A novel NKG2A alpaca nanobody targeting immune checkpoint blockade for the treatment of malignant melanoma by Xiang Guo, Xiang Guo, Xiang Guo, Congfang Guo, Dongxiao Li, Yuting Bai, Mureed Abbas, Mureed Abbas, Ruiwen Fan, Yiyan Zhao, Yiyan Zhao

“…Compared to traditional antibodies, nanoantibodies have several characteristics, including smaller molecular weight, stable structure, high homology with human antibodies, and suitability for prokaryotic expression. …”
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Hypoxic preconditioning modulates BDNF signaling to alleviate depression-like behaviors in mice and its whole transcriptome sequencing analysis by Lizhu Chen, Xujie Wang, Xiaoe Jia, Rengui Bade, Xiaolei Liu, Shuyuan Jiang, Yabin Xie, Wei Xie, Manhai Gao, Guo Shao

“…Subsequent analysis focused on changes in depressive behaviors, biochemical markers, and the levels of BDNF and its ability to modulate synaptic structure and neurogenesis. Furthermore, whole transcriptome sequencing was conducted. …”
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Advancing soil biology research: Empowering European databases with ontological frameworks for enhanced data integration of soil biodiversity data by José F. Aldana-Martín, David J. Russell, Carlos A. Martínez-Muñoz, Christine Driller, Stephan Lesch, Ismael Navas-Delgado

“…However, careful selection of vocabulary is essential to ensure effective interoperability among ontologies, especially when dealing with closely related taxa.While databases like Edaphobase provide comprehensive taxonomic information for soil invertebrate animals, they lack specific ontologies for the underlying taxonomic structure. This research addresses this gap by proposing the EUdaphobase Taxonomy Ontology (EUTaxO) tailored to soil biology taxonomy. …”
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Prognosticating salvage stereotactic radiosurgery outcomes in relapsed primary central nervous system lymphoma: A machine learning-driven decision tree analysis by Huili Zhao, Shenao Zhang, Lang Chen, Xin Liu, Aihong Cao, Peng Du

“…Using multivariate analysis, a decision tree model was developed incorporating three critical prognostic parameters: Karnofsky Performance Status (KPS); deep brain structure involvement; and International Extranodal Lymphoma Study Group (IELSG) score. …”
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Study on the incremental carbon sink of tea plantations under spatio-temporal variation characteristics by Yaxiang Pan, Yaxiang Pan, Jingling Bao, Jingling Bao, Yuxuan Ji, Yuxuan Ji, Wen Li, Wen Li, Weiyu Lin, Shuisheng Fan, Shuisheng Fan, Shuisheng Fan, Liyu Mao, Liyu Mao

“…The results show that: (1) During the period of 2010–2022, the total carbon sink of tea plantations in Fujian Province increased by 133.12 × 105Mg, showing a continuous growth trend; in terms of spatial distribution, the intensity of tea plantation carbon sinks in the study area showed a gradual and present trend of migration and concentration from the southwest to the northeast. (2) Construct the evaluation index system of carbon sinks in tea plantations, divided into social, living, industrial and population factors and other four categories of eight indicators. (3)The single-factor driver of tea plantation carbon sinks shows that it is mainly affected by industrial scale, population density and industrial structure, with q-values exceeding 0.5. (4)The interaction of the drivers shows that the urban-rural disparity and industrial scale have the highest interaction effect, with q-values reaching 0.9698. …”
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ESENA: A Novel Spatiotemporal Event Network Information Approach for Mining Scalp EEG Data by Qiwei Dong, Runchen Yang, Xinrui Wang, Zongwen Feng, Chenggan Liu, Shiyu Chen, Yuxi Zhou, Dezhong Yao, Junru Ren, Qi Xu, Li Dong

“…The essence of this method is to map power events onto network nodes and define connections on the basis of the temporal sequence of these events, thereby establishing a spatiotemporal network structure. Next, the performance and feasibility of ESENA were tested using three resting‐state and game‐playing state EEG datasets. …”
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Conjugation effects on antibiotic resistance genes at various salt Levels: Insights from single-factor and simulation study by Pei Jiang, Yu Xia, Jiali Chang, Cheng Zhang, Xia Li, Le Fang, Xinhui Liu

