Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration by Wu H, Li C, Yuan H, Zhao J, Li S

“…However, compared to traditional small-molecule drugs, the high molecular weight (> 10 kDa) and structural complexity of macromolecular drugs result in extremely low transmembrane permeability. …”
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PCVR: a pre-trained contextualized visual representation for DNA sequence classification by Jiarui Zhou, Hui Wu, Kang Du, Wengang Zhou, Cong-Zhao Zhou, Houqiang Li

“…Machine learning methods learn implicit patterns from data with encoding techniques such as k-mer counting and ordinal encoding, which fail to handle long sequences or sacrifice structural and sequential information. Frequency chaos game representation (FCGR) converts DNA sequences of arbitrary lengths into fixed-size images, breaking free from the constraints of sequence length while preserving more sequential information than other representations. …”
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Social support and adolescent mental health in Kenya: a parallel mediation analysis of perceived control and gratitude by Ming Zhao, Heng Miao, Li-Li Zhu, Xiao-Han Zhang, Li-Wei Zang

“…The data were analyzed using structural equation modeling, controlling for age and gender.ResultsSocial support was directly associated with lower levels of depression (β = −023) and anxiety (β = −023). …”
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Cerium Addition Enhances Impact Energy Stability in S355NL Steel by Tailoring Microstructure and Inclusions by Jiandong Yang, Bijun Xie, Mingyue Sun

“…S355NL structural steel is extensively employed in bridges, ships, and power station equipment owing to its excellent tensile strength, weldability, and low-temperature toughness. …”
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Understanding the layout of emergency scientific research during COVID-19 prevention and control: a comparative analysis of project solicitation and project approval by Jida Liu, Yuxin Wang, Yuwei Song, Qiaoqiao Li

“…Methods On the basis of 1,654 ESR project records collected from provincial-level governments across China (333 solicitations and 1,321 approvals), we apply descriptive statistical methods and structural metrics via social network analysis to construct “subject–research direction” 2-mode networks and association networks. …”
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Shape-controlled aerosol-assisted chemical vapour deposition of iron sulfide thin films using heterocyclic iron(II) dithiocarbamates as single-source molecular precursors by Sixberth Mlowe

“…The deposition of iron sulfide films were carried at temperatures of 350 °C and 450 °C using chloroform solution of precursors, and the resulting films were characterized for structural, optical, and morphological properties. Films deposited using precursor (1) at 350 °C displayed uniform spherical particles ranging from 240 nm to 370 nm and a direct band gap of 2.29 eV while those at 450 °C revealed anisotropic growth (650 – 1050 nm) and a reduced band gap of 2.19 eV, attributed to quantum confinement effects. …”
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Culture, goal orientation and achievement of vocational college students by Xuefei Lin, Xuefei Lin, Peiyao Lei, Qi Tan, Bin Xiong, Bin Xiong

“…IntroductionThis study explored the relationship between cultural values, goal orientation, and mathematics achievement in mainland China.MethodsStructural equation modelling was used to analyze data collected from 1,004 first-year students of four majors in higher vocational colleges. …”
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Analysis of ChatGPT User Acceptance Among Gen Z using UTAUT2 and TPB Methods by Defri Indra Putra, Mona Fronita, Angraini Angraini, Megawati Megawati

“…Based on data analysis using Structural Equation Modeling with the Partial Least Squares (SEM-PLS) approach, the research model demonstrates strong explanatory power, with an R² value of 0.722 for behavioral intention and 0.687 for use behavior. …”
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Traumatic brain injury: Bridging pathophysiological insights and precision treatment strategies by Yujia Lu, Jie Jin, Huajing Zhang, Qianying Lu, Yingyi Zhang, Chuanchuan Liu, Yangfan Liang, Sijia Tian, Yanmei Zhao, Haojun Fan

“…Various physiological changes, such as structural alterations of the blood–brain barrier, inflammatory cascades, and extracellular matrix remodeling, interact with each other and are influenced by genetic, age, sex, and environmental factors. …”
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Stochastic and Percolating Models of Blocking Computer Networks Dynamics during Distribution of Epidemics of Evolutionary Computer Viruses by S. A. Lesko, A. S. Alyoshkin, V. V. Filatov

“…On one hand, this model is based on the use of percolation theory methods, which makes it possible to determine such structural-information characteristics of networks as the dependence of the percolation threshold on the average number of connections per one node (network density). …”
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DYNAMICS OF ROMANIA'S GROSS DOMESTIC PRODUCT, EXPORT AN IMPORT. A STUDY CASE IN AGRO-FOOD SECTOR, 2013-2022 by Agatha POPESCU

