Role of survival post-progression in phase III trials of systemic chemotherapy in advanced non-small-cell lung cancer: a systematic review. by Katsuyuki Hotta, Katsuyuki Kiura, Yoshiro Fujiwara, Nagio Takigawa, Akiko Hisamoto, Eiki Ichihara, Masahiro Tabata, Mitsune Tanimoto

“…The relationship between MPFS and MST was modeled in a linear function. We used the coefficient of determination (r(2)) to assess the correlation between them. …”
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Observation of the liquid metal phase transition in optofluidic microcavities by Zixiang Fu, Zhenlin Zhao, Ruiji Dong, Junqiang Guo, Yan-Lei Zhang, Shusen Xie, Xianzeng Zhang, Qijing Lu

“…Our study provides comprehensive insights into the dynamic behavior of Ga during the complete phase transition, such as measuring a hysteresis loop between the solid-to-liquid and liquid-to-solid transitions, revealing nonreciprocal resonance wavelength shift, and identifying a unique metastability state of Ga during melting. The linear thermal expansion coefficients of Ga were precisely measured to be 0.41 × 10−5 K−1 and −0.75 × 10−5 K−1 for solid and liquid Ga, respectively. …”
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Uncovering potential biomarkers and metabolic pathways in systemic lupus erythematosus and lupus nephritis through integrated microbiome and metabolome analysis by Siyun Cheng, Xiaojie Chu, Zhongyu Wang, Adeel Khan, Yue Tao, Han Shen, Ping Yang

“…Differential microbial taxa and metabolites were identified using Linear Discriminant Analysis Effect Size (LEfSe) and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA). …”
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Comparative analysis and selection of the geometry of the microphone array based on MEMS microphones for sound localisation by Andrii Riabko, Tetiana Vakaliuk, Oksana Zaika, Roman Kukharchuk, Yuriy Smorzhevsky

“…The tasks to be addressed include analyzing spatial-frequency characteristics of various microphone array geometries (Uniform Linear Array, Uniform Planar Array, Uniform Circular Array, and Uniform Concentric Array), comparing beamforming algorithms (delay-and-sum, differential, and superdirective), and evaluating their performance under isotropic noise fields and coherent noise sources. …”
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DNA methylation patterns in cord blood DNA and body size in childhood. by Caroline L Relton, Alexandra Groom, Beate St Pourcain, Adrian E Sayers, Daniel C Swan, Nicholas D Embleton, Mark S Pearce, Susan M Ring, Kate Northstone, Jon H Tobias, Joseph Trakalo, Andy R Ness, Seif O Shaheen, George Davey Smith

“…Five genes were unmethylated and DNA methylation in the remaining 24 genes was analysed using linear regression with bootstrapping. Methylation in 9 of the 24 (37.5%) genes studied was associated with at least one index of body composition (BMI, fat mass, lean mass, height) at age 9 years, although only one of these associations remained after correction for multiple testing (ALPL with height, p(Corrected) = 0.017).…”
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Clinical Pharmacology of Bulevirtide: Focus on Known and Potential Drug–Drug Interactions by Martina Billi, Sara Soloperto, Stefano Bonora, Antonio D’Avolio, Amedeo De Nicolò

“…<b>Results:</b> BLV shows non-linear PK, due to target-mediated drug disposition, so its PK as well as PD is expected to be influenced by interactions of other drugs with NTCP, while it is not substrate of CYPs and ABC transporters. …”
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Dynamic Damage Characteristics of Red Sandstone: An Investigation of Experiments and Numerical Simulations by Yelin Qian, Ying Su, Ruicai Han, Changchun Li, Ran An

“…Dynamic peak stress and average strain rate in sandstone demonstrate an approximately linear relationship, with the correlation coefficient being 0.962. …”
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Growth trajectories of children and adolescents with osteogenesis imperfecta in a reference center in Rio de janeiro, Brazil by Luísa Cunha Pereira, Dayana Rodrigues Farias, Fernanda De Bastiani, Juan Clinton Llerena Jr, Fernanda Rebelo

“…The association with other variables was investigated using linear mixed effects regression. Results 237 participants were included (type I = 134; type III = 41, type IV = 57; type V = 5). …”
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Imageless vs Image-Based Computer Navigation in Total Hip Arthroplasty: An Intracase Comparison Shows Variability Between Technologies by Joseph T. Gibian, MD, Ryan J. Cone, MD, Matthew Booth, MD, Ling Chen, PhD, Kimberly A. Bartosiak, MD, Charles P. Hannon, MD, MBA, Ilya Bendich, MD, MBA

“…Discordant cases (>5° differences) were recorded; linear regression was used to determine if any confounding factors were associated with an increased risk of discordance. …”
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Development and testing of the QDis-MH checklist for discharge letters from specialised mental healthcare: a stakeholder-centred study by Eva Biringer, J Helgeland, H B Hellesen, Jörg Aβmus, M Hartveit

“…Psychometric properties were assessed using estimates of intrascale consistency and linear mixed effects models. Inter-rater and test–retest reliability were assessed using Gwet’s agreement coefficient (Gwet’s AC1) and intraclass correlation coefficients.Results The QDis-MH checklist had satisfactory intrascale consistency. …”
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Relationship between BDNF content in cord blood and early neurobehavior in newborns with subclinical hypothyroidism during pregnancy: a preliminary study by Hui Xu, Ya-Nan Du, Shuai Yang, Yu-Wen Guo

