Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence

Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence

Summary: While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therap...

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Bibliographic Details
Main Authors: Natanael Zarco, Athanassios Dovas, Virginea de Araujo Farias, Naveen K.H. Nagaiah, Ashley Haddock, Peter A. Sims, Dolores Hambardzumyan, Christian T. Meyer, Peter Canoll, Steven S. Rosenfeld, Rajappa S. Kenchappa
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224025367
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