Development of a bispecific antibody–drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors by Meiying Luo, Xiaohuan Wang, Guoji Yu, Jing Ji, Long Li, Fan Song

“…We then modified them into monovalent structures and selected clones with decreased binding and endocytosis activities. …”
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Research on the Influence of the Parameters of the “AO-Shaped” Skywell of Traditional Huizhou Residential Houses on the Indoor Wind Environment by Wenjia Pan, Bin Cheng

“…The objective of this study was twofold: firstly, to examine the characteristics of traditional Chinese residential skywell; and secondly, to investigate and develop climate-adaptive technologies for these structures. To this end, a study was conducted on the Huizhou skywell architecture in China. …”
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Clinical applications of photon-counting CT in neuroimaging by LÜ Haiying, LU Yong, HE Naying

“…At present, PCCT holds broad clinical application prospects in the field of neuroimaging, especially demonstrating unique advantages in the visualization of fine intracranial structures, the diagnosis and treatment monitoring of intracranial aneurysms, and the diagnosis and treatment of intracranial artery stenosis and spinal vascular lesions. …”
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Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia by Mehmet Bulut, Aylin Yaman, Muhammet Kazim Erol, Fatma Kurtuluş, Devrim Toslak, Berna Doğan, Deniz Turgut Çoban, Ebru Kaya Başar

“…CT was reduced in ATD patients and MCI patients. Since vascular structures were affected in ATD patients and MCI patients, they had thin CT. …”
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Drivers of toxic element accumulation in terrestrial ecosystems across elevational gradients by Baba Imoro Musah, Jie Yang, Guorui Xu

“…The accumulation of toxic elements threatens terrestrial biodiversity by disrupting food chains, altering community structures, and causing individual mortality. These disruptions also pose risks to human health through contaminated food sources and food webs, potentially leading to health issues like cancer, organ damage, and reproductive challenges. …”
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Comprehensive Evaluation of <i>Nanhaia speciosa</i> Germplasm Resources Using Agronomic Traits, Molecular Markers, and Metabolomics by Jing Yang, Nanchen Lai, Yiqin Zheng, Ruifeng Ji, Ping Wang, Wei Dai, Gantao Cheng, Xin He

“…The results revealed notable differences in DNA barcodes and secondary structures across the germplasms, with the <i>atp</i>F-<i>atp</i>H sequence successfully distinguishing all 19 germplasms into distinct varieties. …”
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DMoC-UNet: A Dynamic Mixture-of-Convolution Network for Enhanced Pathological Image Segmentation by Jingwei Zhu, Lining Qin, Zixin Teng, Xiaomin Li, Kuiwu Li, Haoran Chu

“…Existing methods face challenges in addressing complex and diverse tissue structures, multi-scale features, and blurred boundaries, limiting their segmentation accuracy and generalization across datasets. …”
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Possibilities of statistical methodology in the study of economic security of the region by Dmitry V. Dianov, Elena A. Radugina

“…., both economic and financial security is estimated, in fact, a polygamous system of indicators on all aspects of financial and economic activity.Purpose: therefore, the purpose of this scientific work, defined as the improvement of information support structures, decision-making in relation to economic security, fully meets the needs of management science and practice.Materials and methods: At the same time, all the methods, necessary for the statistical study of economic and financial security are used in the work: at each stage, an extensive block of statistical tools is involved, represented by the methods of the general theory of statistics and mathematical statistics, including multidimensional groups – cluster analysis, correlation and regression methods. …”
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Probing the Plasmon Coupling, Quantum Yield, and Effects of Tip Geometry of Gold Nanoparticle Using Analytical Models and FDTD Simulation by Abu S. M. Mohsin, Mariam B. Salim

“…Moreover, we believe that our in-depth analysis of AuNP laid the foundation to determine the scattering cross-section, QY, and near-field enhancement for more complex structures and geometries of other novel materials. …”
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Point of Care Ultrasound Guided Management of Lateral Ankle Sprains: A Case Series by Matthew Bush, Jon Umlauf, Bryan Pickens

“…Each grade of ankle sprain corresponded to levels of bracing for the protection of injured structures with each patient receiving physical therapy care based on rehabilitation guidelines. …”
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Global Aerosol Climatology from ICESat-2 Lidar Observations by Shi Kuang, Matthew McGill, Joseph Gomes, Patrick Selmer, Grant Finneman, Jackson Begolka

“…Regional analyses cover the Arabian Sea (ARS), Arabian Peninsula (ARP), South Asia (SAS), East Asia (EAS), Southeast Asia (SEA), the Americas, and tropical oceans. Vertical aerosol structures reveal strong trans-Atlantic dust transport from the Sahara in summer and biomass burning smoke transport from the Savanna during dry seasons. …”
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Simrec: a similarity measure recommendation system for mixed data clustering algorithms by Abdoulaye Diop, Nabil El-Malki, Max Chevalier, André Péninou, Geoffrey Roman-Jimenez, Olivier Teste

