Development of an LC-MS/MS method for quantification of colistin and colistin methanesulfonate in human plasma and its application to stability studies and therapeutic drug monitor... by Tinghui Zhao, Lu Liu, Guangjie Yang, Hengyi Yu, Lihui Qiu, Xiping Li, Dong Xiang, Xuepeng Gong

“…Results: Colistin A and colistin B showed excellent linearity in the concentration range of 0.1–10.0 μg/mL (R2 > 0.995) with acceptable specificity, accuracy (90.97 %–114.65 %), precision (RSD < 15 %), matrix effect (RSD < 15 %), and recovery (91.93 %–100.93 %). …”
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MMP-9 Knockdown Inhibits Oral Squamous Cell Carcinoma Lymph Node Metastasis in the Nude Mouse Tongue-Xenografted Model through the RhoC/Src Pathway by Panpan Yin, Ying Su, Suhong Chen, Jinlin Wen, Feng Gao, Yanlin Wu, Xinyan Zhang

“…And the bioinformatic analysis showed that MMP-9, RhoC, and Src mRNA expression was positively and linearly correlated in OSCC on TCGA database. Together, our findings indicated that MMP-9 plays a very important role in OSCC growth, migration, angiogenesis, and lymph node metastasis, and its potential mechanism may be mediated by RhoC and Src gene expression.…”
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Development of a multicentre cohort study to understand the role of MRI and ultrasound in the diagnosis of acute haematogenous bone and joint infection in children (the PIC Bone st... by Marie-Caroline Nogaro, Stuart Hartshorn, Mariea Brady, Amaka Offiah, Saul Faust, Gregory Firth, Jie Ma, Paula Dhiman, Joanna O'Mahoney, Loretta Davies, Catherine Spowart, Amy Moscrop, Bridget Young, Catrin Tudur-Smith, Gary Collins, Daniel C. Perry, Tim Theologis

“…Continuous predictors will be examined for non-linearity with confirmed BJI using fractional polynomials. …”
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Biomechanical Behavior of Bioactive Material in Dental Implant: A Three-Dimensional Finite Element Analysis by Vathsala Patil, Nithesh Naik, Srikanth Gadicherla, Komal Smriti, Adithya Raju, Udit Rathee

“…In this study, the FEA model of the bones and the tissues are modeled as homogeneous, isotropic, and linearly elastic material with a titanium implant system with an assumption of it 100% osseointegrated into the bone. …”
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Validation and standardization of the content of three di-caffeoylquinic acid in Korean Ligularia fischeri by region of origin by Hun Hwan Kim, Se Hyo Jeong, Pritam Bhangwan Bhosale, Tae Yang Kim, Jeong Woo Park, Kwang Il Kim, Yeon Gyu Moon, Kwang Hyun Hwang, Kwang Il Park, Meejung Ahn, Je Kyung Seong, Gon Sup Kim

“…Potential compounds were identified through MS/MS analysis, and their identities were confirmed using three DCQA (Di-caffeoylquinic acid) standard samples. The linearity, precision, limit of quantification (LOQ) and limit of detection (LOD), and recovery were then measured by quantitative analysis to confirm the content of the three DCQAs. …”
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Development and validation of a LC-MS/MS method for the simultaneous determination of simnotrelvir and ritonavir in human serum and bronchoalveolar lavage fluid by Xiaoyu Yang, Wanling Lin, Yushang Zhao, Chaoyue Zhao, Fei Zhou, Dong Wang, Zhihong Yue, Lin Pei, Mei Jia, Bin Cao, Lin-Lin Cao, Hui Wang

“…Subsequently, the LC-MS/MS method underwent a comprehensive validation in aspects such as sensitivity (LoQs of 2.5 ng/mL, 0.1 ng/mL, and 1 μg/mL for simnotrelvir, ritonavir and urea), linearity, carryover, precision, trueness (recovery rates of simnotrelvir, ritonavir and urea were between 85 and 115%), matrix effect (within 85-115%) and stability (stable for 72 h at room temperature). …”
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Effect of drainage water recycling system management on nutrient load reduction in rice-based irrigation areas by Jie Liu, Dongguo Shao, Wenquan Gu, Yawen Liu, Zhen Wu, Chi Tang, He Wang, Jinping Feng, Jian Liu

