CellSeg3D, Self-supervised 3D cell segmentation for fluorescence microscopy by Cyril Achard, Timokleia Kousi, Markus Frey, Maxime Vidal, Yves Paychere, Colin Hofmann, Asim Iqbal, Sebastien B Hausmann, Stéphane Pagès, Mackenzie Weygandt Mathis

“…Understanding the complex three-dimensional structure of cells is crucial across many disciplines in biology and especially in neuroscience. …”
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Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart by Inge Van de Walle, Laura Bracke, Heidi Gytz Olesen, Tonke van Bragt, Stéphanie Cadour, Phillip De Decker, Giorgia Ciurlia, Erwin Pannecoucke, Emma K. Persson, Olivier Van de Steen, Xinghong Leng, Gregers Rom Andersen, Domenica Gandini, C. Erik Hack

“…Here, we resolve the crystal structure of empasiprubart complexed with C2, providing the molecular basis of its Ca2+ dependency, and report a randomized, double-blind, placebo-controlled trial to assess the safety and tolerability (primary objectives) in addition to pharmacokinetics, pharmacodynamics, and immunogenicity (secondary objectives) of empasiprubart in 78 healthy participants (NCT04532125). …”
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Probe-screened carbon nanotube field-effect transistor biosensor to enhance breast cancer-related gene assay by Pei Liu, Yiwei Liu, Bingjie Cai, Jiahao Li, Guo-Jun Zhang

“…In this study, a semiconductor carbon nanotube (CNT)-based field-effect transistor (FET) DNA sensor, with a floating gate (FG) structure and Y2O3 / HfO2 high κ bilayer gate dielectric, was constructed. …”
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Suburbanization and Local Governance - Positive and Negative Forms: Olomouc Case Study by Kladivo Petr, Roubínek Pavel, Opravil Zdeněk, Nesvadbová Martina

“…And it is not only the morphology of the municipality structure (new housing estates and their urban as well as architectural solutions) that has undergone the transformation, but also the functions municipalities have started to fulfil (the development of civic amenities and services). …”
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Keanekaragaman Burung di Desa Karangasem Kecamatan Wirosari Kabupaten Grobogan Jawa Tengah by Margareta Rahayuningsih, Fajar Adi Purnomo, Bambang Priyono

“…There are differences in composition, structure, and featured bird species of the habitat, which<br />caused low similarity index between the habitat ranges from 19.23% to 25.71%. …”
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Evaluating Proprietary and Open-Weight Large Language Models as Universal Decimal Classification Recommender Systems by Mladen Borovič, Eftimije Tomovski, Tom Li Dobnik, Sandi Majninger

“…Classification prompts utilized the RISEN framework, with evaluation using Levenshtein and Jaro–Winkler similarity, and a novel adjusted hierarchical similarity metric capturing UDC’s faceted structure. Proprietary systems consistently outperformed open-weight alternatives by 5–10% across metrics. …”
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Design and Control of Dual‐Body Negative Pressure Ground‐Wall Transition Robot by Huan Shen, Kai Cao, Jiajun Xu, Wenjun Yan, Xuefei Liu, Huan Wang, Youfu Li, Linsen Xu, Aihong Ji

“…As a typical representative of highly nonlinear and multivariable strongly coupled systems, the wall transition actions of the DNPTR are analyzed and planned based on the mechanical structure characteristics. Subsequently, unified kinematic and dynamic models of the bipedal negative‐pressure climbing robot are established. …”
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GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment by Rong Gao, Yongfeng Zhang, Bo Deng, Jiawei Zhang, Zhuowen Liang, Zhao Wei, Feng Xu, Tan Ding

“…In vivo, both 4 week and 8 week IVDD models demonstrated that GM@mTG-V markedly reduced tissue inflammation, accelerated ECM accumulation, and restored IVD structure, as confirmed by radiographic and histological analyses. …”
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Large system study of chalcopyrite and pyrite flotation surfaces based on SCC-DFTB parameterization method by Jianhua Chen, Yibing Zhang

“…The results of bulk modulus, atomic displacement, band structure, surface relaxation, surface Mulliken charge distribution, and adsorption tests of typical flotation reagents on mineral surfaces demonstrate that CuFeOrg achieves DFT-level accuracy while significantly outperforming DFT in computational efficiency. …”
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SuCCESs – a global IAM for exploring the interactions between energy, materials, land use, and climate systems in long-term scenarios (model version 2024-10-23) by T. Ekholm, N.-C. Freistetter, T. Mattlar, T. Schaber, A. Rautiainen, A. Rautiainen

“…This article introduces the model logic and structure, describes the overall representation of each system, and provides an evaluation by comparing the scenarios produced by SuCCESs with different end-of-century radiative forcing targets to those from other IAMs. …”
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A species-level multi-trophic metaweb for Switzerland by Merin Reji Chacko, Camille Albouy, Florian Altermatt, Joan Casanelles-Abella, Martin Brändle, Victor Boussange, Fadri Campell, Willem N. Ellis, Fabian Fopp, Martin M. Gossner, Hsi-Cheng Ho, Alain Joss, Pascal Kipf, Felix Neff, Andjeljko Petrović, Vincent Prié, Željko Tomanović, Nik Zimmerli, Loïc Pellissier

