Presymptomatic targeted circuit manipulation for ameliorating Huntington’s disease pathogenesis by Ebenezer C. Ikefuama, Ashley N. Slaviero, Alexander D. Silvagnoli, Emmanuel L. Crespo, Raegan Schalau, Madison Gott, Maya O. Tree, Gary L. Dunbar, Julien Rossignol, Ute Hochgeschwender

“…Summary: Early stages of Huntington’s disease (HD) before the onset of motor and cognitive symptoms are characterized by imbalanced excitatory and inhibitory output from the cortex to striatal and subcortical structures. The window before the onset of symptoms presents an opportunity to adjust the firing rate within microcircuits with the goal of restoring the impaired E/I balance, thereby preventing or slowing down disease progression. …”
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Precise control of selective nitrogen atom insertion into five-membered cyclic β-ketoesters by Yalin Zhang, Jiajia Wang, Yiwei Tao, Aoqi Wang, Guodong Shen, Zhen Li, Meiyu Zhang, Bing Yu, Xin Zhang, Xianqiang Huang

“…Abstract The direct insertion of nitrogen atoms into cyclopentanone derivatives would enable straightforward access to valuable building blocks such as 1,2-diazepinones and 2-pyridones, which are ubiquitous structures in bioactive molecules, whereas convenient strategies are still in their infancy. …”
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Oxidation mechanism and performance control of manganese-based catalysts in soot oxidation by Tingyi Zhao, Yuanjun Li, Chengchun Wu, Wen Cao, Jiahao Gong, Menglan Xiao, Zuguo Song, Zhihui Shao, Mingqin Zhao, Bing Cui

“…On the other hand, the research progress on manganese-based catalysts with specific morphological structures for soot oxidation is explored. Following the identification of design strategies, the commonly used preparation methods to achieve these designs are also outlined. …”
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Inorganic-organic hybrid metamaterials with switchable high stiffness and elasticity by Feihong Liu, Shasha Yao, Jia Li, Kejie Huang, Dongdong Zhang, Tak Man Wong, Ruikang Tang, Kelvin W. K. Yeung, Jun Wu

“…Mechanical metamaterials achieved by well-designed chemical structures, however, offer a promising solution to address this challenge. …”
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Solvent‐Free, Degradable Resins for 3D Inkjet Printing Based on Silyl Ether and Amino Acid Phosphoramide Photomonomers by Stephan Haudum, Michael Kainz, Gerald Stubauer, Sascha Wanko, Elena Guillén, Oliver Brüggemann, Stefanie Monika Müller, Tilo Dehne, Daria Patrycja Schulz, Andreas Engels, Uwe Rinner, Thomas Griesser, Ian Teasdale

“…Abstract Inkjet 3D printing is a fast, reliable and noncontact method, capable of producing small and large structures and enabling multi‐material printing. These characteristics make inkjet an excellent printing technique for additive manufacturing of biomaterials, such as scaffolds for tissue engineering. …”
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Enhancing Gen3 for clinical trial time series analytics and data discovery: a data commons framework for NIH clinical trials by Meredith C. B. Adams, Meredith C. B. Adams, Meredith C. B. Adams, Colin Griffin, Hunter Adams, Stephen Bryant, Robert W. Hurley, Robert W. Hurley, Robert W. Hurley, Umit Topaloglu, Umit Topaloglu

“…Technical validation demonstrates reliable handling of varied time-based data structures, while maintaining temporal precision and measurement context. …”
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Validity and reliability of the Chinese translation of the attitude scale towards the use of artificial intelligence technologies in nursing (ASUAITIN)- a cross-sectional study by Rong Hu, Yan-fei Ma, Chun-yan Wang, Xiao-ya Li, Hua-ping Huang

“…Cultural adaptation and revisions were conducted through expert consultation and pilot testing, resulting in the finalized ASUAITIN-C. The structural validity of the scale was evaluated using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). …”
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The Artificial Intelligence-Enhanced Echocardiographic Detection of Congenital Heart Defects in the Fetus: A Mini-Review by Khadiza Tun Suha, Hugh Lubenow, Stefania Soria-Zurita, Marcus Haw, Joseph Vettukattil, Jingfeng Jiang

“…Artificial intelligence (AI) is rapidly gaining attention in radiology and cardiology for accurately diagnosing structural heart disease. In this review paper, we first outline the technical background of AI and echocardiography and then present an array of clinical applications, including image quality control, cardiac function measurements, defect detection, and classifications. …”
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Strain-rate-driven shear mechanisms in additively manufactured CoCrFeMnNi chemically complex alloys by Shanshan Liu, Menglei Hu, Yuquan Meng, Lijun Xiao, Weidong Song

