ANKK1, ANKRD50, GRK5, PACSIN1 and VPS8 are novel candidate genes associated with late onset Parkinson's disease: Definition of a novel predictive protocol based on polygenic model... by Federica Carrillo, Nicole Piera Palomba, Sara Pietracupa, Laura Ianiro, Giorgio Fortunato, Margherita Degasperi, Tiziana Giloni, Maria Ilenia De Bartolo, Luigi Pavone, Teresa Nutile, Nicola Modugno, Danilo Licastro, Teresa Esposito

“…In these genes, we identified both rare probably damaging variants, altering protein structure and dynamics, as well as frequent variants associated with PD risk. …”
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A Hydroacoustic Assessment of the Density, Size, and Biomass of Fish in a Freshwater Reservoir After Non-Classical Biomanipulation by Aihuan Guo, Qingping Lian, Pengcheng Sheng, Aiju Zhang, Julin Yuan, Kohji Iida

“…Stock enhancement plays a critical role in reshaping the fishery population structure in a reservoir. These findings enhance our understanding of fishery resource changes in reservoirs after non-classical biomanipulation and demonstrate how hydroacoustic techniques can be successfully used to quantify the density and size distribution of fish for more effective fishery management.…”
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Theory and engineering practice of coal-water coordinated mining based on constraints of formation bearing capacity by Zhenzhong PANG, Yifan ZENG, Keyao HAN, Qiang WU, Shouqiang LIU, Zhaolai HUA, Gangyi ZHAO, Shuai ZHANG, Huxiong YANG, Xuejun WANG, Feifan LI

“…Dominant factors controlling the formation structure damage were identified using the theory of simply supported beams and hydrogeological theories. …”
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Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis by Zhonghua Xiong, Lei Zhao, Geyu Liu, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Zhi Guo, Peng Zhang, Mantian Zhang, Tianshuang Gao, Jinju Sun, Xin Liu, Yonggang Wang

“…Abstract Background The hypothalamus is a versatile structure comprising several nuclei that play key roles in regulating various biological processes associated with migraine, including hormone secretion, metabolism, circadian rhythm, and autonomic nervous system functions. …”
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Water source of artificial plants in the northeastern margin of Tengger Desert based on hydrogen and oxygen stable isotopes by Zhenyu Zhao, Zhenyu Zhao, Guodong Tang, Guodong Tang, Jinrong Li, Jinrong Li, Meng Wu, Lei Zhang

“…The water use strategies of Corethrodendron scoparium and Calligonum mongolicum were studied in the afforestation area on the northeastern edge of the Tengger Desert, to provide scientific guidance for regional vegetation restoration and stand structure adjustment. We utilize hydrogen and oxygen isotope techniques and the MixSIAR model to calculate the contribution rates of these two plant species to various potential water sources from June to October. …”
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Engagement and Stress Concentration Evaluation of a Novel Two-Part Compression Screw: A Preliminary Finite Element Analysis by Chia-Hao Hsu, Chih-Kuang Wang, Yan-Hsiung Wang, Sung-Yen Lin, Cheng-Chang Lu, Yin-Chih Fu, Hsuan-Ti Huang, Chung-Hwan Chen, Pei-Hsi Chou

“…<b>Background/Objectives:</b> This novel compression screw design offers potential benefits due to its two-part structure and can be used for various bone types, much like a conventional single-piece compression screw. …”
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New insight into Alzheimer's disease: Light reverses Aβ‐obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice by Xiangpei Yue, Yufei Mei, Yun Zhang, Zheng Tong, Dehua Cui, Jun Yang, Aibo Wang, Rui Wang, Xuechao Fei, Li Ai, Yalan Di, Hongjun Luo, Hui Li, Wenhong Luo, Yu Lu, Rui Li, Chunli Duan, Ge Gao, Hui Yang, Binggui Sun, Rongqiao He, Weihong Song, Hongbin Han, Zhiqian Tong

“…Then, a light‐emitting diode with red light at 630 nm (LED‐RL) was selected to illuminate AD mice. The changes in the structure of ECS in the cortex were examined by fluorescent double labeling. …”
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Correlation between facial growth patterns and cortical bone thickness assessed with cone-beam computed tomography in young adult untreated patients by Francesca Gaffuri, Gianguido Cossellu, Cinzia Maspero, Valentina Lanteri, Alessandro Ugolini, Giulio Rasperini, Iury O. Castro, Marco Farronato

