Discovery of CRISPR-Cas12a clades using a large language model by Yuanyuan Feng, Junchao Shi, Zhanwei Li, Yongqian Li, Jiaxi Yang, Shisheng Huang, Jinfang Zheng, Wei Han, Yunbo Qiao, Jun Zhang, Qi Liu, Yao Yang, Chunyi Hu, Lina Wu, Xiaokang Zhang, Jin Tang, Xingxu Huang, Peixiang Ma

“…We discover 7 undocumented Cas12a subtypes with unique CRISPR loci. Structural analyses reveal 8 subtypes of Cas1, Cas2, and Cas4. …”
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DSM-Based Precise Pointing Angle Deviation Measurement Method for Beaconless Free Space Optical Communication by Xueyuan Ao, Yansheng Zou, Yang Zou, Qirun Fan, Xiaoxiao Dai, Chen Liu, Qi Yang, Deming Liu

“…However, the separated beacon laser beam commonly used in ATP will increase the structural complexity of the terminal such as the size, weight, and power. …”
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Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study by Jianmeng Song, Edgardo Carmona-Torres, Yasaman Kambari, Sofia Chavez, Fumihiko Ueno, Teruki Koizum, Aron Amaev, Ali Abdolizadeh, Vincenzo De Luca, Daniel M. Blumberger, Gary Remington, Bruce Pollock, Ariel Graff-Guerrero, Philip Gerretsen

“…Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functional anomalies in frontoparietal brain regions. …”
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Design, synthesis, biological assessment, and in silico analysis of bisthiazolidine amide derivatives as potential anti-bacterial and anti-prostate cancer agents by Sabah Abbas, Ahmed A. Majed, Rehab G. Abood, Dunya AL-Duhaidahawi, Radwan Alanjjar, Huda Hadi Nameh, Naser A. Naser, Ahmed Y. Hammood, Mohammad Y. Alfaifi, Ali A. Shati, Serag Eldin I. Elbehairi, Ahmed M. Hussein, Mohammed Aufy

“…Literature from 2000 to 2023 was reviewed using PubMed and Scopus to guide compound selection. Structural characterization was confirmed via FT-IR, ¹H, ¹³C-NMR, and mass spectrometry. …”
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Geomechanical Basis for Assessing Open-Pit Slope Stability in High-Altitude Gold Mining by Farit Nizametdinov, Rinat Nizametdinov, Denis Akhmatnurov, Nail Zamaliyev, Ravil Mussin, Nikita Ganyukov, Krzysztof Skrzypkowski, Waldemar Korzeniowski, Jerzy Stasica, Zbigniew Rak

“…The developed calculation schemes take into account the structural features of the rock mass, geological conditions, and the design contours of the pit. …”
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Long-lasting sex-specific alteration in left ventricular cardiac transcriptome following gamma and simGCRsim radiation by Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Mary K. Khlgatian, Malik Bisserier, Shihong Zhang, Susmita Sahoo, Lahouaria Hadri, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A. Goukassian

“…We reported heart failure with preserved ejection fraction like cardiac phenotype 660-days following exposure to a single-dose of a simplified galactic cosmic ray simulation (simGCRsim) only in males with functional and structural impairment in left ventricular (LV) function. …”
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The sociodynamics of chemsex: Stakeholders’ perspectives in France - Results from the ANRS-PaacX study by Nicolas Khatmi, Perrine Roux, Bruno Spire, Christel Protière

“…Moreover, this division leads to structural obstacles for clinicians and community health workers providing care.This comprehensive analysis deepens our understanding of the complex mechanisms underlying chemsex and offers essential insights for crafting informed and effective public health interventions. …”
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Long-Term Effects of Musical Training and Functional Plasticity in Salience System by Cheng Luo, Shipeng Tu, Yueheng Peng, Shan Gao, Jianfu Li, Li Dong, Gujing Li, Yongxiu Lai, Hong Li, Dezhong Yao

“…Musicians undergoing long-term musical training show improved emotional and cognitive function, which suggests the presence of neuroplasticity. The structural and functional impacts of the human brain have been observed in musicians. …”
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Genetics, epidemiology and management of clubfoot and related disorders by Muhammad Umar, Liping Tong, Hongting Jin, Tamas Terebessy, Di Chen

“…This serious congenital anomaly results from structural abnormalities in the foot and lower leg, leading to abnormal positioning of the ankle and foot joints. …”
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Development and Validation of High-Performance Soil-Cement Panels: A Sustainable and Economical Alternative for Civil Construction by Bernat Vinolas Prat, Demisson Renato Ferreira, Luis Guilherme Monteiro Oliveira, João Vinícios Wirbitzki da Silveira, Frank Alisson De Carvalho, Marcus Vinícius Felix, Ellem Eva Augusto Rocha, José Domingos Fabris, Alexandre Christófaro Silva

“…Despite its advantages, conventional soil-cement has limitations in terms of mechanical strength and durability, especially in environments with high humidity or high structural demands. The development of high-performance soil-cement (HPSC) presents significantly superior mechanical properties. …”
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The mechanism and pharmacodynamics of 2-((1H-indol-3-yl)thio/sulfinyl)-N-pheny acetamide derivative as a novel inhibitor against human respiratory syncytial virus by Ningning Cheng, Nan Jiang, Yuanhui Fu, Zhuxin Xu, Xianglei Peng, Jiemei Yu, Shan Cen, Yucheng Wang, Guoning Zhang, Yanpeng Zheng, Jinsheng He

