Network Pharmacology Approaches to Myocardial Infarction Reperfusion Injury: Exploring Mechanisms, Pathophysiology, and Novel Therapies by Joy Das, Ashok Kumar Sah, Ranjay Kumar Choudhary, Rabab H. Elshaikh, Utpal Bhui, Shreya Chowdhury, Anass M. Abbas, Manar G. Shalabi, Nadeem Ahmad Siddique, Raji Rubayyi Alshammari, Navjyot Trivedi, Khoula Salim Ali Buwaiqi, Said Al Ghenaimi, Pranav Kumar Prabhakar

“…Post-reperfusion recovery is further complicated by structural and functional abnormalities such as microvascular obstruction, endothelial dysfunction, and myocardial stunning. …”
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Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury by Yang Feng, Yahui Feng, Liming Gu, Wei Mo, Xi Wang, Bin Song, Min Hong, Fenghao Geng, Pei Huang, Hongying Yang, Wei Zhu, Yang Jiao, Qi Zhang, Wei-Qun Ding, Jianping Cao, Shuyu Zhang

“…Here, we showed that ionizing radiation disrupted the structural integrity of BH4 and downregulated GTP cyclohydrolase I (GCH1), which is the rate-limiting enzyme in BH4 biosynthesis, resulting in deficiency in overall protein S-nitrosylation. …”
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Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner by Beatriz Pacheco-Sánchez, Sonia Melgar-Locatelli, Raquel López-Merchán, María José Benítez-Marín, Marta Blasco-Alonso, Ernesto González-Mesa, Rubén Tovar, Pablo Rubio, Juan Suárez, Carlos Sanjuan, Fernando Rodríguez de Fonseca, Francisco Alén, Marialuisa de Ceglia, Patricia Rivera

“…Abstract Background Certain events that occur in early life, such as changes in nutrition, can promote structural and functional modifications in brain development, projecting to either short, medium, and/or long terms, resulting in metabolic programming. …”
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Addressing Soil Fertility Challenges in Arid Agriculture: A Two-Year Evaluation of Combined Soil Organic Amendments Under Saline Irrigation by Houda Oueriemmi, Rahma Inès Zoghlami, Elie Le Guyader, Fatma Mekki, Yosra Suidi, Ali Bennour, Mohamed Moussa, Mahtali Sbih, Sarra Saidi, Xavier Morvan, Mohamed Ouessar

“…However, the sodium adsorption ratio (SAR) and the cation ratio of soil structural stability (CROSS) increased in soils amended with compost alone in the second crop year. …”
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A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice by Jonathan D. Douros, Aaron Novikoff, Barent DuBois, Rebecca Rohlfs, Jacek Mokrosinski, Wouter F.J. Hogendorf, Robert Augustin, Myrte Merkestein, Lene Brandt Egaa Martini, Lars Linderoth, Elliot Gerrard, Janos Tibor Kodra, Jenny Norlin, Nikolaj Kulahin Roed, Anouk Oldenburger, Stephanie A. Mowery, Maria Waldhoer, Diego Perez-Tilve, Brian Finan, Steffen Reedtz-Runge, Timo D. Müller, Patrick J. Knerr

“…The interpretations of these studies are limited by unknowns including how structural modifications to the biased GLP-1R agonist effect physiochemical properties of the molecules.…”
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FcRn-Driven Nanoengineered Mucosal Vaccine with Multi-Epitope Fusion Induces Robust Dual Immunity and Long-Term Protection Against <i>Brucella</i> by Tingting Tian, Yuejie Zhu, Kaiyu Shang, Huidong Shi, Ruixue Xu, Mingzhe Li, Fuling Pu, Junyu Kuang, Jianbing Ding, Fengbo Zhang

“…Methods: The study developed a recombinant antigen (h-tFc-MEV) through computational analyses to validate antigenicity, structural stability, solubility, and allergenic potential. …”
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(In<italic>_x</italic>Ga_1&#x2212;<italic>_x</italic>)₂O₃ Photodetectors Fabricated on Sapphire at Different Temperatures by PL... by Ke Zhang, Qian Feng, Lu Huang, Zhuangzhuang Hu, Zhaoqing Feng, Ang Li, Hong Zhou, Xiaoli Lu, Chunfu Zhang, Jincheng Zhang, Yue Hao

“…The (In<italic>_x</italic>Ga_1&#x2212;<italic>_x</italic>)₂O₃ photodetectors were fabricated on the single-crystalline (In<italic>_x</italic>Ga_1&#x2212;<italic> _x</italic>)₂O₃ films deposited on sapphire substrate by pulsed laser deposition. The structural and optical properties of the epilayers were investigated using high-resolution X-ray diffraction, X-ray photoelectron spectroscopy, spectroscopic ellipsometry, and transmittance spectra. …”
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Knowledge, attitude and practice of rehabilitation management of the caregivers of pediatric patients with hemiplegia by Ya Guo, Xiaoli Li, Gongwei Jia, Jiahong Zhan, Zhongyu He, Guangshen Yuan, Chunyan Liu, Yuanyuan Lai

