A Novel Variant in TUBB4B Causes Progressive Cone‐Rod Dystrophy and Early Onset Sensorineural Hearing Loss by Margherita Scarpato, Francesco Testa, Anna Nesti, Roberta Zeuli, Rosa Boccia, Gennaro Auletta, Sandro Banfi, Francesca Simonelli, Marianthi Karali

“…The functional impact of the Lys350Thr substitution was supported by protein structure modeling studies. The variant segregates in the family members presenting retinal disease with early onset SNHL. …”
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3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration by Wenqiang Lou, Xinzhu Qiu, Yiming Qin, Yingnan Lu, Yong Cao, Hongbin Lu

“…Osteochondral defects (OCDs) pose a significant clinical challenge due to their limited self-repair capacity. The complex structure and distinct biological properties of articular cartilage and subchondral bone further complicate regeneration.In this study, we introduce a novel osteochondral regeneration strategy leveraging single-cell RNA sequencing (ScRNA-seq) to identify a unique population of skeletal stem cells (SSCs) derived from the infrapatellar fat pad (IFP). …”
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Human footprint with machine learning identifies risks of the invasive weed Conyza sumatrensis across land-use types under climate change by Hua Cheng, Kasper Johansen, Baocheng Jin, Shiqin Xu, Xuechun Zhao, Liqin Han, Matthew F. McCabe

“…Biological invasions pose significant threats to ecosystem structure and function, disrupt ecosystem services, cause high economic losses, and negatively impact human well-being. …”
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Effect of Alkali Source on Crystal Regulation and Ethanol Gas Sensing Properties of Nano-ZnO by Yinying Liao, Lu Qiu, Yunfei Ouyang, Dayang Feng, Shiyi Huang, Zhaoyang Zhang, Xinyao Xie, Junwei Ke, Tianhao Liu, Xiangxiang Chen, Hongshan Bi, Weiran Zuo

“…TEM, XPS, and FTIR were employed to further analyze the crystal structure and binding energy of ZnO. To elucidate the underlying mechanisms, density functional theory (DFT) calculations combined with electron depletion layer theory were applied to assess charge transfer processes and identify the most sensitive ZnO crystal planes for ethanol detection. …”
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Understanding the development of mechanically and thermally induced white layers in AISI 52100 steel during hard turning: Process-microstructure-property relationship by Sahith Kokkirala, Uta Klement, Jonas Holmberg, Hirotsugu Iwasaki, Juan Manuel Bello Bermejo, Stefan Kimming, Seyed B. Hosseini

“…During hard turning, the surface microstructure of AISI 52100 steel transforms into a nanocrystalline structure known as white layer, accompanied by significant surface residual stresses. …”
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Cross-cultural adaptation and validation of the Chinese version of the quality of communication questionnaire by Jacqueline K. Yuen, Helen Y. L. Chan, Tracy W. T. Chen, Steven T. Chu, Annie O. L. Kwok, Doris Y. P. Leung, Harinder S. Gill, Kwok-wai Tsang, Doris M. W. Tse, Desmond Y. H. Yap, Terence Yip, Robert M. Arnold

“…The C-QOC has a 3-component structure (general communication skills, communication about illness trajectory, and end-of-life care planning subscales) and demonstrated good internal consistency (Cronbach’s α = 0.88; subscales 0.84–0.90). …”
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Investigating the impact of generative AI integration on the sustenance of higher-order thinking skills and understanding of programming logic by Jemimah Nathaniel, Solomon Sunday Oyelere, Jarkko Suhonen, Matti Tedre

“…The intervention followed a one-group pretest-post-test structure over seven weeks with 25 computer science students with no prior C++ experience. …”
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SURGERY OF BRAIN STEM CAVERNOUSES MALFORMATION by V. V. Stupak, Sh. Aul, A. G. Bobylev, M. V. Kutsenko, D. A. Dentsel, T. M. Shogunbekov, V. M. Bon, A. M. Gazeev, A. E. Simonovich, S. V. Tsvetovskiy

“…Cavernous malformations (CM), also known as cavernous angiomas or cavernomas, are benign vascular hamartomas having a sinusoidal type of wall structure.CM occurs in the brain stem with a frequency of 9–35 % of cases. …”
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Research hotspots and frontiers of neuromodulation technology in the last decade: a visualization analysis based on the Web of Science database by Yanpei Liu, Yanpei Liu, Qian Zhang, Haoran Zhang, Haoran Zhang, Yun Xiang, Yun Xiang, Hui Wang

“…Future research is expected to delve deeper, particularly into exploring deep brain structure stimulation targets and restoring motor function based on neuroplasticity theory.…”
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The clinical spectrum associated with ERCC5 mutations: Is there a relationship between phenotype and genotype? by Jinpeng Zhang, Jiannan Ma, Yuanyuan Luo, Siqi Hong, Li Jiang, Tianyi Li

“…The gene mutation has not been reported and was predicted to seriously affect the protein structure. According to a review of 59 cases of ERCC5 mutations, cerebrooculofacioskeletal syndrome (COFS) occurred in 16 cases, XP in 19 cases, and XP/CS in 24 cases. …”
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Novel pectin/chitosan Mo-MOF hydrogel for dye adsorption and pathogenic bacteria inhibition by Zahraa Sabah Ghnim, Ayat Hussein Adhab, Farag M. A. Altalbawy, Farag M. A. Altalbawy, Morug Salih Mahdi, Aseel Salah Mansoor, Usama Kadem Radi, Nasr Saadoun Abd, Uday Abdul-Reda Hussein, Hadil Hussain Hamza, Khursheed Muzammil, Ahmad Alkhayyat, Ahmad Alkhayyat, Ahmad Alkhayyat