“…Our work suggests that further structural modification and optimisation of 2-((1H-indol-3-yl) thio/sulfinyl)-N-pheny acetamide derivative are needed to obtain drug candidates with effective anti-RSV activities in vivo.…”
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The First Complete Mitogenome Characterization and Phylogenetic Implications of <i>Elops machnata</i> (Teleostei: Elopiformes: Elopidae) by Jia-Yu Li, Xue-Fan Cui, Shu-He Chen, Yang Li, Shui-Yuan Zhang, Yuan-Feng Yang, Yi-Yang Li, Yu-Song Guo, Zhong-Duo Wang, Jian Liao

“…Amino acid composition analysis across 23 Elopomorpha species revealed consistently high leucine contents, and tRNA secondary structure prediction showed 21 tRNAs forming typical cloverleaf structures, except for <i>trnS1</i>(gct), which lacks the dihydrouridine (DHU) arm. …”
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Vascularized skin tissue models featuring adipose cell spheroid-laden GelMA hydrogels by Dongjin Lee, Sangmin Lee, Jeongbok Lee, Dahong Kim, Hyunseok Kwon, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Heungsoo Shin, Su A Park

“…The multifaceted tissue interplay between skin and adipose structures is increasingly recognized to play crucial roles in antimicrobial defense, hair cycling, wound healing, and thermogenesis. …”
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Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice by Anindya Ghosh, Isabelle Chénier, Yat Hei Leung, Abel K. Oppong, Marie-Line Peyot, S. R. Murthy Madiraju, Irina Al-Khairi, Jehad Abubaker, Fahd Al-Mulla, Marc Prentki, Mohamed Abu-Farha

“…AT-A8-KO mice also displayed improved glucose tolerance, a trend for better insulin sensitivity, improved insulin-stimulated glucose uptake in adipose tissues, and reduced visceral adipose tissue crown-like structures, plasma MCP-1 and leptin levels. The results indicate the importance of adipose Angptl8 in the context of nutri-stress and obesity, as its deletion in mice promotes a metabolically healthy obese phenotype by slightly ameliorating obesity, improving glucose and energy homeostasis, and mitigating inflammation.…”
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3D bioprinting of plant and animal cell-based hybrid food by Sushila Maharjan, Camila Yamashita, Cheng Pau Lee, Alejandro Villalobos Zepeda, Ana Karen Michel Farias, Andrea Duarte Rivera, Francisco Javier Aguilar Rojas, David Sebastian Rendon Ruiz, Armando Martinez Hernandez, David Hyram Hernandez Medina, Carlos Ezio Garciamendez-Mijares, Julia Japo, Ludivina Bermea Jimenez, Sonia Golombek, Alessandro Bentivogli, Michinao Hashimoto, Yu Shrike Zhang

“…One of the most promising methods within this domain is three-dimensional (3D) bioprinting, which allows for precise layering of cells to form sophisticated structures. In this study, we introduce fully automated chaotic bioprinting with a custom-built extrusion setup taking advantage of an integrated Kenics static mixer printhead to create plant and animal cell-based hybrid noodles. …”
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Adaptive-learning physics-assisted light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics by Lanxin Zhu, Jiahao Sun, Chengqiang Yi, Meng Zhang, Yihang Huang, Sicen Wu, Mian He, Liting Chen, Yicheng Zhang, Chunhong Zheng, Hao Chen, Jiang Tang, Yu-Hui Zhang, Dongyu Li, Peng Fei

“…While emerging light-field microscopy can mitigate this issue through three-dimensionally capturing biological dynamics with merely single snapshot, it suffers from suboptimal resolution insufficient for resolving subcellular structures. Here we propose an Adaptive Learning PHysics-Assisted Light-Field Microscopy (Alpha-LFM) with a physics-assisted deep learning framework and adaptive-tuning strategies capable of light-field reconstruction of diverse subcellular dynamics. …”
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Femtosecond X-ray cross-correlation analysis of disordered crystals forming in a supercooled atomic liquid by Johannes Möller, Michele Caresana, Alexander Schottelius, Felix Lehmkühler, Ulrike Boesenberg, Frédéric Caupin, Francesco Dallari, Tiberio A. Ezquerra, José M. Fernández, Luca Gelisio, Claudia Goy, Jörg Hallmann, Anton Kalinin, Chan Kim, Ruslan P. Kurta, Dmitry Lapkin, Francesco Mambretti, Markus Scholz, Roman Shayduk, René Steinbrügge, Florian Trinter, Ivan A. Vartanyants, Alexey Zozulya, Davide E. Galli, Gerhard Grübel, Anders Madsen, Robert E. Grisenti

“…We demonstrate an advanced scattering method for accessing the 3D reciprocal space of crystalline structures forming in a rapidly supercooled noble-gas liquid using a combination of femtosecond X-ray diffraction and X-ray cross-correlation analysis. …”
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Lightweight obstacle detection for unmanned mining trucks in open-pit mines by Guangwei Liu, Jian Lei, Zhiqing Guo, Senlin Chai, Chonghui Ren

“…Then the feature extraction structure of the YOLOv8 neck is replaced with the BiFPN (Bi-directional Feature Pyramid Network) structure. …”
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DERMOID AND EPIDERMOID CYSTS OF THE MAXILLOFACIAL AREA AND THE NECK AMONG CHILDREN by P.I. Tkachenko, I.I. Starchenko, S.O. Bilokon, Y.V. Popelo, N.P. Bilokon, V.V. Yarkovy

“…However, if there are no significant issues regarding the etiology and pathogenesis of dermoids and epidermoids, there is a problem of constant monitoring of their prevalence and structure for the formation of administrative organizational measures for the planning of specialized care for this category of patients. …”
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Analysis of Technologies for Applying High-Entropy Coatings by Physical Deposition Method by K. N. Polityko, I. V. Kolesnikov, D. S. Manturov

“…A schematic representation of the fundamental processes of structure formation was given. Defects in vacuum coatings were noted. …”
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