Point-of-care testing of nitrite in oral medicine - Application and validation of an enzymatic biosensor in human saliva by Sara Rodrigues Gaspar, Luís Proença, Ricardo Alves, Maria Gabriela Almeida

“…The nitrite biosensor achieved a suitable linear range of 5–300 μM, with a sensitivity of 0.015 μM−1, validated against the gold-standard Griess method. …”
Get full text

Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 by Xing-An Jiang, Xing-An Jiang, Hong-Li Zhang, Bin-Tao Ye, Shao-Qi Fang, Jia-Jin Zhang, Hao-Lin Yu, Jun-Bo Liang, Jun-Bo Liang

“…The relationship between RFM and lumbar BMD was assessed through weighted multiple linear regression models, subgroup analyses, and smooth curve fitting.ResultsAfter adjusting for multiple covariates, RFM exhibited a statistically significant inverse relationship with lumbar spine BMD. …”
Get full text

Simulation of Net Ecosystem Carbon Flux in Rice Planting Area of Yangtze River Delta based on Multi-layer Perceptron Model by Wenyang XI, Jianjun HE, Zhilin WANG, Lifeng GUO, Yarong LI

“…The Yangtze River Delta in China is a typical rice planting area， and its carbon source and sink have significant impacts on regional climate and environment.This study systematically examines the relationship between NEE and various meteorological factors in the Yangtze River Delta region and reveals that NEE exhibits the strongest correlation with solar short-wave radiation （R=-0.68）， followed by a robust linear association with humidity-related parameters （saturated water vapor pressure difference， relative humidity）.Additionally， diurnal variations are evident in the correlations between NEE and solar radiation， temperature， humidity factor， wind speed， and friction velocity.Based on these analyses， this paper constructed a multi-layer perceptron （MLP） model for simulating rice undersurface NEE in the Yangtze River Delta using observed NEE data alongside meteorological observations.The simulation performance and spatiotemporal stability of this model are evaluated.Results demonstrate that the constructed MLP model effectively captures NEE patterns； it achieves an R value of 0.88 with respect to observed values within the training set while maintaining an RMSE of 5.34 μmol·m-2·s-1.Moreover， this MLP model performs well when predicting NEE in the Yangtze River Delta region as evidenced by high correlation coefficients （>0.78） between simulated results and observations at Dongtai and Shouxian stations-indicating good spatiotemporal stability of the model's predictions.Notably， this MLP model demonstrates superior performance when capturing daily variations in daytime mean NEE compared to nighttime mean values.The research results reveal the main meteorological factors affecting rice carbon cycling， provide support for understanding the spatiotemporal distribution characteristics of carbon cycling in rice planting areas of the Yangtze River Delta， and have important significance for accurately evaluating global and regional carbon flux.…”
Get full text

Development of a four autophagy-related gene signature for active tuberculosis diagnosis by Baoyan Ren, Feng Jia, Qixun Fang, Jingping Xu, Jingping Xu, Kangfeng Lin, Kangfeng Lin, Renhui Huang, Zhenqiong Liu, Xingan Xing, Xingan Xing

“…The optimal gene signature was selected based on optimal performance through a linear Support Vector Machine (SVM) classifier with cross-validation. …”
Get full text

Change of the elasticity COEFFICIENT of the walls of the common carotid artery as a predictor of adverse cardiovascular events in hypertensive patients after ischemic hemispheric s... by O. A. Lisovaya

“…Multivariate analysis showed that after exclusion of all indicators with a high level of mutual associations among the variables that have demonstrated the existence of an independent significant association in linear regression with a total value of cardiovascular events elasticity (R = -0,76; P = 0,006), the level of total MS (R = 0,55; P = 0,009), and LDL cholesterol in plasma (R = 0,62; P = 0,014), diabetes mellitus type 2 (R = 0,62; P = 0,004) remained. …”
Get full text

