Hyperphosphorylated tau-based Alzheimer’s Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity by Hsiao-Tien Hagar, Virneliz Fernandez-Vega, Kuang-Wei Wang, Luis M. Ortiz Jordan, Justin Shumate, Louis Scampavia, April Sweet Tapayan, Hien M Nguyen, Timothy P. Spicer, Min-Hao Kuo

“…Alzheimer’s disease (AD) is a neurodegenerative disorder that affects more than 30 million people worldwide. Underlying the progressive decline of cognitive functions are the neurofibrillary tangles (NFTs) in neurons of the brain. …”
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Laparoscopic Suture Gestures Recognition via Machine Learning: A Method for Validation of Kinematic Features Selection by Juan M. Herrera-Lopez, Alvaro Galan-Cuenca, Antonio J. Reina, Isabel Garcia-Morales, Victor F. Munoz

“…The results show that the aperture angle and orientation of the surgical tools retain enough information about the chosen gestures that the accuracy does not vary between equivalent models by more than 5.84% in any case.…”
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DIAGNOSIS AND TREATMENT OF PATIENTS WITH SEVERE HYPERCHOLESTEROLEMIA IN REAL OUTPATIENT PRACTICE (ACCORDING TO THE RECVASA REGISTRY) by A. I. Ershova, A. N. Meshkov, S. S. Yakushin, M. M. Loukianov, K. A. Moseychuk, S. Yu. Martsevich, A. V. Zagrebelnyy, A. N. Vorobyev, K. G. Pereverzeva, E. A. Pravkina, A. N. Kozminskiy, S. A. Boytsov

“…At that, diagnosis of hyperlipidemia was indicated only in 9% of outpatient cards. Data of one or more blood chemistries including low density cholesterol (LDC) levels were presented only in 7% of outpatient cards. 83.7% of patients with severe hypercholesterolemia were classified as patients at high or very high cardiovascular risk, but statins were recommended only to 17.8% of them. …”
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Radiation situation in the territory of the uranium legacy site in the Bambakai Valley (Transbaikal Territory) by A. V. Titov, N. K. Shandala, Yu. S. Belskikh, V. A. Seregin, T. A. Doroneva, A. A. Filonova, M. P. Semenova, Yu. V. Gushchina, Yu. N. Pavlenko-Mikhaylov

“…Doses of terrestrial environmental media (grass, earthworms) are 100 and more times lower than the safe level of exposure to biota.…”
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Dermatophytoses Caused by <i>Trichophyton indotineae</i>: The First Case Reports in Malaysia and the Global Epidemiology (2018–2025) by Yi Xian Er, Kin Fon Leong, Henry Boon Bee Foong, Anis Amirah Abdul Halim, Jing Shun Kok, Nan Jiun Yap, Yuong Chin Tan, Sun Tee Tay, Yvonne Ai-Lian Lim

“…<i>Trichophyton indotineae</i> is emerging globally from its origin in India, presenting with a terbinafine resistance and causing significant clinical burden. …”
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Design and dermatokinetic appraisal of lornoxicam-loaded ultrafine self-nanoemulsion hydrogel for the management of inflammation: In vitro and in vivo studies by Saleh A. Al-Suwayeh, Mohamed M. Badran, Ghada O. Alhumoud, Ehab I. Taha, Lubna Y. Ashri, Mohsin Kazi

“…The present study aimed to evaluate the impact of ultrafine nanoemulsions on the transdermal delivery of lornoxicam (LOR) for management of the inflammation. …”
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Forecasting large-scale solar power plant energy production based on Monte Carlo simulations and long-short-term memory by Sheeraz Iqbal, Md Shafiullah, Muhammad Aurangzeb, Irfan Jamil, Abdul Rehman, Asif Islam, Amjad Ali, Salah S. Alharbi

“…Designing these models using these approaches gives future energy forecast results in various graphs, and it is proven that MCS and LSTM are more efficient techniques than traditional ones based on their findings. …”
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Evaluating the effectiveness of the Shan-Shui Initiatives in China by Yutong Jiang, Xinghao Shan, Qingyu Liu, Yu Feng, Yuyang Lai, Kaiji Xu, Jinman Wang, Zhongke Bai, Xiaoming Feng

“…Projects with longer implementation periods showed a more pronounced trend of growth in ESs, particularly evident in the ecological space. …”
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Fecal microbiota transplantation through colonoscopy for the management of severe refractory irritable bowel syndrome: Preliminary results by C. von Muhlenbrock, P. Núñez, K. Herrera, N. Pacheco, R. Quera

“…To establish the broader clinical application of FMT, more research on its efficacy according to instillation site and patient results is needed. …”
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NR2F6 as a Disease Driver and Candidate Therapeutic Target in Experimental Cerebral Malaria by Victoria E. Stefan, Victoria Klepsch, Nikolaus Thuille, Martina Steinlechner, Sebastian Peer, Kerstin Siegmund, Peter Lackner, Erich Schmutzhard, Karin Albrecht-Schgör, Gottfried Baier