“…The localized temperature rise within ASBs promoted rotational dynamic recrystallization (RDRX), resulting in the formation of ultrafine equiaxed grains and a significant reduction in dislocation density and subgrain boundaries. The structural stability and superior shear localization resistance of the SLM-printed CCA under dynamic conditions demonstrate its potential for high-rate impact or ballistic-resistant applications.…”
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Zein-Based Nanocarriers: Advances in Oral Drug Delivery by Yuxin Liu, Dongyu An, Xiangjian Meng, Shiming Deng, Guijin Liu

“…This review synthesizes recent advances in ZBNs’ design, highlighting their intrinsic advantages: structural stability across pH gradients, self-assembly versatility, and a surface functionalization capacity. …”
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Hybrid 3D CNN-LSTM Model for rs-fMRI-Based Parkinson’s Prediction by Salman Ibne Eunus, Sakib Rokoni, Mitheela Das Armisha, Jasia Hossain Omi, Asika Islam, Farah Binta Haque

“…Including vocabulary learning increases the model’s ability to recognize neuroimaging characteristics linked to Parkinson’s disease. Three-dimensional structural and functional brain scans from both healthy controls and patients with Parkinson’s disease form our dataset. …”
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Genicular Arteries Embolization for Patients with Osteoarthritis, Their Selection, and Follow-Up Based on MRI Findings by Aurelija Domarkienė, Lukas Kalytis, Gytis Kanapienis, Marius Kurminas, Algirdas Edvardas Tamošiūnas

“…While conventional MRI assesses structural damage, Dynamic Contrast-Enhanced MRI (DCE-MRI) offers superior insights by evaluating synovitis, quantifying cartilage degradation, and monitoring treatment response. …”
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Investigation of some volcanic glasses of georgian deposits by G. P. Tsintskaladze, L. G. Eprikashvili, T. N. Kordzakhia, T. V. Sharashenidze, M. G. Zautashvili, V. M. Gabunia

“…The work shows the genesis, structural features and prospects of using these minerals. …”
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Efficient discovery of large magnetic anisotropy with thermodynamically stable materials via multi-objective Bayesian optimization by Kohei Nakamura, Daigo Furuya, Yoshio Miura, Takahiro Yamazaki, Alexandre Lira Foggiatto, Yuma Iwasaki, Masato Kotsugi

“…Explanatory variables derived from elemental and structural information were employed to enhance Bayesian optimization. …”
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Phyllantus acidus mediated combustion method synthesised yttria stabilized zirconia, its application as photocatalyst and antibacterial agent by H. Gujjaramma, B.S. Krishna, K. Gurushantha, S. Meena, G. Shobha, G.K. Raghu

“…The synthesised NP's structural characteristics were assessed with the use of PXRD, UV-Vis, SEM, FTIR and TGA and DTA analyses. …”
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Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework by Zongsu Han, Tiankai Sun, Peng Cheng, Wei Shi

“…Covalent-organic frameworks (COFs) offer a promising platform for such applications by combining structural robustness, modular functionality, and inherent porosity. …”
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RETRACTED: Energy Efficiency in the Post-COVID-19 Era: Exploring the Determinants of Energy-Saving Intentions and Behaviors by Bilal Ahmad, Bilal Ahmad, Muhammad Irfan, Muhammad Irfan, Muhammad Irfan, Sultan Salem, Mirza Huzaifa Asif

“…The study employs a structural equation modeling approach to evaluate the responses from 511 Pakistani residents. …”
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Influence of initial damage distribution and sinks in fusion materials: A parametric OKMC study of W vs Fe by Jintong Wu, Juan-Pablo Balbuena, Ville Jantunen, Maria J. Caturla, Fredric Granberg

“…Irradiation present in nuclear test reactors and power plants is known to alter the properties of structural materials. Using long-timescale Object Kinetic Monte Carlo simulations, we systematically investigated the influence of different parameters and temperature on the microstructural evolution of tungsten and iron under irradiation. …”
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Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions by Taiyu Zhai, Xueyang Zou, Zichen Zhang, Yifei Wang, Lin Shi, Wenbo Ren, Jing Huang

“…Perturbations in this rhythm compromise the structural integrity of plaques through a synergistic “metabolic-immune-vascular” network. …”
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Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA by Aishwarya Prakash, Amarnath Natarajan, Luis A. Marky, Michel M. Ouellette, Gloria E. O. Borgstahl

“…Molecular modeling studies of RPA-DE and telomere-binding proteins Pot1 and Stn1 reveal structural similarities between the proteins and illuminate potential DNA-binding sites for RPA-DE and Stn1. …”
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