An International Longitudinal Natural History Study of Patients With Danon Disease: Unique Cardiac Trajectories Identified Based on Sex and Heart Failure Outcomes by Kimberly N. Hong, Emily Eshraghian, Tarek Khedro, Alessia Argirò, Jennifer Attias, Garrett Storm, Melina Tsotras, Tanner Bloks, Isaiah Jackson, Elijah Ahmad, Sharon Graw, Luisa Mestroni, Quan M. Bui, Jonathan Schwartz, Stuart Turner, Eric D. Adler, Matthew Taylor

“…Correlations between structural cardiac dysfunction and disease progression may permit risk stratification, refinement of treatment algorithms, and inform therapeutic trial design. …”
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Alleviating cognitive impairments in bipolar disorder with a novel DTI-guided multimodal neurostimulation protocol: a double-blind randomized controlled trial by Minmin Wang, Hetong Zhou, Xiaomei Zhang, Qianfeng Chen, Qiqi Tong, Qiai Han, Xudong Zhao, Dandan Wang, Jianbo Lai, Hongjian He, Shaomin Zhang, Shaohua Hu

“…Methods The novel MNS protocol used individualized diffusion tensor imaging (DTI) data to identify fiber tracts between the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex. The highest structural connectivity point is selected as the individualized stimulation site, which is then targeted using a combination of optimized transcranial alternating current stimulation (tACS) and robot-assisted navigated repetitive transcranial magnetic stimulation (rTMS). …”
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Micro-Computed Tomographic Evaluation of the Shaping Ability of Vortex Blue and TruNatomy^TM Ni-Ti Rotary Systems by Batool Alghamdi, Mey Al-Habib, Mona Alsulaiman, Lina Bahanan, Ali Alrahlah, Leonel S. J. Bautista, Sarah Bukhari, Mohammed Howait, Loai Alsofi

“…Pre- and post-instrumentation micro-CT scans were analyzed to measure the following parameters: percentage of untouched canal surface area, changes in canal surface area, changes in canal volume, structural model index (SMI), changes in canal angulation, changes in dentin thickness, transportation, and centering ability. …”
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Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model by Frankangel Servin, Jarrod A. Collins, Jon S. Heiselman, Katherine C. Frederick-Dyer, Virginia B. Planz, Sunil K. Geevarghese, Daniel B. Brown, William R. Jarnagin, Michael I. Miga

“…Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed from structural, functional, and biomarker-based imaging data to simulate patient-specific therapies and guide clinical decision-making. …”
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Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1 by Sha Xiao, Tianjing Wei, Mingyang Xiao, Mingming Shan, Ziqi An, Na Li, Jing Zhou, Shuang Zhao, Xiaobo Lu

“…Nicotine exposure in SHRs elevated blood pressure and induced oxidative damage through α7nAChR/MAPK/AP1 pathway activation, causing endothelial structural disruption. These effects manifested as decreased NO/eNOS and increased ET-1/ET_ab expression, while these changes were reversed by NAIs. …”
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Barriers and facilitators to COVID-19 testing and vaccination: a qualitative focus group study among Rhode Island’s Latine/Hispanic community by D. Grace Smith, Yovanska Duarte-Velez, Yovanska Duarte-Velez, Elizabeth S. Chen, Elizabeth S. Chen, Mario Bueno, A. Rani Elwy, A. Rani Elwy, Indra Neil Sarkar, Indra Neil Sarkar, Indra Neil Sarkar

“…Many barriers identified by clinicians (e.g., structural determinants to access) were not discussed by Latine/Hispanic community members.DiscussionFacilitators and barriers to test/vaccine implementation were shaped by local communal and individual factors, generally supporting previous arguments on implementation among Latine/Hispanic communities, and revealing the importance of context-specific examinations. …”
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Assessment of clinician well-being and the factors that influence it using validated questionnaires: a systematic review by Claudie Audet, Andréanne Bernier, Marimée Godbout-Parent, Hermine Lore Nguena Nguefack, Liz Ferland, Paula L. Bush, Marie-Dominique Poirier, Sonia Lussier, Tracie A. Barnett, Sylvie D. Lambert, Anaïs Lacasse

