Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant Acinetobacter baumannii via cell membrane disruption and ROS induction by Yongtian Yuan, Yongtian Yuan, Liangliang Zhao, Zhuchun Bei, Baogang Wang, Dongna Zhang, Likun Xu, Jiahui Liu, Jiahui Liu, Meng Lv, Qin Xu, Yabin Song

“…Membrane permeability tests revealed that NQP disrupts cell membrane integrity, enhancing permeability—consistent with TEM/SEM observations showing significant structural damage in NQP-treated A. baumannii, including membrane rupture, cellular deformation, and cytoplasmic disorganization. …”
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Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without by Felix Eckstein, Wolfgang Wirth, Ali Guermazi, Frank Roemer, Michael Nevitt, Christoph Ladel, Leena Sharma, David J. Hunter, C. Kent Kwoh

“…It indicates further that the vKR criterion used here may be useful to explore relationships with other structural (imaging) assessments.…”
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Using Patient-Specific 3D-Printed C1–C2 Interfacet Spacers for the Treatment of Type 1 Basilar Invagination: A Clinical Case Report by Tim T. Bui, Alexander T. Yahanda, Karan Joseph, Miguel Ruiz-Cardozo, Bernardo A. de Monaco, Alexander Perdomo-Pantoja, Joshua P. Koleske, Sean D. McEvoy, Camilo A. Molina

“…<b>Background:</b> Type 1 basilar invagination (BI) is caused by a structural instability at the craniovertebral junction (CVJ) and has been historically treated with distraction and stabilization through fusion of the C1–C2 vertebrae. …”
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Integrated identification of immune-related therapeutic targets for interstitial cystitis via multi-algorithm machine learning: transcriptomic profiling and in vivo experimental va... by Yifan Wang, Chuanzan Zhou, Facai Zhang, Yunkai Yang, Jia Miao, Xuanhan Hu, Xinyu Zhang, Alin Ji, Qi Zhang

“…Molecular docking demonstrated strong binding affinity between IFI27 and Acetohexamide (-19.91 ± 0.98 kcal/mol) or Resiniferatoxin (-32.98 ± 1.74 kcal/mol), with dynamics simulations confirming structural stability. In vivo, both compounds significantly reduced bladder inflammation (p&lt;0.05), with Acetohexamide showing superior efficacy in downregulating IFI27 expression and systemic pro-inflammatory cytokines.ConclusionsThis multi-omics study deciphered immune dysregulation in IC/BPS and established a robust diagnostic framework. …”
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Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis by Scott Sun, Scott Sun, Konstance Knox, Alexander Romashko, Madhu Kundu, Haiying Zhu, Meei-Li Huang, Denise M. Malicki, Denise M. Malicki, John R. Crawford, John R. Crawford, John R. Crawford

“…Retrospective immunohistochemical analysis of the original medulloblastoma revealed HHV-6 late structural glycoprotein H antigens in peritumoral lymphocytes. …”
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South Africa’s male homicide epidemic: Who is killing men and why do we ignore the victims? by Richard Matzopoulos, Morna Cornell, Brett Bowman, Lorna J. Martin, Rachel Jewkes, Naeema Abrahams

“…Broad population-based approaches are required to address the insidious effect of recalcitrant societal norms and structural interventions to overcome the root causes of poverty and inequality and the poor control of alcohol and firearms. …”
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Research trends and hot spots in obesity-induced pain: A bibliometric analysis of the last 20 years by Lei Gao, Yazhou Wen, Kunlin Guo, Renqi Li, Mao Mao, Shanwu Feng, Xian Wang

