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67481
The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies
Published 2025-12-01“…Monoclonal antibodies (mAbs) feature a conserved N-linked glycosylation site in the CH2 domain, which exhibits heterogeneities in both occupancy and glycan structures. Previous studies have suggested that the unoccupied (nonglycosylated) variant exhibits decreased thermal stability, potentially impacting the overall stability of mAb products. …”
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67482
On the correlation between static and dynamic mechanical properties in architected lattice materials
Published 2025-08-01“…Metamaterials are multiscale architected structures with design inspired by nature, which can offer multifunctional properties that surpass those of conventional materials. …”
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67483
Mite Domatia and Associated Mite Density in a North American Eastern Deciduous Forest in Michigan
Published 2025-04-01“…We scored 16 common woody species in a wooded natural area for the presence and number of mite domatia—small structures on the underside of plant leaves that are known to house mutualistic mites. …”
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67484
A plasmonic meta-rotary travelling-wave oscillator with ultrahigh phase accuracy and figure of merit
Published 2025-08-01“…This study demonstrates that Meta-RTWO achieves a significant improvement in both output signal quadrature accuracy and FOM under process limitations without using additional phase adjustment structures.…”
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67485
Fabrication of Ultra‐Thick Masks for X‐Ray Phase Contrast Imaging at Higher Energy
Published 2025-04-01“…The translation to higher energy for industrial applications, where energies above 150 keV are often needed, is hindered by the lack of masks/gratings with sufficiently thick gold septa. Fabricating such structures with apertures of tens of micrometers becomes difficult at depths greater than a few hundreds of micrometers due to aspect ratio‐dependent effects such as anisotropic etching, and preferential gold (Au) deposition at the top of the apertures. …”
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67486
Enantioseparation of new axially chiral carboxylic acids on polysaccharide-based chiral stationary phases under normal phase elution conditions
Published 2023-06-01“…In particular, the impact of analyte and CSP structures on the enantioseparation outcomes as well as mechanisms and noncovalent interactions underlying the enantioseparation were explored by using electrostatic potential analysis and molecular dynamics (MD) simulations.…”
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67487
Launch dynamics modeling and simulation of box-type multiple launch rocket system considering plane clearance contact
Published 2025-05-01“…As the performance of the box-type multiple launch rocket system (BMLRS) improves, its mechanical structures, particularly the plane clearance design between the slider on the rocket and the guide inside the launch canister, have grown increasingly complex. …”
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67488
Usefulness of an intraoperative flipped monitor in laparoscopic surgery with situs inversus totalis: a case report of laparoscopic-assisted ileocecal resection
Published 2024-01-01“…We checked the range of the mobilized region and important anatomical structures by watching the flipped monitor as needed. …”
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67489
Role of LncRNA MRPS28 in Secondary Hair Follicle Development of Cashmere Goats
Published 2025-06-01“…This, in turn, inhibits the formation of dermal papilla structures and ultimately affects the morphogenesis of secondary hair follicles during the embryonic period. …”
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67490
The Pro-Angiogenic Potential of Periodontal Ligament Stem Cells and Dental Pulp Stem Cells: A Comparative Analysis
Published 2025-06-01“…Consistently, VEGF-A gene expression level and its quantification in cell-conditioned media of PDLSCs and DPSCs was comparable between them, and both promoted the formation of vessel-like structures, when co-cultured with HMEC-1 cells. All together, these results showed the heterogeneity of PDLSCs and DPSCs, which are constituted of different cellular subsets, likely modulated by the microenvironmental cues. …”
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67491
Synthesis of Dendritic Oligo‐Glycerol Amphiphiles with Different Hydrophobic Segments to Improve their Performance as Nanocarriers
Published 2025-08-01“…The results show that these amphiphiles form a very uniform micellar supramolecular structures that is independent of the hydrophobic system. …”
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67492
