Dual targeting of CXCR4 and EZH2 in endometriosis

Dual targeting of CXCR4 and EZH2 in endometriosis

Summary: We recently showed that endometriotic peritoneal fluid (PF) altered the regulation of enhancer of zeste homolog 2 (EZH2) and H3K27me3. This study aimed to determine if PF by regulating EZH2/H3K27me3 modulated C-X-C chemokine receptor type 4 (CXCR4), a major chemokine involved in the prolife...

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Bibliographic Details
Main Authors: Sarah Brunty, Kassey Wagner, Taylor Fleshman, Morgan Ruley, Brenda Mitchell, Nalini Santanam
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Body substance sample
Disease
Epigenetics
Small molecule
Treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225004031
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