“…Although exogenous antibiotic resistance bacteria (ARB) introduction marginally reduced α-diversity, phylum-level community structure remained stable. Salinity preferentially suppressed rare taxa, amplifying ARGs co-occurrence networks through niche restructuring. …”
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Morphology of <i>Pulleniatina</i> (planktonic foraminifera) from optical microscopy, micro-CT, and SEM investigations by A. Fabbrini, A. Fabbrini, P. N. Pearson, A. Brombacher, A. Brombacher, F. Iacoviello, T. H. G. Ezard, B. S. Wade

“…We use these observations to document the comparative ontogeny and test structure of the six <i>Pulleniatina</i> morphospecies in the context of an evolutionary model involving two diverging species lineages.…”
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Fatty acids profile in Awassi sheep milk affected by some genes&apos; single and combined effects. by Khaleel I. Jawasreh, Dana Khrais, Muhammad Alu&apos;datt, Nizar J. Haddad, Sami Awabdeh, Mohammad Isam AlMadani, Mohamad Brake, Mohamad Ahmad Al-Araishi, Monther Sadder, Ahmad Al-Amareen.

“…Objective: This study intended to figure out the effects of fixed effects and genes such as beta-lactoglobulin (β-LG), prolactin (PRL), annexin A9 (ANXA9), and acetyl-CoA acyltransferase 2 (ACAA2) on the structure of fatty milk acids in Awassi ewes, as well as any potential genotype-genotype interactions. …”
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Polydopamine/polyvinyl alcohol/graphene oxide transition layer for enhancing adhesive performance of HA coating on Cf/C composites prepared by hydrothermal electrodeposition/hydrot... by Shaoqing Chen, Caiqin Liang, Pengyin Li, Chun Liu, Xierong Zeng, Xinbo Xiong, Xinye Ni

“…Remarkably, scratch tests demonstrated that the HA/PVD-PVA-GO coating on Cf/C exhibited a dense configuration and compact interfacial structure, achieving a maximum critical load of 51.5 N, surpassing other reported electrochemically prepared HA coatings. …”
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Genome-Wide Characterization of <i>9-Cis-Epoxycarotenoid Dioxygenase</i> Genes in Luffa Identifies <i>LcNCED2</i> as Being Associated with ABA Levels During Seed Germination by Pingping Fang, Xifeng Li, Haoxin Mu, Jing Wei, Ting Zhang, Xueyan Wang, Qinwei Guo, Qunfeng Lou

“…Phylogenetic analysis classified these genes into two subgroups. Gene structure and motif composition analyses revealed both similarities and differences among the <i>NCED</i>s. …”
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Morphological, chemical, and crystallographic aspects of interface evolution in Al/Mg dissimilar friction stir welds by Usman Abdul Khaliq, Mohd Ridha Muhamad, Farazila Yusof, Suriani Ibrahim, Zbigniew Brytan, Takuya Miura, Tetsuo Suga, Yoshiaki Morisada, Hidetoshi Fujii

“…Additionally, tensile fractures occurred in the Al12Mg17 phase, attributed to its inherent brittleness, which results from the retardation of slip caused by the covalent bonds between Al atoms within the crystal structure. A three-stage fracture mechanism has been proposed to elucidate the failure behavior of the specimens under tensile loading. …”
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Helminth fauna of the monocled cobra (Naja kaouthia) from central Thailand: community composition and taxonomic perspectives by Napat Ratnarathorn, Urusa Thaenkham, Abigail Hui En Chan, Panithi Laoungbua, Tanapong Tawan, Taksa Vasaruchapong, Vachirapong Charoennitiwat, Kittipong Chaisiri

