Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis by Yang Bai, Ting Xie, Xiangyang Mo, Yong Luo, Man Chen

“…Compared with the GATA3-negative group, GATA3-positive tumors exhibited lower FA but higher MD, Dr, and Da values (P < 0.05), suggesting more preserved tissue structure. Ultrasound analysis showed that GATA3-positive tumors had less vascularity, posterior attenuation, and irregular margins (P < 0.05). …”
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Methods for processing and analyzing images of vascularized micro-organ and tumor systems by Stephanie J. Hachey, Christopher J. Hatch, Daniela Gaebler, Alexander G. Forsythe, Makena L. Ewald, Alexander L. Chopra, Zhangying Chen, Kapil Thapa, Melvin Hodanu, Jennifer S. Fang, Jennifer S. Fang, Jennifer S. Fang, Christopher C. W. Hughes, Christopher C. W. Hughes, Christopher C. W. Hughes

“…Within this system, diverse cell types self-organize into perfused microvascular networks under dynamic flow within tissue chambers, effectively mimicking the structure and function of native tissues. This setup facilitates physiological intravascular delivery of nutrients, immune cells, and therapeutic agents, and creates a realistic microenvironment to study cellular interactions and tissue responses. …”
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R5S4TRAIL ameliorates radiation-induced pulmonary fibrosis by alleviating inflammatory responses and promoting apoptosis of fibroblasts by Yaqin Zhao, Yaqin Zhao, Yaqin Zhao, Yuanfeng Wei, Yuanfeng Wei, Wanting Hou, Wanting Hou, Wanting Hou, Xianzhou Huang, Qiaoqi Li, Qiaoqi Li, Cheng Yi, Cheng Yi

“…In our research, we have constructed a novel TRAIL mutant with CPP-like and Smac-like structure (R5S4TRAIL) and aim to explore the role and molecular mechanism of R5S4TRAIL in RIPF.MethodsFirstly, the RIPF model was established in C57BL/6 mice. …”
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The Role of RNA Polymerase II Contiguity and Long-Range Interactions in the Regulation of Gene Expression in Human Pluripotent Stem Cells by Livia Eiselleova, Viktor Lukjanov, Simon Farkas, David Svoboda, Karel Stepka, Irena Koutna

“…The eukaryotic nucleus is a highly complex structure that carries out multiple functions primarily needed for gene expression, and among them, transcription seems to be the most fundamental. …”
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Domain Knowledge Decomposition for Cross-Domain Few-Shot Scene Classification From Remote Sensing Imagery by Can Li, He Chen, Yin Zhuang, Liang Chen, Lianlin Li

“…First, a cross-domain pseudo-label decomposed learning structure is proposed for DKD to facilitate domain-common knowledge transfer and correct interference with domain-specific knowledge. …”
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Effects of the Gully Land Consolidation Project on soil properties and carbon stocks of farmland in the Chinese Loess Plateau by Zeqiong Qiu, Tingjun Gong, Xiaocao Chen, Xia Yu, Qixin Wu, Yanling An, Jie Zeng

“…These results indicate that although the GLC project can improve soil structure and water retention capacity, it may also lead to the loss of surface SOC, thereby reducing soil fertility. …”
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In silico identification of potential HDAC3 inhibitors through machine learning, molecular docking, and molecular dynamics simulations for drug repurposing by Damilare P. Dosunmu, Rachael Oluwakamiye Abolade, Mujeebat Bashiru, Adedoyin John-Joy Owolade, Muyiwa Kolawole Samuel, Ebunoluwa Omorilewa Boluwatife, Ayomadewa Mercy Olatunya, Precious O. Aribisala, Samuel Aduramurewa Osunnaya, Micheal Abimbola Oladosu, Ebenezer Ayomide Oni, Damilola Samuel Bodun

“…We then employed both virtual and structure-based screening to identify and repurpose current drugs as selective inhibitors against the HDAC3 target protein. …”
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The role of Genipin crosslinked extracellular matrix loaded bFGF in the repair of peripheral nerve injury by Yijia Zhang, Gaobao Zhuo, Fangzheng Yu, Xiaodan Xu, Zejing Ruan, Xinyu Hu, Jian Wang, Junyi Zhu

“…Results The results demonstrated that the thread-like spatial structure of the sciatic nerve was preserved within the extracellular matrix (ECM) after decellularization. …”
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Effects of oilseed meals on black soldier fly larvae: growth, nutritional composition, gut microorganisms, and chemical property by Xifeng Wang, Xiangru Tian, Juli Sun, Jin Zhao, Yanpeng Xu, Zhuoxin Li, Haifeng Li, Pengxiao Chen, Jianhang Qu

“…This finding clearly demonstrates that substrate composition plays a pivotal role in shaping gut microbiota structure. Furthermore, peptide hydrolysates derived from oilseed meal-reared BSFL displayed superior antioxidant capacity over CK, suggesting that oilseed meals enhance the bioactive properties of BSFL-derived products. …”
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Dispersion Characteristics of Complex Resistivity and Petroelectric Parameters of Deep Coal Seam in the Ordos Basin by DENG Ze, ZHAO Qun, FAN liyong, GE Xinmin, HUANG Daojun, SHI Lei, WANG Ziming, ZHANG Yonghao

“…The complex pore structure, metamorphic degree and mineral components have a great impact on the electrical conductivity characteristics of deep coal seams, posing significant challenges to the evaluation of saturation based on electrical parameters. …”
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Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study) by José A. Pérez-Molina, Elena Moreno, Clara Crespillo-Andújar, Sandra Chamorro-Tojeiro, Marta Arsuaga, Leticia Olavarrieta, Oihane Martín, Begoña Monge-Maillo, Francesca Norman, Val F. Lanza, Sergio Serrano-Villar

