Early Development of an Innovative Nanoparticle-Based Multimodal Tool for Targeted Drug Delivery: A Step-by-Step Approach by Chiara Barattini, Angela Volpe, Daniele Gori, Daniele Lopez, Alfredo Ventola, Stefano Papa, Mariele Montanari, Barbara Canonico

“…These nanoparticles featured a core–shell structure to contemporarily conjugate the antibody and the cytotoxic payload monomethyl auristatin E (MMAE) using a step-by-step approach. …”
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Dual-Arm Mobile Manipulator Teleoperation With Coupled Rate-Position Mapping Under Time-Varying Delays by Fernando A. Chicaiza, Emanuel Slawinski, Vicente Mut

“…Preliminary human-in-the-loop tests in dual-arm pick-and-place tasks support the theoretical findings and demonstrate a clear dependence of motion stability on the structure of the command mapping. The results provide foundational insights into the joint optimization of control and mapping strategies and offer practical guidelines for advancing teleoperation in complex, real-world scenarios.…”
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Critical evaluation on the ecosystem service levels of provincial capital cities along the Yellow River Basin by Haifa Jia, Haifa Jia, Haifa Jia, Tianyou Wang, Tianyou Wang, Tianyou Wang, Pengyu Liang, Pengyu Liang, Pengyu Liang, Jianxun Zhang, Jianxun Zhang, Jianxun Zhang, Runhao Zhang

“…This study suggests optimizing the energy structure, promoting clean energy development, supporting industrial green transformation, and strengthening infrastructure to enhance and protect ecosystem services in the Yellow River Basin.…”
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FAM46C Expression Sensitizes Multiple Myeloma Cells to PF-543-Induced Cytotoxicity by Annarita Miluzio, Federica De Grossi, Marilena Mancino, Stefano Biffo, Nicola Manfrini

“…Sphingosine kinases (SphK1 and SphK2) are key regulators of sphingolipid signaling, a pathway essential for maintaining cell structure and function but frequently deregulated in tumors, making them promising targets for cancer therapy. …”
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Lithium adsorption properties of porous LiAl-layered double hydroxides synthesized using surfactants by Mingzhe Dong, Qinglong Luo, Jun Li, Zhijian Wu, Zhong Liu

“…Temperature, solution pH, and other electrolytes had a minor effect on the adsorption performance of porous LiAl-LDHs. The structure of surfactants had a significant influence on the porosity of synthesized LiAl-LDHs, and thus on the adsorption capacity.…”
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FGF mimetic peptide-modified electrospun nanocomposite fibrous membranes for accelerating infectious diabetic wound healing by synergistic antibacterial and pro-angiogenesis effect... by Anle Yang, Jianglong Liu, Wenhua Xu, Xueyan Li, Junxiang Xiong, Shaojuan Chen, Fang Zhou, Yingjun Xu

“…Importantly, owing to the unique structure of the CuCFR NPs, the membrane sustainedly released Cu2+ for 14 days, which effectively inhibited S. aureus (ca. 98 %) and modulated endothelial cell viability. …”
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Bio-synthesis of bacterial cellulose from ramie textile waste for high-efficiency Cu(II) adsorption by Shihang Ma, Guoguo Xi, Xiangyuan Feng, Qi Yang, Zhenghong Peng, Dong Qiu, Yuqin Hu, Xin Zhao, Lifeng Cheng, Shengwen Duan

“…The physical and chemical properties of BC were then analyzed, including Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Thermogravimetric analysis (TGA), confirming its type I α cellulose structure and good thermal stability. In particular, BC shows efficient adsorption capacity for Cu(II) ions in aqueous solution, with the highest adsorption efficiency reaching 95.62%. …”
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Pion pair production in e + e − annihilation at next-to-leading order matched to Parton Shower by Ettore Budassi, Carlo M. Carloni Calame, Marco Ghilardi, Andrea Gurgone, Guido Montagna, Mauro Moretti, Oreste Nicrosini, Fulvio Piccinini, Francesco P. Ucci

“…According to the recent advances in the literature, particular attention is paid to the treatment of the pion composite structure in loop diagrams beyond the commonly used factorised sQED approach, as well as to the modelling of multiple photon radiation through the Parton Shower algorithm. …”
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Regional variation in primary care improvement strategies and policy: case studies that consider qualitative contextual data for performance measurement in three Canadian provinces by John L Campbell, Catherine Scott, Fred Burge, Sabrina T Wong, Ruth Martin-Misener, Sharon Johnston, Stephanie Blackman, William Hogg, Anne M Grool, Sara Wuite

“…NVivo (V.11) was used to manage data and perform content analysis to identify categories within and across cases. The coding structure was developed by researchers through iterative collaboration, using inductive and deductive processes.Results Six overarching primary care improvement strategies, differing in focus and spread, were implemented across the three study regions: interprofessional team-based approaches, provider skill mix expansion, physician groups and networks, information systems, remuneration and performance measurement and reporting infrastructure.Conclusion The addition of information on regional improvement strategies to primary care performance reports could add important contextual insights into primary care performance results. …”
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Noise Pollution Prediction in a Densely Populated City Using a Spatio-Temporal Deep Learning Approach by Marc Semper, Manuel Curado, Jose Luis Oliver, Jose F. Vicent

