Identification of novel therapeutic targets for cognitive performance and associations with brain health by Lu-Yang Zhang, Yu-Xin Liu, Yun-Hui Chu, Yun-Fan You, Luo-Qi Zhou, Sheng Yang, Ming-Hao Dong, Hang Zhang, Xiao-Wei Pang, Lian Chen, Li-Fang Zhu, Jun Xiao, Ke Shang, Wei Wang, Chuan Qin, Dai-Shi Tian

“…The causal effects of candidate druggable genes on brain structure and neurological diseases were assessed to gain insights into the underlying mechanisms. …”
Get full text

The Effect of Short-Term Kinesiology Taping on Neuromuscular Controls in Hallux Valgus During Gait: A Study of Muscle and Kinematic Synergy by Yanyan Liu, Ruiping Liu, Xinzhu Wan, Chunyan Chen, Yining Wang, Wanqi Yu, Jun OuYang, Lei Qian, Gang Liu

“…The number of synergies did not differ within the three groups, but the structure of muscle synergies and kinematic synergies differed in the HV group. …”
Get full text

Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects by Dongqi You, Lining Lin, Minyi Dong, Yunhong Wu, Yijie Hu, Xinyue Hu, Yangjie Shao, Yuan Xie, Menghan Xu, Guancong Chen, Rong Lan, Haiying Ma, Yunting Zhou, Huiming Wang, Binjie Jin, Mengfei Yu

“…Macroscopic deformation enables SMPs to perform functions such as adaptation, filling, and support through overall structural changes. On the other hand, microscopic deformation involves dynamic modulation of the surface morphology of micro- and nanoscale scaffolds, influencing cell morphology and further regulating cell behavior and fate. …”
Get full text

Selective adsorption of CO2 in TAMOF-1 for the separation of CO2/CH4 gas mixtures by Santiago Capelo-Avilés, Mabel de Fez-Febré, Salvador R. G. Balestra, Juanjo Cabezas-Giménez, Raiana Tomazini de Oliveira, Irene I. Gallo Stampino, Anton Vidal-Ferran, Jesús González-Cobos, Vanesa Lillo, Oscar Fabelo, Eduardo C. Escudero-Adán, Larry R. Falvello, José B. Parra, Paolo Rumori, Gemma Turnes Palomino, Carlos Palomino Cabello, Stefano Giancola, Sofia Calero, José Ramón Galán-Mascarós

“…We have identified the key interactions of CO2 within the TAMOF-1 framework by a combination of structural (neutron diffraction), spectroscopic and theoretical analyses which conclude a dual-site adsorption mechanism with the majority of adsorbed CO2 molecules occupying the empty voids in the TAMOF-1 channels without strong, directional supramolecular interactions. …”
Get full text

Deficient of glycosylation site in the envelop protein attenuated Zika virus replication in mosquito cells by Wen-Jing Wang, Wen-Jing Wang, Zi-Han Wang, Zi-Han Wang, Jing Li, Jing Li, Sai-Ya Ma, Sai-Ya Ma, Mei He, Mei He, Meng-Xuan Liu, Meng-Xuan Liu, Yu-Fei Zhan, Yu-Fei Zhan, Feng Jin, Feng Jin, Guosheng Qu, Guosheng Qu, Chunhong Yin, Chunhong Yin, Jie Tong, Jie Tong

“…Notably, several genes involved in the ECM signaling pathway, including THBS1, ITGAL, IL-1A, and CXCL8, were found to inhibit the T156I mutant but not the wild-type ZIKV. Structural analysis and in silico molecular docking suggested that the T156I mutation impaired the stability of the E protein dimer rather than its interactions with neutralizing antibodies.DiscussionCollectively, these findings provide novel insights into the role of E protein glycosylation in ZIKV infection, and may have significant implications for anti-ZIKV strategies.…”
Get full text

Commensal and virulent Escherichia coli strains of vaginal origin are reservoirs of resistance cassettes in class 1 integrons by Manalli Itzahaya Blancarte–Lagunas, Graciela Castro-Escarpulli, Armando Navarro-Ocaña, Gabriela Ibáñez-Cervantes, Laura Margarita Marquez-Valdelamar, José Misael Hernández-Carrillo, Juana Salazar-Salinas, Omar Fernando Mendoza-Vásquez, Gabriel Damazo-Hernández, Oscar Sosa-Hernández, Gregorio León-García, Monica Alethia Cureño-Díaz, Juan Manuel Bello-López