“…This study investigates the helminth fauna, community structure, infection patterns and their co-occurrence dynamics in the monocled cobra (Naja kaouthia) from urbanized areas of central Thailand, based on comprehensive analyses of 34 wild-caught individuals. …”
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Modified Pulsatilla decoction ameliorates ulcerative colitis by affecting gut microbiota and metabolite profiles by Zhixin Fu, Zhixin Fu, Xiangyue Xie, Xiangyue Xie, Yulei Wang, Zhen Wang, Anran Wu, Anran Wu, Shaotang Ye, Shaotang Ye, Yongbo Liu, Yongbo Liu

“…The results indicated that MPD improved the structure and morphology of colon tissue, significantly reducing inflammatory damage in DSS-treated mice. …”
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3D printed chitosan-based flexible electrode with antimicrobial properties for electrical stimulation therapy in wound healing by Moses Kumi, Zishuo Hou, Yibo Zhang, Yutian Yang, Chang Han, Tengjiao Wang, Peng Li

“…The electrode’s porous and hydrophilic structure enhances moisture retention, making it suitable for diverse wound environments. …”
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2D/3D Heterostructure Halide Perovskite Thin Films through an Innovative Spray‐Deposition of Bulky Organic Cation‐Containing Ammonium Salts by Rishabh Sahani, Neetesh Kumar, Carlo A. R. Perini, Azina Rahmani, Daniel Muñoz, Diana LaFollette, Jack Lawton, Kunal Datta, Ruipeng Li, Juan‐Pablo Correa‐Baena, Titel Jurca, Cheng‐Yu Lai, Daniela R. Radu

“…X‐ray diffraction (XRD) and grazing incidence wide‐angle X‐ray scattering measurements confirm the evolution of 2D perovskite layer with distinct crystal structure and dimensionality (n = 1 and 2). Additionally, field‐emission scanning electron microscopy reveals diverse surface morphologies achievable in the 2D perovskite layers. …”
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Coastal salt marsh vegetation classification using hybrid convolutional neural networks and spectral index time series images by Bolu Sun, Dong Zhang, Zhengqing Lai

“…A relatively stable ecosystem subsequently emerged, dominated by P. australis and S. alterniflora (73.4%) with a marginal presence of S. salsa (3.66%). (3) A nationwide S. alterniflora eradication effort launched in 2023 caused major disruptions in habitat structure and temporal spectral profiles. Applying the pre-trained model to 2024 imagery yielded an accuracy of 81.91% with minimal additional sampling, demonstrating the hybrid CNN model’s strong generalization and transfer-learning capabilities for dynamic saltmarsh vegetation mapping.…”
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Effect of Aflatoxin B1 on the Nervous System: A Systematic Review and Network Analysis Highlighting Alzheimer’s Disease by Samira Ranjbar, Pantea Mohammadi, Somayeh Pashaei, Masoud Sadeghi, Masomeh Mehrabi, Sasan Shabani, Ali Ebrahimi, Annette B. Brühl, Reza Khodarahmi, Serge Brand

“…The gene TP53 played a pivotal role in mediating communication among genes, while the EP300 gene significantly influenced the overall network structure. Additionally, KEGG enrichment analysis demonstrated that these 309 genes are substantially involved in pathways related to cancer, the FoxO signaling pathway, apoptosis, and AD. …”
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Electrostatic Field Modification Enhances the Electrocatalytic Oxygen Evolution Reaction Stability of CoFe₂O₄ Catalysts by Liwen Liang, Jiatong Miao, Xiyuan Feng, Yunlei Zhong, Wei Wang

“…This study not only presents a novel strategy for modulating catalyst stability via electric fields but also broadens the design concepts for OER catalytic materials by establishing a structure–activity relationship between electric field strength, microstructure, and catalytic performance, ultimately providing a theoretical foundation and experimental guidance for the development of highly efficient and stable water splitting catalysts.…”
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Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity by Jungeun Lee, Ho Jin Lee, Yeongcheol Lee, Bumhee Lim, Jongsik Gam, Dong-Chan Oh, Jeeyeon Lee

“…We also designed and synthesised PD3-B (5), an affinity-based probe (ABP) from the PD3 structure, which enabled us to pull down PDEδ from bacterial lysates containing a large number of intrinsic bacterial proteins. …”
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