PNUTS:PP1 recruitment to Tox4 regulates chromosomal dispersal in Drosophila germline development by Louise Duncalf, Xinru Wang, Abdulrahman A. Aljabri, Amy E. Campbell, Rawan Q. Alharbi, Ian Donaldson, Andrew Hayes, Wolfgang Peti, Rebecca Page, Daimark Bennett

“…Here, we combine biochemical, structural, cellular, and in vivo experiments to show that, while tox4 is dispensable for viability, it is essential for fertility, having both PNUTS-dependent and -independent roles in Drosophila germline development. …”
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o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2 by Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe

“…Toll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 receptor) domains and the downstream adaptor proteins can help us develop inhibitors targeting this pathway. …”
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Mouse Tumor Tissue‐Derived Extracellular Vesicles Induce Angiogenesis Through VEGF Production From Macrophages by Yae Jin Yoon, Seoyoon Bae, Eun‐Jeong Choi, Sang Soo Kim, Solchan Won, Anita Basukala, HaYoung Shin, Jaewook Lee, Jie‐Oh Lee, Dong‐Sup Lee, Yong Song Gho

“…The purified tumor tEVs showed EV‐like features with nano‐sized, spherical, and lipid bilayered structures, and enriched with EV marker proteins such as tetraspanins, while being de‐enriched with proteins from Golgi apparatus and nucleus. …”
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Influence of Floral Strip Width on Spider and Carabid Beetle Communities in Maize Fields by Jia-Lu Li, Lan-Mei Huang, Zi-Yi Xiang, Jian-Ning Zhao, Dian-Lin Yang, Hui Wang, Yan-Jun Zhang

“…Vegetation characteristics significantly influenced spider and carabid communities, impacting species richness, diversity indices, and community structures across two study years. These insights highlight the necessity of thoughtfully designing floral strips to enhance biodiversity and natural pest control in agricultural landscapes.…”
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Physical simulation of hydrocarbon migration and accumulation in transport systems of allochthonous salt sheet development zone: a case study of Perdido Fold Belt in Burgos Basin,... by Yan FAN, Caifu XIANG, Songling YANG, Lin'an PANG, Jingtan CHEN, Aishan LI, Liang CHEN, Shanbin JIANG, Yongkang SI, Minghui YANG

“…The allochthonous salt sheet development zone in the Perdido Fold Belt of the Burgos Basin has formed an oil and gas transport system comprising the underlying structures of allochthonous salt sheets, faults, and the Paleocene to Eocene Wilcox Formation. …”
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An ABC transporter-mediated transport and metabolism of the pesticide bentazone in rice (Oryza sativa L.) by Yuxin Qiao, Yujue Wang, Yucheng Gu, Nan Zhang, Hong Yang, Jintong Liu

“…Six different metabolites and ten conjugates were well defined in chemical structures. The reduced BNTZ levels and degradation products in the grains of the OE lines supported the robust activity of the OsABC gene function.Using UPLC-Q-TOF/MS, we further identified accumulated basic metabolites of various carbohydrates, amino acids, hormones, and flavonoids, and found that these metabolites involved in BNTZ degradation were increased more in OE lines than in wild-type (WT) rice. …”
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Numerical simulation study on the pressure relief and anti-scour effects of multi-seam coal mining by YANG Guiru, LI Hongping, ZHOU Yu, YANG Xu, LIU Jiang, WANG Jianqi, LIANG Hongbao, LU Anliang, LI Zhenlei

“…To address these issues, based on the engineering background of mining four coal seams in Kuangou Coal Mine, this study used numerical simulation to investigate the impact of complex spatial structures such as multi-seam goaf areas and remaining coal pillars on the mining of underlying coal seams. …”
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Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomiz... by Shuzhe Wang, Junhao Chen, Linxuan Wang, Jingxuan Liu, Lijun Wang, Wenjie Sun, Shen Li, Jie Li

“…Transcranial temporal interference stimulation (tTIS) is a novel, non-invasive brain stimulation technique that enables targeted modulation of deep brain structures with high spatial specificity. While tTIS has shown promise in preliminary studies of other neuropsychiatric conditions, its clinical utility in SCZ has not been established. …”
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Biosafety and biosecurity problems in Ukraine that arise during emergent infections by A. O. Vysotskyi, B. V. Gutyj, O. V. Kozenko, N. Yu. Krempa, I. V. Dvyliuk, N. V. Magrelo, H. V. Klym, T. V. Martyshuk, U. M. Vus

“…Today, cooperation with relevant scientific structures in the USA and other leading countries of the world has significantly improved the capabilities of laboratory research in Ukraine, increasing our country's ability to respond to outbreaks of infectious diseases. …”
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Didemnosides A and B: Antiproliferative Nucleosides from the Red Sea Marine Tunicate <i>Didemnum</i> Species by Lamiaa A. Shaala, Diaa T. A. Youssef, Hadeel Almagthali, Ameen M. Almohammadi, Wafaa T. Arab, Torki Alzughaibi, Noor M. Bataweel, Reham S. Ibrahim

“…Fractionation and purification of the organic extract of the Red Sea tunicate <i>Didemnum</i> species resulted in the isolation and identification of three new compounds, didemnosides A and B (<b>1</b> and <b>2</b>) and 1,1′,3,3′-bisuracil (<b>3</b>), together with thymidine (<b>4</b>), 2′-deoxyuridine (<b>5</b>), homarine (<b>6</b>), and acetamide (<b>7</b>). Planar structures of the compounds were explained through analyses of their 1D (¹H and ¹³C) and 2D (¹H–¹H COSY, HSQC, and HMBC) NMR spectra and high-resolution mass spectral determinations. …”
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A novel paradigm in cleft lip education: integration of 3D-printed simulator and problem-based learning by Xiao-Le Wang, Ying Xie, Ye-Xin Yue, Xue-Wen Yang, Jian Li

