Recognition Accuracy Using 3D Endoscopic Images for Superficial Gastrointestinal Cancer: A Crossover Study by Kosuke Nomura, Mitsuru Kaise, Daisuke Kikuchi, Toshiro Iizuka, Yumiko Fukuma, Yasutaka Kuribayashi, Masami Tanaka, Takahito Toba, Tsukasa Furuhata, Satoshi Yamashita, Akira Matsui, Toshifumi Mitani, Shu Hoteya

“…The evaluation items were as follows: (1) diagnostic accuracy of the tumor extent and (2) confidence levels in assessing (a) tumor extent, (b) morphology, (c) microsurface structure, and (d) comprehensive recognition. Results. …”
Get full text

A Review of Multiscale Interaction Mechanisms of Wind–Leaf–Droplet Systems in Orchard Spraying by Yunfei Wang, Zhenlei Zhang, Ruohan Shi, Shiqun Dai, Weidong Jia, Mingxiong Ou, Xiang Dong, Mingde Yan

“…Key variables affecting spray performance—such as wind speed and turbulence structure, leaf biomechanical properties, droplet size and electrostatic characteristics, and spatial canopy heterogeneity—are identified and analyzed. …”
Get full text

Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases by Irene Sambri, Rosa D'Alessio, Yulia Ezhova, Teresa Giuliano, Nicolina Cristina Sorrentino, Vincenzo Cacace, Maria De Risi, Mauro Cataldi, Lucio Annunziato, Elvira De Leonibus, Alessandro Fraldi

“…By studying mouse models of LSDs, we found that neurodegeneration develops progressively with profound alterations in presynaptic structure and function. In these models, impaired lysosomal activity causes massive perikaryal accumulation of insoluble α‐synuclein and increased proteasomal degradation of cysteine string protein α (CSPα). …”
Get full text

Unveiling diagnostic biomarkers and therapeutic targets in lung adenocarcinoma using bioinformatics and experimental validation by Sixuan Wu, Yuanbin Tang, Qihong Pan, Yaqin Zheng, Yeru Tan, Junfan Pan, Yuehua Li

“…Abstract Lung adenocarcinoma (LUAD) is a major challenge in oncology due to its complex molecular structure and generally poor prognosis. The aim of this study was to find diagnostic markers and therapeutic targets for LUAD by integrating differential gene expression analysis, weighted gene co-expression network analysis (WGCNA), and machine learning methods. …”
Get full text

Community assembly characteristics of abundant and rare bacterial taxa in water, sediment and riparian soil of Wujiang river, China by Yang Yang, Chen Chen, Hans-Peter Grossart, Yingliang Liu

“…A distance-decay relationship appeared only in water communities, indicating stronger spatial structuring, while sediment and soil communities were mainly shaped by environmental factors. …”
Get full text

exoALMA. XVI. Predicting Signatures of Large-scale Turbulence in Protoplanetary Disks by Marcelo Barraza-Alfaro, Mario Flock, William Béthune, Richard Teague, Jaehan Bae, Myriam Benisty, Gianni Cataldi, Pietro Curone, Ian Czekala, Stefano Facchini, Daniele Fasano, Misato Fukagawa, Maria Galloway-Sprietsma, Himanshi Garg, Cassandra Hall, Jane Huang, John D. Ilee, Andrés F. Izquierdo, Kazuhiro Kanagawa, Eric W. Koch, Geoffroy Lesur, Cristiano Longarini, Ryan A. Loomis, Ryuta Orihara, Christophe Pinte, Daniel J. Price, Giovanni Rosotti, Jochen Stadler, Gaylor Wafflard-Fernandez, Andrew J. Winter, Lisa Wölfer, Hsi-Wei Yen, Tomohiro C. Yoshida, Brianna Zawadzki

“…Supporting these scenarios requires further methodically comparing the predicted perturbations and the observed disks’ complex dynamic structure.…”
Get full text

Plant diversity and transcriptional variability assessed by retrotransposon-based molecular markers by R. N. Kalendar, K. S. Aizharkyn, O. N. Khapilina, A. A. Amenov, D. S. Tagimanova

“…Retrotransposon activity can occur during development, cell differentiation and stress, and a source of chromatin instability and genomic rearrangements. Both the overall structure of retrotransposons and the domains responsible for the various phases of their replication are highly conserved in all eukaryotes. …”
Get full text

Analysis of Coordinated Operation of the Clean Energy System Based on the Multiobjective Optimization Model by Xunyang Wang, Zhicheng Ma, Chen Liang, Shien He, Yongqiang Wang

“…The model seeks to maximize power generation and minimize output fluctuations, power purchase costs, and maintenance costs under the constraints of the grid structure. In this paper, the GA_PSO joint algorithm has an accelerated effect on the target optimization calculation, and then the superiority of the GA_PSO algorithm is verified by the IEEE14 standard system. …”
Get full text

Replacing protruding domains of MrNV virus-like particles with sialic acid binding domains enhances binding to SARS-CoV-2 susceptible cells and reduces pseudovirus infection by Supawich Boonkua, Orawan Thongsum, Rueangtip Chantunmapitak, Purimpuch Soongnart, Somkid Jaranathummakul, Kitima Srisanga, Patompon Wongtrakoongate, Somluk Asuvapongpatana, Wattana Weerachatyanukul, Atthaboon Watthammawut, Monsicha Somrit

