The role of nuclear receptors in metabolic homeostasis and disease: From molecular mechanisms to drug discovery by Fangfang He, Haomeng Wu, Feilong Zhao, Xinxin Liu, Qin Yang, Shiquan Zhou, Tianling Xu, Jing Xu, Shuai Wang, Denglang Zou

“…We further examine recent advances in NR-targeted drug discovery, including structure-based drug design, chemical biology approaches, and AI-assisted ligand development. …”
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Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies by Jinshou Yang, Feihan Zhou, Xiyuan Luo, Yuan Fang, Xing Wang, Xiaohong Liu, Ruiling Xiao, Decheng Jiang, Yuemeng Tang, Gang Yang, Lei You, Yupei Zhao

“…This review comprehensively encapsulates the structural attributes of enhancers, delineates the mechanisms underlying their dysregulation in malignant transformation, and evaluates the therapeutic opportunities and limitations associated with targeting enhancers in cancer.…”
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The Efficient Degradation of Oxytetracycline in Wastewater Using Fe/Mn-Modified Magnetic Oak Biochar: Pathways and Mechanistic Investigation by Yujie Zhou, Yuzhe Fu, Xiaoxue Niu, Bohan Wu, Xinghan Liu, Fu Hao, Zichuan Ma, Hao Cai, Yuheng Liu

“…Even after five recycling cycles, the material exhibited minimal changes in degradation efficiency and bimetallic crystal structure, indicating its notable stability and reusability. …”
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Integrating electrospun aligned fiber scaffolds with bovine serum albumin-basic fibroblast growth factor nanoparticles to promote tendon regeneration by Yuwan Li, Zhen Ge, Ziming Liu, Longfei Li, Jian Song, Hongde Wang, Feng Tian, Pengfei Lei, Long Li, Jiajia Xue

“…Abstract Background Electrospun nanofiber scaffolds have been widely used in tissue engineering because they can mimic extracellular matrix-like structures and offer advantages including high porosity, large specific surface area, and customizable structure. …”
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Clinicopathologic and prognosis of 30 patients with FH-deficient renal cell carcinoma: a single-center retrospective study by Junjie Bai, Jianjia Huang, Yushi Ye, Jun Lin, Yahui Wen, Zicheng Cai, Peihuang Chen, Tong Shangguan, Gaoyu Zou, Qianyi Qiu, Ru Chen, Rong Liu, Weizhong Cai, Shaoxing Zhu, Jianhui Chen, Xiaoyan Li

“…Notably, PD-L1 positivity was associated with a higher frequency of simple papillary structures and better outcomes in patients receiving TKI monotherapy. …”
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The Automatic Joint Teeth Segmentation in Panoramic Dental Images using Mask Recurrent Convolutional Neural Networks with Residual Feature Extraction: by Raghavendra H. Bhalerao, Abhijeet Ashok Salunke, Shristi Sharan, Kamlesh Kumar, Priyank Rathod, Prince Kumar, Manish Chaturvedi, Nandlal Bharwani, Krupa Shah, Dhruv Patel, Keval Patel, Vikas Warikoo, Manisha Abhijeet Salunke, Shashank Pandya

“…Introduction Panoramic dental images gives an in-depth understanding of the tooth structure, both lower and upper jaws, and surrounding structures throughout the cavity in our mouth.The Panoramic dental images provided have significance for dental diagnostics since they aid in the detection of an array of dental disorders, including oral cancer. …”
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A numerical investigation to design and performance optimization of lead-free Cs2TiCl6 based perovskite solar cells with different charge transport layers by Sahjahan Islam, M. Khalid Hossain, M. Shihab Uddin, P. Prabhu, Suhas Ballal, K. Phaninder Vinay, V. Kavitha, Satish Kumar Samal, Abdullah M. S. Alhuthali, Mongi Amami, A. Kumar Datta, Gazi F. I. Toki, Rajesh Haldhar