“…The aim of this work was to describe the structural diversity of class 1 integrons in virulent and commensal strains of E. coli isolated from patients with vaginal infection. …”
Get full text

A Multiphysics Dataset Generation Procedure for the Data-Driven Modeling of Traction Electric Motors by Simone Ferrari, Luigi Solimene, Riccardo Torchio, Costanza Anerdi, Fabio Freschi, Luca Giaccone, Gianmarco Lorenti, Francesco Lucchini, Piergiorgio Alotto, Gianmario Pellegrino, Maurizio Repetto

“…., electromagnetic, thermal, structural, etc.) can no longer be neglected, even in preliminary designs. …”
Get full text

A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments by Emilie Ma, Fadma Lakhal, Eleni Litsardaki, Myriam Ruault, Maxime Audin, Natacha Levrier, Emilie Navarro, Mickaël Garnier, Laurent Maloisel, Jordane Depagne, Clémentine Brocas, Aurelien Thureau, Didier Busso, Xavier Veaute, Raphaël Guerois, Angela Taddei, Françoise Ochsenbein, Eric Coïc

“…The molecular basis of these two Rad52 functions remains unclear. Our integrative structural analyses of the Rad51-Rad52 interaction, combining NMR, SAXS, and modeling, reveal that an 85-residue segment of Rad52, conserved in fungi, folds upon binding to a broad surface of a Rad51 monomer. …”
Get full text

Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates by Wanyi He, Congli Chen, Jiwei Zheng, Yanyan Li, Huaihuai Shi, Yimin Zhou, Meiqing Li, Ping Gong, Ke Liu, Ximing Shao, Xiaojun Yao, Hongchang Li, Liang Chen, Lijing Fang

“…Additionally, simpler structural design and broader therapeutic window for CPPTACs are expected since CPPs-mediated endocytosis and lysosomal degradation do not necessitate the three-component binding model typically required by other heterobifunctional degraders. …”
Get full text

Fe-Cu-loaded γ-Al2O3 as an efficient heterogeneous Fenton catalyst for the advanced treatment of petrochemical wastewater by Shiqi Jiang, Changyong Wu, Qi Huang, Yin Yu, Peijian Zhang, Chenjie Wang, Xiyan Ou, Min Xu

“…Characterization techniques (SEM, BET, XRD, XPS) confirmed the structural features, while EPR and quenching experiments revealed that ·OH and HO2− were the dominant reactive species. …”
Get full text

Multifunctional microneedle-mediated photothermo-gas-ion synergic therapy accelerates MRSA infacted diabetic wound healing by Shihao Deng, Yunhao Tai, Chenxu Liu, Kenan Sun, Shaoze Lan, Liu Yang, Canming Ye, Li Huang, Runhuai Yang, Haisheng Qian, Jun Li

“…Secondly, the microneedles employ PH-responsive Zn2+, H2S release, and photothermal therapy to disrupt the structural integrity of Methicillin-Resistant Staphylococcus Aureus (MRSA) and dismantle the dense biofilm produced by this pathogen. …”
Get full text

Production process, rheology, and sensory characterization of Algerian porridge and flatbread derived from Arum italicum tubers by Hayat Bourekoua, Radia Ayad, Hamida Mahroug, Fairouz Djeghim, Rayene Belmouloud, Aya Louifi, Alla Eddine Mansouri, Anis Chikhoune

“…This research aims to contribute to this field and focuses on the comprehensive analysis of Arum italicum tuber powder, encompassing physicochemical and structural characterization. Additionally, it explores the traditional making processes of products derived from these tubers. …”
Get full text

Understanding the future of dengue in Malaysia: Assessing knowledge, attitude, and homeowner practices in mitigating climate-driven risks [version 1; peer review: 2 approved] by Sapna Shridhar Patil, Izzah Athirah Rosli, Fatin Norhasny Leman, Nur Hasnah Ma’amor, Nor Asiah Muhamad, Kulankara Balan Venugopalan, Prabal Bhargava, Mahalingam Dinesh, Weng Keong Yau, Chai Hong Yeong, Eng Hwa Wong, Arasarethinam Mugilarasi, Ameya Ashok Hasamnis, Imam Shaik, Chung Yeng Looi, Pei Pei Chong, Priya Madhavan, Lei Hum Wee, Anitha Ponnupillai, Jo Ann Andoy-Galvan, Yin How Wong

“…Data were collected using a structured questionnaire adapted from a validated Malay version. …”
Get full text