“…Given that the 3D-printed simulator features high-fidelity, multi-layer structures, including skin, muscle, and mucosa layers, we have incorporated it into the conventional PBL approach to address the limitations of traditional PBL in the teaching of cleft lip repair. …”
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Apigenin and its derivatives in breast cancer prevention and therapy: a review on bioavailability and recent developments by Ghumika Pandita, Disha Mittal, Piyush Kashyap, Wing-Fu Lai, Naveen Kumar, Rahul Mehra, Mohd Adnan, Syed Amir Ashraf

“…More research on delivery systems and modifications of their structures is critical for improving their clinical effectiveness. …”
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Effects of Clouds and Shadows on the Use of Independent Component Analysis for Feature Extraction by Marcos A. Bosques-Perez, Naphtali Rishe, Thony Yan, Liangdong Deng, Malek Adjouadi

“…Despite these limitations, ICA proved effective in isolating and delineating cloud structures, allowing us to selectively suppress them in reconstructed images. …”
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DSMF-Net: A One-Stage SAR Ship Detection Network Based on Deformable Strip Convolution and Multiscale Feature Refinement and Fusion by Xingyu Liu, Jun Pan, Rong Hu, Wenli Huang, Jiawei Lin, Jiarui Hu

“…DSConv adaptively adjusts convolution sampling positions based on ship target characteristics, precisely extracting features with directional and strip structures. Second, the dual-stream self-attention feature refinement module is utilized to refine high-level semantic features. …”
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Modulating Osteoclast Activity and Immune Responses with Ultra-Low-Dose Silver Nanoparticle-Loaded TiO₂ Nanotubes for Osteoporotic Bone Regeneration by Zhen Wang, Penghui Xiang, Zhe Xu, Meiqi Gu, Rui Zhang, Yifei Li, Fei Xin, Chengla Yi

“…The morphology and elemental composition of the Ag@TiO₂-NTs structures were characterized using scanning electron microscopy (SEM) and related methods. …”
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Efficient sepsis detection using deep learning and residual convolutional networks by Ahmed S. Almasoud, Ghada Moh Samir Elhessewi, Munya A. Arasi, Abdulsamad Ebrahim Yahya, Menwa Alshammeri, Donia Badawood, Faisal Mohammed Nafie, Mohammed Assiri

“…The combination of AVOA into the model ensures that it is robust and easily transferable, delivering high performance for adaptation to complicated structures inside medical datasets. The proposed model was evaluated on a clinical dataset and achieved outstanding performance, with an accuracy of 99.4%, precision of 98%, recall of 99.2%, F1-score of 99.0%, and an area under the curve (AUC) of 0.998. …”
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The Validation of an Artificial Intelligence-Based Software for the Detection and Numbering of Primary Teeth on Panoramic Radiographs by Heba H. Bakhsh, Dur Alomair, Nada Ahmed AlShehri, Alia U. Alturki, Eman Allam, Sara M. ElKhateeb

“…AI technologies can enhance diagnostic accuracy by automating tasks like identifying and locating dental structures. The aim of the current study was to assess and validate the accuracy of an AI-powered application in the detection and numbering of primary teeth on panoramic radiographs. …”
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Object Detection in Laparoscopic Surgery: A Comparative Study of Deep Learning Models on a Custom Endometriosis Dataset by Andrey Bondarenko, Vilen Jumutc, Antoine Netter, Fanny Duchateau, Henrique Mendonca Abrão, Saman Noorzadeh, Giuseppe Giacomello, Filippo Ferrari, Nicolas Bourdel, Ulrik Bak Kirk, Dmitrijs Bļizņuks

“…This study investigates the application of deep learning models for object detection in laparoscopic videos, aiming to assist surgeons in accurately identifying and localizing endometriosis lesions and related anatomical structures. A custom dataset was curated, comprising of 199 video sequences and 205,725 frames. …”
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Design, synthesis, in silico studies and antiproliferative evaluation of some novel hybrids of pyrimidine-morpholine by Elaheh Ataollahi, Leila Emami, Al-Anood Mohammad Al-Dies, Fateme Zare, Alireza Poustforoosh, Mina Emami, Fateme Saadat, Fateme Motamen, Zahra Rezaei, Soghra Khabnadideh, Soghra Khabnadideh

“…Spectroscopic methods, including infrared spectroscopy (IR), proton and carbon nuclear magnetic resonance (1HNMR &amp; 13CNMR), and mass spectrometry, were employed to confirm the structures of the compounds. The cytotoxic effects of the derivatives were evaluated against cancerous cell lines, including MCF-7 and SW480, using the MTT assay.Results and discussionIt was demonstrated that all derivatives had appropriate cytotoxic potential with IC50 in range of 5.12–117.04 μM. …”
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Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation by Chenyang Cui, Jiaze Tang, Jie Chen, Beining Zhang, Ruonan Li, Qiang Zhang, Chunjing Qiu, Rongchen Chen, Geng Min, Zhaowei Sun, Haibo Weng

“…Moreover, this system can modulate the types and compositional structures of gut microbiota and metabolites to achieve an anti-inflammatory phenotype, which is helpful for the repair of intestinal homeostasis. …”
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