Gut microbiota mediated T cells regulation and autoimmune diseases
Gut microbiota regulates the immune system, the development and progression of autoimmune diseases (AIDs) and overall health. Recent studies have played a crucial part in understanding the specific role of different gut bacterial strains and their metabolites in different AIDs. Microbial signatures...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1477187/full |
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| author | Nabeel Khalid Bhutta Xiujin Xu Cuiqin Jian Yifan Wang Yi Liu Jinlyu Sun Bingnan Han Shandong Wu Ansar Javeed |
| author_facet | Nabeel Khalid Bhutta Xiujin Xu Cuiqin Jian Yifan Wang Yi Liu Jinlyu Sun Bingnan Han Shandong Wu Ansar Javeed |
| author_sort | Nabeel Khalid Bhutta |
| collection | DOAJ |
| description | Gut microbiota regulates the immune system, the development and progression of autoimmune diseases (AIDs) and overall health. Recent studies have played a crucial part in understanding the specific role of different gut bacterial strains and their metabolites in different AIDs. Microbial signatures in AIDs are revealed by advanced sequencing and metabolomics studies. Microbes such as Faecalibacterium prausnitzii, Akkermansia muciniphila, Anaerostipes caccae, Bacteroides sp., Roseburia sp., Blautia sp., Blautia faecis, Clostridium lavalense, Christensenellaceae sp., Coprococcus sp., Firmicutes sp., Ruminococcaceae sp., Lachnospiraceae sp., Megamonas sp., Monoglobus sp., Streptococcus pneumoniae and Bifidobacterium sp. help maintain immune homeostasis; whereas, Prevotella copri, Ruminococcus gnavus, Lactobacillus salivarius, Enterococcus gallinarum, Elizabeth menigoseptica, Collinsella sp., Escherichia sp., Fusobacterium sp., Enterobacter ludwigii, Enterobacteriaceae sp., Proteobacteria, Porphyromonas gingivalis, Porphyromonas nigrescens, Dorea sp., and Clostridium sp. cause immuno-pathogenesis. A complex web of interactions is revealed by understanding the influence of gut microbiota on immune cells and various T cell subsets such as CD4+ T cells, CD8+ T cells, natural killer T cells, γδ T cells, etc. Certain AIDs, including rheumatoid arthritis, diabetes mellitus, atopic asthma, inflammatory bowel disease and non-alcoholic fatty liver disease exhibit a state of dysbiosis, characterized by alterations in microbial diversity and relative abundance of specific taxa. This review summarizes recent developments in understanding the role of certain microbiota composition in specific AIDs, and the factors affecting specific regulatory T cells through certain microbial metabolites and also focuses the potential application and therapeutic significance of gut microbiota-based interventions as novel adjunctive therapies for AIDs. Further research to determine the precise association of each gut bacterial strain in specific diseases is required. |
| format | Article |
| id | doaj-art-ffc759fdd74d43b99cab591f7bcd56b1 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-ffc759fdd74d43b99cab591f7bcd56b12024-12-19T16:37:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-12-011510.3389/fmicb.2024.14771871477187Gut microbiota mediated T cells regulation and autoimmune diseasesNabeel Khalid Bhutta0Xiujin Xu1Cuiqin Jian2Yifan Wang3Yi Liu4Jinlyu Sun5Bingnan Han6Shandong Wu7Ansar Javeed8Laboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaLaboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaLaboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaLaboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaHangzhou Zheda Dixun Biological Gene Engineering Co., Ltd., Hangzhou, ChinaBeijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Department of Allergy, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaLaboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaHangzhou Zheda Dixun Biological Gene Engineering Co., Ltd., Hangzhou, ChinaLaboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaGut microbiota regulates the immune system, the development and progression of autoimmune diseases (AIDs) and overall health. Recent studies have played a crucial part in understanding the specific role of different gut bacterial strains and their metabolites in different AIDs. Microbial signatures in AIDs are revealed by advanced sequencing and metabolomics studies. Microbes such as Faecalibacterium prausnitzii, Akkermansia muciniphila, Anaerostipes caccae, Bacteroides sp., Roseburia sp., Blautia sp., Blautia faecis, Clostridium lavalense, Christensenellaceae sp., Coprococcus sp., Firmicutes sp., Ruminococcaceae sp., Lachnospiraceae sp., Megamonas sp., Monoglobus sp., Streptococcus pneumoniae and Bifidobacterium sp. help maintain immune homeostasis; whereas, Prevotella copri, Ruminococcus gnavus, Lactobacillus salivarius, Enterococcus gallinarum, Elizabeth menigoseptica, Collinsella sp., Escherichia sp., Fusobacterium sp., Enterobacter ludwigii, Enterobacteriaceae sp., Proteobacteria, Porphyromonas gingivalis, Porphyromonas nigrescens, Dorea sp., and Clostridium sp. cause immuno-pathogenesis. A complex web of interactions is revealed by understanding the influence of gut microbiota on immune cells and various T cell subsets such as CD4+ T cells, CD8+ T cells, natural killer T cells, γδ T cells, etc. Certain AIDs, including rheumatoid arthritis, diabetes mellitus, atopic asthma, inflammatory bowel disease and non-alcoholic fatty liver disease exhibit a state of dysbiosis, characterized by alterations in microbial diversity and relative abundance of specific taxa. This review summarizes recent developments in understanding the role of certain microbiota composition in specific AIDs, and the factors affecting specific regulatory T cells through certain microbial metabolites and also focuses the potential application and therapeutic significance of gut microbiota-based interventions as novel adjunctive therapies for AIDs. Further research to determine the precise association of each gut bacterial strain in specific diseases is required.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1477187/fullmuciniphilaAnaerostipes caccaeBacteroides sp.Roseburia sp.Blautia sp.Blautia faecis |
| spellingShingle | Nabeel Khalid Bhutta Xiujin Xu Cuiqin Jian Yifan Wang Yi Liu Jinlyu Sun Bingnan Han Shandong Wu Ansar Javeed Gut microbiota mediated T cells regulation and autoimmune diseases Frontiers in Microbiology muciniphila Anaerostipes caccae Bacteroides sp. Roseburia sp. Blautia sp. Blautia faecis |
| title | Gut microbiota mediated T cells regulation and autoimmune diseases |
| title_full | Gut microbiota mediated T cells regulation and autoimmune diseases |
| title_fullStr | Gut microbiota mediated T cells regulation and autoimmune diseases |
| title_full_unstemmed | Gut microbiota mediated T cells regulation and autoimmune diseases |
| title_short | Gut microbiota mediated T cells regulation and autoimmune diseases |
| title_sort | gut microbiota mediated t cells regulation and autoimmune diseases |
| topic | muciniphila Anaerostipes caccae Bacteroides sp. Roseburia sp. Blautia sp. Blautia faecis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1477187/full |
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