Enzyme‐Responsive Nanoparachute for Targeted miRNA Delivery: A Protective Strategy Against Acute Liver and Kidney Injury by Songhang Li, Yuxuan Zhao, Xiaoying Lyu, Ye Chen, Tao Zhang, Shiyu Lin, Zhiqiang Liu, Xiaoxiao Cai, Taoran Tian, Yunfeng Lin

“…Abstract MicroRNA (miRNA)‐based therapy holds significant potential; however, its structural limitations pose a challenge to the full exploitation of its biomedical functionality. …”
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Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration by Yue-Qi Zhang, Rong Nie, Zi-Yuan Feng, Ming-Hui Fan, Zhi-Xue Shen, Xiu-Zhen Zhang, Qing-Yi Zhang, Chen-Yu Zou, Ji-Ye Zhang, Kai Huang, Li-Ping Mou, Hui-Qi Xie

“…Abstracts: This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering strategies can modulate efferocytosis to optimize these biological processes. The manuscript is structured to first establish a fundamental understanding of efferocytosis, encompassing its core concepts, molecular mechanisms, and physiological functions within tissue repair. …”
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Investigation on the aerobic methanotrophic community and the dominant taxon Methylomarinum in seagrass ecosystem by Tongyin Liang, Junde Dong, Weiguo Zhou, Xiaofang Huang, Hongbin Liu, Yuhang Zhang, Qingsong Yang, Manzoor Ahmad, Luxiang Chen, Juan Ling

“…Moreover, the methanotrophic community structure was characterized by amplicon sequencing, and the dominant methanotroph’s metagenome-assembled genome (MAG) and metabolic pathway was investigated. …”
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Efficacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cell carcinoma: a phase II trial by Zhongzheng Xiang, Xiaoyuan Wei, Zhuoyuan Zhang, Yueyang Tang, Linyan Chen, Chenfeng Tan, Yuanyuan Zeng, Jun Wang, Guile Zhao, Zelei Dai, Mingmin He, Ningyue Xu, Chunjie Li, Yi Li, Lei Liu

“…Exploratory analysis showed that patients with MPR exhibited higher density of baseline CD4_Tfh_CXCL13 cells, and increased density of tertiary lymphoid structures after NAIC. Baseline CD4_Tfh_CXCL13 cells might be potential predictive biomarker of efficacy. …”
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FAST Reveals New Evidence for M94 as a Merger by Ruilei Zhou, Ming Zhu, Yanbin Yang, Haiyang Yu, Lixia Yuan, Peng Jiang, Wenzhe Xi

“…Our results demonstrate that high-sensitivity and wide-field H i imaging is important in revealing diffuse cold gas structures and tidal debris, which is crucial to understand the dynamical evolution of galaxies.…”
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Improving the provision of clinical pharmacy services in low- and middle-income countries: a qualitative study in tertiary health facilities in Tanzania by Fredrick Kalokola, Dorkasi L Mwakawanga, Ritah F Mutagonda, Hamu J Mlyuka, Wigilya P Mikomangwa, Manase Kilonzi, Wema A Kibanga, Alphonce Ignace Marealle, Bertha Mallya, Deogratias Katabalo, Sofia Sanga, John Rwegasha, Rose Magambo, John Mmassy, Sungwa Kabissi, Josephine A Balati, Peter Maduki, Omary Mashiku Minzi, Appolinary A R Kamuhabwa

“…The reported challenges in providing CPS include healthcare structures, public policies, resources, workforce, culture and education inequalities. …”
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The Disks In Scorpius–Centaurus Survey (DISCS). I. Four Newly Resolved Debris Disks in Polarized Intensity Light by Justin Hom, Thomas M. Esposito, Katie A. Crotts, Gaspard Duchêne, Jennifer Patience, Johan Mazoyer, Robert J. De Rosa, Christine H. Chen, Paul Kalas, Bruce Macintosh, Brenda C. Matthews