“…Notably, due to interactions among paddy fields, ditches, and ponds, nutrient removal did not increase linearly with higher maximum ponding water level (Hmax), diverging from previous findings. …”
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Dual-Channel Phase-Tunable Down Converter With LO Frequency Doubling by Yunxin Wang, Hongbiao Zhang, Dayong Wang, Tao Zhou, Feng Yang, Xin Zhong, Zhiyu Chen, Dengcai Yang, Lu Rong

“…Each bias voltage of the DP-PM can linearly vary the phase shift between the RF and LO modulated optical sidebands. …”
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Fatores relacionados a comportamentos de saúde entre jovens estudantes durante a pandemia da COVID-19 by Emanoel Avelar Muniz, Maria Veraci Oliveira Queiroz, Isadora Marques Barbosa, Gabriel Pereira Maciel, Valter Cordeiro Barbosa Filho

“…Foram aplicados um formulário eletrônico e o instrumento Adolescent Health Promotion Scale (versão brasileira), para análise estatística e utilizadas regressões lineares múltiplas. Resultados: a média geral da escala foi de 3,29 (desvio-padrão (DP)=0,56); as subescalas variaram de 2,40 (DP=1,0) exercício físico a 3,76 (DP=0,80) valorização da vida. …”
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Dose sensitivity of MAGIC-f polymer gel using different MRI sequences by Nícollas Gonçalves Cavedini, Ricardo Meurer Papaléo, Nícolas Borges Jobim, Phelipi Nunes Schuck, Fabrício Nery Garrafiel, Elisa Magno Nunes de Oliveira, Marcelo Menna Barreto Schwarcke, Alex Cristóvão Holanda de Oliveira, Paulo Rauli Rafeson Vasconcelos Caribé, Ana Maria Marques da Silva

“…In the SE sequence, dose sensitivity was 0.42 for the first batch and 0.43 Gy-1s-1 for the second batch. Linearity of dose-response was only obtained for doses below 10 Gy. …”
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Development of a UHPLC-UV/Vis Method for Simultaneously Determining Six Beta-Lactam Antibiotics in Plasma: A Tool for the Clinical Implementation of Therapeutic Monitoring of Beta-... by Iria Varela-Rey, Marta Martínez-Guitián, Gonzalo Hermelo-Vidal, Enrique Bandín-Vilar, Ignacio Novo-Veleiro, Pablo Manuel Varela-García, Irene Zarra-Ferro, Miguel González-Barcia, Cristina Mondelo-García, Anxo Fernández-Ferreiro

“…Validation followed EMA bioanalytical guidelines, demonstrating selectivity, precision, accuracy, and linearity within clinically relevant ranges (1.0–50.0 mg/L). …”
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Study on the Influence of Different Soil Stratification Schemes on Soil Freezing and Thawing Process by Zisha LIU, Shihua LÜ, Yiqun BAO

“…In this paper， the BCC_AVIM land model and encrypted observation data are used to evaluate the simulation performance of different soil stratification schemes on soil temperature and humidity.The results indicate that the encryption scheme has the best simulation performance.In the BCC_AVIM land model， the soil layer is defined as ten layers and linearly interpolate the depth of each adjacent node to obtain a new 20-layer scheme， referred to as the encryption scheme in this paper.The soil stratification scheme with 20 soli layers in the reference model CLM5.0 is also applied to the BCC_AVIM land model， which is called CLM5.0 scheme in this paper.Comparing the simulation results of the soil stratification scheme before and after improvement with the encrypted observation data， it shows that： （1） The encrypted observation data and the original observation data can well reflect the changing trend of soil temperature and humidity at the whole vertical level， but for the soil freezing period， the encrypted observation data can better depict the temperature change of shallow soil and the humidity change of deep soil.（2） For the soil temperature and humidity during the freezing period， the simulation performance of the encryption scheme and CLM5.0 scheme show improvements compared with the original scheme.The encryption scheme is closest to the measured temperature and humidity data’s numerical values and amplitude changes.Furthermore， the encryption scheme is more reasonable in determining freezing time in the soil’s shallow and middle layers.（3） For the soil temperature and humidity during ablation， the simulation performance of the encryption scheme and CLM5.0 scheme are enhanced compared with the original scheme.After the shallow and middle soil layers enter the ablation period， the simulated and measured data of soil temperature and humidity by the encryption scheme are closer to the numerical values and curve trends.…”
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Use of an anatomical atlas in real-time EIT reconstructions of ventilation and pulsatile perfusion in preterm infants by Christopher J. Rocheleau, Trevor D. Overton, Nilton Barbosa da Rosa, Gary J. Saulnier, Omid Rajabi Shishvan, Christopher D. Baker, Katelyn G. Enzer, Jennifer L. Mueller