Quinoa Protein/Sodium Alginate Complex-Stabilized Pickering Emulsion for Sustained Release of Curcumin and Enhanced Anticancer Activity Against HeLa Cells
Published 2025-08-01“…The coacervation behavior of QPI and SA was investigated from pH 1.6 to 7.5, and the structural and interfacial characteristics of the complexes were analyzed using zeta potential measurements, Fourier-transform infrared spectroscopy, scanning electron microscopy, and contact angle analysis. …”
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67493
Theory of mind and impulsivity mediate the relationship between anxiety and non-suicidal self-injury in adolescents with depressive disorder
Published 2025-07-01“…Anxiety, depression, impulsivity, NSSI, cognitive ToM, and affective ToM were assessed using the Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, Barratt Impulsivity Scale, Adolescent Self-Harm Scale, Yoni task, and Hinting task. A structural equation model was developed using AMOS 24.0 to investigate the underlying mechanisms of NSSI. …”
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67494
YOLOv9-LSBN: An Improved YOLOv9 Model for Cotton Pest and Disease
Published 2025-01-01“…The RepLanLsk module replaces RepNCSPELAN4 in YOLOv9, dynamically adjusting receptive fields through reparameterizable convolutions and spatial attention, enhancing multi-scale feature diversity while maintaining computational efficiency via structural reparameterization during inference. A simplified weighted bidirectional feature pyramid network is integrated to strengthen bidirectional feature fusion and suppress background interference. …”
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67495
Homozygous FIGLA missense variant in two Japanese sisters with primary ovarian insufficiency: Case reports and literature review
Published 2025-01-01“…(Tyr113Cys)‐FIGLA protein was assessed as “pathogenic” or “likely pathogenic” by protein structural predictions, and was evaluated as “destabilizing” or “decrease stability” by protein stability predictions Conclusion The results, in conjunction with the data reported in the literature, imply that FIGLA variants account for a small but certain fraction of non‐syndromic POI, and pose a question as to the relevance of FIGLA variants to an autosomal dominant form of POI, although FIGLA variants have been identified in both autosomal dominant and autosomal recessive forms of non‐syndromic POI.…”
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67496
A review on the strategy equilibrium stability analysis of demand-side participation in the electricity market from an evolutionary game perspective
Published 2025-05-01“…With the increasing penetration of renewable energy sources, there has been a profound structural transformation in electricity markets, particularly in the operational paradigm where demand-side resources participate in market mechanisms. …”
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67497
Characterizing the Mechanical Performance of Laser Welded Lap Transverse Fillet Joints of Thick AISI 316L Stainless Steel
Published 2025-08-01“… Fillet and double fillet welding are extensively used in numerous structural applications around the globe. Laser welding technology has achieved great appeal due to its superior quality, accuracy, speed, adaptability, and versatility. …”
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67498
Cardiovascular Remodeling and Potential Controversies in Master Endurance Athletes—A Narrative Review
Published 2025-07-01“…Previous research also indicated potential structural, functional, and electrical remodeling in MAs due to prolonged and repeated exposure to high-intensity endurance exercise—a condition known as athlete’s heart. …”
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67499
Next-generation nanocomposites: Optimizing Al2O3-CuO-ZnO and reduced graphene oxide for enhanced performance
Published 2025-01-01“…Nanomaterials with improved optical, magnetic, antibacterial, adsorption, anticorrosive, and photocatalytic characteristics were synthesized, showing synergistic behavior. To understand key structural features, the NCs were thoroughly examined using energy-dispersive X-ray analysis, SEM, X-ray diffraction, FTIR, and UV-Vis. spectroscopy. …”
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67500
Assessing the Effect of Artificial Intelligence Anxiety on Turnover Intention: The Mediating Role of Quiet Quitting in Turkish Small and Medium Enterprises
Published 2025-02-01“…The obtained data were analyzed through structural equation modeling. In addition to detecting significant relationships between concepts as a result of the analysis, it was realized that AI anxiety did not have a considerable effect directly on turnover intention; however, this effect occurred indirectly through quiet quitting. …”
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