Reduced synaptic tagging by complement protein C3 is associated with elevated extracellular matrix in the middle-aged cerebellum of mice by Henning Peter Düsedau, Carla Cangalaya, Stoyan Stoyanov, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev, Ildiko Rita Dunay, Ildiko Rita Dunay, Ildiko Rita Dunay, Ildiko Rita Dunay, Ildiko Rita Dunay

“…Using flow synaptometry to quantify the composition of synapses in more detail, we validated the reduction of C3b-labeled excitatory synaptosomes while the overall frequency of glutamatergic synaptosomes remained unaffected by aging. …”
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Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework by Romain Ollier, Aline Fuchs, Florence Gauye, Katarzyna Piorkowska, Sébastien Menant, Monisha Ratnam, Paolo Montanari, Florence Guilhot, Didier Phillipe, Mickael Audrain, Anne-Laure Egesipe, Damien Névoltris, Tamara Seredenina, Andrea Pfeifer, Marie Kosco-Vilbois, Tariq Afroz

“…The resulting humanized variant, ACI-5891.9, presented a six-fold reduction in clearance in NHPs resulting in a significant increase in half-life. …”
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Comparison of Morphological and DNA‐Based Identification Methods to Assess Earthworm (Clitellata: Lumbricidae) Diversity at 25 Permanent Soil Monitoring Sites in Germany by Stephan Jänsch, Daniela Alves, Luís Cunha, Paul Henning Krogh, Tiago Natal‐da‐Luz, Verónica Rojo, Jörg Römbke, Rumakanta Sapkota, Adam Scheffczyk, Rüdiger M. Schmelz, Letícia Scopel, José Paulo Sousa, Joaquín Vierna, Antón Vizcaíno

“…The comparison of results showed that comDNA detected more species (3.6 on average) than eDNA (3.0) and morphological identification (2.8). …”
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Using text-mining to measure the scientific impact and legacy of ELIXIR, a distributed research infrastructure for life science data [version 3; peer review: 2 approved] by Erika Balsyte, Corinne S. Martin, Ivan Mičetić, Martin Cook, Marilena D’Ambrosio, Robert Petryszak, Francesca De Leo, Chiara Bruno

“…Methods To overcome challenges inherent in ELIXIR’s distributed structure, and the fact that those publishing ELIXIR-supported work are typically working part-time on ELIXIR matters, a semi-automated approach, consisting of text-mining followed by manual curation, is presented. A country-level case study (ELIXIR Italy) refines and expands the methods, notably by introducing more granularity in the curation process (e.g. considering all national-level grants, examining affiliations to report publication per institute) and by additionally looking at the scientific impact of the resources developed and operated by the Italian Node of ELIXIR. …”
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The Voltage-Ear – An Anomaly in Photovoltaic Systems With Undersized Inverters by Ernst Wittmann, Claudia Buerhop-Lutz, Vincent Christlein, Jens Hauch, Christoph J. Brabec, Ian Marius Peters

“…This study presents a phenomenon in photovoltaic field installations we call voltage ear. …”
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How to escape from sudden death: a challenging case of a rare cardiomyopathy with an unexpected twist by Luísa Pinheiro, Margarida de Castro, Filipa Cordeiro, Tamara Pereira, Francisco Ferreira, Víctor Sanfins, António Lourenço, Olga Azevedo

“…The p.F113L variant is associated with late-onset, cardiac-predominant FD, where bradyarrhythmias are more prognostically relevant, but concurrent pathologies like coronary artery disease must be considered in VT presentations. …”
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Obsessive-compulsive symptoms and related risk and protective factors in Black individuals in Canada by Elisabeth Dromer, Elisabeth Dromer, Grace Jacob, Grace Jacob, Monnica T. Williams, Monnica T. Williams, Seyed Mohammad Mahdi Moshirian Farahi, Wina Darius, Wina Darius, Cary Samuel Kogan, Cary Samuel Kogan, Jude Mary Cénat, Jude Mary Cénat

“…Independent t-tests, ANOVA, and multivariable linear regressions were used to assess OC symptom severity and identify risk and protective factors.ResultsBlack individuals presented high levels of OC symptoms. Results showed that Black individuals born in Canada experienced more OC symptoms compared to those born abroad. …”
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Neonatal state and degree of necessity for parental care in Maiasaura based on inferred neonatal metabolic rates by Hugo Bert, Holly Woodward, Nicolas Rinder, Romain Amiot, John R. Horner, Christophe Lécuyer, Mariana Sena, Jorge Cubo

“…The inferred neonatal RMR values for Maiasaura are similar to those of present-day fast-growing endotherms. As for the aerobic scope, M. peeblesorum neonates have a ΔMR value similar to those observed in present-day altricial birds that need intensive parental care. …”
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Numerical Analysis of Masticatory Forces on a Lower First Molar considering the Contact between Dental Tissues by Rosa Alicia Hernández-Vázquez, Beatriz Romero-Ángeles, Guillermo Urriolagoitia-Sosa, Juan Alejandro Vázquez-Feijoo, Ángel Javier Vázquez-López, Guillermo Urriolagoitia-Calderón

“…This reflection will allow the development of more adequate materials, mechanical design of prostheses, implants, and treatment.…”
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Starch–Polyphenol Interactions: Impact on Food Structure and Starch Digestibility by Javier Echave, Sepidar Seyyedi-Mansour, Pauline Donn, Ana Olivia Serra Jorge, Lucia Cassani, Lillian Barros, Miguel Angel Prieto

