Therapeutic Drug Monitoring of Everolimus Using Volumetric Absorptive Microsampling and Quantitative Dried Blood Spot Methods with LC-MS/MS in Adult Solid Organ Transplant Recipien... by Arkadiusz Kocur, Bartosz Olkowski, Mateusz Moczulski, Dorota Miszewska-Szyszkowska, Olga Maria Rostkowska, Katarzyna Polak, Katarzyna Korniluk, Teresa Bączkowska, Magdalena Durlik, Tomasz Pawiński

“…The validation followed EMA and IATDMCT guidelines, assessing linearity (1.27–64.80 ng/mL for WB and 0.50–60 ng/mL for VAMS/qDBS), as well as selectivity, accuracy, precision, matrix effects, recovery, stability, and incurred sample reanalysis. …”
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Microbial biomass – not diversity – drives soil carbon and nitrogen mineralization in Spanish holm oak ecosystems by Elisa Bruni, Jorge Curiel Yuste, Lorenzo Menichetti, Omar Flores, Daniela Guasconi, Bertrand Guenet, Ana-Maria Hereș, Aleksi Lehtonen, Raisa Mäkipää, Marleen Pallandt, Leticia Pérez-Izquierdo, Etienne Richy, Mathieu Santonja, Boris Tupek, Stefano Manzoni

“…., alpha diversity of taxa and of fungal functional groups), and selected the model that optimized prediction accuracy, while minimizing complexity.We found that microbial biomass had a strong and positive effect on both C and N mineralization rates, with heterotrophic respiration being nearly linearly controlled by biomass. In contrast, microbial diversity had minimal but negative effects on mineralization processes, with land-use differences explaining part of the variability in these effects. …”
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Simple, sensitive and specific detection method for polystyrene nanoplastics in food matrix based on peptide-modified Fe3O4@Au magnetic nanoparticles by Beibei Wang, Ling Sun, Kai Liu, Di Wu, Jinqiu Wang, Fang Geng

“…The peptide modified Fe3O4@Au probe (Fe3O4@Au-PSBP) showed excellent linearity in the range from 0 to 80 pg mL−1 with the limit of detection (LOD) of 0.074 pg mL−1. …”
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Study on seismic displacement of coal-rock fracture based on radiation energy by Shengquan He, Maoxin Tian, Xueqiu He, Tingxiang Ren, Dazhao Song, Feng Shen, Tuo Chen, Junjun Feng

“…The peak value of P-wave displacement increased linearly, and the peak value of S-wave displacement was nonlinear. …”
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Simultaneous ratiometric fluorescence determination and removal of copper ions by a magnetic nanocomposite by Lingli Zhong, Yating Chen, Xiaohao Gan, Siqi Jiang, Yuxuan Lin, Qiulin Li, Wenxiang Wang, Ye He

“…When Cu2+ is present in the solution, the red fluorescence of the magnetic ratiometric fluorescence sensor is quenched, and the blue fluorescence remains essentially unchanged, resulting in a ratiometric fluorescence effect, which can be used for the sensitive determination of Cu2+; the magnetism can be used concurrently for the removal of Cu2+ to achieve detection and removal, and the detection results exhibit good linearity within the 2.5–100 μM range, with a limit of detection of 0.23 μM. …”
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Molecular insight into the transport of multicomponent heavy metals in calcium silicate hydrate and its mechanical behavior by Fusheng Zha, Haodong Tai, Qiao Wang, Bo Kang, Long Xu, Chengfu Chu

“…The tensile stress increased approximately linearly with strain until it reached a peak, after which it gradually declined but remained above zero, indicating good ductility and toughness under unsaturated conditions. …”
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On-site salt iodine detector (OSID) kit: An alternative tool for salt iodization monitoring by Mohd Azerulazree Jamilan, Nurul Aznyda Norizan, Ahmad Ali Zainuddin, Noor ul-Aziha Muhammad, Filza Noor Asari, Aswir Abd Rashed, Mohd Fairulnizal Md Noh