“…Spearman correlation analysis explored relationships between variables, and structural equation modeling (SEM) examined direct effects. …”
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Comparisons of Characteristics and Nutritional Inadequacies in Indonesian Older Adults Consuming or Refraining from Dairy Products by Esthika Dewiasty, Siti Setiati, Rina Agustina, Rahmi Istanti, Arya Govinda Roosheroe, Murdani Abdullah, Hamzah Shatri, Edy Rizal Wahyudi, Ikhwan Rinaldi, Pradana Soewondo, Rudy Hidayat, Yudo Murti Mupangati, Nove Zain Wisuda, Lisette CPGM de Groot

“…We collected data on demographic and clinical characteristics as part of a routinely performed comprehensive geriatric assessment. A structured questionnaire was developed to categorize participants as dairy-or non-dairy users based on habitual dairy intake. …”
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ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus by Manish R. Balwani, Vivek B. Kute, Jigar Shrimali, Bharat G. Jagiasi, Pradip Kumar Bhattacharya, Amit Pasari, Manoj Gumber, Sanjeev Gulati, Raj Kanwar Yadav, Shankar Prasad Nagaraju, Gomathy Narasimhan, Natarajan Gopalkrishnan, Divyesh Engineer, Tushar Dighe, Jamal Rizvi, Sanjay P. Kolte, Vishal Vasant Ramteke, Nishant Shantanu Deshpande, Priyanka Tolani, Georgi Abraham, Abhijit Patil, Anurag Gupta, Dhananjai Agarwal, Dinesh Khullar, Narayan Prasad, Pratik Das, Radhika Krishna Patil, Ravi Mohanka, Sandeep Mahajan, Sourabh Sharma, Subho Banerjee, Vinant Bhargava, Jyoti Patodia, Arpita Ray Chaudhury, Aneesh Srivastava

“…It encourages critical care and transplant teams to perform structured assessments of organ viability, apply ethical principles, and pursue informed consent in line with local regulations.…”
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“Watch and wait” approach in the treatment of advanced radioiodine refractory differentiated thyroid cancer: a study of barriers and drivers of use by E. V. Borodavina, A. Yu. Shurinov, S. I. Kutukova, E. N. Nedozorova, A. V. Malanchuk, Yu. V. Semenchenko, S. M. Povarkov, K. V. Narovenkova, A. V. Khodkevich, Yu. V. Komoza, K. A. Kofanova, S. P. Dmitriev, E. B. Vasilyeva, S. A. Shikhamirova, M. N. Gorshenina, L. N. Volodina, O. A. Snezhko, O. A. Stativko, D. V. Xenodokhov, Yu. G. Dzhemageldieva, A. I. Khryapa, D. M. Ulimaeva, E. M. Dagba, M. V. Volkonsky, V. M. Filippova, M. O. Skorina, O. V. Romanchuk, I. I. Andrienko, M. V. Shorin, A. A. Ishchenko, R. A. Dumbrava, M. B. Bolieva, F. V. Tsarakhova, Z. A. Gojieva, S. S. Dzhamirzaeva, P. Z. Aidaeva, M. O. Maximov, I. S. Usoltseva, A. O. Milyukova, O. V. Toporkova, V. D. Sychev, S. A. Rudakov, S. T. Sagdieva, M. A. Klochikhin, V. V. Molokova, R. A. Skotnikov, E. N. Yeremina, Yu. A. Panaseikin, Ya. A. Tyugina, Yu. I. Murzina, S. O. Podvyaznikov

“…Materials and methods. We conducted 35 structured interviews with oncologists observing patients after radioiodine therapy in order to evaluate the “watch and wait” approach. unfortunately, data on use and prevalence of this approach in Russia are limited. …”
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Human exposure to green spaces and monoterpenes: discovery and use of α-pinene metabolites as biomarkers by Zhengzhi Xie, Saurin R. Sutaria, Jin Y. Chen, Hong Gao, Daniel J. Conklin, Rachel J. Keith, Sanjay Srivastava, Pawel Lorkiewicz, Aruni Bhatnagar

“…Through a combination of pseudo-targeted and untargeted analyses, we discovered 22 α-pinene metabolites post-inhalation including nine novel structures, with two confirmed against synthetic standards. …”
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Identification and isolation of human testicular peritubular myoid cells and Leydig cells by a combination of ITGA9 and NGFR by Sha Han, Liangyu Zhao, Jiaqiang Luo, Chenkun Shi, Chencheng Yao, Zhiyong Ji, Junwei Xu, Shuai Xu, Ruhui Tian, Erlei Zhi, Yuhua Huang, Xin Liu, Yuchuan Zhou, Zhi Zhou, Zheng Li, Peng Li

