Development and Validation of an LC–MS/MS Method for Quantifying Gabapentin in Plasma: Application to a Pharmacokinetic Study in Cats by Feifei Zhao, Changcheng Lin, Yunying Wu, Xinyue Luo, Ning Han, Wenguang Xiong, Zhenling Zeng

“…The results demonstrated that the method exhibited satisfactory precision, accuracy and linearity. The pharmacokinetic results showed that the T_max, C_max, T_1/2 and AUC_0–t of GBP in cats after oral administration of 25  mg/kg were (1.83 ± 0.75) h, (13.94 ± 3.75) μg/mL, (5.60 ± 1.79) h and (115.54 ± 27.56) (μg/mL) h, respectively. …”
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A nationwide analysis of resource utilization and safety in patients undergoing mitral transcatheter edge-to-edge repair by Tharusan Thevathasan, Sophie Berlinghof, Daniel Elschenbroich, Julia M. Wiedenhofer, Sêhnou Degbeon, Luise Holzhauser, Fabian Barbieri, Mario Kasner, Anna Brand, Henryk Dreger, Steffen Desch, Ulf Landmesser, Markus Reinthaler, Carsten Skurk

“…All adverse outcomes increased linearly with increasing comorbidity burden (P for trend < 0.001). …”
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Investigation of illicit pregabalin in seized samples from Saudi Arabia by Fatimah M. Alamri, Fatimah M. Alamri, Sultan K. Alshmmari, Monerah A. Altamimy, Ibrahim A. Al Othaim, Yahya M. Alshehri, Rayed M. Alafraa, Ahmed D. Almalki, Turki A. Alkhalifah, Taher Sahlabji, Abubakr M. Idris, Abubakr M. Idris, Haitham Al-Hamoud, Yahya F. Jamous, Fahad S. Aldawasri

“…A complementary liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used to detect potential adulterants.ResultsThe UPLC-PDA method demonstrated linearity (r = 0.9973) for PGL quantification (0.50–3.00 mg/mL), with an accuracy of 96%–102%. …”
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Avaliação das habilidades culinárias de estudantes ingressantes em uma universidade pública by Giuliana Caruso Tangerino, Ricardo Teixeira Quinaud, Daniela Silva Canella, Maria Eduarda Ribeiro, Patrícia Maria Périco Perez, Ana Cláudia Mazzonetto

“…A análise estatística foi realizada por regressões lineares multiníveis e as variações de respostas foram analisadas de acordo com as dimensões do QBHC agregadas por faixa etária, se considera que sabe cozinhar e se mora com os pais e sem filhos. …”
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Determination of A1 and A2 β-casein in cow milk by high-performance liquid chromatography tandem mass spectrometry by Fengen Wang, Min Ding, Ruiju Li, Kun Wang, Xiuxin Zhao, Xia Li, Zengmei Li, Shiming Guo, Ligang Deng, Jianbin Li

“…The method demonstrated good specificity, sensitivity, and linearity for both A1 and A2 characteristic peptides, with limit of detection of 0.01 and 0.03 mg/L, limit of quantitation of 0.03 and 0.1 mg/L, and determination coefficients of 0.9994 and 0.9992, respectively. …”
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A double-layered paper-based analytical device for speciation and simultaneous determination of iron in waters within single-shot analysis by Surachet Thongchan, Punyapat Sookpotarom, Wiboon Praditweangkum, Panumart Thongyoo, Neso Sojic, Nathawut Choengchan

“…Under the optimal conditions, the calibrations, ranging from 0–0.5 mg L-1 Fe (II) and 0–10 mg L-1 Fe (III) are observed with good linearity (r2 > 0.99). Detection limits (3SD) of 0.02 mg Fe (II) L-1 and 0.21 mg Fe (III) L-1 are achieved. …”
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Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [11C]DPA713 PET/CT by Ivo J. Lutke Schipholt, Ivo J. Lutke Schipholt, Gwendolyne G. M. Scholten-Peeters, Meghan A. Koop, Michel W. Coppieters, Michel W. Coppieters, Ronald Boellaard, Elsmarieke van de Giessen, Elsmarieke van de Giessen, Bastiaan C. ter Meulen, Bastiaan C. ter Meulen, Marieke Coenen, Carmen Vleggeert-Lankamp, Paul R. Depaauw, Bart N. M. van Berckel, Adriaan A. Lammerstma, Adriaan A. Lammerstma, Maqsood Yaqub

