Anti-gene oligonucleotides targeting Friedreich’s ataxia expanded GAA⋅TTC repeats increase Frataxin expression by Negin Mozafari, Salomé Milagres, Tea Umek, Cristina S.J. Rocha, Claudia M. Vargiu, Fiona Freyberger, Osama Saher, Marek Napierala, Jill S. Napierala, Pontus Blomberg, Per T. Jørgensen, Tanel Punga, C. I. Edvard Smith, Jesper Wengel, Rula Zain

“…In our previous study, we demonstrated that DNA-binding anti-gene oligonucleotides specifically targeting the GAA⋅TTC repeat expansion effectively disrupted the formation of intramolecular triplex structures. In this study, we extend these findings by showing that targeting repeat-expanded chromosomal DNA with anti-gene oligonucleotides leads to an increase in Frataxin mRNA and protein levels in cells derived from Friedreich’s ataxia patients. …”
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Eif2s3y Promotes the Proliferation of Spermatogonial Stem Cells by Activating ERK Signaling by Mengfei Zhang, Na Li, Wenqing Liu, Xiaomin Du, Yudong Wei, Donghui Yang, Zhe Zhou, Fanglin Ma, Sha Peng, Shiqiang Zhang, Xin He, Chunling Bai, Guangpeng Li, Jinlian Hua

“…Eukaryotic translation initiation factor 2 subunit 3 and structural gene Y-linked (Eif2s3y) located on the Y chromosome of male animals is a coding gene of eIF2γ which mainly functions in translation initiation. …”
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Fundus changes in healthy adults after high altitude exposure by Jiaxin Li, Yunzhu Kong, Peiyu Wang, Chen Chen, Juping Liu, Xiaorong Li, Yan Shao

“…Conclusion: The systemic adaptive changes due to high altitude exposure may cause varying degrees of structural and functional changes in the fundus. The current findings require large-scale longitudinal studies to obtain more definitive data on this topic.…”
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Transgenerational hepatotoxicity induced by bisphenol B as a substitute for bisphenol A by Huifeng Yue, Yangcheng Hu, Xiaoyun Wu, Yuchai Tian, Xiaomin Liang, Jiyue Zhang, Bin Li, Huizhen Zhu, Xiaotong Ji

“…Accumulating evidence identifies bisphenol A (BPA) as an endocrine disruptor with demonstrated hepatotoxicity, driving the adoption of structural analogs like bisphenol B (BPB). Pregnancy constitutes a critical developmental window for endocrine disruptor-mediated hepatotoxicity in offspring. …”
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The GhWL1‐GhH1‐GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology by Jingjing Zhan, Xiaoshuang Zhang, Ye Wang, Hang Zhao, Yu Chu, Peng Wang, Yanli Chen, Xi Wei, Wenqiang Qin, Menghan Liu, Jie Kong, Fuguang Li, Xiaoyang Ge

“…Further analysis demonstrated that GhWL1 interacts with GhH1, a protein with a KNOX1 structural domain, to regulate leaf development. Overexpression of GhH1 in WT results in a leaf shrinkage phenotype similar to wl‐D, whereas suppressing GhH1 in wl‐D restored normal leaf morphology, indicating that GhH1 acts downstream of GhWL1. …”
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Encapsulation of menthol by cyclodextrins-comparison between experiments and molecular simulations by Sa Xu, Fang Wei, Ximing Xu, Rui Wang, Xiujuan Xu, Wu Fan, Guobi Chai, Qidong Zhang, Qingzhao Shi

“…Given the substantial structural differences among flavor ingredients, experimentally deriving the selection criteria for CDs suitable for these flavor substances is a time-consuming process. …”
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Targeted Restoration of T-Cell Subsets by a Fluorinated Piperazine Derivative β-Cyclodextrin Complex in Experimental Pulmonary Inflammation by Valentina Yu, Marina Balabekova, Assel Ten, Tolganay Zharkynbek, Sulev Koks, Milana Alimova, Raushan Koizhaiganova, Meruyert Mussilim, Aigul Malmakova, Tulegen Seilkhanov, Khaidar Tassibekov