“…The most frequently addressed measurement properties are: (1) Internal consistency (88.2%), (2) Structural validity (75.7%), and (3) Content validity (68.4%). …”
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Compatibility Testing of New Insulating Fluids and Materials in Distribution Transformer by Pavel Trnka, Jaroslav Hornak, Magdalena Trnkova, Ondrej Michal, Zdislava Mokra, Pavel Slama, Jiri Kopriva, Pavel Prosr, Jan Leffler, Zdenek Frana

“…Compatibility tests of liquids with the structural internal materials of transformers are conducted to prevent undesired interactions between insulating fluids and the formation of products that could lead to the generation of undesirable ions, sediments, or chemical compounds that result in a reduction in the dielectric property performance of the fluid. …”
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UGT708S6 from Dendrobium catenatum, catalyzes the formation of flavonoid C-glycosides by Luyao Yu, Kun He, Yu Wu, Kai Hao, Yun Wang, Jinbo Yao, Yuxue Zhao, Qiaoxian Yu, Yanghui Shen, Mengxuan Chen, Ke Xu, Xinfeng Zhang, Lei Zhang

“…Furthermore, the catalytic characteristics of UGT708S6 were explored, shedding light on the structural basis of substrate promiscuity and the catalytic mechanism involved in the formation of flavonoid C-glycosides. …”
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Enhanced reactivity and electron efficiency of nanoscale zero-valent iron for nitroaromatic compounds reduction through modification with anthraquinone-2-carboxylic acid by Yuxin Li, Shiqi Yang, Zihan Liu, Yiyang Pan, Pengfei Zhang, Zhiqiu Qu, Chao Shan

“…Humic substances (HS) modification favors the reactivity of nanoscale zero-valent iron (nZVI) for water decontamination from nitro-compounds like nitrobenzene (NB), whereas the structural complexity of HS hinders the elucidation of its mechanism. …”
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Comparison of Molnupiravir Exposure‐Response Relationships for Virology Response and Mechanism of Action Biomarkers With Clinical Outcomes in Treatment of COVID‐19 by Akshita Chawla, Ruthie Birger, Brian M. Maas, Youfang Cao, Hong Wan, Julie Strizki, Arthur Fridman, Amanda Paschke, Carisa deAnda, Wei Gao, Matthew L. Rizk, Wendy Painter, Wayne Holman, Susanne Sardella, George Painter, Julie A. Stone

“…E‐R relationships were best represented by an Emax structural model with reasonable consistency in the estimated AUC50s (~2.3‐fold), across the models, of 10,260 and 4390 nM*hr. for day 5 viral load change from baseline and LNS error rate, respectively. …”
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Effects and potential pathways of goose astrovirus infection on gosling hepatic lipid metabolism by Chao Yin, Yun Shi, Haiqin Li, Zhihua Lu, Xiaona Gao, Guoliang Hu, Xiaoquan Guo

“…IntroductionThe adverse effects of goose astrovirus (GoAstV) on avian growth and health have been widely reported previously, while the stress reactions and corresponding mechanism of gosling liver responding to GoAstV infection remain not entirely clear.MethodsOne-day-old goslings inoculated subcutaneously with 2 × 10−6 TCID50 of GoAstV were employed as an experimental model, and the potential effects and pathways of GoAstV infection on gosling liver functions were investigated by combining the morphological, biochemical and RNA sequencing (RNA-seq) techniques.ResultsStructural and functional impairments were found in gosling livers post the virus infection, as characterized by the histological alterations in liver index and morphology of hepatic cord and sinuses, as well as the abnormal expression patterns of the cellular antioxidant, inflammation and apoptosis-related genes. …”
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Trapped by debt: an ethnographic study of medical indebtedness and hospital detention in the Fundong Health District, Cameroon by Ashangwa Constantine Tanywe, Ashangwa Constantine Tanywe, Ngambouk Vitalis Pemunta, Ngambouk Vitalis Pemunta, Vidarah Nimar, Cybel Nji Angwe, Mathias Alubafi Fubah, Mathias Alubafi Fubah, Maurine Ekun Nyok, Tom Obara Bosire, Nguyen Ngoc Bich Tram, Brendabell Ebanga Njee, Womma Habiba Hira