“…The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [11C]DPA713 uptake in the spinal cord and neuroforamina in patients with painful cervical radiculopathy, (2) evaluate the performance of linearized methods (e.g., Logan) and simplified (e.g., standardized uptake value - SUV) methods, and (3) assess the test-retest reliability of these methods. …”
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Assessment of pan coefficient performance: A comparative study of empirical and model-driven approaches using a hill-climbing-based alternating model tree and MOORA by Saad Javed Cheema, Aitazaz A. Farooque, Mehdi Jamei, Khabat Khasravi, Farhat Abbas, Suqi Liu, Travis J. Esau, Kuljeet Singh Grewal

“…However, this is quite challenging due to variations in climate change and the deep non-linearity of meteorological data. Intensive experiments for pan evaporation (Epan) were conducted to develop a model, which includes hill-climbing based BestFirst-ClassifierSubsetEval (BF), alternating model tree (AMT), and multi-objective optimization by ratio analysis (MOORA). …”
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Stress hyperglycemia ratio and risk of incident myocardial infarction in the general population: a large-scale cohort study by Wenke Cheng, Xianlin Zhang, Jiqian Shi, Huaiyu Ruan, Pinfang Kang, Hongyan Sun, Meiyang Xu, Zhongyan Du, Bi Tang

“…RCS analysis revealed a U-shaped relationship between SHR and incident AMI risk (P for non-linearity &lt; 0.001), with the lowest risk at an SHR of 0.966.ConclusionIn the general population without known CVD, SHR exhibited a U-shaped association with incident AMI risk, with the lowest risk observed at an SHR of 0.966, particularly at levels below this threshold.…”
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A Massive Black Hole 0.8 kpc from the Host Nucleus Revealed by the Offset Tidal Disruption Event AT2024tvd by Yuhan Yao, Ryan Chornock, Charlotte Ward, Erica Hammerstein, Itai Sfaradi, Raffaella Margutti, Luke Zoltan Kelley, Wenbin Lu, Chang Liu, Jacob Wise, Jesper Sollerman, Kate D. Alexander, Eric C. Bellm, Andrew J. Drake, Christoffer Fremling, Marat Gilfanov, Matthew J. Graham, Steven L. Groom, K. R. Hinds, S. R. Kulkarni, Adam A. Miller, James C. A. Miller-Jones, Matt Nicholl, Daniel A. Perley, Josiah Purdum, Vikram Ravi, R. Michael Rich, Nabeel Rehemtulla, Reed Riddle, Roger Smith, Robert Stein, Rashid Sunyaev, Sjoert van Velzen, Avery Wold

“…This result aligns with expectations from cosmological simulations that the number of offset MBHs scales linearly with the host halo mass.…”
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An Optimized Liquid Chromatography–Mass Spectrometry Method for Ganglioside Analysis in Cell Lines by Akeem Sanni, Andrew I. Bennett, Yifan Huang, Isabella Gidi, Moyinoluwa Adeniyi, Judith Nwaiwu, Min H. Kang, Michelle E. Keyel, ChongFeng Gao, C. Patrick Reynolds, Brian Haab, Yehia Mechref

“…A standard gangliosides calibration curve demonstrated excellent linearity (R² = 0.9961–0.9975). The ZIC-HILIC column provided the best separation of ganglioside GD1 isomers with a 25 min runtime. …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…title=Population_structure_and_ageing…”
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Numerical study on the mechanism of shear performance degradation of thawing glacial debris by Qiujie MENG, Yixiang SONG, Da HUANG, Wenzhu MA, Zhu ZHONG

“…The temperature of the critical point decreases with an increase in initial shear stress, and they are approximately linearly related. At higher shear stress levels, the shear strain of glacial debris is highly sensitive to temperature changes. …”
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Development of a green GC-FID method for residual solvent analysis in paliperidone nanocrystal formulations: Validation and greenness assessment by Manohar S K, Gowrav M P, Mounika P, Karthika Paul, Hemanth Vikram P R, Maged Mohammed Abdo Mohsen, Bannimath Gurupadayya

“…Validation following ICH guidelines confirmed method specificity, sensitivity and linearity within a 2–10 µL/mL range. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were found to be 0.0047 µL/mL and 0.0136 µL/mL, respectively. …”
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PRINCIPLES OF FUTURE INTERPRETERS’ COMMUNICATIVE CULTURE DEVELOPMENT by Zavizion Kateryna

