order, exhibited an opposite trend. …”
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Updated Mass, Eccentricity, and Tidal Heating Constraints for the Earth-sized Planet LP 791-18 d by Michael Greklek-McKeon, Heather A. Knutson, W. Garrett Levine, Renyu Hu, Morgan Saidel, Jonathan Gomez Barrientos, Konstantin Batygin, Björn Benneke

“…We reduce the mass uncertainty by more than a factor of two ( M _d = 0.91 ±0.19 M _⊕ ). …”
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Value of hospital administrative data linked to national cancer registry records to identify metastatic disease at time of primary diagnosis in colorectal cancer patients: a study... by Orouba Almilaji, Linda Sharples, Ajay Aggarwal, David Cromwell, Kieran Horgan, Michael Braun, Robert Arnott, Julie Nossiter, Angela Kuryba, Alexandra Lewin, Brian Rous, Thomas Cowling, Jan Van Der Meulen, Kate Walker

“…Conclusions HAD should be linked to CR data to provide more accurate information on metastatic CRC at diagnosis including sites of metastasis. …”
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Multiparametric MRI for local staging in patients with suspected muscle-invasive bladder cancer: study protocol for a multicentre, non-inferiority randomised controlled trial (the... by Lambertus ALM Kiemeney, Janneke PC Grutters, Erik J.R.J. van der Hoeven, Janneke P.C. Grutters, Antoine G van der Heijden, Sebastiaan W van Koeverden, Lisa MC van Hoogstraten, Maarten de Rooij, Marloes van der Leest, Arnold Baars, Thierry N. Boellaard, Joost L. Boormans, Lars E.J. Bosboom, Quirijn J.A. van den Bouwhuijsen, Siebren Dijkstra, Cristina E. Firanescu, Jurgen J. Fütterer, Ernst P. van Haarst, Tom J.N. Hermans, Marina C. Hovius, Josephine C.B.M. Huige, Michael D.H. Kortleve, Anneke Kusters, Geert J.L.H. van Leenders, Saskia van der Meer, Richard P. Meijer, Harm H.E. van Melick, Laura S. Mertens, Gerd-Jan Molijn, Rinze Reinhard, Ivo G. Schoots, Petra C.G. Simons, Ruth Smit, Femke Struik, Julie Swillens, Charlotte J Tutein Nolthenius, Jeroen Veltman, Andre N. Vis, Thijn F. de Vocht, Jeanette van Vooren, Frank J. Wessels, Carl J. Wijburg, Dennis de Witte, Monique Arts-Thijssen, Guus Venderbosch

“…Findings of this study will be disseminated through peer-reviewed, open-access publications, presentations at scientific conferences and stakeholder briefings.Trial registration number NCT05779631.…”
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Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, co... by Liem Thanh Nguyen, Phuong Mai Nguyen, Hoang-Phuong Nguyen, Hau Thi Bui, Lan Thi Mai Dao, Minh Van Pham, Chi Khanh Hoang, Phuong Thi Nguyen, Thao Thi Phuong Nguyen, Anh Thi Phuong Nguyen, Van Thi Hoang, Hoa Thi Phuong Bui, Ngan Kim Vuong, Doan Van Ngo

“…Conclusions Intrathecal BMMNC combined with an educational intervention improved disease severity and adaptability more than education alone in children with ASD. Trial registration clinicaltrials.gov, NCT05307536. …”
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Clinical Case of a Patient with Acute Tricuspid Valve Infective Endocarditis and A Multiplex Approach to Evaluation of The Complication Risk by E. O. Kotova, Zh. D. Kobalava, A. S. Pisaryuk, A. V. Lokhonina, A. Y. Moiseeva, E. A. Domonova, J. I. Babukhina, P. V. Kakhktsyan, Т. Kh. Fatkhudinov

“…At the moment, there is a great need for the introduction of molecular biological methods to improve the quality of etiological diagnosis and in-depth study of possible biomarkers from simple (neutrophil/lymphocytic, platelet/lymphocytic and systemic immuno-inflammatory index) to more complex (neutrophil extracellular traps, cytokine profile). …”
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A Case for Automated Segmentation of MRI Data in Neurodegenerative Diseases: Type II GM1 Gangliosidosis by Connor J. Lewis, Jean M. Johnston, Precilla D’Souza, Josephine Kolstad, Christopher Zoppo, Zeynep Vardar, Anna Luisa Kühn, Ahmet Peker, Zubir S. Rentiya, Muhammad H. Yousef, William A. Gahl, Mohammed Salman Shazeeb, Cynthia J. Tifft, Maria T. Acosta

“…Fully automated segmentation pipelines offer faster and more reproducible results. However, since these analysis pipelines were trained on or run based on atlases consisting of neurotypical controls, it is important to evaluate how accurate these methods are for neurodegenerative diseases. …”
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Evolution of radiation profiles in a strongly baffled divertor on MAST Upgrade by Fabio Federici, Matthew L. Reinke, Bruce Lipschultz, Jack J. Lovell, Kevin Verhaegh, Nicola Lonigro, Cyd Cowley, Mike Kryjak, Peter Ryan, Andrew J. Thornton, James R. Harrison, Byron J. Peterson, Bartosz Lomanowski, Jeremy D. Lore, Yacopo Damizia

“…., 2023), enables this mapping with higher spatial resolution than more established methods like resistive bolometers.In previous preliminary work (Federici et al., 2023a), the detachment of the radiation from the target (radiative detachment) was characterised in L-mode (power entering the scrape-off layer, PSOL∼0.4 MW). …”
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