“…The methodology used in this study included; fixed basis and structural indices, growth rate, statistical econometric modeling using regression equations, coefficient of correlations, coefficient of determination, comparison and illustrative methods. …”
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The potential for interstate high-tech oil and gas cluster formation in the Caspian region by A. A. Khachaturyan, N. V. Lyasnikov, A. S. Abdulkadyrov, S. V. Zubkova

“…As a result of the revealed imbalance between the accumulated potential of socio-economic development and the level of development of high-tech industries in the states of the Caspian region, the necessity of formation and implementation of state policy measures aimed at the structural transformation of regional economic systems is determined.   …”
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Comorbidity: alobar holoprosencephaly and pulmonary tuberculosis in a child (a case report) by Yu. V. Myronchuk, O. O. Pushnova, L. V. Taran, O. V. Dvizov

“…Alobar holoprosencephaly is a severe and rare structural brain abnormality with complex and multifactorial causes. …”
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Thermal deformations and brightness temperature of the ice cover of freshwater bodies by S. V. Tsyrenzhapov, A. A. Gurulev

“…We assume that the dry cracks can also be formed when the stress state of ice is released at even lower temperatures. Interest in these structural changes had been arisen in connection with possible variations in the electromagnetic properties of the ice cover, which can be detected by non-contact radio wave measurements. …”
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Traction Calculation for Modular Energotechnological Unit Given Kinematic Mismatch of Driving Axles by A. V. Lavrov, V. А. Voronin, M. V. Sidorov, I. A. Pekhalskiy

“…Analyzing the dependence of the running system efficiency on the kinematic mismatch of the first and third axles at the traction of 30 kilonewtons, the extremes of all the dependencies at the kinematic mismatch between the third bridge and the second one different unit were detected.Conclusions It has been revealed that the change in the efficiency of the chassis system of the modular energotechnological unit depends on the kinematic mismatch between the third axle and the second one at a predetermined kinematic mismatch between the first axle and the second axle, which is a structural feature for 4K4 wheeled tractors. The excess in the values of running system efficiency equals 1.04-1.06 if the constructive kinematic mismatch between the third bridge and the second one is within 1.06-1.08.…”
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Comparative Analysis of Expression of the Main Virulence Genes in Various <i>Vibrio cholerae</i> О1 Strains by N. B. Cheldyshova, Z. L. Devdariani

“…Determination of gene expression was performed using real-time PCR with reverse transcription.Results and discussion. The expression of structural (ctxA, tcpA) and regulatory (toxR, toxT, tcpP, tcpH) virulence genes has been investigated in V. cholerae strains of the classical biovar, typical and genetically modified strains of the El Tor biovar. …”
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Assessment of the hydrocarbon potential of the Bering Sea by E. A. Lavrenova, S. A. Guryanov, V. Yu. Kerimov

“…In the process of preparing the input data for modelling, a number of necessary structural constructions, lithological-paleogeographic and paleodynamic reconstructions and other special studies were performed, which made it possible to determine the modelling boundary conditions.Results. …”
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The mediating role of spiritual well-being in the relationship between self-care agency and hope in patients diagnosed with schizophrenia: a cross-sectional and correlational study by Zeynep Öztürk, Mustafa Durmuş, Emrah Ay, Ayşe Okanli

“…Descriptive Information Form, Self-Care Agency Scale, Herth Hope Index and Functional Assessment of Chronic Illness Therapy - Spiritual Well-Being Scale were used to collect the data. Structural equation modelling and bootstrapping method were used to analyse the data. …”
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Circular business models for whey valorization in the Kenyan dairy sector through product life extension and resource recovery by Celestine Mutio, Dickson Okello, Stanley Karanja, Bockline Bebe, Simon Bolwig

“…Future research should investigate cooperative valorization models, consumer demand for whey-based products, and lifecycle assessments of environmental outcomes. By addressing structural and institutional barriers, Kenya’s dairy sector can unlock significant environmental, nutritional, and economic benefits through scalable whey valorization strategies.…”
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Comprehensive Assessment of the Manufacturability of Products by P. Yu. Bochkaryov, R. D. Korolev, L. G. Bokova

“…The degree of influence of the indicators of manufacturability relative to other indicators was determined by using the apparatus of paired comparisons in decision-making in relation to all structural elements of production costs.Discussion and Conclusion. …”
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