“…In terms of mechanism, we detected less severe endotheliopathy and, hence, less damage to the blood–brain barrier (BBB), accompanied by decreased sequestered parasites and less cytotoxic T-lymphocytes within the brain, manifesting in a better disease outcome. We present evidence that NR2F6 deficiency renders mice more resistant to experimental cerebral malaria (ECM), confirming a causal and non-redundant role for NR2F6 in the progression of ECM disease. …”
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Adverse Childhood Experiences (ACEs) in Specific Vulnerable Developmental Periods Can Increase the Likelihood of Chronic Pain in Adulthood—Results from a Cross-Sectional Study by David Riedl, Christina Kirchhoff, Ulrich T. Egle, Tobias Nolte, Michael Tschuggnall, Gerhard Rumpold, Wilhelm Kantner-Rumplmair, Vincent Grote, Michael J. Fischer, Astrid Lampe

“…This is the first study to present evidence for a timing-dependent association of ACEs with CP. …”
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Proteomic characterization of MET-amplified esophageal adenocarcinomas reveals enrichment of alternative splicing- and androgen signaling-related proteins by Bastian Grothey, Su Ir Lyu, Alexander Quaas, Adrian Georg Simon, Jin-On Jung, Wolfgang Schröder, Christiane J. Bruns, Lars M. Schiffmann, Felix C. Popp, Thomas Schmidt, Karl Knipper

“…Methods In this study, we determined the MET amplification status in a cohort of more than 900 EACs using fluorescence in situ hybridization (FISH) and compared the proteomes of MET-amplified (n = 20) versus non-amplified tumors (n = 39) by mass spectrometry. …”
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Protothecosis in Dogs: A Narrative Review by Tomasz Jagielski, Angelika Proskurnicka, Mateusz Iskra, Sylwia Wronka, Zofia Bakuła, Patrizia Danesi, Marconi Rodrigues deFarias, Fábio Vinícius Ramos Portilho, Márcio Garcia Ribeiro, Uwe Rösler, Rui Kano, Richard Malik

“…Although usually saprophytic, Prototheca may, under conditions of immunologic compromise, become pathogenic and even lethal to the host. We present a synthesis of the current literature on protothecosis, with special emphasis on disease features in the dog. …”
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Pain thresholds in elderly individuals: a cross-sectional observational study of the influence of gender and chronic non-cancer pain by Áquila Lopes Gouvêa, Pedro Adde Anuardo, João Paulo Consentino Solano, Ângela Maria Sousa, Hazem Adel Ashmawi

“…Background: The older population is growing, and it is estimated that, by 2050, people aged 60-years or more will have reached two billion. The increased life expectancy has led to a higher incidence of chronic degenerative diseases, contributing to increased pain complaints. …”
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Meals, mealtimes and moments for learning: assessment of quality in early childhood education and care services by Bonnie Searle, Sandy Houen, Sally Staton, Karen Thorpe

“… Abstract Objective: Early education and care (ECEC) is part of the everyday life of most children in developed economies, presenting exceptional opportunity to support nutrition and ongoing food preferences. …”
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Prevalence and distribution of dental anomalies in Hail Province of Saudi Arabia by Abdulrahman K. Alshammari, Muteb A. Algharbi, Freah L. Alshammary, Nabeel S. Almotairy, Hatem D. Alshammari, Maha M. Rashdi, Sukinah H. Alrahin, Fatimah H. Alsalem, Ahmed A. Madfa

“…Dental anomalies were more commonly found in individuals aged 9–25 years compared to those aged >25–55 years.…”
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&#x2018;Over Time Everyone&#x2019;s Gonna Be Open to It&#x2019;: User Attitudes Toward Security and Privacy in Continuous Authentication for Smart Homes by Heting Wang, Yu-Peng Chen, Dinank Bista, Rodrigo Calvo, Niriksha Regmi, Xuanpu Zhang, Tempestt Neal, Jaime Ruiz, Lisa Anthony

“…Participants also envisioned CA systems that offer more granular permission controls over personal data. …”
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Immunological process of T cells and IgM+ B cells in head kidney and peripheral blood in early vertebrate Nile tilapia by Yuying Zheng, Qian Zhang, Yating Zhu, Jiansong Zhang, Ming Geng, Yishan Lu, Kang Li, Xiumei Wei

“…Notably, T cells and IgM+ B cells proliferated rapidly in secondary infection than initial immune response, implying that immune memory as a hallmark feature of adaptive immunity was already present in early vertebrates. More importantly, the inhibition of T cells during bacterial infection impaired the expression of perforin A and granzyme B. …”
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Robotic-assisted total knee arthroplasty: Systematic review of surgical assist robotic systems available in Japan by Keizo Wada, Daisuke Hamada, Yasuaki Tamaki, Shota Shigekiyo, Koichi Sairyo

“…Although there are some characteristic differences among the surgical assistant robots, the present review reveals that robot-controlled osteotomy may be more accurate than conventional techniques using a conventional guide and bone saw, with favorable short-term outcomes after RA-TKA. …”
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Endoscopic combination therapy with photodynamic therapy and endoscopic resection for wide circumferential local recurrence after radiotherapy for esophageal cancer by Nobuhisa Minakata, MD, PhD, Tomohiro Kadota, MD, PhD, Hiroki Yamashita, MD, Takashi Watanabe, MD, Atsushi Inaba, MD, PhD, Hironori Sunakawa, MD, PhD, Keiichiro Nakajo, MD, PhD, Kensuke Shinmura, MD, PhD, Tomonori Yano, MD, PhD

“…The aim of this report is to present the case of a patient in whom we achieved local control with combination therapy. …”
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