Psychiatric hospitalizations in the Unified Health System: an observational study on hospitalization rates from 2012 to 2023 by Karen Murakami Yano, Paola Zucchi, Maykon Anderson Pires de Novais

“…The joinpoint regression model used a log-linear method to set up a series of connected lines on a logarithmic scale and the Monte Carlo permutation method to figure out the direction or statistical significance. …”
Get full text

Use of lung ultrasound in the differential diagnosis of the causes of dyspnea by Bulatović Kristina, Ristić-Anđelkov Anđelka, Perić Vladan, Todorović Jovana, Pandrc Milena, Gojka Gabrijela, Vraneš Danijela, Šipić Maja, Rašić Dragiša, Milenković Aleksandra, Aritonović-Pribaković Jelena, Perić Milica

“…The mean number of “comets” among patients without HF was 8.0 ± 3.7 (p ˂ 0.001). Multivariate linear regression analyses showed the association between the number of “comets” and HF (p ˂ 0.001). …”
Get full text

Socioeconomic disparities in anthropometric status among primary school children: A potential association with school meals. by Mohammed Abdulrahman Alhassan, Fatima Alhasan

“…Statistical analyses included multivariate linear regression to assess predictors of growth and nutritional status, alongside group comparisons using appropriate statistical tests.…”
Get full text

First report of Echinococcus canadensis (G7) in backyard pigs from the western highlands of Guatemala by Roderico Hernández-Chea, Américo Yoel Aragón-Méndez, Alejandro Hun, Paola Morales-Ramírez, Ilde Silva, Federico Villatoro, Marion Wassermann

“…Species identification was performed using nested polymerase chain reaction targeting the cox1 gene, and a haplotype network was constructed. Generalized linear models (GLMs) were applied to assess correlation between cysts fertility, sex of the pig and diameter of the cyst. …”
Get full text

Development of a Colloidal Gold-Based Immunochromatographic Strip Targeting the Nucleoprotein for Rapid Detection of Canine Distemper Virus by Zichen Zhang, Zhuangli Bi, Qingqing Du, Miao Zhang, Linying Cai, Yiming Fan, Jingjie Tang, Mingxing Hu, Shiqiang Zhu, Aoxing Tang, Guijun Wang, Guangqing Liu, Yingqi Zhu

“…The results showed that both mAbs belong to the IgG1 subclass with kappa light chains. 1D3E9 was found to recognize the linear epitope ⁴¹⁰AGPKQSQITFLH⁴²¹, while 1H9B7 targeted the epitope ⁴⁵⁰HFNDERFPGH⁴⁵⁹. …”
Get full text

Exploiting Microperimetry as a Functional End Point in Healthy Aging and Different Stages of Age-Related Macular Degeneration by Johannes Schrittwieser, MD, Klaudia Birner, MD, Leonard M. Coulibaly, MD, Ursula Schmidt-Erfurth, MD, Gregor S. Reiter, MD, PhD

“…Group comparison was performed using linear mixed-effects models and a discriminant analysis to find the parameters that best discriminated the respective AMD stage. …”
Get full text

Evaluation of camelina seed pods as a novel feed ingredient for ruminants: nutritional value, fermentation characteristics and nutrient digestibility by Alireza Jolazadeh, Ayoub Azizi, Afrooz Sharifi, Fatemeh Memarzadeh, Nazanin Fallali, Elham Imani-Rad

“…The activity of fibrolytic enzymes, including CMCase, increased linearly (L, P < 0.05) with higher levels of CSP in the diet. …”
Get full text

Comparison of the clinical performance of a hybrid Alba 4D and the AMC-4 locoregional hyperthermia systems by Akke Bakker, Remko Zweije, H. Petra Kok, Lukas J. A. Stalpers, G. Henrike Westerveld, Karel A. Hinnen, Geertjan van Tienhoven, M. Willemijn Kolff, Hans Crezee