“…While PO provided early immunorestorative effects, (<b><i>o</i>-Fph</b>)<b>PPhβCD</b> exerted a more prolonged response, which was particularly evident by day 14. Structural confirmation of the inclusion complex was achieved through IR and NMR spectroscopy. …”
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Longitudinal changes of blood-brain barrier and transcytolemmal water exchange permeability in Alzheimer's disease mice: A non-contrast MRI study by Chuhan Xiong, Ziyang Yu, Yu Yin, Qinfeng Zhu, Ruicheng Ba, Yao Shen, Haotian Li, Zhiliang Wei, Zixuan Lin, Dan Wu

“…Immunostaining was used to evaluate tight junction proteins associated with BBB structural integrity, aquaporin 4 (AQP4) related to TWE, and AQP4 perivascular space (PVS) polarization that might represent PVS-parenchyma water exchange. …”
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Thermo-hydro-mechanical coupling mechanisms and sensitivity analysis of abandoned mine thermal energy storage systems by Liyuan LIU, Yaohui LI, Tao WANG, Tongbin ZHAO, Qiang KOU, Zerui MI, Le ZHANG

“…The findings substantially contribute to addressing energy structure optimization challenges through the sustainable repurposing of abandoned mine resources.…”
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To criticism of communicative reason: reasons of return of a civilization of images to a starting point / К критике коммуникативного разума: причины возвращения цивилизации изобра... by HRENOV N.A. / ХРЕНОВ Н.А.

“…• as a process from television to the Internet: transformation of mosaic signs of perception into communication structures. • as a genesis of mosaic thinking: splitting of printing culture on literature and the press. …”
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The macromolecular crystallography beamlines of the Helmholtz-Zentrum Berlin at the BESSY II storage ring: history, current status and future directions by Uwe Mueller, Tatjana Barthel, Laila S. Benz, Volodymyr Bon, Thomas Crosskey, Camilla Genter Dieguez, Ronald Förster, Christine Gless, Thomas Hauß, Udo Heinemann, Michael Hellmig, David James, Frank Lennartz, Melanie Oelker, Ruslan Ovsyannikov, Parinita Singh, Markus C. Wahl, Gert Weber, Manfred S. Weiss

“…These beamlines were established to support the emerging structural genomics initiatives founded in Germany, Europe, and overseas around the turn of the century. …”
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Nanoconfinement promotes CO2 electroreduction to methanol on a molecular catalyst by Guoshuai Shi, Wendi Zhang, Yikun Kang, Jin Zhao, Tingyu Lu, Chunlei Yang, Mingwei Chang, Yuluo Shen, Xinyang Gao, Jing Wu, Ye-Fei Li, Kecheng Cao, Liming Zhang

“…Operando spectroelectrochemical measurements and theoretical calculations demonstrate that the nanoconfined environment effectively accumulates CO as an intermediate, introduces structural deformation in CoPc molecules, enhances *CO adsorption on Co sites, and consequently improves CH3OH production. …”
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The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors by Yuteng Yang, Yuteng Yang, Yuteng Yang, Yuteng Yang, Yuteng Yang, Yumei Li, Yumei Li, Yumei Li, Yumei Li, Yaqi Wang, Yaqi Wang, Yaqi Wang, Yaqi Wang, Xi Chen, Xi Chen, Xi Chen, Xi Chen, Yisong Yao, Yisong Yao, Yisong Yao, Yisong Yao, Dongxian Li, Dongxian Li, Dongxian Li, Dongxian Li, Guohua Yu, Guohua Yu, Guohua Yu, Guohua Yu, Xicheng Song, Xicheng Song, Xicheng Song, Xicheng Song

“…LAPTM4B proteins have four transmembrane structural domains and are mainly distributed in lysosomal and endosomal membranes of cells. …”
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Granulated straw incorporation with rotary tillage increases the content of soil organic carbon fractions and available nutrients and shifts bacterial communities in East China by Jianxin Dong, Ping Wang, Ping Cong, Wenjing Song, Xuebo Zheng, Na Liu, Yi Wang, Xin Xiao, Zhen Zhai, Yuyi Li, Huancheng Pang