“…In this work, we propose a real-time linearized reconstruction algorithm that makes use of an anatomical atlas to provide prior spatial information at two stages of the reconstruction with the goal of improving the spatial resolution. …”
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Controlling Factors of Evapotranspiration Predictability Under Diverse Climates With the Effects of Water Storage Change in the Budyko Framework by Chuanhao Wu, Pat J.‐F. Yeh, Jun Zhou, Jiayun Li, Lulu Zhong, Saisai Wang, Zhengjie Gong, Min Shi, Jiali Ju, Guoru Huang

“…Results show that the difference between ET1 and ET2 increases linearly with ΔS, with ET2 < ET1 (ET2 > ET1) when ΔS > 0 (ΔS < 0). …”
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Implementation of a Laboratory-Developed Test for the Diagnosis of <i>Mycoplasma pneumoniae</i> Using a High-Throughput Approach by Valeria Conciatori, Sarah Di Sopra, Elisa Franchin, Ioannis Bekas, Giuseppe Di Pietra, Ignazio Castagliuolo, Cristiano Salata, Claudia Del Vecchio

“…We evaluated the performance in terms of precision, sensitivity, linearity, and analytical sensitivity, comparing it to the original in-house assay. …”
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Development and validation of the method for the quantitative determination of methotrexate in a transport medium by HPLC-MS/MS by P. Yu. Mylnikov, Yu. Tranova, A. V. Shchulkin, E. N. Yakusheva

“…The developed method was validated according to the following parameters: selectivity, linearity, accuracy, precision, limit of quantitative determination, sample transfer, sample stability. …”
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U-shaped association of serum magnesium with mild cognitive impairment among hemodialysis patients: a multicenter study by Yuqi Yang, Yanjun Long, Jing Yuan, Yan Zha

“…A U-shaped association was identified between the serum magnesium and incident MCI (P for non-linearity = 0.004). The optimal range of magnesium level with the lowest risk of MCI was 1.12–1.24 mmol/L. …”
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THE RELATION OF ALCOHOL CONSUMPTION WITH CARDIOVASCULAR DISEASES AND RISK FACTORS (ESSE-RF TRIAL IN KEMEROVSKAYA OBLAST) by S. A. Maksimov, Ya. V. Danilchenko, M. V. Tabakaev, T. A. Mulerova, E. V. Indukaeva, G. V. Artamonova

“…Increase of the mean daily ethanol dosage is positively linearly related with the risk of arterial hypertension (OR 1,04: 1,11-2,75), hypercholesterolemia (OR 1,06: 1,01-1,12), increased level of low density lipoproteins (OR 1,09: 1,02-1,16), smoking (OR 1,17: 1,10-1,24), low physical activity (OR 1,09: 1,02-1,16). …”
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Association of visceral obesity indicators with prostate cancer: a cross-sectional study from Xinjiang by Zhiruo Cai, Xue Guan, Yunyun Xiao, Hengqing An, Ning Tao

“…RCS analysis showed that VAI and CMI were nonlinearly associated with PCa risk, and LAP was linearly associated with PCa risk. The area under the ROC curve (AUC) of VAI, CMI, and LAP was 0.721 (95% CI: 0.651-0.791), 0.711 (95% CI: 0.639-0.782), and 0.593 (95% CI: 0.515-0.671), respectively.ConclusionsVisceral obesity indicators are closely associated with PCa, of which VAI and CMI show good predictive value and robustness, and can be used as potential biomarkers for assessing PCa risk.…”
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Identification and Determination of Impurities in a New Therapeutic Agent for Fatty Liver Disease by Huihui Shao, Jing Feng, Hanyilan Zhang, Yuanyuan Zhang, Tong Qin, Yuhua Hu, Wenxuan Zhang, Tiesong Wang, Song Wu, Qingyun Yang

“…The methods were validated based on the International Council for Harmonization guidelines. Satisfactory linearity was obtained for the analytes over the range of 0.1–2.0 μg/mL for impurities I–IV and 0.3–30.0 ng/mL for impurity V, and in all cases, the fitting correlation coefficients exceeded 0.999. …”
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