“…Possible differences between Alba 4D and AMC-4 sessions in power, achieved temperature T0, T10, T50, T90, T100, treatment time and complaints per session, were evaluated using linear mixed models (LMMs) for repeated measures with patient as random effect.Results From March 2018 to April 2019, eleven patients with cervical, pancreatic, vaginal carcinoma and uterine leiomyosarcoma received 27 locoregional hyperthermia sessions with the Alba 4D and 34 sessions with the AMC-4. …”
Get full text

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformula... by Abdul Mateen, Abad Khan, Ismail Khan, Saifullah Khan Khalil, Lateef Ahmad, Muhammad Junaid, Saqib Jehan, Muhammad Sohail Anwar, Muhammad Faheem, Abdul Salam

“…The internal standard concentration was kept constant (1.0 μg/mL) in all samples. The method was linear for both sorafenib and dexamethasone in the concentration ranges of 25–1,000 ng/mL and 50–2,000 ng/mL, respectively, with a correlation coefficient (r2) of 0.999 for both the analytes. …”
Get full text

Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation by Kristína Mitterová, Eva Výtvarová, Anežka Kovářová, Martin Lamoš, Jan Fousek, Irena Rektorová

“…Robust analyses, such as PERMANOVA, Spearman correlations and general linear models were conducted to study the relationships. …”
Get full text

Lanes, clusters, sightlines: modelling patient flow in medical clinics by Kerstin Sailer, Martin Utley, Rosica Pachilova, Ahmed Tarek Zaky Fouad, Xiaoming Li, Hari Jayaram, Paul J. Foster

“…Moorfields Eye Hospital NHS Trust therefore opened an additional clinic designed with a linear spatial layout and patient flow system, which is analysed in this paper in comparison with an existing clinic. …”
Get full text

Association of weight-adjusted waist index with all-cause and cardiovascular disease mortality among rheumatoid arthritis population: a cohort study from the NHANES 1999–2018 by Song Liu, Siyuan Chen, Yifeng Huang, Qizhang Man, Ying Yang, Jinfeng Wen, Hao Xie, Lei Fan

“…RCS analysis revealed two distinct patterns: the relationship between WWI and all-cause mortality followed an inverted-U configuration, whereas cardiovascular mortality demonstrated a linear association with WWI. Survival analysis indicated that RA patients with lower WWI measurements demonstrated markedly improved survival outcomes. …”
Get full text

Maternal urinary levels of PAH metabolites, umbilical cord blood telomere length and anthropometric indices in newborns by Xiang Li, Xiaofeng Yu, Xin Lian, Longdan Kang, Lei Yang, Fang Ba

“…We employed multiple linear regression (MLR), generalized quantile g-computation (g-comp), Bayesian Kernel Machine Regression (BKMR), and mediation analysis to comprehensively assess the associations between PAH exposure and umbilical TL and neonatal outcomes. …”
Get full text

Housing type and risk of depression – the mediating effects of perceived indoor annoyances and loneliness: a Danish cohort study, 2000–2018 by Anne Marie Kirkegaard, Stine Kloster, Michael Davidsen, Anne Illemann Christensen, Klaus Martiny, Carlo Volf, Steffen Loft, Niss Skov Nielsen, Lars Gunnarsen, Annette Kjær Ersbøll

“…The association between housing type and depression was estimated by using a generalised linear model with Poisson distribution of the number of incident depressions and a logarithmic transformation of risk time as offset. …”
Get full text

Perioperative and oncological outcomes of single position retroperitoneoscopic radical nephroureterectomy for upper urinary tract urothelial carcinoma by Jiaqiang Chen, Luxin Zhang, Zhihong Dai, Cheng Chang, Heyao Tong, Hepeng Cui, Zhuwei Song, Bo Fan, Zhiyu Liu, Liang Wang

“…The data were analyzed using the Mann-Whitney test, Fisher’s exact test, Chi-square test. Linear regressions were applied to explore the effect of surgery approach on the continuous outcomes. …”
Get full text