Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury
Traumatic brain injury (TBI) represents a significant global public health issue, with effective management posing numerous challenges. The pathophysiology of TBI is typically categorized into two phases: primary and secondary injuries. Secondary injury involves pathophysiological mechanisms such as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1515164/full |
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| author | Jiaying Shi Jiaying Shi Jiaying Shi Jiajia Tang Jin Xu Ning Jiang Yuanwei Yang Honglin Chen Yuhan Han Yuhan Han Yuhan Han Xianhua Fu |
| author_facet | Jiaying Shi Jiaying Shi Jiaying Shi Jiajia Tang Jin Xu Ning Jiang Yuanwei Yang Honglin Chen Yuhan Han Yuhan Han Yuhan Han Xianhua Fu |
| author_sort | Jiaying Shi |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) represents a significant global public health issue, with effective management posing numerous challenges. The pathophysiology of TBI is typically categorized into two phases: primary and secondary injuries. Secondary injury involves pathophysiological mechanisms such as blood-brain barrier (BBB) disruption, mitochondrial dysfunction, oxidative stress, and inflammatory responses. Current pharmacological strategies often encounter obstacles in treating TBI effectively, primarily due to challenges in BBB penetration, inadequate target site accumulation, and off-target toxicity. Versatile hydrogels and nanoparticles offer potential solutions to these limitations. This review discusses recent progress in utilizing hydrogels and nanoparticles for TBI treatment over the past 5 years, highlighting their relevance to the underlying injury pathophysiology. Hydrogels and nanoparticles demonstrate substantial promise in addressing secondary brain injury, providing a broad spectrum of future therapeutic opportunities. |
| format | Article |
| id | doaj-art-fff4ecdf009442988716389440c4c43f |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-fff4ecdf009442988716389440c4c43f2025-01-06T06:58:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15151641515164Applications of hydrogels and nanoparticles in the treatment of traumatic brain injuryJiaying Shi0Jiaying Shi1Jiaying Shi2Jiajia Tang3Jin Xu4Ning Jiang5Yuanwei Yang6Honglin Chen7Yuhan Han8Yuhan Han9Yuhan Han10Xianhua Fu11Department of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaDepartment of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, ChinaTraumatic brain injury (TBI) represents a significant global public health issue, with effective management posing numerous challenges. The pathophysiology of TBI is typically categorized into two phases: primary and secondary injuries. Secondary injury involves pathophysiological mechanisms such as blood-brain barrier (BBB) disruption, mitochondrial dysfunction, oxidative stress, and inflammatory responses. Current pharmacological strategies often encounter obstacles in treating TBI effectively, primarily due to challenges in BBB penetration, inadequate target site accumulation, and off-target toxicity. Versatile hydrogels and nanoparticles offer potential solutions to these limitations. This review discusses recent progress in utilizing hydrogels and nanoparticles for TBI treatment over the past 5 years, highlighting their relevance to the underlying injury pathophysiology. Hydrogels and nanoparticles demonstrate substantial promise in addressing secondary brain injury, providing a broad spectrum of future therapeutic opportunities.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1515164/fulltraumatic brain injuryhydrogelnanoparticledrug deliveryneuroprotection |
| spellingShingle | Jiaying Shi Jiaying Shi Jiaying Shi Jiajia Tang Jin Xu Ning Jiang Yuanwei Yang Honglin Chen Yuhan Han Yuhan Han Yuhan Han Xianhua Fu Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury Frontiers in Bioengineering and Biotechnology traumatic brain injury hydrogel nanoparticle drug delivery neuroprotection |
| title | Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury |
| title_full | Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury |
| title_fullStr | Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury |
| title_full_unstemmed | Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury |
| title_short | Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury |
| title_sort | applications of hydrogels and nanoparticles in the treatment of traumatic brain injury |
| topic | traumatic brain injury hydrogel nanoparticle drug delivery neuroprotection |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1515164/full |
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