“…Diversity metrics (Chao1/ACE indices and multidimensional scaling) and sPLS-DA modelling were used to explore community structure. No significant group differences were observed for alpha- and beta-diversity of bacterial functions; only 6–7 % of variance was attributable to infection status or prior benznidazole therapy. …”
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Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany by Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand

“…In contrast, other RTs showed a heterogenic population structure. Conclusions This study provides first insights into the distribution of C. difficile genotypes, corresponding antimicrobial resistance, and clonal relatedness using cgMLST, highlighting RT027 as the second most common genotype for the studied area. …”
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Comparative analysis of mitochondrial genomes in lycoperdaceae fungi reveals intron dynamics and phylogenetic relationships by Xianyi Wang, Guoyu Wang, Jiawei Tao, Zhongyao Guo, Guangyin Xu, Jiayu Li, Jichuan Kang, Qin Zuo, Hongmei Liu, Qirui Li

“…However, mitochondrial genome data for the Lycoperdaceae family is insufficient, and investigating its structure offers valuable insights into the evolutionary relationships between puffball fungi and other Agaricales taxa. …”
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Fractal Properties of Various Clay Minerals Obtained from SEM Images by Naser Golsanami, Shanilka Gimhan Fernando, Madusanka Nirosh Jayasuriya, Weichao Yan, Huaimin Dong, Likai Cui, Xu Dong, Ehsan Barzgar

“…The fractal dimension (D) and lacunarity (L) values of the clays’ internal pore structure fell in the ranges of 1.51-1.85 and 0.18-0.99, respectively. …”
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ChemicalUniverseMachine. I. Uncovering the Cosmic Evolution of Metals in the Galaxy–Interstellar Medium–Circumgalactic Medium Ecosystem by Moka Nishigaki, Peter Behroozi, Masami Ouchi, Hong Guo, Rachel S. Somerville, Anna R. Gallazzi, Kimihiko Nakajima, Kuria Watanabe

“…We present an empirical chemical evolution model that explains the distribution of metals in the interstellar medium (ISM) and the circumgalactic medium (CGM) of galaxies based on the U niverse M achine and N eutral U niverse M achine models in the framework of ΛCDM structure formation. We parameterize the fractions of outflowing metals returned and mixed into the multiphase ISM of the star-forming regions ( f _H2 ) and into the neutral gas regions ( f _H I ); metal production, transfer, and dilution are caused by star formation, galaxy mergers, and gas inflow from the intergalactic medium, respectively, with rates determined by the ( N eutral) U niverse M achine models. …”
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Grain yield and grain moisture associations with leaf, stem and root characteristics in maize by Chen-chen XU, Ping ZHANG, Yuan-yuan WANG, Ning LUO, Bei-jing TIAN, Xi-wei LIU, Pu WANG, Shou-bing HUANG

“…A large maximum leaf area contributed to a high yield, a fast leaf senescence rate accelerated grain dehydration in the late growth period, and a compact root structure resulted in both of high-yield and fast-grain dehydration. …”
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Confinement Effect and Hydrogen Species Modulation toward Enhanced Electrochemical CO2 Reduction to Ethanol by Yuting Zhu, Jiamin Zhu, Huizhi Li, Shuhui Li, Yue Zhai, Shao-Wen Xu, Shanshan Wu, Yuan Chen, Yafu Wang, Rui Ren, Li An, Jiangwei Zhang, Pinxian Xi, Chun-Hua Yan

“…Here, we developed a CuCl-mediated synthesis strategy integrated with rare-earth doping electronic structure engineering, which enriches intermediates and promotes adsorbed hydrogen (*H) participation in reactions, respectively. …”
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Phylogenomic relationships and species delimitation of Cotoneaster ser. Pannosi, ser. Buxifolii, and related taxa by Jiaxuan Huang, Sufang Chen, Kaikai Meng, Mingwan Li, Wanyi Zhao, Na Wang, Qiang Fan, Wenbo Liao

“…Phylogenetic relationships were reconstructed using two datasets: 1) chloroplast genomes generated through shallow genome sequencing and 2) single-nucleotide polymorphisms (SNPs) obtained from restriction site-associated DNA sequencing (RAD-seq), complemented by genetic structure analyses. The taxonomic framework equally prioritizes nuclear clade monophyly [Shimodaira–Hasegawa approximate likelihood ratio test (SH-aLRT) ≥ 80% and ultrafast bootstrap (UFboot) ≥ 95%] and discrete genetic cluster membership (cluster assignment probability ≥ 95%) as primary delimitation criteria, complemented by morphological discontinuity (≥ 2 traits) and chloroplast phylogeny concordance. …”
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PolSAR-MPIformer: A Vision Transformer Based on Mixed Patch Interaction for Dual-Frequency PolSAR Image Adaptive Fusion Classification by Xinyue Xin, Ming Li, Yan Wu, Xiang Li, Peng Zhang, Dazhi Xu

“…However, the lack of local-spatial information within samples and correlation information among samples, as well as the complexity of network structure, limit the application of ViT in practice. …”
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Histone depletion prevents telomere fusions in pre-senescent cells. by Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M Muñoz-Cabello, Félix Prado

“…This protection associates neither with changes in bulk telomere length nor with major changes in the structure of subtelomeric chromatin. We show that the absence of Mec1 and Tel1 strongly augments double-strand break (DSB) repair by non-homologous end joining (NHEJ), which might contribute to the high frequency of T-TFs in mec1Δ tel1Δ cells. …”
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