“…After confirming the structure of the synthetic hydrogel by Elemental Analysis (EA), Energy-Dispersive X-ray Spectroscopy (EDS), EDS mapping, Fourier-transform infrared spectroscopy (FT-IR), X-Ray Diffraction (XRD), Brunauer-Emmett-Teller (BET), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM), its application in wastewater treatment, including the absorption of Congo red and the inhibition of pathogenic bacterial strains in wastewater, was evaluated. …”
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Medical treatment cost for Chinese inpatients with colorectal cancer by sites by Zeng-Bao Hu, Jin-Ying Huang, Stuart McDonald, Bo-Xu Chen, Hao-Xun Mao, Zhou Wu, Xiao-Yu Dai, Hua Yu, Jian-Jiong Li, Yi Lin

“…Using hospitalization data from Ningbo, China, this study aims to estimate the medical treatment cost and cost structure of CRC based on tumor sites to gain insights with respect to the cost efficiency of early diagnosis.MethodsA retrospective observational study was performed in a real-life clinical setting of a tertiary hospital in Ningbo, China. …”
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Ice‐kNN‐South: A Lightweight Machine Learning Model for Antarctic Sea Ice Prediction by Yongcheng Lin, Qinghua Yang, Xuewei Li, Xiaoran Dong, Hao Luo, Yafei Nie, Jiuke Wang, Yiguo Wang, Chao Min

“…Besides, the improvements of Ice‐kNN‐South are more pronounced in regions with high SICA variability by implementing a multi‐scale structure that combines field‐to‐field and grid‐to‐grid predictions. …”
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Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation by Chelsy Chesterman, Thomas Desautels, Luz-Jeannette Sierra, Kathryn T. Arrildt, Adam Zemla, Edmond Y. Lau, Shivshankar Sundaram, Jason Laliberte, Lynn Chen, Aaron Ruby, Mark Mednikov, Sylvie Bertholet, Dong Yu, Kate Luisi, Enrico Malito, Corey P. Mallett, Matthew J. Bottomley, Robert A. van den Berg, Daniel Faissol

“…The top mutant identified underwent biophysical and x-ray crystallographic characterization to confirm that the overall structure of fHbp was maintained throughout this epitope engineering experiment. …”
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Heavy metal pollution simplifies microbial networks and enhances modularity during tailings primary succession: divergent assembly dynamics for bacterial and fungal communities by Min Li, Jun Liu, Dan Cao, Xueyi Chen, Jiaxin Shi, Wenzhe Hu, Chunqiao Xiao, Yun Fang

“…Our results revealed clear differences in soil physicochemical properties, microbial diversity, community structure, and ecological interactions between low and high pollution conditions. …”
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Time-dependent evolution of morphologies and lattice defects in hydrothermal synthesized ceria-zirconia solid solutions for catalytic combustion of diesel soot by Zhengzheng Yang, Zhi Chen, Na Zhang, Yang Zhou, Dezhou Luo, Tai Jin, Huangwei Zhang

“…A moderate hydrothermal processing time can facilitate the engineering of catalyst morphology at micronmeter scale, however, excessive hydrothermal synthesis time would contrarily destroy the micrometer scaled catalyst morphological structure. The result of XPS, O2-TPD and H2-TPR analysis indicates that the hydrothermal synthesis process is conducive to generating lattice defects (oxygen vacancies) of CeO2-ZrO2 solid solution. …”
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Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes by Tobias Brünger, Alina Ivaniuk, Eduardo Pérez-Palma, Ludovica Montanucci, Stacey Cohen, Lacey Smith, Shridhar Parthasarathy, Ingo Helbig, Michael Nothnagel, Patrick May, Dennis Lal

“…Across ten genes encoding voltage-gated sodium channels and 22 expert-curated disorders, we identify cross-paralog correlated phenotypes based on 3D structure spatial position. For example, multiple established loss-of-function related disorders across SCN1A, SCN2A, SCN5A, and SCN8A show overlapping spatial variant clusters. …”
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Ultrasound-assisted ethanol induced gelation of egg white: Effects on gel properties, water distribution and microstructure by Lan Liu, Xin Li, Pei Zhang, Wenjie Yan, Yingmei Wu, Hongbo Song, Fengping An, Peng Luo, Guofeng Jin, Qun Huang

“…SDS-PAGE analysis illustrated that lysozyme and ovomucoid participated in the aggregation process. Regarding gel structure, the β-sheet increased by 2.66 % and 15.48 % at ethanol concentrations of 25 % and 30 %, respectively, accompanied by a reduction in fluorescence intensity, further confirming ultrasound-assisted ethanol induced aggregation of egg white protein (EWP). …”
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Genome-Wide Identification of the GRAS Transcription Factor Family in Sweet Orange and the Regulation of Salt Stress-Enhanced Plant Salt Tolerance in Sweet Orange by <i>CsGRAS15</i... by Hailin Ren, Rong Xu, Jie Wang, Qian Zhang, Lili Nie, Li Zhang, Xianyan Zhou, Xiaozhen Liu, Hanyao Zhang

“…Results: Forty-three <i>CsGRAS</i> genes were identified, phylogenetically classified into ten subfamilies, and found to be structurally conserved. A promoter analysis revealed a high prevalence (58.78%) of hormone- and stress-responsive cis-elements. …”
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Electrochemical Sensor Based on DNA Aptamers Immobilized on V₂O₅/rGO Nanocomposite for the Sensitive Detection of Hg(II) by Mahesh A. Takte, Shubham S. Patil, Akash V. Fulari, Tibor Hianik, Mahendra D. Shirsat

“…The FE-SEM of V₂O₅ disclosed the nanorod-like structure and uniform anchoring of V₂O₅ on the rGO nanosheet. …”
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