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Cost-effectiveness analysis of penpulimab combined with paclitaxel and carboplatin as first-line treatment for advanced squamous non-small cell lung cancer
Published 2025-03-01“…The immaturity of the OS data increased the extrapolation uncertainty, which could potentially alter the economic conclusions.ConclusionPenpulimab, in combination with paclitaxel and carboplatin, demonstrates a cost-effectiveness advantage over placebo as a first-line treatment for advanced or metastatic squamous NSCLC in China, provided that long-term survival benefits align with extrapolations from the base case model. …”
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Optimizing Pharmaceutical Inventory and Investment Strategies During Pandemics: A Dynamic Approach Integrating Environmental Emission Rates and Advanced Optimization Algorithms
Published 2025-01-01“…Theoretical analysis and numerical experiments under a fuzzy learning environment provide a robust foundation for the model. Sensitivity analysis offers practical insights, guiding decision-makers in adapting strategies to real-world challenges. …”
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Navigating perinatal mental health integration in maternal and child health services: progress and priorities for research and practices in Pakistan
Published 2025-05-01“…We synthesise perinatal mental health (PMH) evidence and provide recommendations for future research and practices in Pakistan. …”
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Thoughts and Practices on the Development of Forensic Medicine Discipline in the Perspective of Building a Regional High-Level Medical University
Published 2025-02-01“…Combined with the experiences of carrying out forensic medicine education in our college, this paper supplies our thoughts and practices on improving the discipline system, enhancing the ability to serve society, perfecting the talent cultivation model and promoting forensic culture, to provide reference and inspiration for the development of forensic medicine in other universities, jointly promote the advancement of forensic medicine in China to a new stage, and contribute the wisdom and strength of forensic medical experts to the construction of a law-based China, a safe China and a healthy China.…”
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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer
Published 2025-01-01“…Conclusions This study provided a microecological landscape of the lower respiratory tract with advanced NSCLC to ICI interventions and presented a multidimensional perspective with favoured outcomes that may improve the predictive capacity of the localized microbiome in clinical practices. …”
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Enhancing Teacher Creativity through Educational Game Tools at TK Negeri Pembina, Kediri: A Practical Approach
Published 2024-07-01“…Recognizing the pivotal role of early childhood educators in shaping children's development, the initiative focuses on providing targeted training sessions at Pembina State Kindergarten. …”
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Epidemiological Assessment and Inference in Race-Based Clinical Algorithms: A Narrative Review and Health Policy Analysis Focused on Living Kidney Donation
Published 2025-02-01“…We also identified structural barriers to the interpretation of this evidence to advance health equity, including barriers to the practices of clinical equipoise and shared medical decision-making. …”
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Establishing the VR-haptic thinkers group: Insights and progress in dental training technologies
Published 2024-12-01“…In today’s fast-paced, digitalized world, dental educators and professionals alike need to try and stay up to date on current learning methods to provide the best possible education to the new generations of students. …”
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Rice production in Ghana: a multi-dimensional sustainable approach
Published 2025-08-01“…Furthermore, the study underscores the importance of sustainable agribusiness practices, providing valuable insights and recommendations for policymakers, stakeholders, and researchers. …”
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Implementation and effectiveness of advance care planning in hospitalized older adults with chronic heart failure: a mixed-methods systematic review and meta-analysis
Published 2025-04-01“…Meta-aggregation showed that the ACP intervention has a positive impact on participants, promotes their knowledge and understanding, and makes them share their decision-making with their families.ConclusionACP is a promising and feasible intervention that can help older adults with CHF accurately understand ACP and express their wishes timely. This study provides insights and empirical evidence to improve ACP, and valuable guidance and reference for future clinical practice.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, PROSPERO, identifier: CRD42024580814.…”
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Advancing offline magnetic resonance-guided prostate radiotherapy through dedicated imaging and deep learning-based automatic contouring of targets and neurovascular structures
Published 2025-07-01“…Magnetic resonance imaging (MRI) planning provides superior visualization of potency-related anatomical structures compared to computed tomography (CT), enabling improved sparing. …”
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