“…We identify morphological structures that may be indications of planet–disk interactions. …”
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Improving the high stress abrasive wear resistance of medium carbon quenched and partitioned bainitic steel by controlling the phase transformation sequence by Qiangguo Li, Wandong Li, Mingwei Li, Minghua Su, Zhihua Hu, Hongbo Ma, Zhengyun Wang, Tong Li, Yanan Zhang

“…The wear loss of the B-Q&P sample is lower than that of the Q-B&P and Q&T samples, which can be ascribed to the improved toughness and enhanced surface microhardness that come from the transformation of retained austenite, the production of nanoscale crystalline structures, and the accumulation of dislocation defects. …”
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Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults by Ting Ge, Ting Ge, Ting Ge, Guixin He, Guixin He, Guixin He, Qian Cui, Qian Cui, Qian Cui, Shuangcui Wang, Shuangcui Wang, Shuangcui Wang, Zekun Wang, Yingying Xie, Yingying Xie, Yingying Xie, Yuanyuan Tian, Yuanyuan Tian, Yuanyuan Tian, Juyue Zhou, Juyue Zhou, Juyue Zhou, Wentao Li, Wentao Li, Baohui Wang, Keming Zhang, Jianchun Yu, Jianchun Yu

“…Differences in PBL phenotypes by age group and gender were analyzed using the Wilcoxon rank-sum test. In addition, linear regression analysis was performed to examine the associations between the CD4+/CD8+ ratio and various PBL subsets.ResultsComparative analysis demonstrated that infants had significantly higher absolute counts of CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and both CD4+ and CD8+ subsets of Tn, Tscm, Tcm, and Temra (p < 0.001), despite significantly lower percentages of these cell types (p < 0.001). …”
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Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets by Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu

“…ABSTRACT Extracellular matrix (ECM) is a dynamic, three‐dimensional network that provides structural support and regulates key biological processes, including cell adhesion, migration, differentiation, and signal transduction. …”
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Sixty Degrees of Solutions: Field Techniques for Human–Jaguar Coexistence by John Polisar, Rafael Hoogesteijn, Almira Hoogesteijn, Diego Francis Passos Viana, Skarleth Johana Chinchilla Valdiviezo, Carlos Valderrama Vásquez, Allison Loretta Devlin, Ranni José Arias Herrera, Margaux Babola, Frederick Bauer, Ivonne Cassaigne Guasco, Chia Yu Chang, Daniel Corrales Gutiérrez, J. Antonio De la Torre, Wezddy Del Toro-Orozco, Aline Kotz, Duston Larsen, Nicolás Lodeiro Ocampo, Daniel Monzón, Carmen Angélica Morante Ascanio, Ricardo Daniel Ortiz-Hoyos, Pablo Gastón Perovic, Grasiela Edith de Oliviero Porfirio, María Fernanda Puerto Carrillo, Paul Raad, Thiago Reginato, Yina Paola Serna, Claudio Sillero-Zubiri, Laura Villalba, Armand Ziller

“…Throughout this geographical breadth, jaguars represent an essential component of native biological diversity, but conflict revolving around real and perceived jaguar depredation on livestock is a factor in jaguar mortality. We developed a structured questionnaire to evaluate the effectiveness of anti-depredation strategies from northern Mexico to Argentina, collecting data from 11 countries and 248 livestock operations, 194 with efficacy metrics, and 24 with benefit–cost ratios (value of the livestock losses averted/cost of the intervention). …”
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Improved Constraints on the Faraday Rotation toward Eight Fast Radio Bursts Using Dense Grids of Polarized Radio Galaxies by Ayush Pandhi, B. M. Gaensler, Ziggy Pleunis, Sebastian Hutschenreuter, Casey Law, Ryan Mckinven, Shane P. O’Sullivan, Emily B. Petroff, Tessa Vernstrom