“…The identified principles encompass multiculturalism (developing future interpreters’ abilities to comprehend the national peculiarities of individuals from different nations, the skill to understand ethnosociocultural features of interlocutors, and identifying the cultural subtext of messages), communicativeness (immersing learners in an environment that closely resembles the conditions of their future professional activity; engaging future interpreters in discussions, debates, dialogues, and other forms of communication during the course), interactivity (creating conditions for various ways and forms of interaction among students, e. i. working in pairs, mini and small groups, teams, etc. and with the instructor), non-linearity (a comprehensive approach to form a multicultural language personality capable of effective bilingual mediation between representatives of various nations), systematicity and consistency (formation of the communicative culture of future interpreters based on the logical presentation, sequence, and hierarchy of material in the educational process), professional personal orientation (selecting educational and methodological materials, forms and methods of conducting classes, tasks for independent preparation, which fully correspond to the general strategy of professionalization of academic vocational training), independence (redistribution of time between individual and classroom work in favour of the individual one, which will contribute to the development of student independence, autonomy, the formation of self-organization skills within the framework of preparation and execution of assigned tasks, activation of the use of information technologies, and, as a result, the transformation of the educational information environment into an open system that is constantly enriched by external sources of information), tutoring (shift of emphasis from the teacher to the student and their personal responsibility for the course and results of learning), empathy and tolerance (understanding the experiences, emotions and feelings of the interlocutor that arise during bilingual intercultural communication). …”
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Relationship between multidimensional sleep health and depression during late pregnancy: a cross-sectional study by Yueying Wang, Jinle Wang, Pei Chen, Jiahui Zhang, Qin Lin, Bilgay Izci-Balserk, Yan Li, Bei Bei, Bingqian Zhu

“…There was a dose-response relationship between composite sleep health score and depression, with a higher sleep health score associated with a lower risk of depression (OR = 0.572, 95%CI = 0.423–0.774, p for linearity < 0.001). Controlling for covariates, poor sleep quality (OR = 3.485, 95%CI = 1.817–6.683, p < 0.001), short sleep duration (OR = 3.462, 95%CI = 1.513–7.924, p = 0.003), and excessive daytime sleepiness (OR = 3.409, 95%CI = 1.804–6.442, p < 0.001) were associated with a higher risk of depression. …”
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Optimization of the Method for Spectrofluorimetric Determination of Aluminum Impurities in Substances by E. V. Vishnyakov, A. A. Tolstikova, J. E. Generalova, A. K. Kaldybaeva, I. I. Terninko

“…Method validation was carried out according to three parameters "Specificity", "Linearity" and "Limit of detection". Comparison of the data obtained was carried out using atomic emission spectroscopy, during which the relevance of the technique was proved.Conclusion. …”
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Development and Validation of the HPLC Method for Quantification of the Innovative Drug DD217, Factor Xa Inhibitor, in Rat Plasma for a Pharmacokinetic Study by N. S. Dubovik, D. F. Guranda, G. V. Ramenskaya, D. G. Tovbin, D. N. Tarasov, A. Yu. Savchenko, V. S. Arnautov

“…Method was validated by linearity, lower limit of quantification, selectivity, accuracy and precision, dilution integrity, matrix effect, recovery, carry-over, and stability. …”
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Ecological dichotomies of solar energy expansion: resilience in arid regions versus fragility in humid ecosystems by Jianhua Xiao, Panxing He, Yong Li, Mingjie Shi, Yang Li, Jun Ma

“…Furthermore, the relationship between the scale of PV installations and their ecological impact in the humid region was characterized by a pronounced non-linearity, with large-scale PV plants (spanning &gt;10,000 pixels) causing near-total vegetation collapse, driving NDVI toward near-zero. …”
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Rapid On-site Detection of Microleakage of Lithium Battery Electrolytes by Vacuum-Assisted Volatilization-Portable Gas Chromatography-Mass Spectrometry by Xin-xin LU, Shuo ZHANG, Kai XU, Jun-wei QIU, Hui-jun ZHU, Yu-lin CHEN, Xiao-xu LI

“…The results show a good linearity in the concentration range of 7.85-5270 μg/m3 and 5078-89167 μg/m3 with the coefficient (R2) greater than 0.997, and the recovery of standard addition is between 84.21% and 103.21%. …”
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