Multistakeholder scientific advice for medicinal products used in combination with a medical device or a companion diagnostic in the EU—summary of a Focus group discussion by Stiina Aarum, Claudia Popp, Alexa Hunter, Miha Skvarc, Ilona Reischl, Hilke Zander, Joerg Zinserling, Petra van Leeuwen, Jonathan Sutch, Tim Chesworth, Elisabeth Kapeller, Andreas Emmendoerffer, Iordanis Gravanis, Christelle Bouygues, Claudia Vincenzi, Michael Berntgen

“…Although there is growing use of medicinal products in combination with medical devices, including in vitro diagnostics (IVDs) and software as a medical device, their development in the EU is proving to be more challenging due to the complexities in working across the regulatory frameworks for medicinal products, medical devices and IVDs. …”
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Genetic variations in the IDUA gene in Tunisian MPS I families: Identification of a novel microdeletion disrupting substrate binding and structural insights by Mariem Rebai, Yessine Amri, Chaima Sahli, Hajer Foddha, Taieb Messaoud, Hela Boudabous, Hassen Ben Abdennebi, Salima Ferchichi, Latifa Chkioua

“…This substitution results in the introduction of a bulkier amino acid, requiring more space in the contact region between the β-sheet structure and the substrate-bound helix. …”
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Biocompatibility and Effectiveness of Amphotericin B-Loaded Metal-Organic Structures (AmB-ZIF-8) as Dermal Drug Transporters in Experimental Cutaneous Leishmaniasis by Carreño H, Osorio J, Mejía-Ospino E, Escobar P

“…The particle size of AmB@ZIF-8 was smaller and more polydisperse than ZIF-8 (1370 nm vs 2537 nm). …”
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Questões éticas na esclerose múltipla sob o ponto de vista de médicos e pacientes Ethical issues in multiple sclerosis under physicians and patients point of view by Antonio Paulo Nassar Junior, Daniela Soriano Pignataro, Melissa Martins Fuzaro, Charles Peter Tilbery

“…CONCLUSION: Patients want to know their diagnosis and doctors should tell them in the most adequate moment and give more information. A debate about palliative care is also necessary.…”
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Probability-Based Early Warning for Seasonal Influenza in China: Model Development Study by Jinzhao Cui, Ting Zhang, Yifeng Shen, Xiaoli Wang, Liuyang Yang, Xuefeng Huang, Qiang Huang, Yu Yang, Weizhong Yang, Zhongjie Li

“…Based on probabilistic prediction, public health experts can make more flexible decisions in combination with the actual situation, significantly reducing the uncertainty and pressure in the decision-making process and reducing the waste of public health resources and the risk of social panic. …”
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The effectiveness of aloe vera gel versus 2% chlorhexidine gluconate in preventing phlebitis from peripheral venous catheters: A randomized controlled trial by Mahdiyeh Harati Nassab, Mozhgan Rahnama, Abdolghani Abdollahimohammad, Mahin Naderi Far

“…Conclusion: Based on the observed outcomes, nurses may consider using aloe vera gel to reduce phlebitis in patients requiring catheterization for more than 48 hours, due to its anti-inflammatory properties and non-pharmacological benefits. …”
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Assessing eligibility for lung cancer screening using parsimonious ensemble machine learning models: A development and validation study. by Thomas Callender, Fergus Imrie, Bogdan Cebere, Nora Pashayan, Neal Navani, Mihaela van der Schaar, Sam M Janes

“…Ensemble machine learning could support the development of highly parsimonious prediction models that maintain the performance of more complex models while maximising simplicity and generalisability, supporting the widespread adoption of personalised screening. …”
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Reducing time and computing costs in EC-Earth: an automatic load-balancing approach for coupled Earth system models by S. Palomas, M. C. Acosta, G. Utrera, E. Tourigny

“…Likewise, when compared to the EC-Earth high-resolution EUCP runs, the method presented showed an improvement of 34 % in the speed, with a 6.7 % reduction in the core hours consumed.…”
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Diagnostics and Group Therapy in Patients with Persistent Postural-Perceptual Dizziness and Anxiety Disorder: Biomarkers and Neurofunctional Correlates of Underlying Treatment Effe... by Maximilian Maywald, Oliver Pogarell, Agnieszka Chrobok, Susanne Levai, Daniel Keeser, Nadja Tschentscher, Boris-Stephan Rauchmann, Sophia Stöcklein, Birgit Ertl-Wagner, Boris Papazov, Marco Paolini, Susanne Karch

“…PPPD with comorbid anxiety disorder had significantly more fear of physical symptoms than patients without comorbid anxiety disorder. …”
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Differential Diagnostic Indicators for the Appointment of Non-Steroidal Anti-Inflammatory Therapy in the Treatment of Red Eye Syndrome at the Stage of Primary Outpatient Admission.... by V. N. Trubilin, E. G. Poluninа, A. A. Kozhukhov, V. V. Kurenkov, N. V. Moreva, A. V. Trubilin, K. V. Chinenova

