Ice Sublimation in the Dynamic HD 100453 Disk Reveals a Rich Reservoir of Inherited Complex Organics by Alice S. Booth, Lisa Wölfer, Milou Temmink, Jenny Calahan, Lucy Evans, Charles J. Law, Margot Leemker, Shota Notsu, Karin Öberg, Catherine Walsh

“…We present ALMA observations of the Herbig Ae disk HD 100453 that uncover a rich reservoir of COMs sublimating from the dust cavity edge. …”
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Investigating Transit Timing Variations in the Ultrashort Period Exoplanet WASP-19b by Shraddha Biswas, Ing-Guey Jiang, Li-Chin Yeh, Hsin-Min Liu, Kaviya Parthasarathy, Devesh P. Sariya, D. Bisht, Mohit Singh Bisht, A. Raj

“…In this study, we present a comprehensive analysis of transit timing variations (TTVs) in the ultrashort-period gas giant WASP-19b, which orbits a G-type main-sequence star. …”
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Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway by Xian-Jia Li, Ke-Xin Huang, Ke-Xin Wang, Ru Liu, Dong-Chao Wang, Yu-Ru Liang, Er-Jun Hao, Yang Wang, Hai-Ming Guo

“…Biological information analysis, RNA-sequencing, Gene Set Enrichment Analysis (GSEA), drug affinity responsive target stability (DARTS) assay, cellular thermal shift assay (CETSA), and SPR experiments identified that compounds 33a and 36b showed antitumor activity by suppressing the c-MYC pathway. c-MYC silencing assays indicated that c-MYC proteins participated in 33a-mediated anticancer activities in HCT116 cells. More importantly, compound 33a presented favorable pharmacokinetic properties in mice (T1/2 = 6.8 h) and showed significant antitumor efficacy in vivo without obvious toxicity, showing promising potential for further clinical development.…”
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Immunogenicity Evaluation of Epitope-Based Vaccine on Target of RNAIII-Activating Protein (TRAP) of <i>Staphylococcus Aureus</i> by Simiao Yu, Di Yao, Xintong Wang, Wei Yu, Yuhua Wei, Wei Liu, Liquan Yu, Jinzhu Ma, Chunyu Tong, Jing Chen, Yongzhong Yu, Baifen Song, Yudong Cui

“…Based on the results presented herein, an epitope-based vaccine is a promising and potentially more effective candidate.…”
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Production, Transport, and Destruction of Dust in the Kuiper Belt: The Effects of Refractory and Volatile Grain Compositions by Thomas Corbett, Alex Doner, Mihály Horányi, Pontus Brandt, Will Grundy, Carey M. Lisse, Joel Parker, Lowell Peltier, Andrew R. Poppe, Kelsi N. Singer, S. Alan Stern, Anne J. Verbiscer

“…Thus, we briefly explore simple models of more realistic mixed-grain cases to further gauge the effects of grain composition on the equilibrium dust distribution. …”
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Distinctly different active sites of ZnO-ZrO2 catalysts in CO2 and CO hydrogenation to methanol reactions by Jieqiong Ding, Yao Peng, Wei Xiong, Dongdong Wang, Ziran Xu, Qinxue Nie, Zheng Jiang, Zhi-Pan Liu, Cheng Shang, Weixin Huang

“…The -Zr-O-Zr- structure bonded to the Znn clusters is more easily to be reduced than that bonded to the Zn1 single atoms. …”
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Hydrogen Loss on Venus Driven by Photochemistry by Hao Gu, Jun Cui, Xiaoshu Wu, Xu Huang, Shiqi Wu, Wenlong Li, Jinjin Zhao, Haoyu Lu, Lei Li

“…While Venus continues to lose H today, no consensus has been reached regarding the present dominant escape mechanisms. Recently, photochemical escape via HCO ^+ dissociative recombination (DR) has been proposed as a prevailing process that had previously been overlooked. …”
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GhWRKY75 positively regulates GhPR6-5b via binding to a W-box TTGAC (C/T) to orchestrate cotton resistance to Verticillium dahliae by Qichao Chai, Meina Zheng, Yanli Li, Mingwei Gao, Yongcui Wang, Xiuli Wang, Chao Zhang, Hui Jiang, Ying Chen, Jiabao Wang, Junsheng Zhao