“…After several cell optimizations like thickness, acceptor, donor, and defect concentration of selected four structures, the best cell structure are suggested e.g., FTO/CdS/Cs2TiCl6/CdTe/Au that shows a PCE of 18.15% along with the short circuit current density (J SC) of 17.83 mA/cm2, open-circuit voltage (V OC) of 1.188 V, fill factor (FF) of 89.51%. …”
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Identification and Characterization of Copper-Responsive miRNAs and Their Target Genes in Jerusalem Artichoke by Xi Chen, Tianyun Shao, Wenhan Dong, Jiayan Lin, Lixiang Dai, Yilong Ma, Zhaosheng Zhou, Xiaohua Long

“…These miRNAs possess characteristic stem-loop precursor structures and detectable miRNA* sequences, with miR858 having unusually long precursors (1524–6448 nt). …”
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Multiple Pseudo-Placentational Endometrial Hyperplasia (PEH) as a Rare Uterine Disorder in the Bitch by Andrzej Łobaczewski, Rafał Sapierzyński, Sławomir Giziński, Ewa Kautz-Wasilewska, Anna Jaśkiewicz, Olga Szaluś-Jordanow, Zofia Nowek, Agata Moroz-Fik, Michał Grzegorczyk, Tadeusz Frymus

“…Another, though rarer, condition is pseudo-placentational endometrial hyperplasia (PEH), characterized by abnormal proliferation of the endometrial glands and stroma, forming placental-like structures without the presence of pregnancy. Case presentation: An 8-year-old female Golden Retriever, healthy and intact, was presented for a routine ultrasound examination to confirm pregnancy after natural breeding 25 days earlier. …”
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Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area by Pavel Filip, Andrej Lasica, Dimitra Kiakou, Karsten Mueller, Jiří Keller, Dušan Urgošík, Daniel Novák, Robert Jech

“…Conclusions: All in all, this study not only replicated the results of previous studies on GPi DBS as a modality restoring sensorimotor network connectivity and local activity in dystonia towards the levels in healthy population, but also showed that lower GPi area or even subpallidal structures, be it white matter or even small, but essential nodes in the zona incerta as nucleus basalis of Meynert, are important regions to consider when programming DBS in dystonia patients.…”
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Impact of heat pumps and future energy prices on regional inequalities by Jieyang Xu, Sebastian Mosbach, Jethro Akroyd, Markus Kraft

“…The results suggest that, under appropriate price structures, heat pump adoption could contribute to both decarbonisation and reduced social inequality. …”
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Harnessing macroalgal cell walls to trigger immunity in Arabidopsis thaliana by Jorge Peláez, Carlos Frey, Diego Rebaque, Francisco Vilaplana, Antonio Encina, Hugo Mélida

“…The monosaccharide and glycosidic linkage analysis of these fractions pointed to some specific algal cell wall glycans (e.g. porphyrans and fucoidans) that could contribute to the immunostimulatory capacity, thereby paving the way for the identification of distinct structures with potential agrobiological applications.…”
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Mesoporous Bamboo Biochar from Microwave-assisted Template/Hydrothermal Treatment for Adsorption of Organics by Yin Li, Xinyi Yu, Junfeng Zhang, Zengkun Wang, Tao Zhang, Jian Yang, Jun Dong, Shuqi Li, Chuang Xing, Xikun Gai

“…The biochars were found to have mesoporous structures with BET surface areas of 13.0 to 288 m2/g, total pore volumes in the range of 0.017 to 0.313 cm3/g, and average pore diameters between 4.0 and 6.7 nm in size. …”
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Interconnected nanoconfining pore networks enhance catalyst CO2 interaction in electrified reactive capture by Hengzhou Liu, Lun An, Peiyao Wang, Christine Yu, Jie Zhang, Heejong Shin, Bosi Peng, Jiantao Li, Matthew Li, Hongmin An, Jiaqi Yu, Yuanjun Chen, Peiying Wang, Kug-Seung Lee, Kanika Lalit, Zeyan Liu, Omar K. Farha, Wenyu Huang, Jefferson Zhe Liu, Long Qi, Ke Xie, Edward H. Sargent