“…At the same time, the maximum amount of drug therapy — more than two groups of drugs was prescribed to patients with keratitis. …”
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Prevalence and genetic characteristics of Campylobacter jejuni from laying-hens in Hubei Province, China by Shichang Kuang, Zhaoyang Wang, Xiuzhong Hu, Zeyuan Dong, Chun Wang, Yuncai Xiao, Zili Li, Deshi Shi, Shaowen Li, Zutao Zhou

“…Abstract Background Campylobacter jejuni (C. jejuni), a major global cause of foodborne bacterial diseases, accounts for more than 90% of all reported cases. Poultry is considered a major reservoir for the transmission of Campylobacter to humans. …”
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Enhancing Early Detection of Diabetic Retinopathy Through the Integration of Deep Learning Models and Explainable Artificial Intelligence by Kazi Ahnaf Alavee, Mehedi Hasan, Abu Hasnayen Zillanee, Moin Mostakim, Jia Uddin, Eduardo Silva Alvarado, Isabel de la Torre Diez, Imran Ashraf, Md Abdus Samad

“…It has been shown that the proposed approach of multi-label classification with softmax functions and categorical cross-entropy works more effectively, yielding perfect accuracy, precision, and recall values. …”
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Improving automated deep phenotyping through large language models using retrieval-augmented generation by Brandon T. Garcia, Lauren Westerfield, Priya Yelemali, Nikhita Gogate, E. Andres Rivera-Munoz, Haowei Du, Moez Dawood, Angad Jolly, James R. Lupski, Jennifer E. Posey

“…While large language models (LLMs) hold promise for more context-driven phenotype extraction, they are prone to errors and “hallucinations,” making them less reliable without further refinement. …”
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Efficacy of Cognitive Behavioral Therapy for Kinesiophobia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhu S, Xu Y, Wang L, Chen J, Luo A

“…Notably, effects were more pronounced for lumbar conditions (MD=− 6.97, 95% CI [− 9.97, − 3.96], P< 0.01). …”
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Role of Obstructive Sleep Apnoea in Sensorineural Hearing Loss: A Cross-sectional Study by J Shanmugh, RB Namasivaya Navin, K Gowthame, S Prabakaran, D Balaji, R Muthukumar, S Rajasekaran

“…The Spearman correlation coefficient between the STOP-BANG risk grade and the presence of sensorineural hearing loss was 0.596, and with the severity of hearing loss, it was 0.576, both demonstrating a moderate correlation. Conclusion: The present research shows an association between OSA and sensorineural hearing loss, indicating that individuals with higher OSA risk scores experience more significant hearing impairment. …”
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Molecular and Genetic Pathogenesis of Oral Cancer: A Basis for Customized Diagnosis and Treatment by Leonor Barroso, Pedro Veiga, Joana Barbosa Melo, Isabel Marques Carreira, Ilda Patrícia Ribeiro

“…Oral cancer, the most common form of head and neck cancer, is worldwide a serious public health problem. Most patients present a locally advanced disease, and face poor prognosis, even with multimodality treatment. …”
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Development of a relapse-related RiskScore model to predict the drug sensitivity and prognosis for patients with ovarian cancer by Zhixin Jin, Xuegu Wang, Xiang Li, Shasha Yang, Biao Ding, Jiaojiao Fei, Xiaojing Wang, Chengli Dou

“…Background Ovarian cancer (OC) is a highly aggressive malignancy in the reproductive system of women, with a high recurrence rate. The present research was designed to establish a relapse-based RiskScore model to assess the drug sensitivity and prognosis for patients with OC. …”
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Calculation of mass discharge of the Greenland ice sheet in the Earth System Model by O. O. Rybak, E. M. Volodin, A. P. Nevecherya, P. A. Morozova, M. M. Кaminskaya

“…In practice it means that more or less accurate estimates of the past or future changes of the runoff and total GrIS mass discharge is reasonable to obtain in the form of deviations from a reference undisturbed model state.…”
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Integrated Single Superphosphate with Cattle Manure Increased Growth, Yield, and Phosphorus Availability of Maize (<i>Zea mays</i> L.) Under Rainfed Conditions by Samraiz Ali, Abid Ali

“…Results of this research may further be improved by including rigorous soil samples and field heterogeneity data between the plots and the years, which will provide more clear findings from a combined mixture of organic and inorganic fertilization.…”
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Using GPS and accelerometer data to precisely record egg laying, incubation and chick hatching of Cinereous Vultures (Aegypius monachus) in-situ by Cornel Cotorogea, Emilian Stoynov, Atanas Grozdanov, Simeon Marin, Hristo Valeriev Peshev, Ivelin Ivanov, Georgi P. Stoyanov

“…Traditional methods are often invasive and logistically challenging. This study presents a novel, non-invasive approach utilizing GPS and accelerometer data from tracking devices to precisely record key breeding parameters: egg-laying, incubation onset and duration, and chick hatching. …”
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