“…BackgroundThis study investigates the structural and socio-cultural drivers of medical indebtedness and hospital detention due to unpaid healthcare bills in the Fundong Health District, Cameroon. …”
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Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors by Fariba Peytam, Parham Foroumadi, Hayrettin Ozan Gulcan, Maryam Norouzbahari, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fahimeh Ghasemi, Mohammadreza Torabi, Behnaz Bameri, Maliheh Barazandeh Tehrani, Loghman Firoozpour, Alireza Foroumadi

“…The results of the molecular dynamics simulation demonstrated that the 15j–α-glucosidase complex exhibits high stability and effectively maintains its binding without causing significant structural changes in the enzyme, confirming the stable interaction and selective inhibition of this compound at the enzyme’s active site.…”
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A comprehensive review of the pathogenic mechanisms of Pseudomonas aeruginosa: synergistic effects of virulence factors, quorum sensing, and biofilm formation by Xindan Zhang, Xindan Zhang, Duo Zhang, Duo Zhang, Di Zhou, Di Zhou, Shuai Zheng, Shuai Zheng, Shuang Li, Qinlong Hou, Qinlong Hou, Gen Li, Gen Li, Huiming Han, Huiming Han

“…We propose that future investigations prioritize (1) the structural biology of QS receptors to guide rational inhibitor design; (2) single-cell and organ-on-a-chip models to dissect biofilm heterogeneity; (3) dual-omics approaches to map host–pathogen signaling crosstalk; and (4) environmental modulators-such as iron availability and shear stress-that fine-tune virulence expression. …”
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Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy by Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer, Ulrich Brinkmann

“…We demonstrate that targeted on-cell prodrug conversion is more efficient than nonspecific activation in-solution. Due to the structural similarity between IL-4 and other type I cytokines relevant in cancer immunotherapy such as IL-2, IL-15, and IL-21, cytokine-PACE may be expanded to develop a variety of targeted conditionally active cytokines for cancer immunotherapy.…”
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Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project by Linda Sharp, Sarah Bailey, Colin Rees, Willie Hamilton, Dawn Craig, Joe West, David Humes, Gary Abel, James Turvill, Brian Nicholson, Chloe Thomas, Jim Chilcott, Colin Crooks, Olena Mandrik, John Whelpton

“…Cost-effectiveness improves as risk thresholds rise. High structural uncertainty around cancer progression during diagnostic delay and diagnosis of other serious bowel diseases considerably affects cost-effectiveness.Conclusions COLOFIT is likely to be more cost-effective than FIT alone and could help alleviate pressure on diagnostic services. …”
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Ultrasound-assisted immersion freezing method as a new strategy to improve the quality and microstructure of Chinese beef stewed dishes by Liye Cui, Hengxun Lin, Xiaojia Hu, Wenqiang Guan, Xia Li, Wei Jia, Yiping Yang, Yong Chen, Chunhui Zhang

“…A suitable intensity of UIF treatment (150 W) improved dish quality, and high-intensity UIF treatments (300 and 450 W) caused tissue structure destruction and decreased quality. The hardness of beef and potatoes treated with UIF-150 was significantly higher than that of other treatments (P < 0.05). …”
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Effect of solution and aging on phase stability and mechanical properties of Zr–Ti–Nb–Ta refractory medium entropy alloy by Yongkang Zhou, Yuanyuan Wang, Jingqian Chen, Xiaoya Liu, Aimin Wang, Huameng Fu, Haifeng Zhang, Zhengwang Zhu

“…Refractory high/medium-entropy alloys (RHEAs/RMEAs) are promising structural materials for high-temperature applications due to their unique composition and outstanding properties. …”
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The multifaceted biomimetic titanium implant promotes bone integration with sequential antibacterial and immune modulation properties by Long Chen, Zili Guo, Guowen Duan, Guodong Zhao, Xinyao Liu, Zian Wang, Yuan Liu, Lingling Bai, Hong Xu, Yan Peng, Lei Qiang, Dongbiao Chang, Jun Sheng, Tong Sun, Jie Weng

“…Given that the long-term stability of implants depends on their perfect integration with the surrounding tissues to withstand various environmental stresses, current research mainly focuses on mimicking the structure of the extracellular matrix. The aim is to promote bone tissue formation through regulation of the immune response by metal ions, thereby enhancing the effectiveness of tissue integration. …”
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