“…The validation was by its linearity (10.0–50.0 mg/Kg, R2 = 0.9956) with limit of detection (LOD, 3.6 mg/Kg), method recovery (89.5 %-99.4 %), intra-assay imprecision (coefficient of variation, CV 5.7 %), inter-assay imprecision (CV 7.0 %) and inter-operator imprecision (CV 6.1 %). …”
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Multi-objective bi-level programming algorithm to design transition mechanism for wind farm participation in electricity markets by Wenjing Zhu, Ping Dong, Yuke Lu, Mingbo Liu

“…The bi-level model is transformed into a multi-objective mixed-integer nonlinear programming model using the Karush-Kuhn-Tucker condition and the big M method. Linearization strategies are proposed to handle the product term of price and continuous variables and the absolute value term in the upper-level objective. …”
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The Radio Spectral Energy Distribution and Star Formation Calibration in MIGHTEE-COSMOS Highly Star-forming Galaxies at 1.5 < z < 3.5 by Fatemeh Tabatabaei, Maryam Khademi, Matt J. Jarvis, Russ Taylor, Imogen H. Whittam, Fangxia An, Reihaneh Javadi, Eric J. Murphy, Mattia Vaccari

“…Taking into account the evolution of the SEDs, the IRRC is redshift invariant, and it does not change with stellar mass at 1.5 < z < 3.5, although the correlation deviates from linearity. Similarly, we show that the SFR traced using the integrated MRC luminosity is redshift invariant.…”
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Associations of low-carbohydrate with mortality in chronic kidney disease by Qidong Ren, Yangzhong Zhou, Huiting Luo, Gang Chen, Yan Han, Ke Zheng, Yan Qin, Xuemei Li

“…Total 3683 US adult CKD patients 20 years or older from the National Health and Nutrition Examination Survey (NHANES, 2003–2014) were analyzed (mean age ± SD, 62.4 ± 17.1; 56.5% female), of which 1082 participants with CKD died with a median follow-up time of 67 (IQR 36–99) months.Results Most macronutrients were non-linearly associated with all-cause mortality risk, including carbohydrates and sugar. …”
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Plasma Human Cartilage Glycoprotein‐39 and Cognitive Impairment After Acute Ischemic Stroke by Ziyi Wang, Kaixin Zhang, Chongke Zhong, Zhengbao Zhu, Xiaowei Zheng, Pinni Yang, Bizhong Che, Yaling Lu, Yonghong Zhang, Tian Xu

“…The multiple‐adjusted spline regression model confirmed dose–response relationships between YKL‐40 and poststroke cognitive impairment (P for linearity=0.01). Adding YKL‐40 to a model containing conventional risk factors significantly improved the discriminatory power (area under the receiver operating characteristic curve improved by 0.02, P=0.03). …”
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Design and Fabrication of Silicon Pressure Sensors Based on Wet Etching Technology by Fengchao Li, Shijin Yan, Cheng Lei, Dandan Wang, Xi Wei, Jiangang Yu, Yongwei Li, Pengfei Ji, Qiulin Tan, Ting Liang

“…Simulation results demonstrate that pressure sensors with smoother sensitive membranes exhibit superior performance in terms of sensitivity (5.07 mV/V/MPa), linearity (0.67% FS), hysteresis (0.88% FS), and repeatability (0.75% FS). …”
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Modification of Carbon Paste Electrode with Imprinted Zeolite A as a Sensor for Potentiometric and Voltammetric Amitriptyline Analysis by Miratul Khasanah, Alfa Akustia Widati, Tias Fadillah, Naftalia Wirdatul Ummah, Evrillia Puspitasari, Vina Aminatuz Zuhriyyah, Titah Aldila Budiastanti