“…Results ITGA9+ /NGFR + cells were positive for markers of PTMs (SMA, CNN1) and negative for markers of ALCs (HSD3B, STAR), and were able to form tubular and spheroid structures in vitro. In contrast, ITGA9-/NGFR + cells were positive for ALC markers and negative for PTM markers, and showed a capacity of testosterone production in vitro. …”
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Game changers: scavenging materials for nonaqueous rechargeable battery applications by Xing Chen, Huanrui Zhang, Cizhen Luo, Chenhui Gao, Chenghao Sun, Rongxian Wu, Yifan Gong, Pengzhou Mu, Qingfu Wang, Guanglei Cui

“…We then describe and discuss scavenging materials having various structural characteristics and reaction chemistries with detrimental reactive species, as well as their positive role on battery performance and/or safety with respect to prominent nonaqueous rechargeable batteries, including lithium, sodium, zinc, and magnesium batteries. …”
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Genome evolution and diversity of wild and cultivated rice species by Weixiong Long, Qiang He, Yitao Wang, Yu Wang, Jie Wang, Zhengqing Yuan, Meijia Wang, Wei Chen, Lihua Luo, Laiyang Luo, Weibiao Xu, Yonghui Li, Wei Li, Longan Yan, Yaohui Cai, Huilong Du, Hongwei Xie

“…Additionally, 63,881 gene families absent in cultivated rice species but present in wild rice species are discovered. Extensive structural rearrangements, sub-genomes exchanges, widespread allelic variations, and regulatory sequence variations are observed in wild rice species. …”
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Lentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variants by Wenbo Wang, Qianqian Li, Jiajing Wu, Yu Hu, Gang Wu, Chuanfei Yu, Kangwei Xu, Xumei Liu, Qihui Wang, Weijin Huang, Lan Wang, Youchun Wang

“…We found lentil lectin could block the binding of ACE2 to S trimer and inhibit SARS-CoV-2 at the early steps of infection. Using structural information and determined N-glycan profile of S trimer, taking together with the carbohydrate specificity of lentil lectin, we provide a basis for the observed broad spectrum anti-SARS-CoV-2 activity. …”
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Impact of parental marital status on self-harm in Chinese primary school students: the mediating role of depression and the moderating effect of classmate relationships by Ming Ai, Xiao-Ming Xu, Wo Wang, JianMei Chen, Jinglan He, Qi Zhang, Su Hong, Yao Gan, Jun Cao, Daqin Ding, Jinhui Hu, Shuang Zhang, Li Kuang

“…Data were analyzed using SPSS 26.0 for descriptive statistics and Mplus 8.1 for structural equation modeling (SEM), assessing the effects of parental marital status on self-harm. …”
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An anti-idiotypic single domain antibody as Cry2Aa toxin mimotope and analysis of its binding region through molecular docking by Manman Lin, Guangjie Han, Chuanming Li, Lixin Huang, Qin Liu, Nan Zhang, Yang Xia, Yurong Lu, Xianjin Liu, Yuan Liu, Jian Xu, Johnson Lin

“…In this study, we aimed to isolate an anti-idiotypic single domain antibody against Cry2Aa from a naive phage-display library and investigate its structural and functional mimicry of the Cry2Aa toxin. …”
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Decoding the GRAS code: evolutionary phylogeny and functional diversification of a key gene family in Populus simonii by Junbo Chen, Guowei Yao, Xinru Bi, Yishuang Ren, Luping Jiang, Xiaoyu Xie, Lu Han, Wanying Chen, Yi Hao, Kewei Cai, Dandan Zhang, Xiyang Zhao

“…Conclusions This study systematically identified and characterized 89 GRAS genes in Populus simonii, revealing their uneven chromosomal distribution, conserved structural features, and diverse expression patterns across tissues and stress conditions. …”
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Faster efficacy and reduced nodule occurrence with PLLA (poly-l-lactic acid) porous microspheres by Qihua Cao, Qihua Cao, Qihua Cao, Jiayu Chen, Jiayu Chen, Jiayu Chen, Jiayu Chen, Zijun Zhang, Yufei Xiong, Jinxia Ma, Wei Sun, Xin Chen, Qilei Lou, Kaijia Tang, Kaijia Tang, Kaijia Tang, Kaijia Tang, Feng Lin, Feng Lin, Feng Lin, Yueliang Zhu, Yueliang Zhu, Yueliang Zhu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu

“…Post-euthanasia, tissue sections underwent histological examination through hematoxylin and eosin (H&amp;E) staining and Masson’s trichrome technique, with subsequent statistical analysis of the observational data.ResultsThe PLLA porous microsphere group demonstrated significantly faster onset of action compared to the control, with observable collagen deposition as early as week 2, enhanced inflammatory cell infiltration, more homogeneous tissue distribution, and substantially fewer microaggregates upon histological examination.DiscussionStructural modification of PLLA microspheres has successfully accelerated their onset of action while reducing nodule formation, thereby providing novel insights for clinical applications.…”
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