“…By integrating the metaweb with local species assemblages knowledge, future studies can gain insights into broad patterns of food web structure across spatial scales.…”
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Mexican Sage (Salvia officinalis) Extraction Using Factorial Design and Its Effect on Chemical and Antibacterial Properties by L. A. Conde-Hernández, M. L. Luna-Guevara, J. J. Luna-Guevara, J. Pérez-Vázquez, R. J. Aranda-García

“…Micrographs of sage leaves showed relevant changes in the structure after extraction. The antibacterial activity was confirmed with the inhibition diameter and inhibition percentage of all bacteria, and P. aeruginosa was the most resistant bacteria. …”
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Microbial synthesis of branched-chain β,γ-diols from amino acid metabolism by Peiling Wu, Haofeng Chen, Yueyang Chen, Yang Zhang, Jifeng Yuan

“…In summary, our work demonstrates the synthesis of structurally diverse branched-chain β,γ-diols, highlighting its potential as a versatile carbon elongation system for other β,γ-diol productions.…”
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Multi-decadal spatiotemporal dynamics of alpine plant functional types (PFTs) inferred from Landsat-derived fractional cover across the Yarlung Zangbo river basin, China by Qichi Yang, Lihui Wang, Xiaoqi Li, Xue Yan, Jinliang Huang, Yun Du, Feng Ling

“…Climate-induced shifts in the composition and structure of alpine vegetation cover, both expansion and reduction, are altering alpine ecosystem functions. …”
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3D-printed setup for ocular drug delivery evaluation on ex vivo porcine whole eye by Felipe M. González-Fernández, Daniele A. Cauzzi, Annalisa Bianchera, Paolo Gasco, Cristina Padula, Patrizia Santi, Sara Nicoli, Silvia Pescina

“…The porcine whole eye model proved capable of preserving eye structure integrity for at least 18 hours and, unlike the Franz-cell, enabled the evaluation of the drug’s lateral diffusion along the eye bulb.…”
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Demonstration of safety characteristics and effects on gut microbiota of Lactobacillus gasseri HMV18 by Xianxian Jia, Miaomiao Jia, Xiang Gao, Xiang Li, Mengyuan Wang, Shengqiang Du, Rui Huang, Xiaotong Li, Jun Zhang, Shujin Li, Chunling Ma, Yan Zhang, Bin Cong

“…L. gasseri HMV18 might not colonize in mice’s gut, but can signif icantly affect the structure of gut microbiota. A bibliographical survey suggested that there were as few as 8 opportunistic infection cases from 1984 to 2022 and that the possibility for L. gasseri to cause infection is relatively low. …”
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SAFH-Net: A Hybrid Network With Shuffle Attention and Adaptive Feature Fusion for Enhanced Retinal Vessel Segmentation by Yang Zhou Ling Ou, Joon Huang Chuah, Hua Nong Ting, Shier Nee Saw, Jun Zhao

“…Specifically, a parallel encoder architecture employs a Convolutional (Conv) block with a residual structure for local feature extraction alongside a hierarchical Swin Transformer with Shifted-Window Multi-head Self-Attention (SW-MSA) for global context modeling, thereby achieving comprehensive feature capture with minimal additional parameter overhead. …”
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A new species of the Phalloceros harpagos species complex (Cyprinodontiformes: Poeciliidae) from the middle and lower Uruguay River floodplains by Wilson Serra, Fabrizio Scarabino, Noelia Gobel, Gabriel Laufer

“…This species belongs to the P. harpagos species complex and is diagnosed by the following unique combination of characters: 1) presence of a symmetric hood-like structure located immediately anterior to the urogenital papilla in females, 2) absence of large papillae at the mandibular symphysis of large adult females, 3) possession of well-developed hooks positioned in distal portion of gonopodial appendices of males and 4) lateral spot usually present in both sexes. …”
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Genomic analysis of Plasmodium vivax field isolates circulating in sub-Saharan Africa by Isabelle Bouyssou, Lemu Golassa, Inès Vigan-Womas, Matthieu Schoenhals, Arsène Ratsimbasoa, Ali Ould Mohamed Salem Boukhary, Maria de Fátima Ferreira-da-Cruz, Sandrine Houzé, Laurence Ma, Feng Lu, Chetan Chitnis, Pascal Campagne, Didier Ménard

“…Here, we investigated the global genetic structure and diversity of sub-Saharan African P. vivax populations, exploring possible molecular signatures of adaptation to Duffy-negative hosts. …”
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A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction by V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii

“…To study on the subendocardial ischemia model in rats the peculiarities of the anti-ischemic action of p-FOX inhibitor trimetazidine and trihydrochloride N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine constructed on the basis of its structure (compound ALM-802) under conditions of endothelial dysfunction. …”
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