“…He and colleagues noted a significant correlation between obesity and pain in terms of clinical manifestations, but this connection is indirect and is modulated by certain biomechanical and structural alterations linked to obesity, inflammatory agents, mood disorders, sleep disturbances, and lifestyles. …”
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Nutritional Status and Health Challenges Among Schoolchildren in Nepal’s Solukhumbu Valley by María Teresa Murillo-Llorente, Noemí Gil-Cuñat, Sara Moltó-Dominguez, Javier Pérez-Murillo, Manuel Tejeda-Adell, Miriam Martínez-Peris, Francisco Tomás-Aguirre, María Ester Legidos-García, Marcelino Pérez-Bermejo

“…Conclusions: The findings reveal a high burden of undernutrition and anemia among children in Solukhumbu, linked to poor diet and structural vulnerability. Urgent, community-based interventions—including nutrition education, agricultural diversification, and improved healthcare access—are needed. …”
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High-fat diet promotes lipotoxicity in the podocytes of uninephrectomized mice: a targeted lipidomics and kidney podocyte-specific analysis by Se-Hyun Oh, You-Jin Kim, Subin Bae, Hee-Yeon Jung, So-Young Park, Jeong-Hoon Lim, Jang-Hee Cho, Chan-Duck Kim, Sun-Hee Park, Tae-Hwan Kwon, Yong-Jin Kim, Kwang-Hyeon Liu, Yong-Lim Kim

“…This accumulation potentially contributes to structural and functional deterioration in the kidney and highlights its role in kidney damage and its potential as a therapeutic target in metabolic kidney diseases.…”
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Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids by Jiaying Zhang, Yahui Feng, Ning Zhang, Xiaoqing Wang, Dongmei Li, Dongmei Shi

“…Additionally, ALA-PDT directly induced ferroptosis in KFs, evidenced by characteristic structural destruction. Further studies showed ALA-PDT significantly activated the ferroptosis signaling pathway in KFs, modulating key molecules (GPX4, ACSL4, NOX-1, SLC7A11, NCOA4). …”
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Spatial Localization of Broadleaf Species in Mixed Forests in Northern Japan Using UAV Multi-Spectral Imagery and Mask R-CNN Model by Nyo Me Htun, Toshiaki Owari, Satoshi N. Suzuki, Kenji Fukushi, Yuuta Ishizaki, Manato Fushimi, Yamato Unno, Ryota Konda, Satoshi Kita

“…These consistent improvements across diverse forest conditions highlight the effectiveness of integrating spectral (RGB and NIR) and structural (CHM) data. These findings underscore the value of integrating UAV multi-spectral imagery with deep learning techniques for reliable, large-scale identification of tree species and forest monitoring.…”
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Human Differentiated Adipocytes as Surrogate Mature Adipocytes for Adipocyte-Derived Extracellular Vesicle Analysis by Mangesh Dattu Hade, Bradley L. Butsch, Paola Loreto Palacio, Kim Truc Nguyen, Dharti Shantaram, Sabrena F. Noria, Stacy A. Brethauer, Bradley J. Needleman, Willa Hsueh, Eduardo Reátegui, Setty M. Magaña

“…Brightfield microscopy revealed that difAdipos exhibited morphological characteristics comparable to mature adipocytes (mAdipos) directly isolated from visceral adipose tissue, confirming their structural similarity. Additionally, qPCR analysis demonstrated decreased preadipocyte markers and increased mature adipocyte markers, further validating successful differentiation. …”
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OCTA changes of retinal microvessels and thickness in moyamoya disease by Xian-Zhe Qian, Cheng Chen, Hong-Liang Li, Lei Zhong, Hong Wei, Qian-Min Ge, Jin-Yu Hu, Qi Hong, Xiao-Yu Wang, Yan-Mei Zeng, Xu Chen, Yi-Xin Wang, Chong-Gang Pei, Yi Shao

“…Abstract Moyamoya disease (MMD) is a structural abnormality of the cerebral vasculature characterized by cerebral ischemia, and is rare but its incidence is increasing. …”
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Study on the effects of urea addition on the fermentation quality, nitrogen metabolism, microbial community, and metabolic characteristics of cotton strawlage by Shuaibin Zhou, Zhenxin Zhu, Xiaoping Chen, Qiuju Pu, Shuai Liu, Yuheng Luo, Yongbin Shao, Yaoqiang Sun, Xinwen Sun, Cuiling Shang, Wen Shen, Dengke Hua, Xinfeng Wang