“…In turn, GCNs integrate spatial structure and temporal dynamics through graph representations, achieving superior performance compared to traditional approaches or models based solely on CNN or LSTM architectures. …”
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Growth, nutrient accumulation and yield of onion as a function of micronutrient fertilization by Nubia M. F. Bertino, Leilson C. Grangeiro, João P. N. da Costa, Romualdo M. C. Costa, Rodolfo R. de A. Lacerda, Victor E. de V. Gomes

“…ABSTRACT Micronutrients structurally constitute several enzymes and act as a cofactor of essential proteins to maintain cell function, thereby contributing to crop growth and yield. …”
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Quantifying the intra- and inter-species community interactions in microbiomes by dynamic covariance mapping by Melis Gencel, Gisela Marrero Cofino, Cang Hui, Zahra Sahaf, Louis Gauthier, Chloé Matta, David Gagné-Leroux, Derek K. L. Tsang, Dana P. Philpott, Sheela Ramathan, Alfredo Menendez, Shimon Bershtein, Adrian W. R. Serohijos

“…Our results reveal how ecological and evolutionary dynamics jointly shape microbiome structure over time. The DCM framework provides a scalable method to dissect complex community interactions and is broadly applicable to bacterial ecosystems both in vitro and in situ.…”
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Characterization and Evolutionary Analyses Reveal Differential Selection Pressures on <i>PGIc</i> and <i>PGIp</i> During Domestication in Castor Bean by Jiayu Guo, Lanxin Jiang, Anmin Yu, Bing Han, Aizhong Liu

“…In higher plants, two PGI isoenzymes, plastidic (PGIp) and cytosolic (PGIc), have diverged significantly in sequence, structure, activity, and functional roles, despite catalyzing the same reaction. …”
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Application of a multiple transmitter spacing gradient array TDIP survey in the Huaniushan mining area, Gansu province, China by Shunji Wang, Guanwen Gu, Ye Wu, Xingguo Niu, Beidou Pan, Xingwen Wang, Zhihe Xu, Haoyuan He, Yingjie Wang, Xinglong Lin, Lai Cao

“…Finally, we combined the electrical structure determined from the multi-transmitter gradient surveys with relevant geological data. …”
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Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry by Fanny Eggeler, Jonathan Boulanger-Weill, Flavia De Santis, Laura Belleri, Karine Duroure, Thomas O Auer, Shahad Albadri, Filippo Del Bene

“…Here, we reveal a novel role for the Meteorin protein family in the establishment of the left-right axis and in the formation of Kupffer’s vesicle, the Node equivalent structure in zebrafish. We show that the genetic inactivation of each or all three members of the zebrafish Meteorin family (metrn, metrn-like a, and metrn-like b) leads to defects in properties of the Kupffer’s vesicle, caused by impaired assembly and migration of the Kupffer’s vesicle forming dorsal forerunner cells. …”
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Retrieving 4D landslide displacement using Pléiades satellite stereo pairs on the La Valette landslide by Sheng Fu, Steven M. de Jong, Wiebe Nijland, Mathieu Gravey, Philip Kraaijenbrink, Tjalling de Haas

“…We propose a new 4D landslide displacement framework, combining satellite-based structure-from-motion, cross-correlation feature tracking for horizontal ground-surface deformation measurements with COSI-Corr, and DEM differencing for vertical ground-surface deformation. …”
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Numerical analysis of hybrid electromagnetic coil designs for efficient gradient field generation in magnetic particle imaging by Shahriar Mostufa, Ebrahim Azizi, Bahareh Rezaei, Changzhi Li, Jenifer Gómez-Pastora, Rui He, Kai Wu

“…Additionally, the geometrical parameter of the MFC structure is optimized, and we have achieved a maximum gradient field strength of 5 T/m over a 14.3 cm space, with a tolerance of 98%.…”
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Network toxicology and molecular docking reveal the potential link between acrylamide exposure and breast cancer by Zhaoda Duan, Chunjiao Yu, Wenjie Yang, Wenhui Wang, Qi Zhang, Qiaoling Ruan, Rui Zhang, Yongfang Zhao, Shan Yan

“…Molecular dynamics simulations demonstrated that the complexes remained structurally stable throughout the simulation. Pan-cancer and paired sample analyses further confirmed the aberrant expression of core genes in BC, and immunohistochemistry results supported their altered protein levels. …”
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Emergence of blaKPC-2-carrying megaplasmid in carbapenem-resistant Pseudomonas aeruginosa ST1076: Genomic and functional insights by Jing Chen, Weidong Zhu, Chen Lin, Zhen Li, Haowei Ye, Danfeng Lou

“…The blaKPC-2 gene was located on a 394-kb IncP-2 megaplasmid, displaying a conserved genetic structure (IS6100-ISKpn27-blaKPC-2-ISKpn6-klcA). Transconjugation experiments succeeded after repeated efforts, confirming the plasmid’s ability to transfer at 27°C. …”
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Placental Pathology and Placental Growth Factor (PlGF)/Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Pathway Expression Evaluation in Fetal Congenital Heart Defects by Alexandru Cristian Bolunduț, Ximena Maria Mureșan, Rada Teodora Suflețel, Lavinia Patricia Mocan, Simina Pîrv, Sergiu Șușman, Carmen Mihaela Mihu

“…We analyzed placental gross and microscopic alterations between placentas from pregnancies with CHD fetuses and pregnancies with structurally normal heart fetuses. We also performed the immunohistochemical (IHC) assessment of the placental expression of PlGF and VEGFR-1 in the two groups. …”
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