“…Abstract Clustering algorithms play a pivotal role in data mining, offering powerful tools for uncovering hidden patterns and structures within datasets. These algorithms aim to divide data points into coherent groups based on similarities or dissimilarities, making it easier to explore and understand complex data. …”
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Rapid, season-specific PCR testing versus traditional diagnostics for pneumonia in the emergency department by Yangxiu Yu, Qiuping Li

“…Implementation in other settings should consider local pathogen seasonality, workflow, and cost structures.…”
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NLP-like deep learning aided in identification and validation of thiosulfinate tolerance clusters in diverse bacteria by Brendon K. Myers, Anuj Lamichhane, Brian H. Kvitko, Bhabesh Dutta

“…Leveraging sequences from the RefSeq bacterial database, we conducted comparative analyses of gene synteny, gene/protein sequences, protein structures, and predicted protein interactions. This approach enabled the discovery of several novel alt-like clusters previously undetectable by other methods, which were further validated experimentally. …”
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DEICTIC MITIGATION VS COMMISSIVE ACTS IN POLITICAL INTERVIEW (BASED ON THE MODERN EUROPEAN DISCOURSE OF AID TO UKRAINE) by Nataliia K. Kravchenko, Sviatoslav I. Vylinskyi, Oleksandr I. Yudenko

“…Thirdly, we have singled out and specified a set of illocution-mitigating deictic devices, including means of role-playing deixis, epistemological modal verbs and their substitutes, which denote or connotate semes of “capabilities” and “possibilities”, means of negation, temporary deixis devices, i.e. the lexical and grammatical markers of future tense, resulting in the vagueness of promises / obligations; presuppositional adverbs with inference pattern of “impediment to a promised action”; passive structures that withdraw the speaker from the position of phrasal subject and an agent of the promising action; verbs and adverbs, which in their inference patterns contain the denotative or contextually connotated semes of a temporal reference to an indefinite future; metonymic generalization of the agent of action. …”
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Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility by Kecheng Li, Xiaoli Zhou, Wenna Liu, Yange Wang, Zilong Zhang, Houbin Zhang, Li Jiang

“…The homozygous <i>Sdccag8</i> mutant mice exhibit male infertility characterized by multiple morphological abnormalities of the flagella (MMAF) and dysmorphic structures in the sperm manchette. A mechanistic study revealed that the SDCCAG8 protein is localized to the manchette and centrosomal region and interacts with PCM1, the scaffold protein of centriolar satellites, through its CC domains 5–7. …”
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Wild Service Tree (Sorbus torminalis (L.) Crantz): A Review of Autecology, Silviculture, Dispersal Potential, and Response to Climate Change by Ćemal Višnjić, Besim Balić, Mehmed Čilaš, Sead Vojniković

“…When combined with other drought-resistant tree species, it may contribute to stabilizing forest structures and mitigating the impacts of climate change.…”
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Canna indica silver nanoparticles (AgNPs): a green alternative for medicine by Mathivathani Kandiah, Naiha Rizan, Beneli Gunaratne, Ominda Perera

“…Aim: The science of manipulating matter at almost atomic scales to create new structures and devices that function at nanoscale dimensions is known as nanotechnology, which is essential to many sciences, such as medicine and environment. …”
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Association of TLR2 Arg753Gln gene polymorphism with its expression level in nonagenarians with frailty by S. O. Lukyanova, O. V. Artemieva, E. D. Nasaeva, L. V. Gankovskaya

“…TLR2 is an exceptional pattern-recognizing receptor because of its ability to heterodimerise with different types of TLRs, which allows it to recognize a wide range of molecular structures on the surface of pathogens. Polymorphisms in genes involved in the TLRs signaling cascade may be a factor in host susceptibility to the development of inflammation, affecting the outcome of a number of infectious diseases and immune diseases. …”
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Investigating the scour at piers of successive bridges with debris accumulation by Mahmoud Saleh Al-Khafaji, Layth Abdulameer, Aysar Tuama Al-Awadi, Najah M. L. Al Maimuri, Ahmed N. Al-Dujaili

“…The results revealed that an upstream bridge reduces scour depth at downstream piers by 30–40%, highlighting the protective role of hydraulic interactions between successive structures. Debris accumulation significantly increased contraction scour due to flow constriction, with scour depths rising by up to 40.5% under high discharge, but had minimal impact on pier scour, which remained dominated by localized vortices. …”
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