Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis
Obesity is a major health burden with an increased risk of cardiovascular morbidity and mortality. Endothelial dysfunction is pivotal to the development of cardiovascular disease (CVD). In relation to this, adipose tissue secreted factors termed “adipokines” have been reported to modulate endothelia...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/648239 |
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| author | Raghu Adya Bee K. Tan Harpal S. Randeva |
| author_facet | Raghu Adya Bee K. Tan Harpal S. Randeva |
| author_sort | Raghu Adya |
| collection | DOAJ |
| description | Obesity is a major health burden with an increased risk of cardiovascular morbidity and mortality. Endothelial dysfunction is pivotal to the development of cardiovascular disease (CVD). In relation to this, adipose tissue secreted factors termed “adipokines” have been reported to modulate endothelial dysfunction. In this review, we focus on two of the most abundant circulating adipokines, that is, leptin and adiponectin, in the development of endothelial dysfunction. Leptin has been documented to influence a multitude of organ systems, that is, central nervous system (appetite regulation, satiety factor) and cardiovascular system (endothelial dysfunction leading to atherosclerosis). Adiponectin, circulating at a much higher concentration, exists in different molecular weight forms, essentially made up of the collagenous fraction and a globular domain, the latter being investigated minimally for its involvement in proinflammatory processes including activation of NF-κβ and endothelial adhesion molecules. The opposing actions of the two forms of adiponectin in endothelial cells have been recently demonstrated. Additionally, a local and systemic change to multimeric forms of adiponectin has gained importance. Thus detailed investigations on the potential interplay between these adipokines would likely result in better understanding of the missing links connecting CVD, adipokines, and obesity. |
| format | Article |
| id | doaj-art-ffadfa486ae34f3da5251d3eb7a4f62f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ffadfa486ae34f3da5251d3eb7a4f62f2025-02-03T05:47:33ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/648239648239Differential Effects of Leptin and Adiponectin in Endothelial AngiogenesisRaghu Adya0Bee K. Tan1Harpal S. Randeva2Division of Translational and Systems Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UKDivision of Translational and Systems Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UKDivision of Translational and Systems Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UKObesity is a major health burden with an increased risk of cardiovascular morbidity and mortality. Endothelial dysfunction is pivotal to the development of cardiovascular disease (CVD). In relation to this, adipose tissue secreted factors termed “adipokines” have been reported to modulate endothelial dysfunction. In this review, we focus on two of the most abundant circulating adipokines, that is, leptin and adiponectin, in the development of endothelial dysfunction. Leptin has been documented to influence a multitude of organ systems, that is, central nervous system (appetite regulation, satiety factor) and cardiovascular system (endothelial dysfunction leading to atherosclerosis). Adiponectin, circulating at a much higher concentration, exists in different molecular weight forms, essentially made up of the collagenous fraction and a globular domain, the latter being investigated minimally for its involvement in proinflammatory processes including activation of NF-κβ and endothelial adhesion molecules. The opposing actions of the two forms of adiponectin in endothelial cells have been recently demonstrated. Additionally, a local and systemic change to multimeric forms of adiponectin has gained importance. Thus detailed investigations on the potential interplay between these adipokines would likely result in better understanding of the missing links connecting CVD, adipokines, and obesity.http://dx.doi.org/10.1155/2015/648239 |
| spellingShingle | Raghu Adya Bee K. Tan Harpal S. Randeva Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis Journal of Diabetes Research |
| title | Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis |
| title_full | Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis |
| title_fullStr | Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis |
| title_full_unstemmed | Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis |
| title_short | Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis |
| title_sort | differential effects of leptin and adiponectin in endothelial angiogenesis |
| url | http://dx.doi.org/10.1155/2015/648239 |
| work_keys_str_mv | AT raghuadya differentialeffectsofleptinandadiponectininendothelialangiogenesis AT beektan differentialeffectsofleptinandadiponectininendothelialangiogenesis AT harpalsrandeva differentialeffectsofleptinandadiponectininendothelialangiogenesis |