“…The cord blood BDNF of newborns with SCH during pregnancy was positively correlated with total NBNA score, behavioral ability, active muscle tone, and general assessment. Moreover, multiple linear regression analysis demonstrated an association between cord blood BDNF levels in pregnant patients with SCH and multiple measures of newborn health, including total NBNA score, behavioral ability, active muscle tone, and general assessment.ConclusionInfants born to pregnant women with SCH exhibit reduced behavioral and neural abilities linked to BDNF levels in umbilical cord blood.…”
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Weighted Hypoxemia Index: An adaptable method for quantifying hypoxemia severity. by Diane C Lim, Cheng-Bang Chen, Ankita Paul, Yujie Wang, Jinyoung Kim, Soonhyun Yook, Emily Y Kim, Edison Q Kim, Anup Das, Medhi Wangpaichitr, Virend K Somers, Chi Hang Lee, Phyllis C Zee, Toshihiro Imamura, Hosung Kim

“…<h4>Results</h4>We set varying upper thresholds at 92%, 90%, 88%, and 86%, a lower threshold of 50%, calculated area under the curve and area above the curve, with and without a linear weighted factor (duration of each event [Formula: see text]), and used the same normalization factor of total sleep time <90% divided by total sleep time. …”
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Impact of Trichiasis Surgery on Quality of Life: A Longitudinal Study in Ethiopia. by Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Aderajew Mohammed, Zebideru Zewudie, Kelly Callahan, Paul M Emerson, Robin L Bailey, David C W Mabey, Saul N Rajak, Hannah Kuper, Sarah Polack, Helen A Weiss, Matthew J Burton

“…The mean difference in QoL scores between enrolment and follow-up for cases and comparison participants, and the difference-in-differences by baseline trichiasis status was analysed using random effects linear regression, the later adjusted for age, sex and socioeconomic status. …”
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ENACT (ENvironmental enrichment for infants; parenting with Acceptance and Commitment Therapy): a randomised controlled trial of an innovative intervention for infants at risk of a... by Koa Whittingham, Roslyn N Boyd, Andrea McGlade, Kavindri Kulasinghe, Amy E Mitchell, Honey Heussler

“…Analysis will be by intention to treat using general linear models for RCTs.Ethics and dissemination This protocol has been approved by the Children’s Health Queensland Hospital and Health Service Human Research Ethics Committee (HREC/19/QCHQ/50131) and the University of Queensland Human Research Ethics Committee (2019000558). …”
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Sleep patterns, plasma metabolites, and risk of incident osteoarthritis: a prospective cohort study by Hao Xia, Chen Meng, Rong Chen, Chao Mao, Chuan Li, Yongqing Xu

“…Restricted cubic splines (RCS) with four knots were used in the fully adjusted model to explore the potential non-linear association of sleep score and metabolic profile with OA risk. …”
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Exploring the impact of forage-to-concentrate ratios on the ruminal bacteriome in vitro focusing on ciliate-associated bacteria by Geonwoo Kim, Woohyung Lee, Tansol Park

“…All fermentation parameters, except for NH3-N, showed linear changes with increasing F:C ratios (p ≤ 0.05). …”
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Generation of a cellular model for mucopolysaccharidosis type IVA (MPS IVA) (AOUMEYi003-A) from a patient carrying compound heterozygous mutations p.G116V and p.G290S in the GALNS... by Federica Feo, Silvia Falliano, Anna Caciotti, Marina Rinaldi, Alessia Caroli, Laura Giunti, Martino Calamai, Elena Procopio, Renzo Guerrini, Amelia Morrone, Rodolfo Tonin

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Daily sitting time and all-cause mortality: a meta-analysis. by Josephine Y Chau, Anne C Grunseit, Tien Chey, Emmanuel Stamatakis, Wendy J Brown, Charles E Matthews, Adrian E Bauman, Hidde P van der Ploeg

“…Associations between daily total sitting time and all-cause mortality were not linear. With physical activity adjustment, the spline model of best fit had dose-response HRs of 1.00 (95% CI: 0.98-1.03), 1.02 (95% CI: 0.99-1.05) and 1.05 (95% CI: 1.02-1.08) for every 1-hour increase in sitting time in intervals between 0-3, >3-7 and >7 h/day total sitting, respectively. …”
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Impacts of dental checkups on oral function among Japanese older adults by Tin Zar Tun, Kaung Myat Thwin, Sachiko Takehara, Kumiko Minagawa, Noboru Kaneko, Hiroshi Ogawa

“…Statistical analyses included the Mann‒Whitney U test, chi-squared test, and linear regression analysis. Significant differences between attendees and non-attendees were found in sex, body mass index, and oral hygiene practices. …”
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Integration of seasonal rainfall and irrigation into a water management plan for almond orchards: Should we irrigate in response to drought or to maintain growth potential? by Or Sperling, Niccolò Tricerri, Jessica Orozco, Zachary Ellis, Ido Gardi, Francesca Secchi, Maciej A Zwieniecki

“…Yields (dry kernels) increased by ∼ 2.5 kg ha−1 mm−1 at the linear range of the regression (600–800 mm irrigation).Conclusively, delaying spring irrigation exposes trees to early-season droughts and compromises almond trees’ reproductive potential. …”
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