“…When two-dimensional dental radiographic views are not sufficient for diagnosis and measurements, cone-beam computed tomography (CBCT) images should be used to assess the alveolar bone structure three-dimensionally and with high accuracy and reliability.The aim of the present study was to evaluate the correlation between alveolar bone thickness and facial divergence in young adults untreated patients using a three-dimensional method analysis with CBCT images. …”
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Cognitive-matrix analysis of research on primary health care development in the Russian Federation for the period from 2012 to 2022 by S. A. Orlov, R. N. Shepel, D. V. Voshev, D. O. Savchenko, D. A. Gellekh, А. B. Gorlov, K. S. Mezhidov, M. V. Turlay, A. V. Sentsova, L. M. Zhamalov, A. V. Kontsevaya, O. M. Drapkina

“…The distribution of publications posted in the Elibrary for the period from January 1, 2012 to December 31, 2022, in the structure of a cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation made it possible to establish areas of scientific interest and identify gaps in specific areas and indicators characterizing its current and future development.Aim. …”
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FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…FMO2+ CAFs increase anti-PD-1 treatment efficacy by promoting tertiary lymphoid structure formation and increasing the infiltration of CD8+ T cells and M1-like macrophages through the C-C motif chemokine ligand 19 (CCL19)-C-C motif chemokine receptor 7 axis. …”
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The Therapeutic Effects of <i>Dendropanax morbiferus Lév</i>. Water Leaf Extracts in a Rheumatoid Arthritis Animal Model by Dongho Lee, Min Jung Kim, Chang-Soo Cho, Ye Jin Yang, Jin-Kyung Kim, Ryounghoon Jeon, Sang-Hyun An, Kwang Il Park, Kwangrae Cho

“…Treatment with DMWE in living organisms led to a decrease in joint swelling, improved weight regains, and maintained joint structure, with higher doses exhibiting effects similar to those of the positive control, dexamethasone (Dexa). (4) Conclusions: DMWE was found to have excellent in vitro antioxidant and anti-inflammatory activities. …”
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Discovery of a Pair of Galaxies with Both Hosting X-Ray Binary Candidates at z = 2.544 by Sijia Cai, Zheng Cai, Jianwei Lyu, Yunjing Wu, Xiaojing Lin, Mingyu Li, Junjie Mao, Jiayi Chen, Pengjun Lu

“…XRBs play a crucial role in galaxy evolution, reflecting the stellar populations of galaxies and regulating star formation through feedback, thereby shaping galaxy structure. In this study, we report a spectroscopically confirmed X-ray emitting galaxy pair (UDF3 and UDF3-2) at z = 2.544. …”
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Long-term integrated agronomic optimization maximizes soil quality and synergistically improves wheat yield and nitrogen use efficiency by Xinhu Guo, Jinpeng Chu, Yifan Hua, Yuanjie Dong, Feina Zheng, Mingrong He, Xinglong Dai

“…Based on a 13-year field experiment conducted in Dawenkou, Tai’an, Shadong Province, China, we investigated the effects of four cultivation modes on the grain yield, NUE, and soil aggregate structure, as well as the fraction of organic matter (SOM) and soil quality, reflected by the integrated fertility index (IFI), during the winter wheat maturation periods in 2020–2022. …”
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Dietary resistant starch protects against post-antibiotic intestinal damage by restoring microbial homeostasis and preserving intestinal barrier function in meat duck by Simeng Qin, Yifeng Zhu, Gang Tian, Martin Blomberg Jensen, Keying Zhang, Xuemei Ding, Shiping Bai, Jianping Wang, Yue Xuan, Qiufeng Zeng

“…In conclusion, dietary RS supplementation mitigated antibiotic-induced cecal microbial dysbiosis and restored intestinal structure by promoting enterocyte proliferation and reducing apoptosis. …”
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Surface In Situ Growth of Two-Dimensional/Three-Dimensional Heterojunction Perovskite Film for Achieving High-Performance Flexible Perovskite Solar Cells by Zhiyu Zhang, Huijing Liu, Jing Liu, Jia Xu, Zhan’ao Tan, Jianxi Yao