“…Network analysis identified AK as a key nutrient influencing bacterial community structure under both tillage methods. Structural equation modeling further revealed that SOC fractions were primarily regulated by nutrient factors under rotary tillage, while under deep tillage, bacterial richness and AK played dominant roles. …”
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HYPERTENSIVE HEART DISEASE IN COVERT ARTERIAL HYPERTENSION OF A LARGE FACTORY EMPLOYEE by A. N. Britov, E. M. Platonova, M. I. Smirnova, V. M. Gorbunov, V. P. Shapovalova, V. M. Ryzhov, S. V. Olishevko, N. A. Eliseeva, T. V. Ryzhova, Ya. N. Koshelyavskaya, A. D. Deev

“…Aim. To study structural and functional changes of myocardium, that are explained as the signs of hypertensive heart disease (HHD), in covert arterial hypertension (CAH) at the workplace of a large factory employee using echocardiography (EchoCG). …”
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Efficiency and safety of peripheral regional anesthesia application in urgent traumatology by O. A. Lovkin, V. I. Pertsov, K. I. Lurie

“…In Ukraine, more than 4.5 million people sustain injuries of varying severity annually, and damage to extremities constitutes 60–65 % in the structure of traumatism. Patients with traumatic limb injuries require effective anesthesia / analgesia at an early stage. …”
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Development and validation of scales measuring self-efficacy and behavioral capability in managing common medical emergencies in dental clinics by Yasmine N. Alawaji, Hussam M. Alqahtani, Abdulmohsen Alfadley, Aram Alshehri, Ali Aboalela, Sahr H. Altuwaijri, Farraj Albalawi, Sara A. Kalagi, Abdulrhman Alghamdi, Abdullah Alshibani, Meshal Alharbi, Meshary Binhotan, Nesrin A. Alharthy

“…Using confirmatory factor analysis, the internal structure of self-efficacy scale had a single latent variable and 13 items, and the behavioral capability scale had a single latent variable and 19 items. …”
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Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1) by Xinyi Zhang, Shuhu Liu, Yanshan Su, Ling Zhang, Ting Guo, Xuemin Wang

“…By blocking SIRT1 using EX527 or shSIRT1, we observed mitochondrial structural fragmentation as well as intensified and prolonged mitochondrial calcium overload. …”
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Precision computerised cognitive behavioural therapy (cCBT) intervention for adolescents with depression (SPARX-UK): protocol for the process evaluation of a pilot randomised contr... by Charlotte Lucy Hall, Chris Hollis, Kareem Khan, Peter Fonagy, Kirsty Sprange, Cathy Creswell, Yi Yang, Vibhore Prasad, Kapil Sayal, Nitish Jawahar, Ellen Townsend, Dorothee Auer, Praveetha Patalay, Aja Murray, Yvonne Kelly, Boliang Guo, Christopher R Tench, Paul Stallard, Louise Arseneault, Sieun Lee, Sally Merry, Charlotte Hall, Jo Gregory, Rory O’Connor, Emma Nielsen, Edmund Sonuga-Barke, Hannah Wright, Petr Slovak, Emily Lloyd, Josimar De Alcantara Mendes, Carolyn Ten Holter, Marina Jirotka, Aaron Kandola, Sonia Livingstone, Kasia Kostryka-Allchorne, Jake Bourgaize, Mariya Stoilova, Marianne Etherson, Chris Greenhalgh, Jim Warren, Vajisha Wanniarachchi, Kevin Glover, Mathijs Lucassen, Karolina Stasiak, Camilla Babbage, Adam Parker, Joanna Lockwood, Elvira Perez Vallejos, Rebecca Woodcock, Sarah Doherty, Lucy-Paige Willingham, Camilla May Babbage, Matthew Jeffery, Peiyao Tang, Holly Griffiths, Lily Roberts, A. Jess Williams, Lucy Hitcham

“…This will include analysing data usage of participants in the intervention arms; purposively sampled, semi-structured interviews of adolescents, parents/guardians, eCoaches and clinicians/practitioners from the SPARX-UK trial; and analysis of qualitative comments from a survey from those who dropped out early from the trial. …”
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Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: A cross-sectional analysis within a population-based birth coh... by Sara Fontanella, Clément Frainay, Clare S Murray, Angela Simpson, Adnan Custovic

“…Cluster membership mapped closely to the structural homology of proteins and/or their biological source. …”
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