“…The tsCRD-MrNV-VLPs maintained their icosahedral structure and increased binding and uptake into ACE2-overexpressing cells. …”
Get full text

Characterizing the Observational Properties of the Sun’s High-latitude m = 1 Inertial Mode by Boyang Ding, Junwei Zhao, Ruizhu Chen, Matthias Waidele, Sushant S. Mahajan, Oana Vesa

“…These observational findings underscore the need for a deeper understanding of the internal dynamics of the low- m modes, which may offer valuable insights into the structure and dynamics of the solar interior.…”
Get full text

Alphaflexiviridae in Focus: Genomic Signatures, Conserved Elements and Viral-Driven Cellular Remodeling by Jesús R. Úbeda, Miguel A. Aranda, Livia Donaire

“…In this review, we summarize the current knowledge on the genomic structure, conserved genes, and phylogenetic relationships within <i>Alphaflexiviridae</i>, with a particular focus on the replicase and coat protein genes as signature markers. …”
Get full text

Thyroid‐Targeted Nano‐Bombs Empower HIFU for Graves' Disease by Binhao Wang, Zhuobing Yin, Xiangyue You, Hanwei Peng, Ying Jiang

“…In this study, a thyroid‐targeted nano‐bomb system (PD‐PLGA@Si‐Ab/PDA‐I, PSAPI) is developed to enhance HIFU efficacy and improve therapeutic outcomes for GD. The core structure of PSAPI encapsulates a phase‐transition material, perfluorohexane, and the anti‐inflammatory drug diclofenac within a poly(lactide‐co‐glycolide) (PLGA) and silica shell. …”
Get full text

Mixed Ni-Co sub-stoichiometric spinels as catalytic precursors for dry reforming of methane by Andoni Choya, Amaya Gil-Barbarin, Beatriz de Rivas, Jose Ignacio Gutiérrez-Ortiz, Rubén López-Fonseca

“…On the other hand, all the reduced catalysts presented a comparable structure, with crystallites of sizes between 20 and 30 nm composed of a homogeneous Ni-Co alloy, with the absence of isolated metals. …”
Get full text

Low-Finesse Fabry–Perot Cavity Design Based on a Reflective Sphere by Ju Wang, Ye Gao, Jinlong Yu, Hao Luo, Xuemin Su, Xu Han, Yang Gao, Ben Cai, Chuang Ma

“…By utilizing beam divergence characteristics and geometric parameters, a structure with a finesse of approximately 0.5 is quantitatively designed, enabling a simplified implementation without the need for angular alignment. …”
Get full text

A composite index-based insurance instrument for managing the financial risk of variable hydrometeorology for electric utilities by Yash Amonkar, Corey Pahel-Short, Amir Zeighami, Yufei Su, Jordan D Kern, Gregory W Characklis

“…Overall, this case study represents a new approach to managing financial risk arising from hydrometeorological and market variability for vertically integrated utilities, the most common utility structure.…”
Get full text

Potency evaluation of erythropoietin products: current status by L. A. Gaiderova, N. A. Alpatova, S. L. Lysikova, A. M. Guskov, O. V. Golovinskaya

“…This article presents information on the molecular structure of erythropoietin. The glycosylation profile of erythropoietin not only accounts for most of the differences in the half-life and biodegradation rate but also significantly influences the potency of rhEPO products. …”
Get full text

Effect of Retinoic Acid on the Cerebral Vasculature: Analysis of the Vasoactive Response of Smooth Muscle Cells in Normal and Ischemic Contexts by Manuel R. Pouso, Emanuel Farinha, Henrique E. Costa, Margarida Lorigo, Graça Baltazar, Elisa Cairrao

“…Retinoic acid (RA), a vitamin A derivative, has been shown to prevent the development of neurological disorders by ensuring the integrity of the physiological structure of the neurovascular unit and regulating the physiological cell’s function. …”
Get full text

Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection by Qingrui Huang, Qingyun Lang, Yao Li, Fengjie Wang, Xiaonan Han, Ling Luo, Xiaomin Duan, Xuerong Cao, Yue Wang, Yu Bai, Yaxin Song, Yanpeng Xu, Lianlian Bian, Chenyan Gao, Linqing Zhao, Jinghua Yan

“…The resulting variant, preF7P, is structurally and biochemically validated to maintain the correct prefusion state. …”
Get full text

Amorphous Fe-Doped Manganese Carbonate for Efficient Activation of Peroxymonosulfate: Mechanism and Performance Toward Orange II Degradation by Peng Cheng, Yuqing Li, Yunlong Ma, Cui Qiu, Tengfei Fu, Yajie Wang, Feng Wu

“…Characterization results indicated that Fe doping effectively induced an amorphous structure and increased surface area and oxygen defects, promoting PMS activation. …”
Get full text

Probing solid-state diffusion and its synergistic role with preferential oxidation in enhancing the ablation performance of multiphase multicomponent carbide by Ziming Ye, Jiao Hu, Yi Zeng, Xiang Xiong, Nan Ye, Haiou Zhuo, Ben Huang, Jiancheng Tang, Huilin Lun

“…Multiphase multicomponent ultrahigh-temperature ceramics (UHTCs) hold great promise for achieving better ablation performance because of their broader structure and compositional tunability. However, the knowledge gap with respect to ablation mechanisms hinders the design and optimization of these materials. …”
Get full text