“…Virus-induced gene silencing experiments revealed that cotton was more sensitive to V. dahliae V991 after PR6-5b silencing. …”
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Expectations regarding regenerative medicine and attitudes toward invasive surgical therapies in patients with Parkinson’s disease: A cross-sectional survey by Mika Watabe, Atsushi Shima, Kiyoaki Takeda, Yuta Terada, Yusuke Sakato, Akira Nishida, Ikko Wada, Haruhi Sakamaki-Tsukita, Kenji Yoshimura, Daisuke Kambe, Koji Furukawa, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Ryosuke Takahashi, Nobukatsu Sawamoto

“…Allogeneic iPS cells are considerably more practical, despite potential concerns regarding tumor formation post-transplantation. …”
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Pilot implementation of a telehealth safety planning group intervention for suicidal rural Veterans enhanced by lived experience veteran peer participation by Marianne Goodman, Marianne Goodman, Madison Strouse, Caroline Boucher, Sofie Glatt, James Jacobs, Angie Waliski, Angie Waliski, Emilia Fonseca, Terra Osterberg, Terra Osterberg, Sapana Patel, Sapana Patel

“…One sub-population at elevated risk are Veterans living in rural communities given their heightened availability of firearms coupled with more limited access to mental health services. Telehealth delivery of treatment is a potential solution for the provision of critical services to rural areas. …”
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Immune correlates of anti-BCMA CAR-T products idecabtagene vicleucel and ciltacabtagene autoleucel in a real-world cohort of patients with multiple myeloma by Djordje Atanackovic, Tim Luetkens, Dina Schneider, Peirong Hu, Xu Wang, Amol C. Shetty, Luke Tallon, Imari Patel, Rohan Singh, Etse Gebru, Rediet Mulatu, Destiny Omili, Daniel Yamoah, Xiaoxuan Fan, Aerielle Matsangos, Patricia Lesho, Kenneth A. Dietze, Ariel A. Fromowitz, Kim G. Hankey, Saurabh Dahiya, Jean A. Yared, Nancy M. Hardy, Rima Koka, Michael E. Kallen, Ashraf Badros, Aaron P. Rapoport, Mehmet H. Kocoglu

“…In cilta-cel patients response rates were higher and atypical neurotoxicities/infections more frequent. Peak CAR T counts were significantly higher in cilta-cel patients, driven by CD4+ CAR expansion, correlating with clinical responses. …”
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Evaluation of mechanical properties and determination of the optimal concentration of a new carbonyl-rich graphene oxide in cementitious composites by Aldo Ribeiro de Carvalho, Marcela Martins Carrara, Gabriela dos Santos Pacífico, Natany Pinho Rosa, Letícia Lopardi Leal, Marina Costa Totti, Nayton Claudinei Vicentini, Alessandro Henrique de Lima, Welber Gianini Quirino, Thaís Mayra de Oliveira

“…After 365 days, the durability of carbonation was also assessed using a computational model developed in MATLAB to more accurately calculate the carbonated area. It was noted that incorporating CGO improves the mechanical properties of concrete, diminishes carbonation over time, and boosts the thermal conductivity of the composite. …”
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Title not available by Juncal, Manuel Antonio, Barreiro, Iván Rodriguez, Galtier, Jean, Broutin, Jean, Pellenard, Pierre, Steyer, Jean-Sébastien, Diez, José Bienvenido, Gand, Georges

“…Additionally, a forest dominated by walchian conifers (Voltziales) would be present but more distant from the lake. Vegetation dynamics between these associations are generally stable, except for an increase in Cordaitales at the expense of Voltziales. …”
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RETRACTED ARTICLE: A Tunguska sized airburst destroyed Tall el-Hammam a Middle Bronze Age city in the Jordan Valley near the Dead Sea by Ted E. Bunch, Malcolm A. LeCompte, A. Victor Adedeji, James H. Wittke, T. David Burleigh, Robert E. Hermes, Charles Mooney, Dale Batchelor, Wendy S. Wolbach, Joel Kathan, Gunther Kletetschka, Mark C. L. Patterson, Edward C. Swindel, Timothy Witwer, George A. Howard, Siddhartha Mitra, Christopher R. Moore, Kurt Langworthy, James P. Kennett, Allen West, Phillip J. Silvia