“…Moreover, this greatly impairs starch’s gelatinization and retrogradation during cooking, providing a final structure more akin to resistant starch, with a final reduced hardness and adhesiveness. …”
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Practical Quantum Circuit Implementation for Simulating Coupled Classical Oscillators by Natt Luangsirapornchai, Peeranat Sanglaor, Apimuk Sornsaeng, Stephane Bressan, Thiparat Chotibut, Kamonluk Suksen, Prabhas Chongstitvatana

“…Simulating large-scale coupled-oscillator systems presents substantial computational challenges for classical algorithms, particularly when pursuing first-principles analyses in the thermodynamic limit. …”
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Clinical outcomes and prognostic factors in multiple primary malignancies involving oral cancer by Qiannan Liu, Shanshan Tang, Le Yang, Farong Ou, Kan Li, Huanzi Lu, Zengyu Chen, Guiqing Liao, Yujie Liang

“…We conducted a comparative analysis of clinical characteristics and prognosis between the two groups. Results MPOCs were more common in males, with an average age of 59.4 years, primarily presenting as early-stage squamous cell carcinoma (SCC), with the tongue as the most frequent site for secondary primary cancer (SPC). …”
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Evaluation of APACHE II score as predictor of outcome in patients with ruptured liver abscess: prospective study in a tertiary care hospital by Vaibhav Kuraria, Shivani B. Paruthy, Arun Kumar Singh, Tariq Hameed, Dhananjay Khera, Mohit Dhawaria, Hinduja Raju, Yogesh Saini, Abhinav Kumar, Madhuri Singamsetty

“…Colonic involvement was seen in 41.6% of surgical cases, with 10 cases presenting with colonic perforation. Higher APACHE II scores correlated with longer hospital stays and more severe complications. …”
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Genomic characterization and cross-species transmission potential of hedgehog coronavirus by Andreia V.S. Cruz, Sérgio Santos-Silva, Luís Queirós-Reis, Clarisse Rodrigues, Vanessa Soeiro, Rachael E. Tarlinton, João R. Mesquita

“…Hence, the present study aimed to investigate and characterize the presence and genetic diversity of coronaviruses in hedgehogs from Portugal, as well as their potential for cross-species transmission. …”
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SDN-Based VANET Routing: A Comprehensive Survey on Architectures, Protocols, Analysis, and Future Challenges by Nehad Hameed Hussein, Johnny Siaw Paw Koh, Chong Tak Yaw, Sieh Kiong Tiong, Foo Benedict, Talal Yusaf, Kumaran Kadirgama, Tan Chung Hong

“…As the automotive and telecommunication industries advance, more vehicles are becoming connected, leading to the realization of intelligent transportation systems (ITS). …”
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Multicenter Retrospective Analysis of 702 Pediatric Cases of Bone and Joint Infections: Definition of Clinical and Biological Features to Discriminate <i>K. kingae</i>, <i>S. aureu... by Marco Roversi, Francesca Pignatelli, Giacomo De Marco, Oscar Vazquez, Dimitri Ceroni, Antonio Musolino, Marco Cirillo, Laura Lancella, Alberto Villani, Andrzej Krzysztofiak, on behalf of the Osteomyelitis Collaborative Study Group

“…Differentiating these infections is crucial due to their nonspecific clinical presentations and overlapping laboratory and radiological findings, particularly when isolates are unavailable. …”
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Comparative clinical characteristics of untreated early rheumatoid arthritis in patients with early and late onset according to the All-Russian Register of Patients with Arthritis... by A. M. Satybaldyev, N. V. Demidova, G. I. Gridneva, N. Yu. Nikishina, E. V. Gerasimova, K. A. Kasumova, A. S. Misiyuk, O. A. Rumyantseva, E. A. Strebkova, V. N. Sorotskaya, N. V. Chichasova, E. L. Nasonov

“…At the same time, the issues of age-related features of as yet untreated early rheumatoid arthritis have not been previously presented in the literature studied by the authors. …”
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SHERA: SHAP-Enhanced Resource Allocation for VM Scheduling and Efficient Cloud Computing by Ashwin Singh Slathia, Abhiram Sharma, P. B. Krishna, Saksham Anand, Ayush Rathi, Linda Joseph, Xiao-Zhi Gao

“…However, excessive resource use can result in higher energy demand, higher operating expenses, and a more significant adverse effect on the environment as per study by Berl et al. (2010). …”
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Clinical and Paraclinical Peculiarities of SARS-CoV-2 and Influenza Infections in Children: A Comparative Study by Maria Oana Săsăran, Carmen Viorica Muntean, Andreea Bianca Stoica, Carmen Schwesig, Anca Meda Văsieșiu, Anca Doina Pleșca, Cristina Oana Mărginean

“…Results: SARS-CoV-2 infections were more commonly associated with digestive symptoms, whereas influenza infections implied longer hospital stays and higher likelihood of PICU admission necessity. …”
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RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure by Konstantinos Ioannidis, Paul Wilkinson, Paul Fletcher, Samantha N Sallie, Laura Moreno-López, Muzaffer Kaser, Katja Schueler, Adrian Dahl Askelund, Lorinda Turner, Anne-Laura van Harmelen, Alicia J Smith, Camilla Nord, Eugenia M Davidson, Nadia González-García, Oksana Berhe, Rosalie Shrofer, Sofia Orellana, Sophie L Bellow, Suzanne Schweizer

“…The results of the RAISE study will be disseminated through (1) publications in scientific peer reviewed journals, (2) presentations on relevant scientific conferences and meetings, (3) publications and presentations for the general public and (4) through social media.…”
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