“…The organic cation (CMBA⁺) bound to uncoordinated Pb²⁺ ions and residual PbI₂, while the chlorine anion (Cl⁻) filled iodine vacancies in the perovskite lattice, thereby forming a high-quality 2D/3D heterojunction structure. The CMBACl treatment effectively passivated surface defects in the perovskite films, prolonged charge carrier lifetimes, and enhanced the operational stability of the photovoltaic devices. …”
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Wetland dynamics in northern Australia’s tropical savanna (1987–2024): a multi-index Google Earth Engine approach for long-term monitoring by Kaline de Mello, Edimilson Rodrigues dos Santos Junior, Erica A. Garcia, Anna E. Richards, Peter Scott Waugh, Jessica Huxley, Simon Linke

“…Wetlands were categorized into twelve classes based on hydrological regime and vegetation structure. Validation showed high accuracy (93 % ± 1 %), with class-level accuracy above 80 % for most wetland types, including water bodies, mangroves, salt flats, swamps, marshes, and floodplains. …”
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Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics by Ji-Peng Liu, Long-Teng Tu, Ke-Zhen Yang, Yin-Yin Li, Yu Gong, Bing-Xuan Han, Chuan Liu, Tian-Qi Xia, Yu Liu, Xiao-Min Hao, Bing-Nan Yue, Jing Zhang, Bing-Hui Wang, Gui-Rong Luo, Qing-Guo Liu, Meng Xu

“…EA and MA influence the composition of intestinal microbiota in SHRs, aligning the microbial structure more closely with that of the WKY group. …”
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Study on the effect of microbial agent M44 on straw decay promoting in cold soils by Lijie Wang, Wenshan Zhao, Ruizhi Liu, Haoran Jiang, Xiaofang Yu, Julin Gao, Shuping Hu, Qinggeer Borjigin

“…The average enzyme activities of soil β-glucosidase (BG), β-xylosidase (BX), laccase (EC), acetyl glucosaminidase (NAG), and leucine aminopeptidase (LAP) increased by9.82, 4.13, 9.46, 2.73, and 5.55 [nmol/(g·h)], respectively, which promoted the degradation of methoxyl carbon and alkoxy carbon, increased the relative content of alkyl carbon, anomeric carbon, aromatic carbon, and carbonyl carbon, and decreased the O-alkyl C/alkyl C value by 2.52; the composition and structure of soil bacterial and fungal communities were significantly changed, and Pseudomonas, Stenotrophomonas, Microbacterium, Penicillium, and Gibberella were significantly enriched, which increased the overall microbial activity through the production of degrading enzymes such as cellulase, thereby promoting the rapid degradation of straw. …”
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Impact assessment of differential chlormequat chloride exposure on soil fungal community dynamics by Qiujun Lin, Qiujun Lin, Xianxin Wu, Xianxin Wu, Lina Li, Lina Li, Tianshu Peng, Tianshu Peng, Xun Zou, Xun Zou, Guang Li, Guang Li, Jianzhong Wang, Jianzhong Wang, Chunjing Guo, Chunjing Guo

“…IntroductionThis study investigated the dose-dependent effects of chlormequat chloride (CC) applications on soil fungal community structure and diversity in a peanut cultivation system.MethodsA controlled field experiment was conducted with four treatment regimes: control (CK, no CC application), low-dose (D, 45g active ingredient/ha), medium-dose (M, 75g a.i.…”
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Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity by Yanhong Liu, Liming Gong, Jing Feng, Congcong Xiao, Chenfei Liu, Bohan Chen, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang

“…With NGR-mediated tumor homing and active targeting, Axi/siRNAPD−L1@NGR-Lipo could act on tumor vascular endothelial cells to inhibit neo-angiogenesis, increase pericyte coverage and vascular perfusion, and normalize the structure and function of tumor blood vessels. Meanwhile, it also enhanced immune effector T cells and NK cells infiltration and reduced the proportion of immunosuppressive T cells including MDSC cells and Tregs, thus improving the tumor immunosuppressive microenvironment. …”
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