“…We develop a templated synthesis to define pore structures and the sites of Ni single atoms, and find that carbon-nitrogen-based nanopores are effective in accumulating i-CO2 via short-range, non-electrostatic interactions between CO2 molecules and the nanochannel walls. …”
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Ice flow line maps of three large freshwater calving glaciers in the Southern Patagonian Icefield by E. Lannutti, E. Lannutti, E. Lannutti, P. Marmolejo, J. Sanchez, I. Ortíz, M. G. Lenzano, S. Moragues, S. Moragues, A. Rivera, P. Vacaflor, G. Pereyra, H. Morales

“…The resulting maps reveal detailed flow structures, highlighting flow lines from accumulation to ablation zones, increased velocities in central areas, tributary flows merging with main channels, and regions of flow convergence and divergence. …”
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A hyperfine-transition-referenced vector spectrum analyzer for visible-light integrated photonics by Baoqi Shi, Ming-Yang Zheng, Yue Hu, Yunkai Zhao, Zhenyuan Shang, Zeying Zhong, Zhen Chen, Yi-Han Luo, Jinbao Long, Wei Sun, Wenbo Ma, Xiu-Ping Xie, Lan Gao, Chen Shen, Anting Wang, Wei Liang, Qiang Zhang, Junqiu Liu

“…The VSA is further referenced to hyperfine structures of alkaline atoms and iodine molecules, enabling megahertz frequency accuracy. …”
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Identification of Immune Related LRR-Containing Genes in Maize (Zea mays L.) by Genome-Wide Sequence Analysis by Wei Song, Baoqiang Wang, Xinghua Li, Jianfen Wei, Ling Chen, Dongmin Zhang, Wenying Zhang, Ronggai Li

“…Their predicted amino acid sequences have similar protein structures with their respective homologues in other plants, indicating that these maize LRR-RLK/RLPs have the same functions as their homologues act as immune receptors. …”
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Efficient Multipath Mitigation in GNSS Using Dynamic Selection and Weighting of Early-Late Correlators by Ayoub Bengherabi, Mustapha Flissi, Khaled Rouabah, Salim Attia, Diana W. Dawoud, Yassine Himeur, Shadi Atalla, Wathiq Mansoor

“…The proposed method is compatible with various Global Navigation Satellite Systems (GNSS) signal structures, including binary phase shift keying (BPSK) and advanced binary offset carrier (BOC) modulations, which exhibit high-resolution autocorrelation functions (ACFs) with multiple spectral side lobes, leading to synchronization ambiguities. …”
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Synergistic effects of Lespedeza and artichoke extracts in the therapy of chronic kidney disease: mechanisms and perspectives by Z.O. Serebrovska, D.О. Tolstun, N.V. Sykalo, I.O. Farkhidinov, V. Kropyva, S.A. Myhovan, V.P. Chizhova, T.I. Kovtonyuk, I.A. Samots, B.M. Mankovsky

“…This is achieved through both direct antioxidant action, protecting membrane structures, DNA, and mitochondria, and indirect anti-inflammatory action, reducing NF-κB and inflammasome activity, as well as the release of pro-inflammatory cytokines and chemokines. …”
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The impact of sintering and Mg doping on the ionic conductivity of Sm2Zr2O7 pyrochlores by Silvia Blasco-Zarzoso, Emerson Luiz dos Santos-Veiga, U-Chan Chung, Sebastien Fourcade, Catherine Elissalde, Fabrice Mauvy, Eloísa Cordoncillo, Hector Beltrán-Mir

“…Pyrochlore structures based on Sm2Zr2-xMgxO7-x (x = 0, 0.1, 0.15 and 0.2) were synthesized by hydrothermal method at 180 °C and the resulting powders fired at 1200 °C for 2h. …”
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