“…Measurement of the AMT using the modified electrode by voltammetry resulted in linearity of the calibration curve (R) of 0.9904, detection limit of 4.2×10-8 M, precision of 82.9-97.7%, sensitivity of 552 nA/M, and recovery of 103.1% (n = 3). …”
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Calculating Relative Correction Factors for Quantitative Analysis with HILIC-HPLC-ELSD Method: Eight Fructooligosaccharides of Morinda Officinalis as a Case Study by Lihong Zhou, Hui Ni, Linlin Zhang, Wenyong Wu, Tengqian Zhang, Qi Su, Jing Zhou, Huali Long, Jinjun Hou, Jiyu Gong, Wanying Wu

“…The QAMS of eight fructooligosaccharides of Morinda officinalis was validated with good linearity (R2 > 0.9998) and accepted the accuracy of 95–105% (RSD < 1.81%) based on nystose. …”
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Association Between Cardiometabolic Index and Mortality Among Patients with Atherosclerotic Cardiovascular Disease: Evidence from NHANES 1999–2018 by Duo Yang, Wei Li, Wei Luo, Yunxiao Yang, Jiayi Yi, Chen Li, Hai Gao, Xuedong Zhao

“…There was a nonlinear J-shaped relationship between CMI and all-cause mortality, while the risk of cardiovascular mortality increased linearly with increasing CMI. <i>Conclusions:</i> These findings underscore the importance of monitoring and managing CMI in patients with ASCVD in clinical practice and suggest that optimizing CMI levels may help reduce the risk of death and improve the long-term prognosis of patients.…”
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Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats by Putri Reno Intan, Sukmayati Alegantina, Ani Isnawati, Nanang Yunarto, Fitrine Ekawasti, Ratih Rinendyaputri, Sunarno Sunarno, Yulvian Sani, Sela Septima Mariya, Ekowati Handharyani

“…Results: The results showed that, while the rate of milk production did not increase linearly with the duration of lactation, rats treated with the blended extract at a dose of 75 mg/kg exhibited higher milk production than the control group. …”
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Method of Entry Layout under Synergistic Effects of Abutment Stress and Dynamic Stress by Wenlong Shen, Guocang Shi, Meng Wang, Tenglong Rong, Yungang Wang, Ruifeng Zhang, Xiangyu Wang, Jianbiao Bai

“…The model results validated that the entry should keep away from the dynamic stress of Violent Impact Type firstly and then be arranged in the zone where the dynamic stress belongs to Slightly Disturbed Type. DDT increases linearly and DLT decreases with a power function as the increasing of the abutment stress. …”
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Optimization and Validation of a QuEChERS-Based Method Combined with Gas Chromatography–Tandem Mass Spectrometry for Analyzing Pesticide Residues in Edible Insect Samples by Phannika Tongchai, Nootchakarn Sawarng, Anurak Wongta, Udomsap Jaitham, Kunrunya Sutan, Saweang Kawichai, Chuleui Jung, Bajaree Chuttong, Surat Hongsibsong

“…The method was optimized by evaluating various extraction parameters and showed strong linearity for all 47 target pesticides, with correlation coefficients (R²) ranging from 0.9940 to 0.9999. …”
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Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly by Yu Zhang, Xiaopeng Guo, Gang Tan, Mengyun Zhao, Yuguang Huang, Wei Chen, Xiaodong Shi, Lijian Pei, Bing Xing

“…Changes in the levels and burdens of GH and IGF-1 and body composition were linearly correlated with intraoperative NMB in acromegaly patients.…”
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Stressless sampling to improve diagnostics of catecholamine excess: new assay to determine metanephrines in saliva by Per M Thorsby, Sandra R Dahl, Tone Smetop, Tone Hæg Lindholm, Svetlana N Zykova

“…Selectivity, interferences, matrix effects, limits of quantification, linearity of calibration, sample volume, trueness, within-run and total analytical repeatability, robustness, carry-over and stability were evaluated. …”
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