“…After 45 days of fermentation, samples of the strawlage were collected and analyzed for their chemical composition, fermentation quality, nitrogen fractions, bacterial community, and metabolic characteristics.ResultCompared to the U0 group, the U3 group significantly increased total nitrogen (TN), non-protein nitrogen (NPN), acetic acid, and propionic acid contents by 17.93%, 0.08%, 13.26%, and 0.01%, respectively, while significantly reducing free gossypol and non-structural nitrogen (NSN) levels by 48.50% and 14.22%, respectively, thereby optimizing the protein composition of cotton straw. …”
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Climate, soil and management factors drive the quantitative relationships between soil fertility and spring maize water productivity in northern China by Jiao Shi, Minggang Xu, Xinhua He, Huaiping Zhou, Jianhua Li

“…The random forest, partial least squares structural equation modeling and variance partitioning analysis were then applied to address the quantitative relationships (QRs) and relevant differences. …”
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Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…Statistical analyses included: Analysis of Variance (ANOVA) and Permutational Multivariate Analysis of Variance (PERMANOVA) to test interannual differences; Non-metric Multidimensional Scaling (NMDS) to visualize community structure; Pearson correlation analysis to examine relationships among diversity indices; and Multiple Linear Regression (MLR) models to quantify the driving effects of riparian land use on fish diversity. …”
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Fertilization Alters Indicator Species Serving as Bioindicators for Evaluating Agricultural Practices Related to Maize Grain Yield by Guoqiang Li, Jiaqing Liu, Wenya Zhang, Jvshui Hu, Peng Shi, Gehong Wei

“…Results showed that fertilization significantly altered soil properties, increased maize grain yield by 23.9%, and reshaped bacterial and fungal community structures, increasing bacterial richness by 23% but reducing fungal richness and Shannon index by 15% and 20%, respectively. …”
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Synthesis and biological evaluation of 1,4-pentadien-3-one derivatives containing 1,2,4-triazole by Mei Chen, Yihui Wang, Shijun Su, Ying Chen, Feng Peng, Qing Zhou, Tingting Liu, Hui Luo, Hua Wang, Wei Xue

“…A series of new 1,4-pentadien-3-one derivatives containing 1,2,4-triazole moiety were synthesized. The structures of the synthesized compounds were charactered via 1H NMR, 13C NMR and HRMS. …”
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Impact of three sequential orthogeriatric care models on time to surgery after hip fracture: a retrospective study by Sabine Drevet, Jérôme Tonetti, Pierre Bouzat, Mehdi Boudissa, Jules Greze, Olga Fajfrova, Laure Allan-Pattoglia, Frederic Olive, Magali Bouisse, Bastien Boussat, Catherine Bioteau, Gaetan Gavazzi

“…Monitoring TTS is key to finding the optimal model, but strong professional values and structures are vital.…”
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Bioassay-Guided Isolation of <i>cis</i>-Clerodane Diterpenoids and Monoglycerides from the Leaves of <i>Solidago gigantea</i> and Their Antimicrobial Activities by Márton Baglyas, Péter G. Ott, Zoltán Bozsó, Ildikó Schwarczinger, József Bakonyi, Dénes Dlauchy, András Darcsi, Szilárd Varga, Ágnes M. Móricz

“…The bioassay-guided isolation procedure included thin-layer chromatography (TLC) coupled with a <i>Bacillus subtilis</i> antibacterial assay, preparative flash column chromatography, and TLC–mass spectrometry (MS). Their structures were elucidated via extensive spectroscopic and spectrometric techniques such as one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and high-resolution tandem mass spectrometry (HRMS/MS). …”
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