“…Abstract We present evidence that in ~ 1650 BCE (~ 3600 years ago), a cosmic airburst destroyed Tall el-Hammam, a Middle-Bronze-Age city in the southern Jordan Valley northeast of the Dead Sea. …”
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Remarkably promoting strength-ductility synergy in thin-wall Al-Si die castings with a lower content of in-situ TiB2 particles by Hongyi Zhu, Zeyu Bian, Chengyang Hu, Cunjuan Xia, Siming Ma, Yihao Wang, Mingliang Wang, Huawei Zhang, Zhe Chen, Haowei Wang

“…Compared to alloy counterpart, the yield strength and elongation of 0.3 wt%TiB2/Al-Si composite presented the substantial increment of ∼15 % and 9.2 %, respectively. …”
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Risk factors for glucocorticoid induced osteoporosis in young adults by Helena Florez, Josep Lluis Carrasco, Martina Barberá, José Hernández-Rodríguez, Africa Muxi, Anastasia Mocritcaia, Sergio Prieto-González, Maria C. Cid, Ana Monegal, Núria Guañabens, Pilar Peris

“…Five subjects &lt;50 (13.9%) and 30 ≥50 years (33%) presented FF (p=0.046). Having a higher body mass index (BMI), disease activity was a differential risk factor for FF in young subjects, whereas hypogonadism was a risk factor independent of age.ConclusionsMore than 40% of young subjects on chronic GC therapy had GIOP. …”
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Immunological consequences of CAR T-cell therapy: an analysis of infectious complications and immune reconstitution by Andreas Riedel, Laurent Phely, Stefan Hug, Philipp Faustmann, Jan Christian Schroeder, Britta Besemer, Anna M. Paczulla Stanger, Christoph Faul, Claudia Lengerke, Jan Frederic Weller, Wolfgang Bethge

“…CD4+ T cells and CD19+ B cells exhibited impaired regeneration after treatment. Infections were more frequent during the first 30 days. In the short-term follow-up, density of infections within 100 days at risk was 1.8 in patients with DLBCL and 4.6 in patients with MM, with bacterial infections predominating in this early period after CAR T-cell infusion. …”
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Blue light-emitting diode: a new adjuvant approach to conventional treatment of recurrent vulvovaginal candidiasis by Isadora Bastiani Biondo, Rodrigo Rossi Balbinotti, Fernanda Santos Grossi, Eduardo Vettorazzi-Stuczynski, Janete Vettorazzi

“…Recurrent vulvovaginal candidiasis (RVVC) presents challenges due to the adverse effects and resistance associated with prolonged antifungal therapy, highlighting the need for alternative treatments. …”
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Vascularized skin tissue models featuring adipose cell spheroid-laden GelMA hydrogels by Dongjin Lee, Sangmin Lee, Jeongbok Lee, Dahong Kim, Hyunseok Kwon, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Heungsoo Shin, Su A Park

“…HUVEC cells growing on the surface of the microgel exhibited a 3D structure that allowed vascular cells to become concentrated in the microgel area much more efficiently than in 2D culture. Three-dimensional printing allows efficient mass production, removing challenges that cannot be easily addressed via in vivo experiments. …”
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Residue 365 in Hemagglutinin–Neuraminidase Is a Key Thermostable Determinant of Genotype VI.2.1.1.2.2 Newcastle Disease Virus by Tao Di, Ran Zhao, Qiankai Shi, Fangfang Wang, Zongxi Han, Huixin Li, Yuhao Shao, Junfeng Sun, Shengwang Liu

“…It was indicated that all three viruses presented resistance to heat treatment, but P0713 was more robust than P0813 and P0506. …”
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