Haemato‐Urological Profile and Asymptomatic Urinary Tract Infection in Ghanaian Steady‐State Sickle Cell Disease Patients: A Case‐Control Study by Stephen Twumasi, Richard Owusu Ansah, Samuel Essien‐Baidoo, Laud Anthony W. Basing, Alexander Yaw Debrah, Enoch Odame Anto, Allwell Adofo Ayirebi, Rebecca Asiamah‐Broni, Waldemer Attivor, Eric Twum Ameyaw, Gabriel Addai Manu, Edward Afriyie, Thomas Kwabena Gyampomah, Joseph Nkrumah Opoku, Prince Kwadwo Amoafo, Samuel Kelvin Owusu, Vincent Akwai, Matthew Talmang, Amos Mensah, Isaac Kusi‐Amponsah, Angela Opoku, Lilian Antwi Boateng

“…Participants' information was thoroughly documented using a well‐structured questionnaire and patient case records. To achieve the study's aims, a mid‐stream urine in a cleaned dry aseptic urine capped container and venous blood were collected for laboratory analysis. …”
Get full text

Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota by Xingduo Liu, Chaoqun Sun, Yuqiong Dai, Feifei Duan, Tianzhen He, Menglu Zhen, Enxi Liang, Shuting Zhang, Yun Xia, Nianchun Hu, Ruoting Zhan, Ruoting Zhan, Dong Deng, Sijun Liu

“…Beta diversity revealed structural divergence between treatment and model groups. …”
Get full text

A novel methodology for the extraction, purification and characterization of immunoglobulin G (IgG) nanoparticles from bovine colostrum: implications for food and therapeutic indus... by Fawze Alnadari, Yusof A.Y.A. Mohammed, Mustapha Muhammad Nasiru, Amirah S. Alahmari, Mohammed A. Alqahtani, Osama Abdulaziz, Isaiah Henry Ibeogu, Rongchang Wang, Chao Chen, Salem Baldi, Ibrahim Khalifa, Mohamed Abdin, Ahmed M. Saad, Mohamed T. El-Saadony

“…FT-IR and XRD analyses confirmed that the chemical structure of IgG remained intact during nanoparticle formation, preserving its native functionality. …”
Get full text

Investigating the Location-Spatial Effects of Urban Tourism on the Stability of the Urban Spatial System (Case Study: Region 3 of Isfahan City) by Mina Kazemi, Aboozar Vafaei, Rasool Heydari Sureshjani

“…For data analysis, a sample t-test was conducted using SPSS software, while Structural Equation Modeling (SEM) was utilized in AMOS software to assess the type and strength of relationships among the factors influencing the spatial effects of urban tourism on the stability of the city's spatial system. …”
Get full text

Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV... by Sarah E. Rutstein, Valerie A. Lucas, Mina C. Hosseinipour, Michael E. Herce, Jessie Edwards, Caitlin Cassidy, Jimmy Villiera, Funny Kamanga, Maganizo Chagomerana, Joep J. van Oosterhout, Elijah Chikuse, Ethel Rambiki, Agness Thawani, Bridget Malewezi, Lazola Makhupula, Clement Udedi, Patrick Mbulaje, Mitch Matoga, Wiza Kumwenda, Tisungane Mvalo, Agatha Bula, Lovemore Nkhalamba, Innocent Mofolo, Lameck Chinula, Virginia Thonyiwa, Owen Kumwenda, Mike Nenani Chisema, Irving F. Hoffman, William C. Miller, Vivian F. Go, Brian Pence, Madeleine A. Squibb, Friday Saidi

“…Implementation outcomes rely on in-depth interviews, surveys, site assessments, structured observations, and other tools. Human centered design workshops prior to implementation will further inform site-specific procedures for LINK model integration and launch. …”
Get full text

The prevalence and the correlates of mental disorders among the elderly population: results from China Mental Health Survey by Jingjuan Pang, Minghui Li, Zhaorui Liu, Yueqin Huang, Xiaofei Hou, Guoli Yan, Xiangdong Xu, Limin Wang, Yongping Yan, Shuiyuan Xiao, Lingjiang Li, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Tingting Zhang, Huifang Yin, Guangming Xu

“…CMHS employed Composite International Diagnostic Interview (CIDI), a structured diagnostic tool, to collect relevant data. …”
Get full text

Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Abstract Background 3D-spatial interaction between cancer cells influences tumor behavior, making it essential to replicate tumor structures for predicting patient outcomes. Methods We collected data from three multicenter prospective studies to evaluate the ability to establish Patient-Derived Organoids (PDOs) from different biological samples and timepoints, correlating their characteristics and drug sensitivity with clinical outcomes. …”
Get full text