“…Despite the positions of all eight FRBs being located far from the Galactic plane, we constrain previously unresolved small-scale Galactic RM structures around six of the eight FRBs. In two of these fields, we find potential changes in the sign of the Galactic RM that are not captured by previous, sparsely sampled RM grid observations. …”
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Project quality, regulation quality by Elena Mussinelli

“…The didactics of design, which have long been the focus of Architecture studies, rarely envisage a structured discussion on regulatory and normative aspects, leaving them to the discretion of professors. …”
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High-entropy argyrodite glass–ceramic electrolytes for all-solid-state batteries by Jing Lin, Mareen Schaller, Ruizhuo Zhang, Volodymyr Baran, Hao Liu, Ziming Ding, Sylvio Indris, Aleksandr Kondrakov, Torsten Brezesinski, Florian Strauss

“…Collectively, the results highlight the importance of considering structural aspects across different length scales when optimizing the properties of lithium argyrodites for SSB applications.…”
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Comportamiento mecánico de mezclas de resina furanopoxídica con polisulfuros para su uso como adhesivos de alta resistencia. Acción de las cargas estáticas. // Mechanical behaviour... by D. Díaz Batista, M. Dopico Paz, J. L. García González, M. E. Rodríguez Dorrego, A. Gómez Estévez, M. Torres Ferrer, A. Gutierrez Castrezana

“…Four substrates commonly used in<br />structural parts were evaluated.</p><p><br />Key words: Resin, polysul fyde, high strength adhesive.…”
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Impact of residential density on heavy metal mobilization in urban soils: Human activity patterns and eco-health risks in the Beijing-Tianjin-Hebei region by Siyu Wang, Lingqing Wang, Xiaoyong Liao, Guangjin Zhou, Yizhong Huan, Shun Li, Tao Liang

“…Co-occurrence network and Partial Least Squares Structural Equation Modeling (PLS-SEM) suggested that human activities may indirectly influence metal dispersion by altering soil organic carbon (TOC) and nitrogen dynamics, rather than directly increasing bulk metal content. …”
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RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis by Xuhang Wang, Yuhan Zhang, Xinru Chen, Kailai Fu, Jiaqi Cui, Jiaoling Wu, Yu Sun, Jianluan Ren, Feng Xue, Jianjun Dai, Fang Tang

“…Brain microvascular endothelial cells (BMECs), the primary structural component of the BBB, play a central role in defending against pathogen invasion. …”
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Integrated multi-omics analyses of molecular pathways underlying microcystin-LR toxicity in the earthworm Eisenia fetida by Xiang Liu, Wen-Hua Zhai, Rao Liu, Bai-Lin Liu, Rong-Jun Gao, Yan-Wen Li, Lei Xiang, Quan-Ying Cai, Hai-Ming Zhao, Ce-Hui Mo

“…MC-LR exposure induced dose-dependent structural damage to the epidermal and intestinal tissues, disrupting antioxidant systems while elevating detoxification enzyme activity. …”
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Collecting Data on the Social Determinants of Health to Advance Health Equity in Cancer Care in Canada: Patient and Community Perspectives by Jacqueline L. Bender, Eryn Tong, Ekaterina An, Zhihui Amy Liu, Gilla K. Shapiro, Jonathan Avery, Alanna Chu, Christian Schulz-Quach, Sarah Hales, Alies Maybee, Ambreen Sayani, Andrew Pinto, Aisha Lofters

“…In phase 2, broader perspectives were sought through a community consultation with patient partners experiencing structural inequality (<i>n</i> = 15). Most participants were comfortable with SDOH data collection. …”
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NQO1 antagonizes PM2.5-induced apoptosis of Sertoli cells by activating the UPRmt pathway by Cao Wang, Qing Xiao, Mingchen Xiao, Yu Chu, Yaya Ai, Zhen Luo, Guangxu Zhou, Kaiyi Mao, Bin Liu

“…Phenotypic analysis showed that PM2.5 exposure significantly increased intracellular ROS levels (P < 0.01), induced structural disintegration of mitochondrial cristae (as observed by TEM), and activated apoptosis pathways. …”
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