Depletion of conventional CD4+ T cells is required for robust priming and dissemination of tumor antigen-specific CD8+ T cells in the setting of anti-CD4 therapy by Keisuke Shirai, Tiffany Chen, Mary Jo Turk, Delaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Joseph D Phillips, Pamela C Rosato, Yina H Huang

“…We also show that depletion of CD4-expressing antigen-presenting cell subsets is not required for anti-CD4 efficacy. …”
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Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma by Won Hyung Park, In Kang, Keun Bon Ku, Chae Won Kim, Yumin Kim, Byeong Hoon Kang, Jeongwoo La, Stephen Ahn, Sung Ki Lee, Heung Kyu Lee

“…Several studies have explored ways to preserve stem-like T cells and prevent terminal exhaustion. …”
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Adversarial denoising of EEG signals: a comparative analysis of standard GAN and WGAN-GP approaches by Imad Eddine Tibermacine, Samuele Russo, Francesco Citeroni, Giuseppe Mancini, Abdelaziz Rabehi, Amal H. Alharbi, El-Sayed M. El-kenawy, El-Sayed M. El-kenawy, Christian Napoli, Christian Napoli, Christian Napoli

“…In contrast, the conventional GAN model excelled in preserving finer signal details, reflected in a PSNR of 19.28 dB and a correlation coefficient exceeding 0.90 in several recordings. …”
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Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes by Anushka Deshpande, Leo Weirauch, Tapan Kumar Baral, Marco Steier, Ankush Borlepawar, Manju Kumari, Lucia S. Kilian, Karsten Richter, Elke Hammer, Derk Frank, Constanze Schmidt, Norbert Frey, Ashraf Y. Rangrez

“…By disrupting OXPHOS, calcium handling, and cell survival pathways, Letm1 contributes to ischemic remodeling and cardiac dysfunction. Targeting Letm1 presents a promising therapeutic strategy to alleviate ischemic damage and preserve cardiac function. …”
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Physiological mechanisms of 2,4-epibrassinolide treatment in enhancing salt-alkali stress tolerance in Corylus heterophylla × C. avellana hybrid seedlings by MA Chao, CHEN Weiqing, LIU Zaiguo, HAO Jing, ZHAO Mengjiong, LU Juan

“…[Objective] The present study was conducted to assess the impact of exogenous 2,4-epibrassionolide (EBR) on the growth and physiological responses of Corylus heterophylla × C. avellana hybrid seedlings under saline-alkali stress, with the objective of enhancing their tolerance to such adverse conditions. …”
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A study of morpho-phonological processes in the Zanjani dialect of Azerbaijani Turkish based on optimality theory by farnaz ebadi, Mohammad Reza Oroji, Sakine Jafari, Mehri Talkhabi

“…Considering that a considerable portion of Iran's population speaks Azerbaijani Turkishm and the Zanjani dialect is part of it, studying it is a necessary step toward preserving our country's cultural and linguistic heritage. …”
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Characterization of Malnutrition in Atrial Functional Mitral Regurgitation by Tsukasa Murakami, MD, PhD, Nobuyuki Kagiyama, MD, PhD, Tomohiro Kaneko, MD, PhD, Kazuki Kagami, MD, PhD, Masashi Amano, MD, PhD, Taiji Okada, MD, PhD, Yukio Sato, MD, PhD, Yohei Ohno, MD, PhD, Kimi Sato, MD, PhD, Kojiro Morita, MPH, PhD, RN, PHN, Tomoko Machino-Ohtsuka, MD, PhD, Yukio Abe, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Patients with a decreased GNRI over time had higher rates of the composite outcome than those with preserved GNRI (adjusted hazard ratio, 3.83; 95% confidence interval, 1.97-7.43; P < 0.01). …”
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